AR078786A1 - Derivados de la cromenona - Google Patents

Derivados de la cromenona

Info

Publication number
AR078786A1
AR078786A1 ARP100103937A AR078786A1 AR 078786 A1 AR078786 A1 AR 078786A1 AR P100103937 A ARP100103937 A AR P100103937A AR 078786 A1 AR078786 A1 AR 078786A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
halogen
independently selected
ring
Prior art date
Application number
Other languages
English (en)
Inventor
Bernand Christophe Barlaam
Van Der Brempt Christine Marie Paul Lambert
Remy Robert Morgentin
Sebastian Louis Degorce
Patrick Ple
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR078786A1 publication Critical patent/AR078786A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Abstract

Composiciones farmacéuticas que los contienen y sus usos en la elaboracion de un medicamento para utilizar en el tratamiento de trastornos de proliferacion celular. Reivindicacion 1: Un compuesto de formula (1) caracterizado porque: R1 es H o alquilo C1-4 sustituido opcionalmente por 1, 2 o 3 sustituyentes seleccionados independientemente de halogeno, hidroxi o alcoxi C1-3; R2 es alquilo C1-4 o alcoxi C1-4, cualquiera de los cuales puede estar opcionalmente sustituido por 1, 2 o 3 sustituyentes seleccionados independientemente de halogeno, hidroxi, alquenilo C2-3, alquinilo C2-3, alcoxi C1-3, ciano, alquil C1-3amino o di[alquil C1-3]amino; o R1 y R2 juntos forman un nitrogeno de 3 a 8 miembros que contiene un sistema de anillo heterociclilo, que contiene opcionalmente 1 o 2 heteroátomos más seleccionados de oxígeno, nitrogeno y azufre, donde un átomo de azufre del anillo se oxida opcionalmente para formar el/los S-oxido(s), y dicho anillo puede estar opcionalmente sustituido por 1, 2 o 3 sustituyentes seleccionados independientemente de halogeno, hidroxi, alquilo C1-3, alquenilo C2-3, alquinilo C2-3, alcoxi C1-3, oxo, hidroxialquilo C1-3, halogeno-alquilo C1-3 y alcoxi C1-3-alquilo C1-3; R3 es H o alquilo C1-3; R4 y R5 se seleccionan independientemente de H, halogeno, alquilo C1-3, alquenilo C2-3, alquinilo C2-3, alcoxi C1-3 y ciano; o R4 y R5 juntos forman un anillo fenilo o un anillo heterociclilo de 5 o 6 miembros o un anillo heteroarilo de 5 o 6 miembros, donde el anillo heterociclilo o anillo heteroarilo contiene 1, 2 o 3 heteroátomos seleccionados de oxígeno y nitrogeno, y dicho anillo fenilo, heterociclilo o heteroarilo puede estar opcionalmente sustituido por 1, 2 o 3 sustituyentes seleccionados independientemente de halogeno, alquilo C1-3, alquenilo C2-3, alquinilo C2-3, alcoxi C1-3 y ciano; R6, R7 y R8 se seleccionan independientemente de H, halogeno, alquilo C1-3, alquenilo C2-3, alquinilo C2-3, alcoxi C1-3 y ciano; n es 0, 1, 2, 3 o 4; cada grupo R9 es alquilo C1-3; o una sal farmacéuticamente aceptable de este.
ARP100103937 2009-10-27 2010-10-26 Derivados de la cromenona AR078786A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09306017 2009-10-27

Publications (1)

Publication Number Publication Date
AR078786A1 true AR078786A1 (es) 2011-11-30

Family

ID=43085922

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100103937 AR078786A1 (es) 2009-10-27 2010-10-26 Derivados de la cromenona

Country Status (41)

Country Link
US (5) US8399460B2 (es)
EP (1) EP2493870B1 (es)
JP (2) JP5657010B2 (es)
KR (1) KR101738195B1 (es)
CN (2) CN102712615B (es)
AR (1) AR078786A1 (es)
AU (1) AU2010311107B9 (es)
BR (1) BR112012010124B8 (es)
CA (1) CA2776994C (es)
CL (1) CL2012001056A1 (es)
CO (1) CO6541528A2 (es)
CR (1) CR20120217A (es)
CU (1) CU20120069A7 (es)
CY (1) CY1116143T1 (es)
DK (1) DK2493870T3 (es)
DO (1) DOP2012000124A (es)
EA (1) EA020523B9 (es)
EC (1) ECSP12011838A (es)
ES (1) ES2530943T3 (es)
GT (1) GT201200126A (es)
HK (2) HK1174027A1 (es)
HN (1) HN2012000889A (es)
HR (1) HRP20150146T1 (es)
IL (1) IL219191A0 (es)
IN (1) IN2012DN03328A (es)
ME (1) ME02050B (es)
MX (1) MX2012005027A (es)
MY (1) MY179833A (es)
NI (1) NI201200081A (es)
NZ (1) NZ599457A (es)
PE (1) PE20130149A1 (es)
PL (1) PL2493870T3 (es)
PT (1) PT2493870E (es)
RS (1) RS53813B1 (es)
SA (1) SA110310808B1 (es)
SI (1) SI2493870T1 (es)
SM (1) SMT201500036B (es)
TW (1) TWI483939B (es)
UA (1) UA107474C2 (es)
UY (1) UY32978A (es)
WO (1) WO2011051704A1 (es)

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Also Published As

Publication number Publication date
GT201200126A (es) 2014-03-03
US20160060240A1 (en) 2016-03-03
SMT201500036B (it) 2015-05-05
KR101738195B1 (ko) 2017-05-19
BR112012010124B1 (pt) 2021-02-17
JP5872016B2 (ja) 2016-03-01
MX2012005027A (es) 2012-09-07
TW201121960A (en) 2011-07-01
UY32978A (es) 2011-05-31
JP5657010B2 (ja) 2015-01-21
US8399460B2 (en) 2013-03-19
EA020523B9 (ru) 2015-01-30
TWI483939B (zh) 2015-05-11
CN102712615A (zh) 2012-10-03
PT2493870E (pt) 2015-02-18
US8673906B2 (en) 2014-03-18
CA2776994A1 (en) 2011-05-05
IL219191A0 (en) 2012-06-28
HRP20150146T1 (hr) 2015-05-22
CR20120217A (es) 2012-06-28
DOP2012000124A (es) 2012-07-15
HN2012000889A (es) 2015-08-03
AU2010311107A1 (en) 2012-05-03
SA110310808B1 (ar) 2013-11-24
EA201200618A1 (ru) 2012-12-28
US20140194419A1 (en) 2014-07-10
CO6541528A2 (es) 2012-10-16
AU2010311107B2 (en) 2014-03-27
US9029374B2 (en) 2015-05-12
CN104447657B (zh) 2016-08-17
JP2015078202A (ja) 2015-04-23
ME02050B (me) 2015-05-20
CY1116143T1 (el) 2017-02-08
JP2013508449A (ja) 2013-03-07
PE20130149A1 (es) 2013-03-10
US20110098271A1 (en) 2011-04-28
CN102712615B (zh) 2014-12-17
CN104447657A (zh) 2015-03-25
US20130158026A1 (en) 2013-06-20
IN2012DN03328A (es) 2015-10-23
HK1206335A1 (zh) 2016-01-08
CL2012001056A1 (es) 2012-10-05
BR112012010124B8 (pt) 2021-05-25
CA2776994C (en) 2017-10-31
AU2010311107B9 (en) 2014-06-19
UA107474C2 (uk) 2015-01-12
ES2530943T3 (es) 2015-03-09
US20160272607A1 (en) 2016-09-22
EA020523B1 (ru) 2014-11-28
CU20120069A7 (es) 2012-10-15
NI201200081A (es) 2012-11-07
MY179833A (en) 2020-11-17
HK1174027A1 (en) 2013-05-31
NZ599457A (en) 2014-04-30
EP2493870A1 (en) 2012-09-05
SI2493870T1 (sl) 2015-03-31
KR20120098724A (ko) 2012-09-05
US9718800B2 (en) 2017-08-01
EP2493870B1 (en) 2014-12-17
WO2011051704A1 (en) 2011-05-05
ECSP12011838A (es) 2012-06-29
PL2493870T3 (pl) 2015-04-30
BR112012010124A2 (pt) 2016-06-07
DK2493870T3 (en) 2015-02-23
RS53813B1 (en) 2015-06-30

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