CY1108715T1 - Νεες πυριδοπυραζινες και η χρηση τους ως διαμορφωτες kinασων - Google Patents
Νεες πυριδοπυραζινες και η χρηση τους ως διαμορφωτες kinασωνInfo
- Publication number
- CY1108715T1 CY1108715T1 CY20091100081T CY091100081T CY1108715T1 CY 1108715 T1 CY1108715 T1 CY 1108715T1 CY 20091100081 T CY20091100081 T CY 20091100081T CY 091100081 T CY091100081 T CY 091100081T CY 1108715 T1 CY1108715 T1 CY 1108715T1
- Authority
- CY
- Cyprus
- Prior art keywords
- firefighters
- models
- chinese
- new
- malignant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η εφεύρεση αναφέρεται σε νέα παράγωγα πυριδο[2,3-b]πυραζίνης του γενικού τύπου (I), στην παραγωγή και στη χρήση αυτών ως φαρμακευτικά μέσα, ιδίως για την αγωγή κακοηθών παθήσεων και άλλων παθήσεων βασιζόμενων σε παθολογικό πολλαπλασιασμό κυττάρων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10323345A DE10323345A1 (de) | 2003-05-23 | 2003-05-23 | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
DE102004022383A DE102004022383A1 (de) | 2004-05-06 | 2004-05-06 | Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen |
EP04733768A EP1636228B1 (de) | 2003-05-23 | 2004-05-19 | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108715T1 true CY1108715T1 (el) | 2014-04-09 |
Family
ID=33477517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100081T CY1108715T1 (el) | 2003-05-23 | 2009-01-21 | Νεες πυριδοπυραζινες και η χρηση τους ως διαμορφωτες kinασων |
Country Status (26)
Country | Link |
---|---|
US (1) | US7276507B2 (el) |
EP (1) | EP1636228B1 (el) |
JP (2) | JP4571944B2 (el) |
KR (1) | KR101111464B1 (el) |
AR (1) | AR045686A1 (el) |
AT (1) | ATE411992T1 (el) |
AU (1) | AU2004240747B2 (el) |
BR (1) | BRPI0410633A (el) |
CA (1) | CA2524525C (el) |
CY (1) | CY1108715T1 (el) |
DE (1) | DE502004008322D1 (el) |
DK (1) | DK1636228T3 (el) |
ES (1) | ES2316985T3 (el) |
HK (1) | HK1090643A1 (el) |
HR (1) | HRP20090036T3 (el) |
ME (1) | ME00541B (el) |
MX (1) | MXPA05012645A (el) |
NO (1) | NO332005B1 (el) |
NZ (1) | NZ544112A (el) |
PL (1) | PL1636228T3 (el) |
PT (1) | PT1636228E (el) |
RU (1) | RU2330851C9 (el) |
SI (1) | SI1636228T1 (el) |
TW (1) | TWI341839B (el) |
UA (1) | UA78929C2 (el) |
WO (1) | WO2004104003A1 (el) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006091395A2 (en) * | 2005-02-14 | 2006-08-31 | Merck & Co., Inc. | Inhibitors of akt activity |
US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
EP1785423A1 (de) * | 2005-11-11 | 2007-05-16 | Zentaris GmbH | Neue Pyridopyrazine und deren Verwendung als Modulatoren von Kinasen |
WO2007054556A1 (de) | 2005-11-11 | 2007-05-18 | Æterna Zentaris Gmbh | Neue pyridopyrazine und deren verwendung als modulatoren von kinasen |
EP1790342A1 (de) * | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
JO2985B1 (ar) * | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
EP1990342A1 (en) * | 2007-05-10 | 2008-11-12 | AEterna Zentaris GmbH | Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof |
CA2774999A1 (en) | 2009-09-30 | 2011-04-07 | President And Fellows Of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
EP2508184A1 (en) | 2011-04-06 | 2012-10-10 | Æterna Zentaris GmbH | Pyridopyrazine derivatives and their use |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
AU2015238301B2 (en) | 2014-03-26 | 2020-06-25 | Astex Therapeutics Ltd | Combinations |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
KR102479696B1 (ko) | 2014-03-26 | 2022-12-22 | 아스텍스 테라퓨틱스 리미티드 | Fgfr 억제제 및 igf1r 억제제의 조합물 |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
US11542247B2 (en) | 2015-09-23 | 2023-01-03 | Janssen Pharmaceutica Nv | Bi-heteroaryl substitute 1,4-benzodiazepines and uses thereof for the treatment of cancer |
BR112018005637B1 (pt) | 2015-09-23 | 2023-11-28 | Janssen Pharmaceutica Nv | Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos |
US11117894B2 (en) | 2017-06-22 | 2021-09-14 | City Of Hope | Pyridopyrazine compounds and uses thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9413975D0 (en) * | 1994-07-11 | 1994-08-31 | Fujisawa Pharmaceutical Co | New heterobicyclic derivatives |
TW274550B (el) | 1992-09-26 | 1996-04-21 | Hoechst Ag | |
US5700823A (en) * | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
UA71555C2 (en) * | 1997-10-06 | 2004-12-15 | Zentaris Gmbh | Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives |
BR0212510A (pt) | 2001-09-14 | 2004-08-24 | Methylgene Inc | Inibidor de histona desacetilase, composto e composição |
AU2003223467B2 (en) | 2002-04-08 | 2007-10-04 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
EP1496981A2 (en) * | 2002-04-08 | 2005-01-19 | Merck & Co., Inc. | Method of treating cancer |
AU2003230802B2 (en) | 2002-04-08 | 2007-08-09 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
AU2003281340B2 (en) | 2002-07-02 | 2009-04-09 | Southern Research Institute | Inhibitors of FtsZ and uses thereof |
AU2003282726B2 (en) | 2002-10-03 | 2010-10-07 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
DE10323345A1 (de) | 2003-05-23 | 2004-12-16 | Zentaris Gmbh | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
-
2004
- 2004-05-19 EP EP04733768A patent/EP1636228B1/de not_active Expired - Lifetime
- 2004-05-19 MX MXPA05012645A patent/MXPA05012645A/es active IP Right Grant
- 2004-05-19 PT PT04733768T patent/PT1636228E/pt unknown
- 2004-05-19 CA CA2524525A patent/CA2524525C/en not_active Expired - Fee Related
- 2004-05-19 AT AT04733768T patent/ATE411992T1/de active
- 2004-05-19 RU RU2005140377/04A patent/RU2330851C9/ru not_active IP Right Cessation
- 2004-05-19 JP JP2006529872A patent/JP4571944B2/ja not_active Expired - Fee Related
- 2004-05-19 ME MEP-2008-831A patent/ME00541B/me unknown
- 2004-05-19 BR BRPI0410633-4A patent/BRPI0410633A/pt not_active IP Right Cessation
- 2004-05-19 ES ES04733768T patent/ES2316985T3/es not_active Expired - Lifetime
- 2004-05-19 DK DK04733768T patent/DK1636228T3/da active
- 2004-05-19 PL PL04733768T patent/PL1636228T3/pl unknown
- 2004-05-19 NZ NZ544112A patent/NZ544112A/en unknown
- 2004-05-19 SI SI200431009T patent/SI1636228T1/sl unknown
- 2004-05-19 DE DE502004008322T patent/DE502004008322D1/de not_active Expired - Lifetime
- 2004-05-19 WO PCT/EP2004/005388 patent/WO2004104003A1/de active Application Filing
- 2004-05-19 KR KR1020057022424A patent/KR101111464B1/ko not_active IP Right Cessation
- 2004-05-19 AU AU2004240747A patent/AU2004240747B2/en not_active Ceased
- 2004-05-19 UA UAA200510686A patent/UA78929C2/uk unknown
- 2004-05-20 TW TW093114324A patent/TWI341839B/zh not_active IP Right Cessation
- 2004-05-21 US US10/851,976 patent/US7276507B2/en not_active Expired - Fee Related
- 2004-05-21 AR ARP040101772A patent/AR045686A1/es not_active Application Discontinuation
-
2005
- 2005-12-19 NO NO20056032A patent/NO332005B1/no not_active IP Right Cessation
-
2006
- 2006-10-18 HK HK06111425.6A patent/HK1090643A1/xx not_active IP Right Cessation
-
2009
- 2009-01-21 CY CY20091100081T patent/CY1108715T1/el unknown
- 2009-01-21 HR HR20090036T patent/HRP20090036T3/xx unknown
-
2010
- 2010-07-01 JP JP2010150895A patent/JP5447855B2/ja not_active Expired - Fee Related
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