HK1232071A1 - 使用 抑制劑治療 感染 - Google Patents

使用 抑制劑治療 感染

Info

Publication number
HK1232071A1
HK1232071A1 HK17105755.5A HK17105755A HK1232071A1 HK 1232071 A1 HK1232071 A1 HK 1232071A1 HK 17105755 A HK17105755 A HK 17105755A HK 1232071 A1 HK1232071 A1 HK 1232071A1
Authority
HK
Hong Kong
Prior art keywords
mtan
pylori
treatment
inhibitors
infections
Prior art date
Application number
HK17105755.5A
Other languages
English (en)
Inventor
Vern L Schramm
Keith Clinch
Shivali Ashwin Gulab
Original Assignee
Albert Einstein College Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Einstein College Medicine Inc filed Critical Albert Einstein College Medicine Inc
Publication of HK1232071A1 publication Critical patent/HK1232071A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK17105755.5A 2014-02-12 2017-06-09 使用 抑制劑治療 感染 HK1232071A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938755P 2014-02-12 2014-02-12
PCT/US2015/014778 WO2015123101A1 (en) 2014-02-12 2015-02-06 Treatment of h. pylori infections using mtan inhibitors

Publications (1)

Publication Number Publication Date
HK1232071A1 true HK1232071A1 (zh) 2018-01-05

Family

ID=53800544

Family Applications (1)

Application Number Title Priority Date Filing Date
HK17105755.5A HK1232071A1 (zh) 2014-02-12 2017-06-09 使用 抑制劑治療 感染

Country Status (12)

Country Link
US (2) US10118928B2 (zh)
EP (1) EP3104707B1 (zh)
JP (1) JP6512613B2 (zh)
AU (1) AU2015217416B2 (zh)
BR (1) BR112016019469B1 (zh)
CA (1) CA2974916C (zh)
HK (1) HK1232071A1 (zh)
IL (1) IL247218B (zh)
NZ (1) NZ724103A (zh)
RU (1) RU2663803C2 (zh)
SG (2) SG10201806381VA (zh)
WO (1) WO2015123101A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014025842A1 (en) 2012-08-07 2014-02-13 Albert Einstein College Of Medicine Of Yeshiva University Treatment of helicobacter pylori infections
CN108794628A (zh) * 2018-05-28 2018-11-13 广东工业大学 一种抗幽门螺杆菌的卵黄抗体制备方法及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
DE60309701T2 (de) * 2002-06-13 2007-09-06 Vertex Pharmaceuticals Inc., Cambridge 2-ureido-6-heteroaryl-3h-benzoimidazol-4-carbonsäurederivate und verwandte verbindungen als gyrase und/oder topoisomerase iv inhibitoren zur behandlung von bakteriellen infektionen
DK1539783T3 (da) 2002-08-21 2011-06-20 Einstein Coll Med Inhibitorer af nucleosidphosphorylaser og nucleosidaser
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
US8541567B2 (en) 2005-07-27 2013-09-24 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5′-methylthioadenosine/s-adenosylhomocysteine nucleosidases
WO2008030118A1 (en) * 2006-09-07 2008-03-13 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
DE602007013252D1 (de) 2006-09-07 2011-04-28 Einstein Coll Med Azyklische amininhibitoren von nukleosidphosphorylasen und hydrolasen
ES2385759T3 (es) 2006-12-22 2012-07-31 Industrial Research Limited Análogos azetidina de inhibidores de nucleosidasa y fosforilasa
WO2008115531A1 (en) 2007-03-21 2008-09-25 Novacea, Inc. Prevention and treatment of infectious conditions with active vitamin d compounds or mimics thereof
US20110190265A1 (en) 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
WO2011008110A1 (en) 2009-07-17 2011-01-20 Albert Einstein College Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US9290501B2 (en) * 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2014025842A1 (en) 2012-08-07 2014-02-13 Albert Einstein College Of Medicine Of Yeshiva University Treatment of helicobacter pylori infections
WO2014043046A1 (en) 2012-09-11 2014-03-20 Albert Einstein College Of Medicine Of Yeshiva University Treatment and prevention of p. aeruginosa infections using coformycin analogs
EP3527554A3 (en) 2012-11-12 2019-09-25 Victoria Link Limited Salt and polymorphic forms of (3r,4s)-l-((4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrrolidin-3-ol(mtdia)

Also Published As

Publication number Publication date
US20190016730A1 (en) 2019-01-17
JP2017506238A (ja) 2017-03-02
EP3104707A1 (en) 2016-12-21
IL247218A0 (en) 2016-09-29
US20170166571A1 (en) 2017-06-15
RU2663803C2 (ru) 2018-08-09
EP3104707A4 (en) 2017-12-13
NZ724103A (en) 2020-07-31
CA2974916A1 (en) 2015-08-20
SG11201606595RA (en) 2016-09-29
US10118928B2 (en) 2018-11-06
AU2015217416B2 (en) 2018-10-04
JP6512613B2 (ja) 2019-05-15
CA2974916C (en) 2022-05-31
SG10201806381VA (en) 2018-08-30
RU2016136533A3 (zh) 2018-06-06
AU2015217416A1 (en) 2016-09-29
US10294233B2 (en) 2019-05-21
EP3104707B1 (en) 2020-07-15
BR112016019469A2 (pt) 2018-07-24
WO2015123101A1 (en) 2015-08-20
BR112016019469B1 (pt) 2022-12-06
RU2016136533A (ru) 2018-03-13
IL247218B (en) 2020-06-30

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