DE60005502D1 - 4'-c-ethynyl-purin-nukleoside - Google Patents

4'-c-ethynyl-purin-nukleoside

Info

Publication number
DE60005502D1
DE60005502D1 DE60005502T DE60005502T DE60005502D1 DE 60005502 D1 DE60005502 D1 DE 60005502D1 DE 60005502 T DE60005502 T DE 60005502T DE 60005502 T DE60005502 T DE 60005502T DE 60005502 D1 DE60005502 D1 DE 60005502D1
Authority
DE
Germany
Prior art keywords
ethynyl
nucleosides
purine
hydrogen atom
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005502T
Other languages
English (en)
Other versions
DE60005502T2 (de
Inventor
Hiroshi Ohrui
Eiichi Kodama
Satoru Kohgo
Hiroaki Mitsuya
Masao Matsuoka
Kenji Kitano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Corp
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of DE60005502D1 publication Critical patent/DE60005502D1/de
Application granted granted Critical
Publication of DE60005502T2 publication Critical patent/DE60005502T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60005502T 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside Expired - Lifetime DE60005502T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP13153999 1999-05-12
JP17492099 1999-06-22
JP17492099 1999-06-22
JP31824699 1999-11-09
JP31824699 1999-11-09
JP2000081117 2000-03-23
JP2000081117 2000-03-23
PCT/JP2000/003025 WO2000069877A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl purine nucleosides

Publications (2)

Publication Number Publication Date
DE60005502D1 true DE60005502D1 (de) 2003-10-30
DE60005502T2 DE60005502T2 (de) 2004-06-24

Family

ID=27471622

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60005502T Expired - Lifetime DE60005502T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside
DE60005501T Expired - Lifetime DE60005501T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60005501T Expired - Lifetime DE60005501T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside

Country Status (10)

Country Link
US (3) US6291670B1 (de)
EP (2) EP1177202B1 (de)
AT (2) ATE250623T1 (de)
AU (2) AU4431300A (de)
BR (1) BR0011521B8 (de)
CA (2) CA2308677C (de)
DE (2) DE60005502T2 (de)
ES (1) ES2207504T3 (de)
MX (1) MXPA01011517A (de)
WO (2) WO2000069877A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005502T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-purin-nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
JP2005536440A (ja) * 2001-09-28 2005-12-02 イデニクス（ケイマン）リミテツド ４’位が修飾されたヌクレオシドを使用するフラビウイルスおよびペスチウイルスの治療のための方法および組成物
AU2003211483A1 (en) * 2002-02-15 2003-09-04 Yamasa Corporation 4'-c-cyano-2'-deoxypurine nucleosides
BRPI0407374A (pt) 2003-02-19 2006-01-10 Univ Yale Análogos de nucleosìdeo antiviral e métodos para tratar infecções virais, especialmente infecções de hiv
CA2502109C (en) 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
DE602005015466D1 (de) 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
AU2006294807B2 (en) 2005-09-26 2013-01-17 Gilead Pharmasset Llc Modified 4'-nucleosides as antiviral agents
EP2361922B1 (de) 2006-10-10 2012-08-22 Janssen Products, L.P. Zwischenprodukt zur Herstellung von HCV-Nukleosin Inhibitoren
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
HUE041509T2 (hu) 2011-12-22 2019-05-28 Janssen Biopharma Inc Szubsztituált nukleozidok, nukleotidok és ezek analógjai
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9862743B2 (en) 2013-10-11 2018-01-09 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
CA2998646C (en) 2015-09-23 2021-05-18 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof
WO2018092728A1 (ja) 2016-11-16 2018-05-24 国立研究開発法人国立国際医療研究センター 抗ウイルス活性等の生理活性を有するヌクレオシド誘導体
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
MX2020006864A (es) * 2017-12-27 2020-11-11 Univ Emory Modalidades combinadas para inhibidores de nucleosidos y/o nadph oxidasa (nox) como agentes antivirales especificos de mieloides.
WO2020014041A1 (en) * 2018-07-09 2020-01-16 Merck Sharp & Dohme Corp. Enzymatic synthesis of 4'-ethynyl nucleoside analogs
US20210323993A1 (en) * 2018-08-30 2021-10-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
UA128041C2 (uk) 2019-01-25 2024-03-20 Браун Юніверсіті Спосіб лікування пов'язаного з віком запалення у пацієнта
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
TW202200161A (zh) 2020-03-20 2022-01-01 美商基利科學股份有限公司 4’-c-經取代-2-鹵基-2’-去氧腺苷核苷之前藥及其製造與使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005502T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-purin-nukleoside

Also Published As

Publication number Publication date
BR0011521A (pt) 2002-03-26
BR0011521B8 (pt) 2021-05-25
MXPA01011517A (es) 2003-08-20
CA2308677C (en) 2007-09-18
CA2308192C (en) 2007-09-18
WO2000069877A1 (en) 2000-11-23
CA2308192A1 (en) 2000-11-12
CA2308677A1 (en) 2000-11-12
US6291670B1 (en) 2001-09-18
DE60005501T2 (de) 2004-06-24
EP1177201A1 (de) 2002-02-06
ATE250622T1 (de) 2003-10-15
US6403568B1 (en) 2002-06-11
BR0011521B1 (pt) 2013-12-24
DE60005501D1 (de) 2003-10-30
EP1177202A1 (de) 2002-02-06
AU4431300A (en) 2000-12-05
US20020022722A1 (en) 2002-02-21
EP1177202B1 (de) 2003-09-24
ES2207504T3 (es) 2004-06-01
AU4431200A (en) 2000-12-05
WO2000069876A1 (en) 2000-11-23
US6333315B1 (en) 2001-12-25
ATE250623T1 (de) 2003-10-15
EP1177201B1 (de) 2003-09-24
DE60005502T2 (de) 2004-06-24

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Legal Events

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