BR112012010124A2 - composto, uso de um animal composto, derivado de cromenona, e, método para o tratamento ou prevenção de um animal de sangue quente tendo tumores que são sensíveis á inibição das enzimas de pi 3-cinase - Google Patents

composto, uso de um animal composto, derivado de cromenona, e, método para o tratamento ou prevenção de um animal de sangue quente tendo tumores que são sensíveis á inibição das enzimas de pi 3-cinase

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Publication number
BR112012010124A2
BR112012010124A2 BR112012010124A BR112012010124A BR112012010124A2 BR 112012010124 A2 BR112012010124 A2 BR 112012010124A2 BR 112012010124 A BR112012010124 A BR 112012010124A BR 112012010124 A BR112012010124 A BR 112012010124A BR 112012010124 A2 BR112012010124 A2 BR 112012010124A2
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BR
Brazil
Prior art keywords
compound
chromone
tumors
inhibition
warm
Prior art date
Application number
BR112012010124A
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English (en)
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BR112012010124B1 (pt
BR112012010124B8 (pt
Inventor
Bernard Christophe Barlaam
Christine Marie Paul Lambert-Van Der Brempt
Patrick Ple
Remy Robert Morgentin
Sebastien Louis Degorce
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Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR112012010124A2 publication Critical patent/BR112012010124A2/pt
Publication of BR112012010124B1 publication Critical patent/BR112012010124B1/pt
Publication of BR112012010124B8 publication Critical patent/BR112012010124B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

composto, uso de um composto, derivado de cromenona, e, método para o tratamento ou prevenção de um animal de sangue quente tendo tumores que são sensíveis á inibição das enzimas de pi3-cinase. a invenção diz respeito aos derivados de cromenona da fórmula (i) ou um sal farmaceuticamente aceitável do mesmo, em que cada um de r^1 1^, r^2 2^, r^ 3^, r^4 4^, r^5 5^, r^6 6^, r^7 7^, r^8 8^, n e r^ 9^ têm qualquer um dos significados definidos mais acima na descrição; processos para a sua preparação, composições farmacêuticas que as contenham e o seu uso na fabricação de um medicamento para o uso no tratamento de distúrbios de célula proliferativa.
BR112012010124A 2009-10-27 2010-10-25 composto derivado de cromenona ou um sal farmaceuticamente aceitavel do mesmo que possui atividade antitumor BR112012010124B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09306017.6 2009-10-27
EP09306017 2009-10-27
PCT/GB2010/051788 WO2011051704A1 (en) 2009-10-27 2010-10-25 Chromenone derivatives with anti-tumour activity

Publications (3)

Publication Number Publication Date
BR112012010124A2 true BR112012010124A2 (pt) 2016-06-07
BR112012010124B1 BR112012010124B1 (pt) 2021-02-17
BR112012010124B8 BR112012010124B8 (pt) 2021-05-25

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BR112012010124A BR112012010124B8 (pt) 2009-10-27 2010-10-25 composto derivado de cromenona ou um sal farmaceuticamente aceitavel do mesmo que possui atividade antitumor

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US (5) US8399460B2 (pt)
EP (1) EP2493870B1 (pt)
JP (2) JP5657010B2 (pt)
KR (1) KR101738195B1 (pt)
CN (2) CN104447657B (pt)
AR (1) AR078786A1 (pt)
AU (1) AU2010311107B9 (pt)
BR (1) BR112012010124B8 (pt)
CA (1) CA2776994C (pt)
CL (1) CL2012001056A1 (pt)
CO (1) CO6541528A2 (pt)
CR (1) CR20120217A (pt)
CU (1) CU20120069A7 (pt)
CY (1) CY1116143T1 (pt)
DK (1) DK2493870T3 (pt)
DO (1) DOP2012000124A (pt)
EA (1) EA020523B9 (pt)
EC (1) ECSP12011838A (pt)
ES (1) ES2530943T3 (pt)
GT (1) GT201200126A (pt)
HK (2) HK1174027A1 (pt)
HN (1) HN2012000889A (pt)
HR (1) HRP20150146T1 (pt)
IL (1) IL219191A0 (pt)
IN (1) IN2012DN03328A (pt)
ME (1) ME02050B (pt)
MX (1) MX2012005027A (pt)
MY (1) MY179833A (pt)
NI (1) NI201200081A (pt)
NZ (1) NZ599457A (pt)
PE (1) PE20130149A1 (pt)
PL (1) PL2493870T3 (pt)
PT (1) PT2493870E (pt)
RS (1) RS53813B1 (pt)
SA (1) SA110310808B1 (pt)
SI (1) SI2493870T1 (pt)
SM (1) SMT201500036B (pt)
TW (1) TWI483939B (pt)
UA (1) UA107474C2 (pt)
UY (1) UY32978A (pt)
WO (1) WO2011051704A1 (pt)

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BR112012010124B1 (pt) 2021-02-17
CN104447657B (zh) 2016-08-17
AU2010311107B2 (en) 2014-03-27
SMT201500036B (it) 2015-05-05
CR20120217A (es) 2012-06-28
CA2776994A1 (en) 2011-05-05
AU2010311107B9 (en) 2014-06-19
CN102712615B (zh) 2014-12-17
SI2493870T1 (sl) 2015-03-31
NZ599457A (en) 2014-04-30
SA110310808B1 (ar) 2013-11-24
US9029374B2 (en) 2015-05-12
GT201200126A (es) 2014-03-03
DOP2012000124A (es) 2012-07-15
DK2493870T3 (en) 2015-02-23
IN2012DN03328A (pt) 2015-10-23
JP5872016B2 (ja) 2016-03-01
BR112012010124B8 (pt) 2021-05-25
MY179833A (en) 2020-11-17
AU2010311107A1 (en) 2012-05-03
JP2013508449A (ja) 2013-03-07
ES2530943T3 (es) 2015-03-09
CL2012001056A1 (es) 2012-10-05
HRP20150146T1 (hr) 2015-05-22
US9718800B2 (en) 2017-08-01
JP5657010B2 (ja) 2015-01-21
CN104447657A (zh) 2015-03-25
RS53813B1 (en) 2015-06-30
ECSP12011838A (es) 2012-06-29
JP2015078202A (ja) 2015-04-23
TW201121960A (en) 2011-07-01
CU20120069A7 (es) 2012-10-15
US20110098271A1 (en) 2011-04-28
UA107474C2 (uk) 2015-01-12
HN2012000889A (es) 2015-08-03
TWI483939B (zh) 2015-05-11
EA020523B1 (ru) 2014-11-28
HK1174027A1 (en) 2013-05-31
WO2011051704A1 (en) 2011-05-05
KR20120098724A (ko) 2012-09-05
CY1116143T1 (el) 2017-02-08
US20140194419A1 (en) 2014-07-10
UY32978A (es) 2011-05-31
CN102712615A (zh) 2012-10-03
US8673906B2 (en) 2014-03-18
US8399460B2 (en) 2013-03-19
US20160060240A1 (en) 2016-03-03
HK1206335A1 (zh) 2016-01-08
PL2493870T3 (pl) 2015-04-30
US20130158026A1 (en) 2013-06-20
CA2776994C (en) 2017-10-31
KR101738195B1 (ko) 2017-05-19
ME02050B (me) 2015-05-20
US20160272607A1 (en) 2016-09-22
EA020523B9 (ru) 2015-01-30
EP2493870A1 (en) 2012-09-05
NI201200081A (es) 2012-11-07
PE20130149A1 (es) 2013-03-10
AR078786A1 (es) 2011-11-30
EA201200618A1 (ru) 2012-12-28
CO6541528A2 (es) 2012-10-16
MX2012005027A (es) 2012-09-07
IL219191A0 (en) 2012-06-28
PT2493870E (pt) 2015-02-18
EP2493870B1 (en) 2014-12-17

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