DE60005501D1 - 4'-c-ethynyl-pyrimidine nukleoside - Google Patents

4'-c-ethynyl-pyrimidine nukleoside

Info

Publication number
DE60005501D1
DE60005501D1 DE60005501T DE60005501T DE60005501D1 DE 60005501 D1 DE60005501 D1 DE 60005501D1 DE 60005501 T DE60005501 T DE 60005501T DE 60005501 T DE60005501 T DE 60005501T DE 60005501 D1 DE60005501 D1 DE 60005501D1
Authority
DE
Germany
Prior art keywords
ethynyl
pyrimidine nucleosides
hydrogen atom
pyrimidine
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005501T
Other languages
English (en)
Other versions
DE60005501T2 (de
Inventor
Hiroshi Ohrui
Shiro Shigeta
Eiichi Kodama
Haruhiko Machida
Satoru Kohgo
Hiroaki Mitsuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Corp
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of DE60005501D1 publication Critical patent/DE60005501D1/de
Publication of DE60005501T2 publication Critical patent/DE60005501T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60005501T 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside Expired - Lifetime DE60005501T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP13153999 1999-05-12
JP17492099 1999-06-22
JP17492099 1999-06-22
JP31824699 1999-11-09
JP31824699 1999-11-09
JP2000081117 2000-03-23
JP2000081117 2000-03-23
PCT/JP2000/003024 WO2000069876A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl pyrimidine nucleosides

Publications (2)

Publication Number Publication Date
DE60005501D1 true DE60005501D1 (de) 2003-10-30
DE60005501T2 DE60005501T2 (de) 2004-06-24

Family

ID=27471622

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60005501T Expired - Lifetime DE60005501T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside
DE60005502T Expired - Lifetime DE60005502T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60005502T Expired - Lifetime DE60005502T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Country Status (10)

Country Link
US (3) US6333315B1 (de)
EP (2) EP1177201B1 (de)
AT (2) ATE250623T1 (de)
AU (2) AU4431200A (de)
BR (1) BR0011521B8 (de)
CA (2) CA2308677C (de)
DE (2) DE60005501T2 (de)
ES (1) ES2207504T3 (de)
MX (1) MXPA01011517A (de)
WO (2) WO2000069877A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005501T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-pyrimidine nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
WO2003026675A1 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
JPWO2003068796A1 (ja) * 2002-02-15 2005-06-02 ヤマサ醤油株式会社 ４’−ｃ−シアノ−２’−デオキシプリンヌクレオシド
MXPA05008736A (es) 2003-02-19 2005-10-05 Univ Yale Analogos de nucleosido antivirales y metodos para tratar infecciones virales, especialmente infecciones por vih.
CA2502109C (en) 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
CN101044151B (zh) 2004-08-23 2011-01-19 弗·哈夫曼-拉罗切有限公司 抗病毒的4＇-叠氮基-核苷
CA2904692A1 (en) * 2005-09-26 2007-04-05 Gilead Pharmasset Llc Modified 4'-nucleosides as antiviral agents
EP2084175B1 (de) 2006-10-10 2010-12-29 Medivir AB Hcv-nukleosidinhibitor
US20090318380A1 (en) * 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
SG11201402826YA (en) 2011-12-22 2014-12-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
SG10201804835VA (en) 2013-10-11 2018-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
RU2720811C2 (ru) 2015-09-23 2020-05-13 Мерк Шарп И Доум Лимитед 4'-замещенные нуклеозидные ингибиторы обратной транскриптазы и их получение
JP6912100B2 (ja) 2016-11-16 2021-07-28 国立研究開発法人国立国際医療研究センター 抗ウイルス活性等の生理活性を有するヌクレオシド誘導体
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
CN111971284A (zh) * 2017-12-27 2020-11-20 埃默里大学 核苷和/或nadph氧化酶(nox)抑制剂作为髓样特异性抗病毒剂的联合模式
WO2020014041A1 (en) * 2018-07-09 2020-01-16 Merck Sharp & Dohme Corp. Enzymatic synthesis of 4'-ethynyl nucleoside analogs
US20210323993A1 (en) * 2018-08-30 2021-10-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
WO2020154656A1 (en) 2019-01-25 2020-07-30 Brown University Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
WO2021188959A1 (en) 2020-03-20 2021-09-23 Gilead Sciences, Inc. Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005501T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-pyrimidine nukleoside

Also Published As

Publication number Publication date
EP1177201B1 (de) 2003-09-24
US20020022722A1 (en) 2002-02-21
EP1177201A1 (de) 2002-02-06
CA2308192C (en) 2007-09-18
ES2207504T3 (es) 2004-06-01
EP1177202A1 (de) 2002-02-06
ATE250623T1 (de) 2003-10-15
EP1177202B1 (de) 2003-09-24
BR0011521B8 (pt) 2021-05-25
DE60005502T2 (de) 2004-06-24
US6403568B1 (en) 2002-06-11
CA2308677C (en) 2007-09-18
US6291670B1 (en) 2001-09-18
WO2000069877A1 (en) 2000-11-23
CA2308677A1 (en) 2000-11-12
WO2000069876A1 (en) 2000-11-23
MXPA01011517A (es) 2003-08-20
BR0011521A (pt) 2002-03-26
CA2308192A1 (en) 2000-11-12
AU4431300A (en) 2000-12-05
US6333315B1 (en) 2001-12-25
DE60005502D1 (de) 2003-10-30
AU4431200A (en) 2000-12-05
DE60005501T2 (de) 2004-06-24
BR0011521B1 (pt) 2013-12-24
ATE250622T1 (de) 2003-10-15

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