CA2239053A1 - Diphenyl pyridyl ethane derivatives as pde iv inhibitors - Google Patents
Diphenyl pyridyl ethane derivatives as pde iv inhibitorsInfo
- Publication number
- CA2239053A1 CA2239053A1 CA002239053A CA2239053A CA2239053A1 CA 2239053 A1 CA2239053 A1 CA 2239053A1 CA 002239053 A CA002239053 A CA 002239053A CA 2239053 A CA2239053 A CA 2239053A CA 2239053 A1 CA2239053 A1 CA 2239053A1
- Authority
- CA
- Canada
- Prior art keywords
- pde
- inhibitors
- ethane derivatives
- pyridyl ethane
- diphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WZFQXURMGGLMOB-UHFFFAOYSA-N 2-(1,1-diphenylethyl)pyridine Chemical class C=1C=CC=CC=1C(C=1N=CC=CC=1)(C)C1=CC=CC=C1 WZFQXURMGGLMOB-UHFFFAOYSA-N 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
The invention encompasses the novel compound of formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of formula (I).
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US876695P | 1995-12-15 | 1995-12-15 | |
| US60/008,766 | 1995-12-15 | ||
| GBGB9603723.9A GB9603723D0 (en) | 1996-02-22 | 1996-02-22 | Diphenyl pyridyl derivatives as pde iv inhibitors |
| GB9603723.9 | 1996-02-22 | ||
| PCT/CA1996/000838 WO1997022585A1 (en) | 1995-12-15 | 1996-12-11 | Diphenyl pyridyl ethane derivatives as pde iv inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2239053A1 true CA2239053A1 (en) | 1997-06-26 |
| CA2239053C CA2239053C (en) | 2005-04-26 |
Family
ID=56289724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002239053A Expired - Fee Related CA2239053C (en) | 1995-12-15 | 1996-12-11 | Diphenyl pyridyl ethane derivatives as pde iv inhibitors |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0873310A1 (en) |
| JP (1) | JP3468777B2 (en) |
| CA (1) | CA2239053C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY123585A (en) * | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
| CN1537018A (en) | 2001-05-23 | 2004-10-13 | 田边制药株式会社 | Therapeutic compositions for repairing chondropathy |
-
1996
- 1996-12-11 EP EP96940966A patent/EP0873310A1/en not_active Withdrawn
- 1996-12-11 JP JP52237697A patent/JP3468777B2/en not_active Expired - Fee Related
- 1996-12-11 CA CA002239053A patent/CA2239053C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000501741A (en) | 2000-02-15 |
| JP3468777B2 (en) | 2003-11-17 |
| EP0873310A1 (en) | 1998-10-28 |
| CA2239053C (en) | 2005-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |