UA99141C2 - Замещенные производные индазола, активные в качестве ингибиторов киназы - Google Patents

Замещенные производные индазола, активные в качестве ингибиторов киназы

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Publication number
UA99141C2
UA99141C2 UAA201001753A UAA201001753A UA99141C2 UA 99141 C2 UA99141 C2 UA 99141C2 UA A201001753 A UAA201001753 A UA A201001753A UA A201001753 A UAA201001753 A UA A201001753A UA 99141 C2 UA99141 C2 UA 99141C2
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Ukraine
Prior art keywords
indazole derivatives
kinase inhibitors
substituted indazole
derivatives active
active
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UAA201001753A
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English (en)
Ukrainian (uk)
Inventor
Борджиа Андреа Ломбарди
Мария Меникинкери
Паоло Орсини
Акилле Панцери
Этторе Перроне
Эрмес Ванотти
Марчелла Нези
Кьяра Маркионни
Original Assignee
НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39764856&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99141(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. filed Critical НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.
Publication of UA99141C2 publication Critical patent/UA99141C2/ru

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    • C—CHEMISTRY; METALLURGY
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Изобретение касается замещенных производных индазола формулы (I) и их фармацевтически приемлемых солей, способа их получения и фармацевтических композиций, которые их содержат. Соединения по изобретению могут быть использованы в лечении заболеваний, связанных с аномальной активностью протеинкиназы, таких как рак.
UAA201001753A 2007-07-20 2008-07-08 Замещенные производные индазола, активные в качестве ингибиторов киназы UA99141C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07112881 2007-07-20

Publications (1)

Publication Number Publication Date
UA99141C2 true UA99141C2 (ru) 2012-07-25

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ID=39764856

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UAA201001753A UA99141C2 (ru) 2007-07-20 2008-07-08 Замещенные производные индазола, активные в качестве ингибиторов киназы

Country Status (28)

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US (11) US8299057B2 (ru)
EP (1) EP2176231B1 (ru)
JP (1) JP5506674B2 (ru)
KR (2) KR101567763B1 (ru)
CN (2) CN103923072B (ru)
AR (1) AR067599A1 (ru)
AU (1) AU2008280283B2 (ru)
BR (1) BRPI0814628B1 (ru)
CA (1) CA2693901C (ru)
CL (1) CL2008002129A1 (ru)
DK (1) DK2176231T3 (ru)
EA (1) EA018503B1 (ru)
ES (1) ES2605230T3 (ru)
FR (1) FR20C1064I2 (ru)
HK (2) HK1141278A1 (ru)
HU (2) HUE030929T2 (ru)
IL (1) IL203292A (ru)
NL (1) NL301090I2 (ru)
NO (1) NO2020042I1 (ru)
NZ (1) NZ583450A (ru)
PL (1) PL2176231T3 (ru)
PT (1) PT2176231T (ru)
SG (1) SG183049A1 (ru)
SI (1) SI2176231T1 (ru)
TW (1) TWI421073B (ru)
UA (1) UA99141C2 (ru)
WO (1) WO2009013126A1 (ru)
ZA (1) ZA201001086B (ru)

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