DE60005501D1 - 4'-c-ethynyl-pyrimidine nukleoside - Google Patents

4'-c-ethynyl-pyrimidine nukleoside

Info

Publication number
DE60005501D1
DE60005501D1 DE60005501T DE60005501T DE60005501D1 DE 60005501 D1 DE60005501 D1 DE 60005501D1 DE 60005501 T DE60005501 T DE 60005501T DE 60005501 T DE60005501 T DE 60005501T DE 60005501 D1 DE60005501 D1 DE 60005501D1
Authority
DE
Germany
Prior art keywords
ethynyl
pyrimidine nucleosides
hydrogen atom
pyrimidine
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005501T
Other languages
English (en)
Other versions
DE60005501T2 (de
Inventor
Hiroshi Ohrui
Shiro Shigeta
Eiichi Kodama
Haruhiko Machida
Satoru Kohgo
Hiroaki Mitsuya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Corp
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Publication of DE60005501D1 publication Critical patent/DE60005501D1/de
Application granted granted Critical
Publication of DE60005501T2 publication Critical patent/DE60005501T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60005501T 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside Expired - Lifetime DE60005501T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP13153999 1999-05-12
JP17492099 1999-06-22
JP17492099 1999-06-22
JP31824699 1999-11-09
JP31824699 1999-11-09
JP2000081117 2000-03-23
JP2000081117 2000-03-23
PCT/JP2000/003024 WO2000069876A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl pyrimidine nucleosides

Publications (2)

Publication Number Publication Date
DE60005501D1 true DE60005501D1 (de) 2003-10-30
DE60005501T2 DE60005501T2 (de) 2004-06-24

Family

ID=27471622

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60005502T Expired - Lifetime DE60005502T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside
DE60005501T Expired - Lifetime DE60005501T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60005502T Expired - Lifetime DE60005502T2 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Country Status (10)

Country Link
US (3) US6291670B1 (de)
EP (2) EP1177201B1 (de)
AT (2) ATE250623T1 (de)
AU (2) AU4431300A (de)
BR (1) BR0011521B8 (de)
CA (2) CA2308677C (de)
DE (2) DE60005502T2 (de)
ES (1) ES2207504T3 (de)
MX (1) MXPA01011517A (de)
WO (2) WO2000069877A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005502T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-purin-nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
US20040006002A1 (en) * 2001-09-28 2004-01-08 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
AU2003211483A1 (en) * 2002-02-15 2003-09-04 Yamasa Corporation 4'-c-cyano-2'-deoxypurine nucleosides
US7589078B2 (en) 2003-02-19 2009-09-15 Yale University Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections
CA2502109C (en) * 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
CA2577526A1 (en) 2004-08-23 2006-03-02 Joseph Armstrong Martin Antiviral 4'-azido-nucleosides
CA2623522C (en) * 2005-09-26 2015-12-08 Pharmasset, Inc. Modified 4'-nucleosides as antiviral agents
ES2358853T3 (es) 2006-10-10 2011-05-16 Medivir Ab Inhibidor nucleosídico de vhc.
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
US9073960B2 (en) * 2011-12-22 2015-07-07 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
TW201524990A (zh) 2013-10-11 2015-07-01 Alios Biopharma Inc 經取代之核苷、核苷酸及其類似物
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MX2018003212A (es) 2015-09-23 2018-07-06 Merck Sharp & Dohme Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos.
EP3543238B1 (de) 2016-11-16 2021-05-19 National Center for Global Health and Medicine Nukleosidderivate mit antiviraler aktivität
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
WO2019133712A1 (en) * 2017-12-27 2019-07-04 Schinazi Raymond F Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
CN112996511B (zh) 2018-07-09 2024-08-09 默沙东有限责任公司 4’-乙炔基核苷类似物的酶促合成
EP3844164A1 (de) * 2018-08-30 2021-07-07 GlaxoSmithKline Intellectual Property (No.2) Limited Verbindungen zur verwendung in der hiv-therapie
EP3914604A4 (de) 2019-01-25 2022-10-19 Brown University Zusammensetzungen und verfahren zur behandlung, vorbeugung oder umkehrung von altersbedingten entzündungen und erkrankungen
EP4021916A1 (de) * 2019-08-28 2022-07-06 GlaxoSmithKline Intellectual Property (No. 2) Limited 4'-ethynyl-2'-deoxyadenosinderivate und ihre verwendung in der hiv-therapie
AU2021237718B2 (en) 2020-03-20 2023-09-21 Gilead Sciences, Inc. Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005502T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-purin-nukleoside

Also Published As

Publication number Publication date
WO2000069877A1 (en) 2000-11-23
US6403568B1 (en) 2002-06-11
BR0011521A (pt) 2002-03-26
CA2308677A1 (en) 2000-11-12
DE60005502T2 (de) 2004-06-24
CA2308192A1 (en) 2000-11-12
EP1177202B1 (de) 2003-09-24
EP1177202A1 (de) 2002-02-06
EP1177201A1 (de) 2002-02-06
US20020022722A1 (en) 2002-02-21
EP1177201B1 (de) 2003-09-24
ATE250623T1 (de) 2003-10-15
MXPA01011517A (es) 2003-08-20
BR0011521B1 (pt) 2013-12-24
CA2308192C (en) 2007-09-18
BR0011521B8 (pt) 2021-05-25
ATE250622T1 (de) 2003-10-15
AU4431300A (en) 2000-12-05
DE60005502D1 (de) 2003-10-30
US6291670B1 (en) 2001-09-18
ES2207504T3 (es) 2004-06-01
AU4431200A (en) 2000-12-05
DE60005501T2 (de) 2004-06-24
WO2000069876A1 (en) 2000-11-23
CA2308677C (en) 2007-09-18
US6333315B1 (en) 2001-12-25

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Legal Events

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