BR112013021638A2 - "compostos inibidores de trk, seu uso e composições que os compreendem" - Google Patents

"compostos inibidores de trk, seu uso e composições que os compreendem"

Info

Publication number
BR112013021638A2
BR112013021638A2 BR112013021638A BR112013021638A BR112013021638A2 BR 112013021638 A2 BR112013021638 A2 BR 112013021638A2 BR 112013021638 A BR112013021638 A BR 112013021638A BR 112013021638 A BR112013021638 A BR 112013021638A BR 112013021638 A2 BR112013021638 A2 BR 112013021638A2
Authority
BR
Brazil
Prior art keywords
trk
compositions
compounds
use
inhibiting compounds
Prior art date
Application number
BR112013021638A
Other languages
English (en)
Inventor
Brenton T Flatt
Jeffrey M Smith
Jon Loren
Valentina Molteni
Yi Fan
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US201161446572P priority Critical
Application filed by Irm Llc filed Critical Irm Llc
Priority to PCT/US2012/026377 priority patent/WO2012116217A1/en
Publication of BR112013021638A2 publication Critical patent/BR112013021638A2/pt
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45815979&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013021638(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Abstract

compostos e composições como inibidores de trk. a presente invenção refere-se a compostos, composições farmacêuticas compreendendo tais compostos e métodos de usar tais compostos para tratar ou prevenir doenças ou distúrbios associados com a atividade de trk cinase anormal ou desregulada: fórmula (i) em que: a é x1 é ch ou n.
BR112013021638A 2011-02-25 2012-02-23 "compostos inibidores de trk, seu uso e composições que os compreendem" BR112013021638A2 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201161446572P true 2011-02-25 2011-02-25
PCT/US2012/026377 WO2012116217A1 (en) 2011-02-25 2012-02-23 Compounds and compositions as trk inhibitors

Publications (1)

Publication Number Publication Date
BR112013021638A2 true BR112013021638A2 (pt) 2016-08-02

Family

ID=45815979

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013021638A BR112013021638A2 (pt) 2011-02-25 2012-02-23 "compostos inibidores de trk, seu uso e composições que os compreendem"

Country Status (26)

Country Link
US (1) US9102671B2 (pt)
EP (1) EP2678338B1 (pt)
JP (1) JP5959541B2 (pt)
KR (1) KR20140014184A (pt)
CN (1) CN103492384B (pt)
AP (1) AP201307103A0 (pt)
AU (1) AU2012220572A1 (pt)
BR (1) BR112013021638A2 (pt)
CA (1) CA2828219A1 (pt)
CL (1) CL2013002430A1 (pt)
CO (1) CO6751270A2 (pt)
CR (1) CR20130410A (pt)
CU (1) CU20130115A7 (pt)
DO (1) DOP2013000192A (pt)
EA (1) EA201391230A1 (pt)
ES (1) ES2551592T3 (pt)
GE (1) GEP20156285B (pt)
GT (1) GT201300209A (pt)
IL (1) IL227987D0 (pt)
MA (1) MA34969B1 (pt)
MX (1) MX2013009767A (pt)
PE (1) PE03782014A1 (pt)
SG (1) SG192795A1 (pt)
TN (1) TN2013000348A1 (pt)
WO (1) WO2012116217A1 (pt)
ZA (1) ZA201306221B (pt)

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