JOP20190092A1 - عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها - Google Patents

عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها

Info

Publication number
JOP20190092A1
JOP20190092A1 JOP/2019/0092A JOP20190092A JOP20190092A1 JO P20190092 A1 JOP20190092 A1 JO P20190092A1 JO P20190092 A JOP20190092 A JO P20190092A JO P20190092 A1 JOP20190092 A1 JO P20190092A1
Authority
JO
Jordan
Prior art keywords
pyrazolo
pyrimidines
salts
preparation
formula
Prior art date
Application number
JOP/2019/0092A
Other languages
English (en)
Inventor
Stacey Spencer
Qian Zhao
Yutong Jiang
Julia Haas
Charles Todd Eary
Original Assignee
Array Biopharma Inc
Loxo Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62023982&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20190092(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2016/058951 external-priority patent/WO2017075107A1/en
Application filed by Array Biopharma Inc, Loxo Oncology Inc filed Critical Array Biopharma Inc
Publication of JOP20190092A1 publication Critical patent/JOP20190092A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

في بعض التجسيدات، يتم هنا توفير عمليات لتحضير مركب له الصيغة C أو ملح منه، كما تم الكشف عنه هنا. في بعض التجسيدات، يتم هنا توفير مركب له الصيغة I أو ملح مقبول صيدليًا منه، ذوابة أو هيدرات. في بعض التجسيدات، يتم هنا توفير صورة صلبة من المركب، مثل صورة بلورية من الصورة البلورية للمركب I. صورة الصيغة C صورة الصيغة I
JOP/2019/0092A 2016-10-26 2017-06-16 عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها JOP20190092A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2016/058951 WO2017075107A1 (en) 2015-10-26 2016-10-26 Point mutations in trk inhibitor-resistant cancer and methods relating to the same
US201762524801P 2017-06-26 2017-06-26

Publications (1)

Publication Number Publication Date
JOP20190092A1 true JOP20190092A1 (ar) 2019-04-25

Family

ID=62023982

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0092A JOP20190092A1 (ar) 2016-10-26 2017-06-16 عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها

Country Status (28)

Country Link
US (1) US11091486B2 (ar)
EP (1) EP3532475A2 (ar)
JP (1) JP2019532089A (ar)
KR (1) KR20190082808A (ar)
CN (1) CN110267958A (ar)
AR (1) AR112207A1 (ar)
AU (1) AU2017348259B2 (ar)
BR (1) BR112019008341A2 (ar)
CA (1) CA3041316A1 (ar)
CL (2) CL2019001094A1 (ar)
CO (1) CO2019004123A2 (ar)
CR (1) CR20190255A (ar)
DO (1) DOP2019000109A (ar)
EA (1) EA201991055A1 (ar)
EC (1) ECSP19036765A (ar)
IL (1) IL266170A (ar)
JO (1) JOP20190092A1 (ar)
MA (2) MA45802A1 (ar)
MX (1) MX2019004951A (ar)
NI (1) NI201900037A (ar)
PE (1) PE20191543A1 (ar)
PH (1) PH12019500930A1 (ar)
SG (1) SG11201903487SA (ar)
TN (2) TN2019000133A1 (ar)
TW (1) TW201906840A (ar)
UA (1) UA124271C2 (ar)
UY (1) UY37781A (ar)
WO (2) WO2018081417A2 (ar)

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WO2019233461A1 (zh) * 2018-06-08 2019-12-12 江苏威凯尔医药科技有限公司 原肌球蛋白受体激酶抑制剂及其制备方法和应用
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CN111253402B (zh) * 2018-11-30 2021-08-03 广州白云山医药集团股份有限公司白云山制药总厂 一种trk激酶抑制剂化合物的中间体化合物及制备方法
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