AU2003215469A1 - Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors - Google Patents

Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors

Info

Publication number
AU2003215469A1
AU2003215469A1 AU2003215469A AU2003215469A AU2003215469A1 AU 2003215469 A1 AU2003215469 A1 AU 2003215469A1 AU 2003215469 A AU2003215469 A AU 2003215469A AU 2003215469 A AU2003215469 A AU 2003215469A AU 2003215469 A1 AU2003215469 A1 AU 2003215469A1
Authority
AU
Australia
Prior art keywords
pyridoxal
hiv integrase
integrase inhibitors
phosphate derivatives
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003215469A
Other versions
AU2003215469A8 (en
Inventor
Gilles Sauve
Brent Richard Stranix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procyon Biopharma Inc
Original Assignee
Pharmacor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002379526A external-priority patent/CA2379526A1/en
Application filed by Pharmacor Inc filed Critical Pharmacor Inc
Publication of AU2003215469A8 publication Critical patent/AU2003215469A8/en
Publication of AU2003215469A1 publication Critical patent/AU2003215469A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
AU2003215469A 2002-03-28 2003-03-19 Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors Abandoned AU2003215469A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CA2,379,526 2002-03-28
CA002379526A CA2379526A1 (en) 2002-03-28 2002-03-28 Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors
US10/183,468 2002-06-28
US10/183,468 US6638921B1 (en) 2002-03-28 2002-06-28 Pyridoxal-5-phosphate derivatives as HIV integrase inhibitors
PCT/CA2003/000427 WO2003082881A2 (en) 2002-03-28 2003-03-19 Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
AU2003215469A8 AU2003215469A8 (en) 2003-10-13
AU2003215469A1 true AU2003215469A1 (en) 2003-10-13

Family

ID=28675950

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003215469A Abandoned AU2003215469A1 (en) 2002-03-28 2003-03-19 Pyridoxal-5-phosphate derivatives as hiv integrase inhibitors

Country Status (2)

Country Link
AU (1) AU2003215469A1 (en)
WO (1) WO2003082881A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8586801A1 (en) * 2002-10-31 2005-02-04 Pfizer HIV-INTEGRESS INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
UA88297C2 (en) * 2004-03-15 2009-10-12 Бристол-Майэрс Сквибб Компани Prodrugs of piperazine and substituted piperidine antiviral agents
EP1873155A1 (en) * 2004-04-26 2008-01-02 Pfizer Inc. Inhibitors of the HIV integrase enzyme
BRPI0510306A (en) 2004-04-26 2007-09-04 Pfizer hiv integrase enzyme inhibitors, pharmaceutical composition containing said inhibitors as well as their use
EP1756103A2 (en) 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
WO2009005469A2 (en) * 2007-07-03 2009-01-08 David Erlinge The use of compounds such as pyridoxal derivatives for the treatment of diabetes or diseases associated with the metabolic syndrome
EP2853565A1 (en) * 2013-09-27 2015-04-01 Consejo Superior De Investigaciones Científicas Glutamate receptor photomodulators
EP3412651A1 (en) * 2017-06-06 2018-12-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Inhibitors of rac1 and uses thereof for inducing bronchodilatation
CN110330454B (en) * 2019-08-28 2021-05-14 北华航天工业学院 Synthesis method of pyridine heterocyclic azobenzene

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3546100A (en) * 1999-03-30 2000-10-23 Pharmacor Inc. Hydroxyphenyl derivatives with hiv integrase inhibitory properties
US6313177B1 (en) * 1999-04-30 2001-11-06 Pharmacor Inc. D-mannitol derivatives as HIV aspartyl protease inhibitors

Also Published As

Publication number Publication date
AU2003215469A8 (en) 2003-10-13
WO2003082881A2 (en) 2003-10-09
WO2003082881A3 (en) 2003-12-04

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase