ATE250622T1 - 4'-c-ethynyl-pyrimidine nukleoside - Google Patents

4'-c-ethynyl-pyrimidine nukleoside

Info

Publication number
ATE250622T1
ATE250622T1 AT00925624T AT00925624T ATE250622T1 AT E250622 T1 ATE250622 T1 AT E250622T1 AT 00925624 T AT00925624 T AT 00925624T AT 00925624 T AT00925624 T AT 00925624T AT E250622 T1 ATE250622 T1 AT E250622T1
Authority
AT
Austria
Prior art keywords
ethynyl
hydrogen atom
nucleosides
pyrimidine
pyrimidines
Prior art date
Application number
AT00925624T
Other languages
English (en)
Inventor
Hiroshi Ohrui
Shiro Shigeta
Eiichi Kodama
Haruhiko Machida
Satoru Kohgo
Hiroaki Mitsuya
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE250622T1 publication Critical patent/ATE250622T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT00925624T 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside ATE250622T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP17492099 1999-06-22
JP31824699 1999-11-09
JP2000081117 2000-03-23
PCT/JP2000/003024 WO2000069876A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl pyrimidine nucleosides

Publications (1)

Publication Number Publication Date
ATE250622T1 true ATE250622T1 (de) 2003-10-15

Family

ID=27471622

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00925625T ATE250623T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside
AT00925624T ATE250622T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00925625T ATE250623T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Country Status (10)

Country Link
US (3) US6333315B1 (de)
EP (2) EP1177201B1 (de)
AT (2) ATE250623T1 (de)
AU (2) AU4431200A (de)
BR (1) BR0011521B8 (de)
CA (2) CA2308677C (de)
DE (2) DE60005502T2 (de)
ES (1) ES2207504T3 (de)
MX (1) MXPA01011517A (de)
WO (2) WO2000069877A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005502T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-purin-nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
WO2003026675A1 (en) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
WO2003068796A1 (en) * 2002-02-15 2003-08-21 Yamasa Corporation 4’-c-cyano-2’-deoxypurine nucleosides
CN1777432B (zh) * 2003-02-19 2011-06-08 耶鲁大学 用于hiv感染的抗病毒核苷类似物
CA2502109C (en) 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
CA2577526A1 (en) 2004-08-23 2006-03-02 Joseph Armstrong Martin Antiviral 4'-azido-nucleosides
CA2623522C (en) 2005-09-26 2015-12-08 Pharmasset, Inc. Modified 4'-nucleosides as antiviral agents
AP2009004812A0 (en) 2006-10-10 2009-04-30 Medivir Ab HCV nucleoside inhibitor
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
PL2794627T3 (pl) 2011-12-22 2019-04-30 Alios Biopharma Inc Podstawione nukleozydy, nukleotydy i ich analogi
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
SG10201804835VA (en) 2013-10-11 2018-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
CA2998646C (en) 2015-09-23 2021-05-18 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof
US10933067B2 (en) 2016-11-16 2021-03-02 National Center For Global Health And Medicine Nucleoside derivative having physiological activity such as antiviral activity
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
US20210060051A1 (en) * 2017-12-27 2021-03-04 Raymond F. Schinazi Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
CA3105823C (en) * 2018-07-09 2023-07-25 Merck Sharp & Dohme Corp. Enzymatic synthesis of 4'-ethynyl nucleoside analogs
US20210323993A1 (en) * 2018-08-30 2021-10-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
MX2021008751A (es) 2019-01-25 2021-11-12 Univ Brown Composiciones y metodos para tratar, prevenir o revertir la inflamacion y los trastornos asociados a la edad.
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
AU2021237718B2 (en) 2020-03-20 2023-09-21 Gilead Sciences, Inc. Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005502T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-purin-nukleoside

Also Published As

Publication number Publication date
ES2207504T3 (es) 2004-06-01
EP1177202A1 (de) 2002-02-06
WO2000069877A1 (en) 2000-11-23
CA2308192A1 (en) 2000-11-12
CA2308192C (en) 2007-09-18
DE60005502T2 (de) 2004-06-24
DE60005502D1 (de) 2003-10-30
US20020022722A1 (en) 2002-02-21
WO2000069876A1 (en) 2000-11-23
US6333315B1 (en) 2001-12-25
EP1177202B1 (de) 2003-09-24
BR0011521B8 (pt) 2021-05-25
CA2308677C (en) 2007-09-18
AU4431200A (en) 2000-12-05
CA2308677A1 (en) 2000-11-12
DE60005501D1 (de) 2003-10-30
EP1177201B1 (de) 2003-09-24
AU4431300A (en) 2000-12-05
US6291670B1 (en) 2001-09-18
MXPA01011517A (es) 2003-08-20
BR0011521A (pt) 2002-03-26
DE60005501T2 (de) 2004-06-24
BR0011521B1 (pt) 2013-12-24
ATE250623T1 (de) 2003-10-15
US6403568B1 (en) 2002-06-11
EP1177201A1 (de) 2002-02-06

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