AR060658A1 - Derivados de diceto-piperazina y piperidina como agentes antivirales - Google Patents

Derivados de diceto-piperazina y piperidina como agentes antivirales

Info

Publication number
AR060658A1
AR060658A1 ARP070101807A ARP070101807A AR060658A1 AR 060658 A1 AR060658 A1 AR 060658A1 AR P070101807 A ARP070101807 A AR P070101807A AR P070101807 A ARP070101807 A AR P070101807A AR 060658 A1 AR060658 A1 AR 060658A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
nitrogen
halogen
monocyclic heteroaryl
Prior art date
Application number
ARP070101807A
Other languages
English (en)
Inventor
Zhongxing Zhang
David J Carini
Jacob Swidorski
John F Kadow
Zhiwel Yin
Nicholas A Meanwell
Alicia Regueiro-Ren
Ying Han
Tao Wang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR060658A1 publication Critical patent/AR060658A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos que tienen propiedades de fármacos y bio-afectantes, sus composiciones farmacéuticas y métodos de uso. En particular, derivados de diceto piperazina y piperadina que poseen actividad antiviral unica, Más particularmente, compuestos utiles para el tratamiento del VIH y SIDA. Reivindicacion 1: Un compuesto de la formula 1, o sales farmacéuticamente aceptables de los mismos, caracterizado porque: A se selecciona del grupo que consiste de las formulas (2); R1 es H, o alquil C1-4; R2 es H; R4 se selecciona del grupo que consiste de H, halogeno, hidroxi, y Oalquil C1-4; R5 es H, halogeno, o alquil C1-4; R6 se selecciona del grupo que consiste de H, halogeno, halogeno, o alquil C1-4; R7 es independientemente seleccionado del grupo que consiste de hidrogeno, halogeno, y B; R4N no existe; en donde --- representa un enlace carbono-carbono o no existe; X es N o CH, (cuando X es CH la configuracion en el centro X puede ser racémico o puro (R) o puro (S) configuracion); Y se selecciona del grupo que consiste de fenilo, un heteroarilo monocíclico de 5 miembros que contiene 1 a 4 nitrogenos, un heteroarilo monociclico de 5 miembros que contiene 0 hasta 2 nitrogenos y ya sea un átomo de azufre o un oxigeno, un heteroarilo monocíclico de 5 miembros que contiene 1 hasta 2 nitrogenos fusionados a un anillo fenilo para formar 9 átomos que contienen heteroarilo bicíclico con la condicion de que el anillo de fenilo fusionado no contenga un enlace directo ya sea con X o Z un heteroarilo monocíclico de 6 miembros que contiene 1 hasta 3 nitrogenos, un heteroarilo monocíclico de 6 miembros que contiene 1 hasta 2 nitrogenos fusionados a un anillo de fenilo para formar 10 átomos que contienen heteroarilo bicíclico con la condicion de que el anillo de fenilo fusionado no contiene un enlace directo ya sea con X o Z, cicloalquil C4-6, cicloalquenilo C4-6, un heteroalicíclico C4-7 que contiene un nitrogeno, una lactama C4-7-, piridazin3(2H)-ona, o 1H-inden-1-ona con la condicion de que el anillo de 6 miembros no contenga ningun enlace directo a ya sea X o Z en donde el arilo o heteroarilo son independientemente opcionalmente substituidos con uno o dos grupos seleccionados de halogeno, hidroxilo, alquil C1-6, o alquil-OC1-3; Z se selecciona del grupo que consiste de CF3, alquil C4-7, fenilo, cicloalquil C4-7, piridinilo, alcoxi C2-5, un heteroarilo monocíclico de 5 miembros que contiene 1 hasta 2 nitrogenos, un heteroalicíclico de 6 miembros ligado a N que contiene 1 o 2 nitrogenos, una lactama C4-6 enlazada por medio de lactama de nitrogeno o ciano en donde el arilo o heteroarilo o lactama son independientemente opcionalmente substituidos con uno o dos grupos seleccionados de halogeno o alquil C1-3; B se selecciona del grupo que consiste de cloro, metoxi, tetrazolilo, -triazolilo, pirazolilo, imidazolilo, pirrolilo, piracinilo, y UR8a, en donde son opcionalmente substituidos con uno o tres mismos o diferentes halogenos o desde uno hasta tres mismos o diferentes substituyentes seleccionados del grupo de F; F se selecciona del grupo que consiste de alquil C1-3, heteroalicíclico, hidroximetilo, halogeno, -COOH, alquil-COOC1-3, amino, -NHCH3, -N(CH3)2, o el grupo de formulas (3); R8a es un miembro seleccionado del grupo que consiste de C(O)CH3, C(O)NH2, C(O)NHCH3 y C(O)N(CH3)2; R9, R10, R11, R12, R13, R14, R15, R16, son cada uno independientemente seleccionados del grupo que consiste de hidrogeno y metilo; con la condicion de que no más que dos pueden ser metilo; U se selecciona del grupo que consiste de NH o NCH3.
ARP070101807A 2006-04-25 2007-04-25 Derivados de diceto-piperazina y piperidina como agentes antivirales AR060658A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79470006P 2006-04-25 2006-04-25
US79470306P 2006-04-25 2006-04-25
US11/733,283 US7807671B2 (en) 2006-04-25 2007-04-10 Diketo-piperazine and piperidine derivatives as antiviral agents

Publications (1)

Publication Number Publication Date
AR060658A1 true AR060658A1 (es) 2008-07-02

Family

ID=38335673

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101807A AR060658A1 (es) 2006-04-25 2007-04-25 Derivados de diceto-piperazina y piperidina como agentes antivirales

Country Status (17)

Country Link
US (2) US7807671B2 (es)
EP (1) EP2010525B1 (es)
JP (1) JP5214590B2 (es)
KR (1) KR101450349B1 (es)
AR (1) AR060658A1 (es)
AU (1) AU2007242989B2 (es)
BR (1) BRPI0710919A2 (es)
CA (1) CA2650382C (es)
EA (1) EA014957B1 (es)
ES (1) ES2432758T3 (es)
IL (1) IL194540A (es)
MX (1) MX2008013265A (es)
NO (1) NO341412B1 (es)
NZ (1) NZ571995A (es)
PE (1) PE20080318A1 (es)
TW (1) TWI394754B (es)
WO (1) WO2007127635A2 (es)

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US7807676B2 (en) 2010-10-05
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BRPI0710919A2 (pt) 2012-06-26
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