AU2001280438A1 - Substituted heterocyclic amides - Google Patents

Substituted heterocyclic amides

Info

Publication number
AU2001280438A1
AU2001280438A1 AU2001280438A AU8043801A AU2001280438A1 AU 2001280438 A1 AU2001280438 A1 AU 2001280438A1 AU 2001280438 A AU2001280438 A AU 2001280438A AU 8043801 A AU8043801 A AU 8043801A AU 2001280438 A1 AU2001280438 A1 AU 2001280438A1
Authority
AU
Australia
Prior art keywords
substituted heterocyclic
heterocyclic amides
amides
inhibitor
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001280438A
Inventor
David Kent Herron
Sajan Joseph
Angela Lynn Marquart
John Joseph Masters
David Mendel
Gerald Floyd Smith
Philip Parker Waid
Michael Robert Wiley
Ying Kwong Yee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2001280438A1 publication Critical patent/AU2001280438A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
AU2001280438A 2000-07-27 2001-07-18 Substituted heterocyclic amides Abandoned AU2001280438A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22109200P 2000-07-27 2000-07-27
US60221092 2000-07-27
PCT/US2001/016528 WO2002010154A2 (en) 2000-07-27 2001-07-18 Substituted heterocyclic amides

Publications (1)

Publication Number Publication Date
AU2001280438A1 true AU2001280438A1 (en) 2002-02-13

Family

ID=22826311

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001280438A Abandoned AU2001280438A1 (en) 2000-07-27 2001-07-18 Substituted heterocyclic amides

Country Status (7)

Country Link
US (1) US7160878B2 (en)
EP (1) EP1307444B1 (en)
AT (1) ATE374765T1 (en)
AU (1) AU2001280438A1 (en)
DE (1) DE60130771T2 (en)
ES (1) ES2292607T3 (en)
WO (1) WO2002010154A2 (en)

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RU2276137C2 (en) * 2000-11-22 2006-05-10 Астеллас Фарма Инк. Substituted derivatives of benzene or their salts, pharmaceutical composition based on thereof
US7163938B2 (en) 2000-11-28 2007-01-16 Eli Lilly And Company Substituted carboxamides
DE60143671D1 (en) * 2001-06-07 2011-01-27 Sang Christine TREATMENT OF NEUROPATHIC PAIN BY N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONISTS
US7449457B2 (en) 2001-12-07 2008-11-11 Eli Lilly And Company Substituted heterocyclic carboxamides with antithrombotic activity
US7390813B1 (en) 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
DE602004011064T2 (en) * 2003-05-30 2008-12-11 Eli Lilly And Co., Indianapolis ANTIBROMOTIC AETHER
JP4884219B2 (en) * 2003-07-29 2012-02-29 ゼノン・ファーマシューティカルズ・インコーポレイテッド Pyridyl derivatives and their use as therapeutic agents
US7754711B2 (en) * 2003-07-30 2010-07-13 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
EP1651620B1 (en) * 2003-07-30 2011-11-09 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
ES2375134T3 (en) * 2003-07-30 2012-02-27 Xenon Pharmaceuticals Inc. DERIVATIVES OF PIPERAZINE AND ITS USE AS THERAPEUTIC AGENTS.
EP1651616B1 (en) * 2003-07-30 2012-05-02 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
US7759348B2 (en) 2003-07-30 2010-07-20 Xenon Pharmaceuticals Inc. Pyridazine derivatives and their use as therapeutic agents
EP1670783A2 (en) 2003-09-30 2006-06-21 Eli Lilly And Company Antithrombotic aromatic ethers
US7371743B2 (en) 2004-02-28 2008-05-13 Boehringer Ingelheim International Gmbh Carboxylic acid amides, the preparation thereof and their use as medicaments
SE0401342D0 (en) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
CN1997371A (en) * 2004-07-06 2007-07-11 泽农医药公司 Nicotinamide derivatives and their use as therapeutic agents
CA2580856A1 (en) * 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
TW200626138A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
BRPI0515482A (en) * 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc heterocyclic derivatives and their uses as therapeutic agents
EP1799668A1 (en) * 2004-09-20 2007-06-27 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
JP4958787B2 (en) * 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド Pyridine derivatives for inhibiting human stearoyl-CoA desaturase
AU2005286647A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP1804792A1 (en) * 2004-09-20 2007-07-11 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd)
AU2005286793A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
TW200626155A (en) * 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
WO2006057845A1 (en) 2004-11-24 2006-06-01 Eli Lilly And Company Aromatic ether derivatives useful as thrombin inhibitors
US7666866B2 (en) * 2004-11-29 2010-02-23 Eli Lilly And Company Antithrombotic diamides
US7264402B2 (en) * 2005-03-10 2007-09-04 Corning Cable Systems Llc Multi-fiber optic receptacle and plug assembly
CA2618646A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
NZ583495A (en) 2007-09-20 2011-11-25 Irm Llc Compounds and compositions as modulators of gpr119 activity
US20130261130A1 (en) * 2010-11-01 2013-10-03 Shaheen Ahmed Neurotrypsin inhibitors

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US4994456A (en) 1989-03-01 1991-02-19 Nisshin Flour Milling Co., Ltd. Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
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AU7453498A (en) 1997-05-30 1998-12-30 Takeda Chemical Industries Ltd. Sulfonamide derivatives, their production and use
IL133621A0 (en) 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
EP1007037A4 (en) 1997-06-26 2004-10-06 Lilly Co Eli Antithrombotic agents
IL133627A0 (en) 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
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AU735144B2 (en) * 1997-07-23 2001-07-05 Yamanouchi Pharmaceutical Co., Ltd. Novel hexahydro-1,4-diazepine derivatives or their salts
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AU3352899A (en) 1997-12-11 1999-07-12 American Home Products Corporation 2,4,6-trisubstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
EP1040108B1 (en) * 1997-12-19 2004-02-25 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
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IL141183A0 (en) * 1998-08-04 2002-02-10 Astrazeneca Ab Amide derivatives useful as inhibitors of the production of cytokines
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ATE272633T1 (en) 1998-12-23 2004-08-15 Lilly Co Eli AROMATIC AMIDES
EP1140881B1 (en) 1998-12-23 2006-05-17 Eli Lilly And Company Antithrombotic amides
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DE60115394T2 (en) 2000-02-29 2006-10-19 Millennium Pharmaceuticals, Inc., Cambridge BENZAMID AND SIMILAR INHIBITORS FROM FACTOR XA
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof

Also Published As

Publication number Publication date
EP1307444A2 (en) 2003-05-07
EP1307444B1 (en) 2007-10-03
ES2292607T3 (en) 2008-03-16
US7160878B2 (en) 2007-01-09
ATE374765T1 (en) 2007-10-15
DE60130771D1 (en) 2007-11-15
WO2002010154A2 (en) 2002-02-07
DE60130771T2 (en) 2008-07-17
US20040097491A1 (en) 2004-05-20
WO2002010154A3 (en) 2002-06-27

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