DK1539783T3 - Inhibitorer af nucleosidphosphorylaser og nucleosidaser - Google Patents

Inhibitorer af nucleosidphosphorylaser og nucleosidaser

Info

Publication number
DK1539783T3
DK1539783T3 DK03792904.9T DK03792904T DK1539783T3 DK 1539783 T3 DK1539783 T3 DK 1539783T3 DK 03792904 T DK03792904 T DK 03792904T DK 1539783 T3 DK1539783 T3 DK 1539783T3
Authority
DK
Denmark
Prior art keywords
inhibitors
compounds
phosphorylases
nucleosidases
methylthioadenosine
Prior art date
Application number
DK03792904.9T
Other languages
English (en)
Inventor
Gary Brian Evans
Dirk Henning Lenz
Vern L Schramm
Olga Vladimirovna Zubkova
Peter Charles Tyler
Richard Hubert Furneaux
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Application granted granted Critical
Publication of DK1539783T3 publication Critical patent/DK1539783T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Seal Device For Vehicle (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK03792904.9T 2002-08-21 2003-08-21 Inhibitorer af nucleosidphosphorylaser og nucleosidaser DK1539783T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ52091902 2002-08-21
PCT/NZ2003/000186 WO2004018496A1 (en) 2002-08-21 2003-08-21 Inhibitors of nucleoside phosphorylases and nucleosidases

Publications (1)

Publication Number Publication Date
DK1539783T3 true DK1539783T3 (da) 2011-06-20

Family

ID=31944950

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03792904.9T DK1539783T3 (da) 2002-08-21 2003-08-21 Inhibitorer af nucleosidphosphorylaser og nucleosidaser

Country Status (18)

Country Link
US (2) US7553839B2 (da)
EP (1) EP1539783B1 (da)
JP (1) JP4682314B2 (da)
KR (1) KR101081226B1 (da)
CN (1) CN100379750C (da)
AT (1) ATE505474T1 (da)
AU (1) AU2003258911B2 (da)
BR (1) BRPI0313664B8 (da)
CA (1) CA2496698C (da)
CY (1) CY1111700T1 (da)
DE (1) DE60336734D1 (da)
DK (1) DK1539783T3 (da)
ES (1) ES2363766T3 (da)
HK (1) HK1085219A1 (da)
PT (1) PT1539783E (da)
RU (1) RU2330042C2 (da)
SI (1) SI1539783T1 (da)
WO (1) WO2004018496A1 (da)

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EP1539783B1 (en) 2002-08-21 2011-04-13 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside phosphorylases and nucleosidases
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NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
EP1924684A4 (en) * 2005-07-27 2009-02-11 Einstein Coll Med STRUCTURE OF TRANSITION STATUS OF 5'-METHYLTHIOADENOSINE / S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES
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AU2007218334A1 (en) * 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
AU2006200809B2 (en) * 2006-02-24 2013-11-07 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
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EP2395005A1 (en) 2006-09-07 2011-12-14 Industrial Research Limited Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
US8283345B2 (en) 2006-12-22 2012-10-09 Industrial Research Limited Azetidine analogues of nucleosidase and phosphorylase inhibitors
WO2009082247A1 (en) * 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
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WO2011008110A1 (en) 2009-07-17 2011-01-20 Albert Einstein College Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US9290501B2 (en) 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2012122532A2 (en) * 2011-03-09 2012-09-13 Biocryst Pharmaceuticals, Inc. Compositions and methods for treatment of hyperuricemia
LT2734186T (lt) 2011-07-22 2018-12-10 Glaxosmithkline Llc Kompozicija
JP6063571B2 (ja) * 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
ES2653254T3 (es) 2012-08-24 2018-02-06 Glaxosmithkline Llc Compuestos de pirazolopirimidina
EP2920179A4 (en) 2012-11-12 2016-03-30 Victoria Link Ltd SALT FORMS AND POLYMORPHIC FORMS OF (3R, 4S) -1 - ((4-AMINO-5H-PYRROLO [3,2-D] PYRIMIDIN-7-YL) METHYL) -4- (METHYLTHIOMETHYL) PYRROLIDIN-3-OL (MTDIA)
CN104780922B (zh) 2012-11-20 2016-09-07 葛兰素史克有限责任公司 干扰素诱导剂化合物
AU2013348216B2 (en) 2012-11-20 2016-10-13 Glaxosmithkline Llc Novel compounds
WO2014081644A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
US9452217B2 (en) 2013-06-22 2016-09-27 Nitor Therapeutics Methods for potentiating immune response for the treatment of infectious diseases and cancer
JP6512613B2 (ja) 2014-02-12 2019-05-15 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド Ｍｔａｎ阻害剤を使用するピロリ菌（ｈ．ｐｙｌｏｒｉ）感染の治療
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NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
US20090012104A1 (en) 2004-07-27 2009-01-08 Babu Yarlagadda S Inhibitors of 5'-Methylthioadenosine Phosphorylase and 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
EP1924684A4 (en) 2005-07-27 2009-02-11 Einstein Coll Med STRUCTURE OF TRANSITION STATUS OF 5'-METHYLTHIOADENOSINE / S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097647A1 (en) 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
AU2007218334A1 (en) 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
EP2395005A1 (en) 2006-09-07 2011-12-14 Industrial Research Limited Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
AU2007293773B2 (en) * 2006-09-07 2013-01-31 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
CA2663562A1 (en) * 2006-09-26 2008-04-03 Vern L. Schramm Transition state structure of human 5'-methylthioadenosine phosphorylase
US8283345B2 (en) * 2006-12-22 2012-10-09 Industrial Research Limited Azetidine analogues of nucleosidase and phosphorylase inhibitors
WO2009082247A1 (en) 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
EP2348854A4 (en) 2008-09-22 2012-03-14 Einstein Coll Med METHOD AND COMPOSITIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS BY INHIBITING THE "QUORUM SENSING
WO2011008110A1 (en) 2009-07-17 2011-01-20 Albert Einstein College Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase

Also Published As

Publication number Publication date
ATE505474T1 (de) 2011-04-15
KR101081226B1 (ko) 2011-11-07
US20060160765A1 (en) 2006-07-20
CN1692120A (zh) 2005-11-02
CN100379750C (zh) 2008-04-09
BRPI0313664B1 (pt) 2021-03-23
US20090239885A1 (en) 2009-09-24
US7553839B2 (en) 2009-06-30
JP4682314B2 (ja) 2011-05-11
RU2005107714A (ru) 2006-01-20
BRPI0313664B8 (pt) 2021-05-25
EP1539783B1 (en) 2011-04-13
CA2496698A1 (en) 2004-03-04
RU2330042C2 (ru) 2008-07-27
EP1539783A4 (en) 2010-05-19
CA2496698C (en) 2012-01-24
AU2003258911A1 (en) 2004-03-11
KR20050093756A (ko) 2005-09-23
CY1111700T1 (el) 2015-10-07
ES2363766T3 (es) 2011-08-16
DE60336734D1 (de) 2011-05-26
BR0313664A (pt) 2005-07-12
PT1539783E (pt) 2011-06-01
SI1539783T1 (sl) 2011-08-31
EP1539783A1 (en) 2005-06-15
JP2006501239A (ja) 2006-01-12
HK1085219A1 (en) 2006-08-18
AU2003258911B2 (en) 2009-11-19
WO2004018496A1 (en) 2004-03-04
US8173662B2 (en) 2012-05-08

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