BR112013021638A2 - "compostos inibidores de trk, seu uso e composições que os compreendem" - Google Patents

"compostos inibidores de trk, seu uso e composições que os compreendem"

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Publication number
BR112013021638A2
BR112013021638A2 BR112013021638A BR112013021638A BR112013021638A2 BR 112013021638 A2 BR112013021638 A2 BR 112013021638A2 BR 112013021638 A BR112013021638 A BR 112013021638A BR 112013021638 A BR112013021638 A BR 112013021638A BR 112013021638 A2 BR112013021638 A2 BR 112013021638A2
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BR
Brazil
Prior art keywords
compositions
compounds
trk
inhibiting compounds
trk inhibiting
Prior art date
Application number
BR112013021638A
Other languages
English (en)
Inventor
Brenton T Flatt
Jeffrey M Smith
Jon Loren
Valentina Molteni
Yi Fan
Original Assignee
Irm Llc
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45815979&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013021638(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Irm Llc filed Critical Irm Llc
Publication of BR112013021638A2 publication Critical patent/BR112013021638A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

compostos e composições como inibidores de trk. a presente invenção refere-se a compostos, composições farmacêuticas compreendendo tais compostos e métodos de usar tais compostos para tratar ou prevenir doenças ou distúrbios associados com a atividade de trk cinase anormal ou desregulada: fórmula (i) em que: a é x1 é ch ou n.
BR112013021638A 2011-02-25 2012-02-23 "compostos inibidores de trk, seu uso e composições que os compreendem" BR112013021638A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161446572P 2011-02-25 2011-02-25
PCT/US2012/026377 WO2012116217A1 (en) 2011-02-25 2012-02-23 Compounds and compositions as trk inhibitors

Publications (1)

Publication Number Publication Date
BR112013021638A2 true BR112013021638A2 (pt) 2016-08-02

Family

ID=45815979

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013021638A BR112013021638A2 (pt) 2011-02-25 2012-02-23 "compostos inibidores de trk, seu uso e composições que os compreendem"

Country Status (27)

Country Link
US (1) US9102671B2 (pt)
EP (1) EP2678338B1 (pt)
JP (1) JP5959541B2 (pt)
KR (1) KR20140014184A (pt)
CN (1) CN103492384B (pt)
AP (1) AP2013007103A0 (pt)
AU (1) AU2012220572A1 (pt)
BR (1) BR112013021638A2 (pt)
CA (1) CA2828219A1 (pt)
CL (1) CL2013002430A1 (pt)
CO (1) CO6751270A2 (pt)
CR (1) CR20130410A (pt)
CU (1) CU20130115A7 (pt)
DO (1) DOP2013000192A (pt)
EA (1) EA201391230A1 (pt)
ES (1) ES2551592T3 (pt)
GE (1) GEP20156285B (pt)
GT (1) GT201300209A (pt)
IL (1) IL227987A0 (pt)
MA (1) MA34969B1 (pt)
MX (1) MX2013009767A (pt)
NI (1) NI201300073A (pt)
PE (1) PE20140378A1 (pt)
SG (1) SG192795A1 (pt)
TN (1) TN2013000348A1 (pt)
WO (1) WO2012116217A1 (pt)
ZA (1) ZA201306221B (pt)

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EP2678338A1 (en) 2014-01-01
GT201300209A (es) 2015-06-02
SG192795A1 (en) 2013-09-30

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