AR049331A1 - Derivados de imidazopiridinas, imidazoquinolinas e iimidazonaftiridinas sustituidas con amidas como moduladores de biosintesis de citoquinas. composiciones farmaceuticas. - Google Patents

Derivados de imidazopiridinas, imidazoquinolinas e iimidazonaftiridinas sustituidas con amidas como moduladores de biosintesis de citoquinas. composiciones farmaceuticas.

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Publication number
AR049331A1
AR049331A1 ARP050101195A ARP050101195A AR049331A1 AR 049331 A1 AR049331 A1 AR 049331A1 AR P050101195 A ARP050101195 A AR P050101195A AR P050101195 A ARP050101195 A AR P050101195A AR 049331 A1 AR049331 A1 AR 049331A1
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AR
Argentina
Prior art keywords
group
alkyl
substituted
aryl
heteroaryl
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ARP050101195A
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English (en)
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3M Innovative Properties Co
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Publication of AR049331A1 publication Critical patent/AR049331A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente trata de derivados de imidazopiridinas, imidazoquinolinas e imidzonaftiridinas sustituidas con amidas como moduladores de biosíntesis de citoquinas. Composiciones farmacéuticas que los contienen. Reivindicacion 1: Un compuesto de formula (1) donde R1 se selecciona del grupo integrado por -X'-C(O)-N(R1')(R1") y el resto de formula (2), X' se selecciona del grupo integrado por -CH(R9)-, -CH(R9)-alquileno- y -CH(R9)-alquenileno-; X" se selecciona del grupo integrado por -CH(R9)- , -CH(R9)-alquileno- y -CH(R9)-alquenileno-; donde el alquileno y alquenileno son interrumpidos opcionalmente con uno o más grupos -O-; R1' y R1" se seleccionan independientemente del grupo integrado por: H, alquilo, alquenilo, arilo, arilalquilenilo, heteroarilo, heteroarilalquilenilo, heterociclilo, heterociclilalquilenilo, y alquilo, alquenilo, arilo, arilalquilenilo, heteroarilo, heteroarilalquilenilo, heterociclilo o heterociclilalquilenilo, sustituido con uno o más sustituyentes seleccionados del grupo integrado por: hidroxi, alquilo, haloalquilo, hidroxialquilo, alcoxi, haloalcoxi, halogeno, ciano, nitro, amino, alquilamino, dialquilamino, arilsulfonilo y alquilsulfonilo; A' se selecciona del grupo integrado por -O-, -C(O)-, -CH2-, -S(O)0-2- y -N(Q-R4)-; a y b independientemente son numeros enteros de 1 a 6 con la salvedad de que a + b es menor igual 7; RA y RB se seleccionan independientemente del grupo integrado por: H, halogeno, alquilo, alquenilo, alcoxi, alquiltio y -N(R9)2; o RA y RB en conjunto forman un anillo arilo fusionado que no está sustituido o está sustituido con 1 o más grupos Ra, o un anillo saturado fusionado de 5 a 7 miembros que no está sustituido o está sustituido con uno o más grupos Rc; o RA y RB en conjunto forman un heteroarilo fusionado o un anillo saturado de 5 a 7 miembros que contiene un heteoátomo seleccionado del grupo integrado por N y S, donde el anillo heteroarilo no está sustituido o está sustituido con 1 o más grupos Rb, y el anillo saturado de 5 a 7 miembros no está sustituido o está sustituido con 1 o más grupos Rc; Ra se selecciona del grupo integrado por: halogeno, alquilo, haloalquilo, alcoxi y -N(R9)2; Rb se selecciona del grupo integrado por: halogeno, hidroxi, alquilo, haloalquilo, alcoxi y -N(R9)2; Rc se selecciona del grupo integrado por: halogeno, hidroxi, alquilo, alquenilo, haloalquilo, alcoxi, alquiltio y -N(R9)2; Q se selecciona del grupo integrado por un enlace, -C(R6)-, - C(R6)- C(R6)-, -S(O)2-, -C(R6)-N(R8)-W-, -S(O)2-N(R8)-, -C(R6)-O- y -C(R6)-N(OR9)-; W se selecciona del grupo integrado por un enlace, -C(O)-, y -S(O)2-; R4 se selecciona del grupo integrado por H, alquilo, alquenilo, alquinilo, arilo, arilalquinlenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo, alquilheteroarilenilo, y heterociclilo donde los grupos alquilo, alquenilo, alquinilo, arilo, arilalquilenilo, ariloxialquilenilo, alquilarilenilo, heteroarilo, heteroarilalquilenilo, heteroariloxialquilenilo, alquilheteroarilenilo, y heterociclilo no están sustituidos o están sustituidos con uno o más sustituyentes seleccionados independientemente del grupo integrado por alquilo, alcoxi, hidroxialquilo, haloalquilo, haloalcoxi, halogeno, nitro, hidroxi, mercapto, ciano, arilo, ariloxi, arilalquilenoxi, heteroarilo, heteroariloxi, heteroarilalquilenoxi, heterociclilo, amino, alquilamino, dialquilamino, (dialquilamino)alquilenoxi y, en el caso de alquilo, alquenilo, alquinilo, y heterociclilo, oxo; R6 se selecciona del grupo integrado por =O y =S; R8 se selecciona del grupo integrado por H, alquilo, alcoxialquilenilo y arilalquilenilo; R9 se selecciona del grupo integrado por H y alquilo; y R" es H o un sustituyente no interferente; con la salvedad de que cuando RA y RB forman un heteroarilo fusionado o un anillo saturado de 5 a 7 miembros que contiene un heteroátomo seleccionado del grupo integrado por N y S, donde el anillo heteroarilo no está sustituido o está sustituido con uno o más grupos Rb, y el anillo saturado de 5 a 7 miembros no está sustituido o está sustituido con uno o más grupos Rc, entonces R1 también puede ser -X"-C(O)-N(R1')(R1"); o una sal aceptable para uso farmacéutico del mismo.
ARP050101195A 2004-03-24 2005-03-28 Derivados de imidazopiridinas, imidazoquinolinas e iimidazonaftiridinas sustituidas con amidas como moduladores de biosintesis de citoquinas. composiciones farmaceuticas. AR049331A1 (es)

Applications Claiming Priority (2)

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US55575304P 2004-03-24 2004-03-24
US57876904P 2004-06-10 2004-06-10

Publications (1)

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AR049331A1 true AR049331A1 (es) 2006-07-19

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Country Status (7)

Country Link
US (1) US8697873B2 (es)
EP (1) EP1730143A2 (es)
AR (1) AR049331A1 (es)
AU (1) AU2005228150A1 (es)
CA (1) CA2559863A1 (es)
TW (1) TW200612932A (es)
WO (1) WO2005094531A2 (es)

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