ATE250623T1 - 4'-c-ethynyl-purin-nukleoside - Google Patents

4'-c-ethynyl-purin-nukleoside

Info

Publication number
ATE250623T1
ATE250623T1 AT00925625T AT00925625T ATE250623T1 AT E250623 T1 ATE250623 T1 AT E250623T1 AT 00925625 T AT00925625 T AT 00925625T AT 00925625 T AT00925625 T AT 00925625T AT E250623 T1 ATE250623 T1 AT E250623T1
Authority
AT
Austria
Prior art keywords
ethynyl
purine nucleosides
hydrogen atom
pyrimidine
ethynyl purine
Prior art date
Application number
AT00925625T
Other languages
English (en)
Inventor
Hiroshi Ohrui
Eiichi Kodama
Satoru Kohgo
Hiroaki Mitsuya
Masao Matsuoka
Kenji Kitano
Original Assignee
Yamasa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Corp filed Critical Yamasa Corp
Application granted granted Critical
Publication of ATE250623T1 publication Critical patent/ATE250623T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT00925625T 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside ATE250623T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13153999 1999-05-12
JP17492099 1999-06-22
JP31824699 1999-11-09
JP2000081117 2000-03-23
PCT/JP2000/003025 WO2000069877A1 (en) 1999-05-12 2000-05-11 4'-c-ethynyl purine nucleosides

Publications (1)

Publication Number Publication Date
ATE250623T1 true ATE250623T1 (de) 2003-10-15

Family

ID=27471622

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00925624T ATE250622T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside
AT00925625T ATE250623T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-purin-nukleoside

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00925624T ATE250622T1 (de) 1999-05-12 2000-05-11 4'-c-ethynyl-pyrimidine nukleoside

Country Status (10)

Country Link
US (3) US6333315B1 (de)
EP (2) EP1177201B1 (de)
AT (2) ATE250622T1 (de)
AU (2) AU4431300A (de)
BR (1) BR0011521B8 (de)
CA (2) CA2308677C (de)
DE (2) DE60005502T2 (de)
ES (1) ES2207504T3 (de)
MX (1) MXPA01011517A (de)
WO (2) WO2000069877A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069877A1 (en) * 1999-05-12 2000-11-23 Yamasa Corporation 4'-c-ethynyl purine nucleosides
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives
EP1438054A4 (de) * 2001-09-28 2006-07-26 Idenix Cayman Ltd Verfahren und zusammensetzungen zur behandlung von flaviviren und pestiviren mit 4'-modifiziertem nucleosid
AU2003211483A1 (en) * 2002-02-15 2003-09-04 Yamasa Corporation 4'-c-cyano-2'-deoxypurine nucleosides
BRPI0407374A (pt) 2003-02-19 2006-01-10 Univ Yale Análogos de nucleosìdeo antiviral e métodos para tratar infecções virais, especialmente infecções de hiv
CA2502109C (en) 2004-03-24 2010-02-23 Yamasa Corporation 4'-c-substituted-2-haloadenosine derivative
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
DE602005015466D1 (de) 2004-08-23 2009-08-27 Hoffmann La Roche Antivirale 4'-azidonucleoside
NZ567272A (en) * 2005-09-26 2012-02-24 Pharmasset Inc Modified 4'-nucleosides as antiviral agents
MX2009003452A (es) 2006-10-10 2009-04-14 Medivir Ab Inhibidores nucleosidicos del vhc.
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
JP6562908B2 (ja) 2013-10-11 2019-08-21 ヤンセン バイオファーマ インク． 置換ヌクレオシド、置換ヌクレオチドおよびその類似体
WO2015143712A1 (en) 2014-03-28 2015-10-01 Merck Sharp & Dohme Corp. 4'-substituted nucleoside reverse transcriptase inhibitors
MA41213A (fr) 2014-12-19 2017-10-24 Alios Biopharma Inc Nucléosides substitués, nucléotides et analogues de ceux-ci
MX391226B (es) 2015-09-23 2025-03-21 Merck Sharp & Dohme Llc Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos.
WO2018092728A1 (ja) 2016-11-16 2018-05-24 国立研究開発法人国立国際医療研究センター 抗ウイルス活性等の生理活性を有するヌクレオシド誘導体
US11040975B2 (en) 2017-12-08 2021-06-22 Merck Sharp & Dohme Corp. Carbocyclic nucleoside reverse transcriptase inhibitors
CA3087192A1 (en) * 2017-12-27 2019-07-04 Raymond F. Schinazi Combined modalities for nucleosides and/or nadph oxidase (nox) inhibitors as myeloid-specific antiviral agents
CN118995846A (zh) * 2018-07-09 2024-11-22 默沙东有限责任公司 4’-乙炔基核苷类似物的酶促合成
EP3844164A1 (de) * 2018-08-30 2021-07-07 GlaxoSmithKline Intellectual Property (No.2) Limited Verbindungen zur verwendung in der hiv-therapie
US12227536B2 (en) 2018-12-20 2025-02-18 Merck Sharp & Dohme Llc Crystalline forms of an NRTTI compound
MX2021008751A (es) 2019-01-25 2021-11-12 Univ Brown Composiciones y metodos para tratar, prevenir o revertir la inflamacion y los trastornos asociados a la edad.
EP3934760A1 (de) 2019-03-06 2022-01-12 GlaxoSmithKline Intellectual Property (No.2) Limited Verbindungen zur verwendung in der hiv-therapie
US20220298160A1 (en) * 2019-08-28 2022-09-22 Glaxosmithkline Intellectual Property (No.2) Limited Compounds useful in hiv therapy
JP7719769B2 (ja) 2019-09-11 2025-08-06 ザ スクリプス リサーチ インスティテュート 抗ウイルスプロドラッグ及びその医薬組成物
CA3169348A1 (en) 2020-03-20 2021-09-23 Gilead Sciences, Inc. Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
EP4493573A1 (de) 2022-03-15 2025-01-22 Rome Therapeutics, Inc. Verbindungen und verfahren zur behandlung von krankheiten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069877A1 (en) * 1999-05-12 2000-11-23 Yamasa Corporation 4'-c-ethynyl purine nucleosides

Also Published As

Publication number Publication date
EP1177202B1 (de) 2003-09-24
EP1177201A1 (de) 2002-02-06
CA2308192A1 (en) 2000-11-12
DE60005501D1 (de) 2003-10-30
ATE250622T1 (de) 2003-10-15
DE60005502T2 (de) 2004-06-24
EP1177202A1 (de) 2002-02-06
ES2207504T3 (es) 2004-06-01
EP1177201B1 (de) 2003-09-24
CA2308677C (en) 2007-09-18
CA2308677A1 (en) 2000-11-12
BR0011521B8 (pt) 2021-05-25
AU4431300A (en) 2000-12-05
BR0011521B1 (pt) 2013-12-24
US20020022722A1 (en) 2002-02-21
WO2000069877A1 (en) 2000-11-23
AU4431200A (en) 2000-12-05
DE60005502D1 (de) 2003-10-30
US6291670B1 (en) 2001-09-18
MXPA01011517A (es) 2003-08-20
US6403568B1 (en) 2002-06-11
DE60005501T2 (de) 2004-06-24
CA2308192C (en) 2007-09-18
BR0011521A (pt) 2002-03-26
WO2000069876A1 (en) 2000-11-23
US6333315B1 (en) 2001-12-25

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