AR051202A1 - Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa - Google Patents

Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa

Info

Publication number
AR051202A1
AR051202A1 ARP050103903A ARP050103903A AR051202A1 AR 051202 A1 AR051202 A1 AR 051202A1 AR P050103903 A ARP050103903 A AR P050103903A AR P050103903 A ARP050103903 A AR P050103903A AR 051202 A1 AR051202 A1 AR 051202A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
independently selected
rings
group
Prior art date
Application number
ARP050103903A
Other languages
English (en)
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Publication of AR051202A1 publication Critical patent/AR051202A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Métodos para tratar una enfermedad o afeccion mediada por la SCD en un mamífero, preferentemente un ser humano. Los métodos comprenden administrar a un mamífero que lo necesita un compuesto de formula (1). También se revelan composiciones farmacéuticas que comprenden los compuestos de formula (1). Reivindicacion 13: Un compuesto de formula (1), caracterizado porque: x e y son cada uno en forma independiente 0, 1, 2 o 3; J y K son cada uno en forma independiente N o C(R10); V es un enlace directo, -N(R1)-, -N(R1)C(O)-, -O-, -C(O)-, -C(O)O-, -C(S)-, -C(O)N(R1)-, -S(O)p- (donde p es 1 o 2) o -S(O)pN(R1)- (donde p es 1 o 2); W es R2-N(R1)C(O)-, R2-C(O)N(R1)-, R2-OC(O)N(R1)-, R2-N(R1)C(O)N(R1)-, R2-N(R1)-, R2-S(O)t- (donde t es 0, 1 o 2), R2-N(R1)S(O)p- (donde p es 1 o 2), R2-S(O)pN(R1)- (donde p es 1 o 2), R2-C(O)-, -R2-OS(O)2N(R1)-, R2-OC(O)-, R2-C(O)O-, R2-N(R1)C(O)O- o R2-C(R1)2-; cada R1 se selecciona en forma independiente del grupo formado por hidrogeno, C1-12 alquilo, C2-12 hidroxialquilo, C4-12 cicloalquilalquilo y C7-19 aralquilo; cada R2 se selecciona del grupo formado por C1-12 alquilo, C2-12 alquenilo, C2-12 hidroxialquilo, C2-12 hidroxialquenilo, C2-12 alcoxialquilo, C3-12 cicloalquilo, C4-12 cicloalquilalquilo, arilo, C7-19 aralquilo, C3-12 heterociclilo, C3-12 heterociclilalquilo, C1-12 heteroarilo, y C3-12 heteroarilalquilo; o cada R2 es una estructura de anillos multiples que tiene entre 2 y 4 anillos en donde los anillos se seleccionan en forma independiente del grupo formado por cicloalquilo, heterociclilo, arilo y heteroarilo y donde algunos o todos los anillos pueden estar fusionados entre sí; R3 se selecciona del grupo formado por hidrogeno, C1-12 alquilo, C2-12 alquenilo, C2-12 hidroxialquilo, C2-12 hidroxialquenilo, C1-12 alcoxialquilo, C3-12 cicloalquilo, C4-12 cicloalquilalquilo, arilo, C7-19 aralquilo, C3-12 heterociclilo, C3-12 heterociclilalquilo, C1-12 heteroarilo y C3-12 heteroarilalquilo, con la salvedad de que R3 no sea ciclopentilo opcionalmente sustituido o un anillo heterociclilo de 5 miembros opcionalmente sustituido; o R3 es una estructura de anillos multiples que tiene entre 2 y 4 anillos en donde los anillos se seleccionan en forma independiente del grupo formado por cicloalquilo, heterociclilo, arilo y heteroarilo y donde algunos o todos los anillos pueden estar fusionados entre sí; R4 es hidrogeno, fluoro, cloro, C1-12 alquilo, C1-12 alcoxi, haloalquilo, ciano, nitro o - N(R9)2; R5, R5a, R6, R6a, R7, R7a, R8 y R8a se seleccionan cada uno en forma independiente entre nitrogeno o C1-3 alquilo; o R5 y R5a juntos, R6 y R6a juntos, o R7 y R7a juntos, o R8 y R8a juntos constituyen un grupo oxo, con la salvedad de que cuando V es -C(O)-, R6 y R6a juntos o R8 y R8a juntos no formen un grupo oxo, mientras los restantes R5, R5a, R6, R6a, R7, R7a, R8 y R8a se seleccionan cada uno en forma independiente entre hidrogeno o C1-13 alquilo; o uno de R5, R5a, R6 y R6a junto con uno de R7, R7a, R8 y R8a forma un enlace directo o un puente alquileno, mientras los restantes R5, R5a, R6, R6a, R7, R7a, R8 y R8a se seleccionan cada uno en forma independiente entre hidrogeno o C1-3 alquilo; cada R9 se selecciona en forma independiente entre hidrogeno o C1-6 alquilo; y cada R10 se selecciona en forma independiente entre hidrogeno, fluoro, cloro, C1-12 alquilo o C1-12 alcoxi; en forma de uno de sus estereoisomeros, enantiomeros o tautomeros, en forma de mezcla de estereoisomeros, en forma de sal aceptable para uso farmacéutico, o como prodroga del mismo.
ARP050103903A 2004-09-20 2005-09-20 Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa AR051202A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61164804P 2004-09-20 2004-09-20

Publications (1)

Publication Number Publication Date
AR051202A1 true AR051202A1 (es) 2006-12-27

Family

ID=35768112

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103903A AR051202A1 (es) 2004-09-20 2005-09-20 Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa

Country Status (11)

Country Link
US (1) US8071603B2 (es)
EP (1) EP1799664A1 (es)
JP (2) JP2008513515A (es)
CN (1) CN101084207A (es)
AR (1) AR051202A1 (es)
AU (1) AU2005286648A1 (es)
BR (1) BRPI0515489A (es)
CA (1) CA2580856A1 (es)
MX (1) MX2007003332A (es)
TW (1) TW200624427A (es)
WO (1) WO2006034441A1 (es)

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CA2580856A1 (en) 2006-03-30
EP1799664A1 (en) 2007-06-27
WO2006034441A1 (en) 2006-03-30
JP2013053161A (ja) 2013-03-21
US20080188488A1 (en) 2008-08-07
US8071603B2 (en) 2011-12-06
BRPI0515489A (pt) 2008-07-29

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