DE60001586D1 - Diphenyl-piperidin derivate - Google Patents
Diphenyl-piperidin derivateInfo
- Publication number
- DE60001586D1 DE60001586D1 DE60001586T DE60001586T DE60001586D1 DE 60001586 D1 DE60001586 D1 DE 60001586D1 DE 60001586 T DE60001586 T DE 60001586T DE 60001586 T DE60001586 T DE 60001586T DE 60001586 D1 DE60001586 D1 DE 60001586D1
- Authority
- DE
- Germany
- Prior art keywords
- diphenyl
- piperidine derivatives
- therapy
- processes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- BTVVEKSXUOEVAY-UHFFFAOYSA-N 4,4-diphenylpiperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=CC=CC=C1 BTVVEKSXUOEVAY-UHFFFAOYSA-N 0.000 title 1
- 102000009410 Chemokine receptor Human genes 0.000 abstract 1
- 108050000299 Chemokine receptor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9902765 | 1999-07-21 | ||
| SE9902765A SE9902765D0 (sv) | 1999-07-21 | 1999-07-21 | Novel compounds |
| PCT/GB2000/002756 WO2001005782A1 (en) | 1999-07-21 | 2000-07-18 | Novel diphenyl-piperidine derivate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60001586D1 true DE60001586D1 (de) | 2003-04-10 |
| DE60001586T2 DE60001586T2 (de) | 2004-02-12 |
Family
ID=20416552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60001586T Expired - Fee Related DE60001586T2 (de) | 1999-07-21 | 2000-07-18 | Diphenyl-piperidin derivate |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6566376B1 (de) |
| EP (1) | EP1202984B1 (de) |
| JP (1) | JP2003505383A (de) |
| KR (1) | KR20020027498A (de) |
| CN (1) | CN1152873C (de) |
| AT (1) | ATE233754T1 (de) |
| AU (1) | AU771344B2 (de) |
| BR (1) | BR0012610A (de) |
| CA (1) | CA2378084A1 (de) |
| DE (1) | DE60001586T2 (de) |
| IL (1) | IL147149A0 (de) |
| MX (1) | MXPA02000671A (de) |
| NO (1) | NO20020282L (de) |
| NZ (1) | NZ516606A (de) |
| SE (1) | SE9902765D0 (de) |
| WO (1) | WO2001005782A1 (de) |
| ZA (1) | ZA200110540B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200303304A (en) * | 2002-02-18 | 2003-09-01 | Astrazeneca Ab | Chemical compounds |
| SE0400208D0 (sv) | 2004-02-02 | 2004-02-02 | Astrazeneca Ab | Chemical compounds |
| WO2007070433A2 (en) * | 2005-12-12 | 2007-06-21 | Merck & Co., Inc. | 2-arylthiazole derivatives as cxcr3 receptor modulators |
| US10344095B2 (en) * | 2006-02-16 | 2019-07-09 | University Of Kentucky Research Foundation | CCR3 inhibition for ocular angiogenesis and macular degeneration |
| TW200812582A (en) * | 2006-04-06 | 2008-03-16 | Astrazeneca Ab | Medicaments |
| AU2008270438B2 (en) * | 2007-07-02 | 2013-10-10 | F. Hoffmann-La Roche Ag | Imidazole derivatives as CCR2 receptor antagonists |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| US8778616B2 (en) | 2009-05-26 | 2014-07-15 | University Of Kentucky Research Foundation | Method of using CCR3 binding agents to detect choroidal neovascularization |
| WO2014144659A1 (en) | 2013-03-14 | 2014-09-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| EP2970220A2 (de) | 2013-03-14 | 2016-01-20 | Epizyme, Inc. | Argininmethyltransferaseinhibitoren und verwendungen davon |
| WO2014153214A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyl transferase inhibtors and uses thereof |
| JP2016514164A (ja) | 2013-03-14 | 2016-05-19 | エピザイム，インコーポレイティド | アルギニンメチルトランスフェラーゼ阻害剤としてのピラゾール誘導体およびその使用 |
| US9447079B2 (en) | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
| US9365527B2 (en) | 2013-03-14 | 2016-06-14 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| DK2970132T3 (da) | 2013-03-14 | 2020-12-21 | Epizyme Inc | Argininmethyltransferaseinhibitorer og anvendelser deraf |
| EP2970134B1 (de) | 2013-03-14 | 2018-02-28 | Epizyme, Inc. | Pyrazolderivate als prmt1 inhbitoren und ihre verwendung |
| US9763957B2 (en) | 2013-07-18 | 2017-09-19 | Novartis Ag | Autotaxin inhibitors |
| CN108299411B (zh) * | 2017-01-13 | 2021-02-05 | 中国人民解放军军事医学科学院毒物药物研究所 | 4,4-二苯基哌啶类化合物或其可药用盐、药物组合物及用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2139084C3 (de) * | 1971-08-04 | 1979-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Verfahren zur Herstellung von 4,4-Diphenyl-piperidinen |
| IL90858A (en) | 1988-07-07 | 1994-08-26 | Rhone Poulenc Sante | History (Aza) Naftalensultam, their preparation and preparations containing them |
| JPH05506216A (ja) | 1990-04-10 | 1993-09-16 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 医薬としてのピリジン |
| DE4140542A1 (de) | 1991-12-09 | 1993-06-17 | Bayer Ag | Piperdylmethyl substituierte chormanderivate |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| DE19756235A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| US6046331A (en) * | 1998-12-17 | 2000-04-04 | Synaptic Pharmaceutical Corporation | Imidazolones and their use in treating benign prostatic hyperplasia and other disorders |
-
1999
- 1999-07-21 SE SE9902765A patent/SE9902765D0/xx unknown
-
2000
- 2000-07-18 CN CNB008106703A patent/CN1152873C/zh not_active Expired - Fee Related
- 2000-07-18 NZ NZ516606A patent/NZ516606A/en unknown
- 2000-07-18 IL IL14714900A patent/IL147149A0/xx unknown
- 2000-07-18 MX MXPA02000671A patent/MXPA02000671A/es active IP Right Grant
- 2000-07-18 AU AU60016/00A patent/AU771344B2/en not_active Ceased
- 2000-07-18 CA CA002378084A patent/CA2378084A1/en not_active Abandoned
- 2000-07-18 DE DE60001586T patent/DE60001586T2/de not_active Expired - Fee Related
- 2000-07-18 JP JP2001511441A patent/JP2003505383A/ja not_active Withdrawn
- 2000-07-18 AT AT00946134T patent/ATE233754T1/de not_active IP Right Cessation
- 2000-07-18 KR KR1020027000797A patent/KR20020027498A/ko not_active Application Discontinuation
- 2000-07-18 EP EP00946134A patent/EP1202984B1/de not_active Expired - Lifetime
- 2000-07-18 US US09/623,744 patent/US6566376B1/en not_active Expired - Fee Related
- 2000-07-18 BR BR0012610-1A patent/BR0012610A/pt not_active IP Right Cessation
- 2000-07-18 WO PCT/GB2000/002756 patent/WO2001005782A1/en active IP Right Grant
-
2001
- 2001-12-21 ZA ZA200110540A patent/ZA200110540B/xx unknown
-
2002
- 2002-01-18 NO NO20020282A patent/NO20020282L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6001600A (en) | 2001-02-05 |
| IL147149A0 (en) | 2002-08-14 |
| DE60001586T2 (de) | 2004-02-12 |
| MXPA02000671A (es) | 2002-07-02 |
| NO20020282D0 (no) | 2002-01-18 |
| ATE233754T1 (de) | 2003-03-15 |
| CA2378084A1 (en) | 2001-01-25 |
| EP1202984A1 (de) | 2002-05-08 |
| NO20020282L (no) | 2002-03-21 |
| ZA200110540B (en) | 2003-03-24 |
| WO2001005782A1 (en) | 2001-01-25 |
| CN1361775A (zh) | 2002-07-31 |
| JP2003505383A (ja) | 2003-02-12 |
| CN1152873C (zh) | 2004-06-09 |
| KR20020027498A (ko) | 2002-04-13 |
| SE9902765D0 (sv) | 1999-07-21 |
| AU771344B2 (en) | 2004-03-18 |
| EP1202984B1 (de) | 2003-03-05 |
| BR0012610A (pt) | 2002-04-09 |
| US6566376B1 (en) | 2003-05-20 |
| NZ516606A (en) | 2003-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |