BRPI0418939A - derivados de nicotinamida e sua utilização como agentes terapêuticos - Google Patents
derivados de nicotinamida e sua utilização como agentes terapêuticosInfo
- Publication number
- BRPI0418939A BRPI0418939A BRPI0418939-6A BRPI0418939A BRPI0418939A BR PI0418939 A BRPI0418939 A BR PI0418939A BR PI0418939 A BRPI0418939 A BR PI0418939A BR PI0418939 A BRPI0418939 A BR PI0418939A
- Authority
- BR
- Brazil
- Prior art keywords
- therapeutic agents
- nicotinamide derivatives
- mammal
- formula
- disclosed
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
DERIVADOS DE NICOTINAMIDA E SUA UTILIZAçãO COMO AGENTES TERAPêUTICOS Uso de um composto de fórmula (I) onde: m, n, p, V, R¬ 1¬, R¬ 2¬, R¬ 3¬ , R¬ 4¬, R¬ 5¬ e R¬ 6¬ são aqui definidos, para tratar uma doença ou condição SCD-mediada em um mamífero, preferivelmente um humano, é revelado. Composições farmacêuticas compreendendo os compostos de fórmula (I) são também revelados.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2004/021792 WO2006014168A1 (en) | 2004-07-06 | 2004-07-06 | Nicotinamide derivatives and their use as therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0418939A true BRPI0418939A (pt) | 2008-04-08 |
Family
ID=34958141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0418939-6A BRPI0418939A (pt) | 2004-07-06 | 2004-07-06 | derivados de nicotinamida e sua utilização como agentes terapêuticos |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1763350B1 (pt) |
JP (1) | JP2008505891A (pt) |
CN (1) | CN1997371A (pt) |
AT (1) | ATE537830T1 (pt) |
AU (1) | AU2004321997A1 (pt) |
BR (1) | BRPI0418939A (pt) |
CA (1) | CA2573198A1 (pt) |
ES (1) | ES2380020T3 (pt) |
MX (1) | MX2007000028A (pt) |
WO (1) | WO2006014168A1 (pt) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
CA2580845A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
AR051202A1 (es) | 2004-09-20 | 2006-12-27 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
CN101083994A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途 |
MX2007003321A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
WO2006034315A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
AU2005329423A1 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
RU2384576C2 (ru) | 2004-10-29 | 2010-03-20 | Калипсис, Инк | Сульфонил-замещенные бициклические соединения в качестве модуляторов ppar |
WO2007044085A2 (en) * | 2005-05-19 | 2007-04-19 | Xenon Pharmaceuticals Inc. | Heteroaryl compounds and their uses as therapeutic agents |
BRPI0611187A2 (pt) | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
ES2691548T3 (es) | 2005-10-25 | 2018-11-27 | Kalypsys, Inc. | Sales de moduladores de PPAR y métodos para tratar desórdenes metabólicos |
PE20080714A1 (es) | 2006-06-05 | 2008-07-31 | Novartis Ag | DERIVADOS HETEROCICLICOS COMO MODULADORES DE LA ACTIVIDAD DE LA ESTEARIL-CoA-DESATURASA |
AU2007288245A1 (en) | 2006-08-24 | 2008-02-28 | Novartis Ag | 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyrazol-3-yl) -thiazole derivatives as well as related compounds as stearoyl-CoA desaturase (SCD) inhibitors for the treatment of metabolic, cardiovascular and other disorders |
US20080176861A1 (en) | 2007-01-23 | 2008-07-24 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
US7842696B2 (en) | 2007-06-21 | 2010-11-30 | Forest Laboratories Holdings Limited | Piperazine derivatives as inhibitors of stearoyl-CoA desaturase |
WO2009019149A1 (en) | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as taar1 ligands |
JP4691669B2 (ja) | 2007-08-22 | 2011-06-01 | アストラゼネカ・アクチエボラーグ | シクロプロピルアミド誘導体 |
AU2008290864A1 (en) * | 2007-08-23 | 2009-02-26 | Sanofi-Aventis | Azoloraine derivatives, method for the production thereof, pharmaceuticals containing these compounds, and the use thereof |
CN101597278B (zh) | 2008-06-04 | 2013-04-17 | 中国中化股份有限公司 | 酰胺类化合物及其制备与应用 |
JP5597210B2 (ja) | 2009-02-17 | 2014-10-01 | メルク カナダ インコーポレイテッド | ステアロイル−補酵素aデルタ−9デサチュラーゼの阻害剤として有用な新規スピロ化合物 |
TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
EP2459568A4 (en) | 2009-07-28 | 2013-02-27 | Merck Frosst Canada Ltd | NOVEL SPIRO COMPOUNDS USEFUL AS DELTA-9 DEATURASE STEAROYL COENZYME INHIBITORS |
US20130012709A1 (en) | 2009-09-10 | 2013-01-10 | Centre National De La Recherche Scientifique | NOVEL INHIBITORS OF STEAROYL-CoA-DESATURASE-1 AND THEIR USES |
KR20130002316A (ko) | 2010-02-18 | 2013-01-07 | 아스트라제네카 아베 | 시클로프로필 벤즈아미드 유도체의 신규 결정질 형태 |
EP2576539B1 (de) * | 2010-05-27 | 2017-12-13 | Bayer CropScience AG | Pyridinylcarbonsäure derivate als fungizide |
KR101271538B1 (ko) | 2011-06-24 | 2013-06-05 | (주)이뮤노텍 | 유기산, l―카르니틴, l―아르기닌 및 니코틴아미드를 유효성분으로 포함하는 비만의 예방 및 개선용 조성물 |
KR20140084164A (ko) | 2011-10-15 | 2014-07-04 | 제넨테크, 인크. | 암의 치료를 위한 scd1 길항제 |
JP6293127B2 (ja) | 2012-05-22 | 2018-03-14 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド | 未分化細胞の選択的阻害剤 |
EP3566055A4 (en) | 2017-01-06 | 2020-12-02 | Yumanity Therapeutics, Inc. | TREATMENT METHODS FOR NEUROLOGICAL DISORDERS |
EP3700934A4 (en) | 2017-10-24 | 2021-10-27 | Yumanity Therapeutics, Inc. | COMPOUNDS AND USES OF THESE COMPOUNDS |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1140901A2 (en) * | 1998-12-24 | 2001-10-10 | Aventis Pharmaceuticals Products Inc. | Substituted (aminoiminomethyl or aminomethyl)benzoheteroaryl compounds as factor xa inhibitors |
AU2319100A (en) * | 1999-01-28 | 2000-08-18 | Nippon Shinyaku Co. Ltd. | Amide derivatives and drug compositions |
ES2226622T3 (es) * | 1999-02-24 | 2005-04-01 | F. Hoffmann-La Roche Ag | Derivados de 4-fenil piridina y su empleo como antagonistas del receptor nk-1. |
US6677452B1 (en) * | 1999-09-30 | 2004-01-13 | Lion Bioscience Ag | Pyridine carboxamide or sulfonamide derivatives and combinatorial libraries thereof |
AU1887401A (en) * | 1999-12-14 | 2001-06-25 | Nippon Shinyaku Co. Ltd. | Medicinal composition |
PT1315831E (pt) * | 2000-02-24 | 2010-11-04 | Xenon Pharmaceuticals Inc | Estearoil-coa dessaturase para identificar agentes terapêuticos que reduzem triglicéridos |
AU2001280438A1 (en) * | 2000-07-27 | 2002-02-13 | Eli Lilly And Company | Substituted heterocyclic amides |
TWI259180B (en) * | 2000-08-08 | 2006-08-01 | Hoffmann La Roche | 4-Phenyl-pyridine derivatives |
JP4186518B2 (ja) * | 2001-06-15 | 2008-11-26 | アステラス製薬株式会社 | フェニルピリジン誘導体 |
US7196080B2 (en) * | 2001-06-15 | 2007-03-27 | Astellas Pharma Inc. | Phenylpyridinecarbonylpiperazinederivative |
WO2003037862A1 (fr) * | 2001-10-30 | 2003-05-08 | Nippon Shinyaku Co., Ltd. | Derives amide, et medicaments correspondants |
US6620811B2 (en) * | 2001-11-19 | 2003-09-16 | Hoffmann-La Roche Inc. | Isonicotin- and nicotinamide derivatives of benzothiazoles |
EP1456175A1 (en) * | 2001-12-07 | 2004-09-15 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
ES2416304T3 (es) * | 2002-01-18 | 2013-07-31 | Astellas Pharma Inc. | Derivado de 2-acilaminotiazol o sal del mismo |
EP1485365B1 (en) * | 2002-03-13 | 2008-05-14 | Janssen Pharmaceutica N.V. | Sulfonyl-derivatives as novel inhibitors of histone deacetylase |
CA2493584A1 (en) * | 2002-07-25 | 2004-02-05 | Wisconsin Alumni Research Foundation | Inhibition of stearoyl-coa desaturase 1 (scd1) increases insulin sensitivity and treats diabetes |
-
2004
- 2004-07-06 AU AU2004321997A patent/AU2004321997A1/en not_active Abandoned
- 2004-07-06 CN CNA2004800435489A patent/CN1997371A/zh active Pending
- 2004-07-06 CA CA002573198A patent/CA2573198A1/en not_active Abandoned
- 2004-07-06 BR BRPI0418939-6A patent/BRPI0418939A/pt not_active IP Right Cessation
- 2004-07-06 JP JP2007520281A patent/JP2008505891A/ja active Pending
- 2004-07-06 EP EP04756752A patent/EP1763350B1/en not_active Not-in-force
- 2004-07-06 AT AT04756752T patent/ATE537830T1/de active
- 2004-07-06 WO PCT/US2004/021792 patent/WO2006014168A1/en active Application Filing
- 2004-07-06 ES ES04756752T patent/ES2380020T3/es active Active
- 2004-07-06 MX MX2007000028A patent/MX2007000028A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008505891A (ja) | 2008-02-28 |
MX2007000028A (es) | 2007-07-20 |
EP1763350B1 (en) | 2011-12-21 |
ES2380020T3 (es) | 2012-05-07 |
WO2006014168A1 (en) | 2006-02-09 |
AU2004321997A1 (en) | 2006-02-09 |
CA2573198A1 (en) | 2006-02-09 |
CN1997371A (zh) | 2007-07-11 |
EP1763350A1 (en) | 2007-03-21 |
ATE537830T1 (de) | 2012-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |