HRP20050184B1 - Uporaba alkilfosfoholina u kombinaciji s protutumorskim lijekovima - Google Patents
Uporaba alkilfosfoholina u kombinaciji s protutumorskim lijekovimaInfo
- Publication number
- HRP20050184B1 HRP20050184B1 HRP20050184AA HRP20050184A HRP20050184B1 HR P20050184 B1 HRP20050184 B1 HR P20050184B1 HR P20050184A A HRP20050184A A HR P20050184AA HR P20050184 A HRP20050184 A HR P20050184A HR P20050184 B1 HRP20050184 B1 HR P20050184B1
- Authority
- HR
- Croatia
- Prior art keywords
- combination
- alkyl phosphocholines
- phosphocholines
- alkyl
- antitumor medicaments
- Prior art date
Links
- -1 alkyl phosphocholines Chemical class 0.000 title abstract 4
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Izum se odnosi na uporabu alkil fosfoholina u kombinaciji s protutumorskim lijekovima za liječenje benignih i malignih tumorskih bolesti u ljudi i sisavaca. Alkil fosfoholini se mogu koristiti u novoj kombinaciji s jednim ili nekoliko odobrenih citostatika. Poželjni alkil fosfoholini predstavljeni su u formuli II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39961502P | 2002-07-30 | 2002-07-30 | |
PCT/EP2003/008346 WO2004012744A1 (de) | 2002-07-30 | 2003-07-29 | Anwendung von alkylphosphocholinen in kombination mit antitumormedikamenten |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20050184A2 HRP20050184A2 (en) | 2005-04-30 |
HRP20050184B1 true HRP20050184B1 (hr) | 2014-04-11 |
Family
ID=31495746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20050184AA HRP20050184B1 (hr) | 2002-07-30 | 2005-02-25 | Uporaba alkilfosfoholina u kombinaciji s protutumorskim lijekovima |
Country Status (27)
Country | Link |
---|---|
US (3) | US8389497B2 (hr) |
EP (2) | EP2301551A1 (hr) |
JP (1) | JP2005535688A (hr) |
KR (3) | KR20130016413A (hr) |
CN (1) | CN1302780C (hr) |
AR (1) | AR040717A1 (hr) |
AT (1) | ATE516036T1 (hr) |
AU (2) | AU2003253350B2 (hr) |
BR (1) | BR0313048A (hr) |
CA (1) | CA2493023C (hr) |
CY (1) | CY1111902T1 (hr) |
DK (1) | DK1545553T3 (hr) |
ES (1) | ES2369535T3 (hr) |
HK (1) | HK1080751A1 (hr) |
HR (1) | HRP20050184B1 (hr) |
IL (1) | IL166329A (hr) |
MX (1) | MXPA05001203A (hr) |
NO (1) | NO335196B1 (hr) |
NZ (1) | NZ538428A (hr) |
PL (1) | PL375493A1 (hr) |
PT (1) | PT1545553E (hr) |
RU (1) | RU2005105693A (hr) |
SI (1) | SI1545553T1 (hr) |
TW (1) | TWI332007B (hr) |
UA (1) | UA82322C2 (hr) |
WO (1) | WO2004012744A1 (hr) |
ZA (1) | ZA200500453B (hr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2005105693A (ru) | 2002-07-30 | 2005-07-10 | Центарис ГмбХ (DE) | Применение алкилфосфохолинов и лекарственное средство для лечения опухолевых заболеваний |
US8383605B2 (en) | 2002-07-30 | 2013-02-26 | Aeterna Zentaris Gmbh | Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals |
WO2006081452A2 (en) * | 2005-01-28 | 2006-08-03 | Robert Birch | Co-administration of perifosine with chemotherapeutics |
AR058397A1 (es) * | 2005-12-19 | 2008-01-30 | Zentaris Gmbh | Derivados de alquilfosfolipidos con citotoxicidad reducida y usos de los mismos |
UA99434C2 (ru) * | 2005-12-19 | 2012-08-27 | Аетерна Центаріс Гмбх | Применение производных алкилфосфолипидов со сниженной цитотоксичностью |
EP1800684A1 (en) * | 2005-12-20 | 2007-06-27 | Zentaris GmbH | Novel alkyl phospholipid derivatives and uses thereof |
US8703179B2 (en) | 2006-05-11 | 2014-04-22 | Kimberly-Clark Worldwide, Inc. | Mucosal formulation |
MX2010001244A (es) * | 2007-07-30 | 2010-08-31 | Ardea Biosciences Inc | Derivados de n-(arilamino) sulfonamidas que incluyen polimorfos como inhibidores de mek asi como composiciones, metodos de uso y de preparacion de los mismos. |
EP2367425B1 (en) * | 2008-12-11 | 2018-02-28 | Abraxis BioScience, LLC | Combination therapy including a taxane and a further therapeutic agent |
MX2011011596A (es) | 2010-03-31 | 2012-02-01 | Keryx Biopharmaceuticals Inc | Perifosina y capecitabina como un tratamiento combinado para cancer. |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000033917A1 (de) * | 1998-12-04 | 2000-06-15 | Max-Delbrück-Centrum für Molekulare Medizin | Mittel zur tumortherapie auf liposomenbasis die tamoxifen enthalten |
WO2002066019A2 (en) * | 2001-02-19 | 2002-08-29 | Novartis Ag | Cancer treatment |
WO2003055522A1 (en) * | 2002-01-02 | 2003-07-10 | Pharmacia Italia Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors |
WO2005000318A2 (en) * | 2003-06-23 | 2005-01-06 | Neopharm, Inc. | Method of inducing apoptosis and inhibiting cardiolipin synthesis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5942639A (en) * | 1991-07-04 | 1999-08-24 | Asta Medica Aktiengesellschaft | Process for the preparation of alkylphosphocholines and the production thereof in pure form |
ES2086026T3 (es) * | 1991-07-04 | 1996-06-16 | Asta Medica Ag | Farmaco con efecto antineoplasico que contiene como sustancia activa (2-(n-metil-piperidino)-etil)-fosfato de octadecilo y procedimiento para su preparacion. |
US6172050B1 (en) * | 1992-07-11 | 2001-01-09 | Asta Medica Aktiengesellschaft | Phospholipid derivatives |
JP3079993B2 (ja) * | 1996-03-27 | 2000-08-21 | 日本電気株式会社 | 真空マイクロデバイスおよびその製造方法 |
DE19650778C2 (de) * | 1996-12-06 | 2001-01-04 | Asta Medica Ag | Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie |
HUP0004363A3 (en) | 1998-01-22 | 2002-12-28 | Zentaris Gmbh | Solid pharmaceutical compositions containing miltefosine for use in the treatment of leishmaniasis |
JP2002532553A (ja) | 1998-12-21 | 2002-10-02 | インケイサ.ソシエダ アノニマ | 有害な胃腸副作用を引き起こさない有力な抗炎症剤としてのエーテルリゾリン脂質の使用 |
EP1370270B1 (en) * | 2001-03-23 | 2009-12-02 | Shire Canada Inc. | Pharmaceutical combinations for the treatment of cancer comprising dioxolane nucleoside analogs |
WO2003005522A1 (es) | 2001-07-04 | 2003-01-16 | Acuna Arturo | Tapones para sellado de ductos para redes electricas, telefonicas y de fibra optica. |
RU2005105693A (ru) | 2002-07-30 | 2005-07-10 | Центарис ГмбХ (DE) | Применение алкилфосфохолинов и лекарственное средство для лечения опухолевых заболеваний |
WO2006081452A2 (en) | 2005-01-28 | 2006-08-03 | Robert Birch | Co-administration of perifosine with chemotherapeutics |
UA99434C2 (ru) | 2005-12-19 | 2012-08-27 | Аетерна Центаріс Гмбх | Применение производных алкилфосфолипидов со сниженной цитотоксичностью |
MX2011011596A (es) | 2010-03-31 | 2012-02-01 | Keryx Biopharmaceuticals Inc | Perifosina y capecitabina como un tratamiento combinado para cancer. |
-
2003
- 2003-07-29 RU RU2005105693/15A patent/RU2005105693A/ru unknown
- 2003-07-29 EP EP10010451A patent/EP2301551A1/de not_active Withdrawn
- 2003-07-29 AU AU2003253350A patent/AU2003253350B2/en not_active Ceased
- 2003-07-29 PT PT03766336T patent/PT1545553E/pt unknown
- 2003-07-29 KR KR1020127034433A patent/KR20130016413A/ko not_active Application Discontinuation
- 2003-07-29 KR KR1020057001510A patent/KR101066804B1/ko active IP Right Grant
- 2003-07-29 WO PCT/EP2003/008346 patent/WO2004012744A1/de active Application Filing
- 2003-07-29 DK DK03766336.6T patent/DK1545553T3/da active
- 2003-07-29 JP JP2004525354A patent/JP2005535688A/ja active Pending
- 2003-07-29 AT AT03766336T patent/ATE516036T1/de active
- 2003-07-29 BR BR0313048-7A patent/BR0313048A/pt not_active IP Right Cessation
- 2003-07-29 MX MXPA05001203A patent/MXPA05001203A/es active IP Right Grant
- 2003-07-29 UA UAA200500510A patent/UA82322C2/uk unknown
- 2003-07-29 ES ES03766336T patent/ES2369535T3/es not_active Expired - Lifetime
- 2003-07-29 SI SI200332027T patent/SI1545553T1/sl unknown
- 2003-07-29 TW TW092120705A patent/TWI332007B/zh not_active IP Right Cessation
- 2003-07-29 CN CNB038181010A patent/CN1302780C/zh not_active Expired - Fee Related
- 2003-07-29 AR AR20030102710A patent/AR040717A1/es unknown
- 2003-07-29 NZ NZ538428A patent/NZ538428A/en not_active IP Right Cessation
- 2003-07-29 PL PL03375493A patent/PL375493A1/xx unknown
- 2003-07-29 EP EP03766336A patent/EP1545553B1/de not_active Expired - Lifetime
- 2003-07-29 KR KR1020117017914A patent/KR20110102485A/ko active Application Filing
- 2003-07-29 CA CA2493023A patent/CA2493023C/en not_active Expired - Lifetime
- 2003-07-30 US US10/632,187 patent/US8389497B2/en not_active Expired - Lifetime
-
2005
- 2005-01-17 IL IL166329A patent/IL166329A/en not_active IP Right Cessation
- 2005-01-18 ZA ZA2005/00453A patent/ZA200500453B/en unknown
- 2005-02-25 HR HRP20050184AA patent/HRP20050184B1/hr not_active IP Right Cessation
- 2005-02-25 NO NO20051040A patent/NO335196B1/no not_active IP Right Cessation
-
2006
- 2006-01-20 HK HK06100926A patent/HK1080751A1/xx not_active IP Right Cessation
-
2008
- 2008-07-10 AU AU2008203060A patent/AU2008203060B2/en not_active Ceased
-
2010
- 2010-03-31 US US12/751,608 patent/US8507710B2/en not_active Expired - Fee Related
- 2010-03-31 US US12/751,454 patent/US8551977B2/en not_active Expired - Lifetime
-
2011
- 2011-09-30 CY CY20111100944T patent/CY1111902T1/el unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000033917A1 (de) * | 1998-12-04 | 2000-06-15 | Max-Delbrück-Centrum für Molekulare Medizin | Mittel zur tumortherapie auf liposomenbasis die tamoxifen enthalten |
WO2002066019A2 (en) * | 2001-02-19 | 2002-08-29 | Novartis Ag | Cancer treatment |
WO2003055522A1 (en) * | 2002-01-02 | 2003-07-10 | Pharmacia Italia Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors |
WO2005000318A2 (en) * | 2003-06-23 | 2005-01-06 | Neopharm, Inc. | Method of inducing apoptosis and inhibiting cardiolipin synthesis |
Non-Patent Citations (6)
Title |
---|
BERKOVIC D ET AL: "The influence of 1-beta-D-arabinofuranosylcytosine on the metabolism of phosphatidylcholine in human leukemic HL 60 and Raji cells." LEUKEMIA: OFFICIAL JOURNAL OF THE LEUKEMIA SOCIETY OF AMERICA, LEUKEMIA RESEARCH FUND, U.K. ENGLAND DEC 1997, Bd. 11, Nr. 12, Dezember 1997 (1997-12),2079-2086 str. * |
DATABASE MEDLINE [Online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; Februar 1991 (1991-02) SHOJI M ET AL: "Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells." Database accession no. NLM2051897 XP002256716 & LIPIDS. UNITED STATES FEB 1991, Bd. 26, Nr. 2, Februar 1991 (1991-02), 145-149 str. * |
GEORGIEVA MILKA C ET AL: "Combination effects of alkylphosphocholines and gemcitabine in malignant and normal hematopoietic cells." CANCER LETTERS. IRELAND 28 AUG 2002, Bd. 182, Nr. 2, 28. August 2002 (2002-08-28), 163-174 str. * |
HILGARD P ET AL: "Heterocyclic alkylphospholipids with an improved therapeutic range." ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. UNITED STATES 1996, Bd. 416, 1996,157-164 str. * |
SPRUSS T ET AL: "ANTITUMOUR ACTIVITY OF MILTEFOSINE ALONE AND AFTER COMBINATION WITHPLATINUM COMPLEXES ON MXT MOUSE MAMMARY CARCINOMA MODELS" JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER INTERNATIONAL, BERLIN, DE, Bd. 119, Nr. 3, 1993,142-149 str. * |
STEKAR J ET AL: "Opposite effect of miltefosine on the antineoplastic activity and haematological toxicity of cyclophosphamide." EUROPEAN JOURNAL OF CANCER (OXFORD, ENGLAND: 1990) ENGLAND 1995, Bd. 31A, Nr. 3, 1995, 372-374 str. * |
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Legal Events
Date | Code | Title | Description |
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A1OB | Publication of a patent application | ||
AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
PNAN | Change of the applicant name, address/residence |
Owner name: ZENTARIS GMBH, DE |
|
PNAN | Change of the applicant name, address/residence |
Owner name: ÆTERNA ZENTARIS GMBH, DE |
|
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20160714 Year of fee payment: 14 |
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PBON | Lapse due to non-payment of renewal fee |
Effective date: 20170729 |