MX9805023A - Derivados de 1-metilcarbapenem. - Google Patents

Derivados de 1-metilcarbapenem.

Info

Publication number
MX9805023A
MX9805023A MX9805023A MX9805023A MX9805023A MX 9805023 A MX9805023 A MX 9805023A MX 9805023 A MX9805023 A MX 9805023A MX 9805023 A MX9805023 A MX 9805023A MX 9805023 A MX9805023 A MX 9805023A
Authority
MX
Mexico
Prior art keywords
substituted
ylcarbonyl
hydroxy
ethyl
represents hydrogen
Prior art date
Application number
MX9805023A
Other languages
English (en)
Inventor
Isao Kawamoto
Yasuo Shimoji
Katsuya Ishikawa
Katsuhiko Kojima
Hiroshi Yasuda
Satoshi Ohya
Yukio Utsui
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of MX9805023A publication Critical patent/MX9805023A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de 1-metilcarbapenem, representado por la siguiente formula (I), en donde R1 representa un átomo de hidrogeno o un grupo alquilo inferior; R2 representa un átomo de hidrogeno o un residuo éster; y A representa un propilaminopirrolidin-1-ilcarbonilo sustituido, aminoalcanoilaminopirrolidin-1-ilcarbonilo sustituido, 1-hidroxi-2-(aminoalquilipirrolidin-1-ilcarbonil sustituido)etilo, 1-hidroxi-2-(piperazin-1-ilcarbonil sustituido)etilo y 1-hidroxi-2-(pirrolidinilaminocarbonil sustituido)etilo o similares; o una sal farmacologicamente aceptable del mismo; los compuestos de 1-metilcarbapenem de la presente invencion tienen excelente actividad antibacteriana y son agentes utiles para la prevencion o el tratamiento de enfermedades infecciosas.
MX9805023A 1995-12-21 1998-06-19 Derivados de 1-metilcarbapenem. MX9805023A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33313595 1995-12-21
JP30894096 1996-11-20

Publications (1)

Publication Number Publication Date
MX9805023A true MX9805023A (es) 1998-11-30

Family

ID=26565749

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9805023A MX9805023A (es) 1995-12-21 1998-06-19 Derivados de 1-metilcarbapenem.

Country Status (18)

Country Link
US (1) US6090802A (es)
EP (1) EP0882728B1 (es)
KR (1) KR100386993B1 (es)
CN (1) CN1095843C (es)
AT (1) ATE223411T1 (es)
AU (1) AU711135B2 (es)
CA (1) CA2241092C (es)
CZ (1) CZ298246B6 (es)
DE (1) DE69623497T2 (es)
DK (1) DK0882728T3 (es)
ES (1) ES2181927T3 (es)
HK (1) HK1015766A1 (es)
HU (1) HUP9901376A3 (es)
MX (1) MX9805023A (es)
NO (1) NO310684B1 (es)
NZ (1) NZ324447A (es)
PT (1) PT882728E (es)
WO (1) WO1997023483A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0000952A3 (en) 1997-02-07 2000-12-28 Kyoto Pharma Ind Carbapenem compounds, process for their preparation and pharmaceutical compositions containing them
AU760386B2 (en) 1998-05-01 2003-05-15 Kyoto Pharmaceutical Industries, Ltd. Carbapenem derivatives, utilization thereof and intermediate compounds of the same
WO2000034282A1 (fr) * 1998-12-07 2000-06-15 Sankyo Company, Limited Derives de 1-methylcarbapenem
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
TWI250160B (en) * 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US6531594B2 (en) * 2000-08-24 2003-03-11 Mitsubishi Chemical Corporation Process for producing 1H-3-aminopyrrolidine and derivatives thereof
KR100825243B1 (ko) * 2000-11-20 2008-04-25 상꾜 가부시키가이샤 카르바페넴계 항균제의 제조방법
HUP0400444A3 (en) * 2001-05-21 2007-02-28 Kyoto Pharmaceutical Ind Carbapenem compound, pharmaceutical compositions containing them and their use
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
JP4619655B2 (ja) 2001-09-14 2011-01-26 ハイ・ポイント・ファーマスーティカルズ、エルエルシー 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体
BRPI0413842A (pt) * 2003-08-25 2006-10-24 Sankyo Co composto de 1-metil-carbapenem ou um seu sal farmacologicamente aceitável, etanolato e tetra-hidrato de composto de 1-metil-carbapenem, processo para a preparação da forma cristalina, processo para a preparação de um tri-hidrato de etanolato de composto de 1-metil-carbapenem, tri-hidrato de etanolato de composto de 1-metil-carbapenem, composição farmacêutica para prevenir ou tratar infecções bacterianas, e, uso da forma cristalina
WO2006101062A1 (ja) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited １－アルキルピロリジン構造を有するカルバペネム誘導体の製造方法
JPWO2006121151A1 (ja) * 2005-05-13 2008-12-18 第一三共株式会社 １−メチルカルバペネム化合物の結晶
ES2533826T3 (es) 2008-01-18 2015-04-15 Merck Sharp & Dohme Corp. Inhibidores de beta-lactamasa

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
EP0182213B1 (en) * 1984-11-08 1990-09-26 Sumitomo Pharmaceuticals Company, Limited Carbapenem compounds and production thereof
JPS62155279A (ja) * 1984-11-08 1987-07-10 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物
JP3005045B2 (ja) * 1990-02-14 2000-01-31 住友製薬株式会社 新規なβ―ラクタム化合物及びその製造法
TW198034B (es) * 1990-03-27 1993-01-11 Manyu Seiyaku Kk
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
RU2093514C1 (ru) * 1991-06-04 1997-10-20 Санкио Компани Лимитед Производные 1-метилкарбапенема и способ их получения
JP3048196B2 (ja) * 1991-06-20 2000-06-05 第一製薬株式会社 カルバペネム誘導体
HU218676B (hu) * 1992-03-11 2000-10-28 Sankyo Co. Ltd. Antimikrobiális karbapenemszármazékok, ilyen vegyületeket tartalmazó gyógyászati készítmények és eljárás ezek előállítására
JP3411589B2 (ja) * 1992-05-11 2003-06-03 第一製薬株式会社 カルバペネム誘導体
JP3344662B2 (ja) * 1992-09-14 2002-11-11 三共株式会社 カルバペネム−３−カルボン酸誘導体
JPH06199860A (ja) * 1992-09-16 1994-07-19 Sankyo Co Ltd カルバペネム誘導体
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
GB9320816D0 (en) * 1993-10-08 1993-12-01 Fujisawa Pharmaceutical Co Novel compounds
CN1093861C (zh) * 1996-04-26 2002-11-06 三共株式会社 1－甲基碳青霉烯衍生物

Also Published As

Publication number Publication date
ATE223411T1 (de) 2002-09-15
HK1015766A1 (en) 1999-10-22
NO982873L (no) 1998-08-21
CN1209130A (zh) 1999-02-24
NO982873D0 (no) 1998-06-19
CA2241092A1 (en) 1997-07-03
CZ191898A3 (cs) 1998-09-16
AU1171897A (en) 1997-07-17
CA2241092C (en) 2004-04-27
HUP9901376A2 (hu) 1999-08-30
DE69623497T2 (de) 2003-05-28
AU711135B2 (en) 1999-10-07
US6090802A (en) 2000-07-18
HUP9901376A3 (en) 2000-03-28
NZ324447A (en) 1999-08-30
DE69623497D1 (de) 2002-10-10
NO310684B1 (no) 2001-08-13
EP0882728A4 (en) 1999-03-24
EP0882728B1 (en) 2002-09-04
CZ298246B6 (cs) 2007-08-01
KR100386993B1 (ko) 2003-12-18
DK0882728T3 (da) 2003-01-06
PT882728E (pt) 2002-11-29
KR19990071960A (ko) 1999-09-27
WO1997023483A1 (en) 1997-07-03
EP0882728A1 (en) 1998-12-09
ES2181927T3 (es) 2003-03-01
CN1095843C (zh) 2002-12-11

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