ATE250622T1 - 4'-c-ethynyl-pyrimidine nukleoside - Google Patents

4'-c-ethynyl-pyrimidine nukleoside

Info

Publication number
ATE250622T1
ATE250622T1 AT00925624T AT00925624T ATE250622T1 AT E250622 T1 ATE250622 T1 AT E250622T1 AT 00925624 T AT00925624 T AT 00925624T AT 00925624 T AT00925624 T AT 00925624T AT E250622 T1 ATE250622 T1 AT E250622T1
Authority
AT
Austria
Prior art keywords
ethynyl
hydrogen atom
nucleosides
pyrimidine
pyrimidines
Prior art date
Application number
AT00925624T
Other languages
English (en)
Inventor
Hiroshi Ohrui
Shiro Shigeta
Eiichi Kodama
Haruhiko Machida
Satoru Kohgo
Hiroaki Mitsuya
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE250622T1 publication Critical patent/ATE250622T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT00925624T 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside ATE250622T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP17492099 1999-06-22
JP31824699 1999-11-09
JP2000081117 2000-03-23
PCT/JP2000/003024 WO2000069876A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl pyrimidine nucleosides

Publications (1)

Publication Number Publication Date
ATE250622T1 true ATE250622T1 (de) 2003-10-15

Family

ID=27471622

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00925624T ATE250622T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside
AT00925625T ATE250623T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00925625T ATE250623T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Country Status (10)

Country Link
US (3) US6333315B1 (de)
EP (2) EP1177201B1 (de)
AT (2) ATE250622T1 (de)
AU (2) AU4431200A (de)
BR (1) BR0011521B8 (de)
CA (2) CA2308677C (de)
DE (2) DE60005501T2 (de)
ES (1) ES2207504T3 (de)
MX (1) MXPA01011517A (de)
WO (2) WO2000069877A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005501T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-pyrimidine nukleoside
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
US20040006002A1 (en) * 2001-09-28 2004-01-08 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside
AU2003211483A1 (en) * 2002-02-15 2003-09-04 Yamasa Corporation 4'-c-cyano-2'-deoxypurine nucleosides
CA2514466C (en) * 2003-02-19 2015-05-26 Yale University Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections
CA2502109C (en) 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
CN101044151B (zh) 2004-08-23 2011-01-19 弗·哈夫曼-拉罗切有限公司 抗病毒的4＇-叠氮基-核苷
CA2623522C (en) 2005-09-26 2015-12-08 Pharmasset, Inc. Modified 4'-nucleosides as antiviral agents
HRP20110193T1 (hr) 2006-10-10 2011-05-31 Medivir Ab Inhibitor hcv nukleozida
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2014331863C1 (en) 2013-10-11 2019-05-16 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
KR102185996B1 (ko) 2015-09-23 2020-12-02 머크 샤프 앤드 돔 코포레이션 4'-치환된 뉴클레오시드 리버스 트랜스크립타제 억제제 및 그의 제조법
EP3543238B1 (de) 2016-11-16 2021-05-19 National Center for Global Health and Medicine Nukleosidderivate mit antiviraler aktivität
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
MX2020006864A (es) * 2017-12-27 2020-11-11 Univ Emory Modalidades combinadas para inhibidores de nucleosidos y/o nadph oxidasa (nox) como agentes antivirales especificos de mieloides.
MX2021000278A (es) 2018-07-09 2021-03-31 Merck Sharp & Dohme Llc Sintesis enzimatica de analogos de nucleosido de 4'-etinilo.
US20210323993A1 (en) * 2018-08-30 2021-10-21 Glaxosmithkline Intellectual Property (No. 2) Limited Compounds Useful in HIV Therapy
AU2019403024A1 (en) 2018-12-20 2021-07-15 Merck Sharp & Dohme Llc Novel crystalline forms of an NRTTI compound
EP3914604B1 (de) 2019-01-25 2026-03-04 Brown University Zusammensetzungen enthaltend censavudin oder elvucitabin zur behandlung der altersbedingten entzündung und der störungen
EA202192433A1 (ru) 2019-03-06 2021-12-28 Глэксосмитклайн Интеллекчуал Проперти (№2) Лимитед Соединения, полезные в терапии вич
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
EP4028020A4 (de) 2019-09-11 2023-09-27 The Scripps Research Institute Antivirale prodrugs und deren formulierungen
AR121620A1 (es) 2020-03-20 2022-06-22 Gilead Sciences Inc Profármacos de nucleósidos 4’-c-sustituidos-2-halo-2’-deoxiadenosina y métodos de preparación y uso de los mismos
JP2025509635A (ja) 2022-03-15 2025-04-11 ローム・セラピューティクス・インコーポレイテッド 疾患を治療するための化合物及び方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60005501T2 (de) * 1999-05-12 2004-06-24 Yamasa Corp., Choshi 4'-c-ethynyl-pyrimidine nukleoside

Also Published As

Publication number Publication date
ES2207504T3 (es) 2004-06-01
ATE250623T1 (de) 2003-10-15
BR0011521B1 (pt) 2013-12-24
MXPA01011517A (es) 2003-08-20
AU4431300A (en) 2000-12-05
CA2308677C (en) 2007-09-18
DE60005502D1 (de) 2003-10-30
DE60005501T2 (de) 2004-06-24
DE60005501D1 (de) 2003-10-30
BR0011521A (pt) 2002-03-26
US6291670B1 (en) 2001-09-18
AU4431200A (en) 2000-12-05
WO2000069877A1 (en) 2000-11-23
DE60005502T2 (de) 2004-06-24
CA2308192C (en) 2007-09-18
US20020022722A1 (en) 2002-02-21
CA2308192A1 (en) 2000-11-12
US6403568B1 (en) 2002-06-11
EP1177202B1 (de) 2003-09-24
WO2000069876A1 (en) 2000-11-23
EP1177201B1 (de) 2003-09-24
CA2308677A1 (en) 2000-11-12
EP1177202A1 (de) 2002-02-06
US6333315B1 (en) 2001-12-25
BR0011521B8 (pt) 2021-05-25
EP1177201A1 (de) 2002-02-06

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