PE20060426A1 - DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa - Google Patents
DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfaInfo
- Publication number
- PE20060426A1 PE20060426A1 PE2005000615A PE2005000615A PE20060426A1 PE 20060426 A1 PE20060426 A1 PE 20060426A1 PE 2005000615 A PE2005000615 A PE 2005000615A PE 2005000615 A PE2005000615 A PE 2005000615A PE 20060426 A1 PE20060426 A1 PE 20060426A1
- Authority
- PE
- Peru
- Prior art keywords
- tace
- alkyl
- mmps
- adams
- inhibitors
- Prior art date
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE A ES (R1)(R2)NCO-, (R1)(R2)NCS-, ENTRE OTROS; J Y E SON O, S O NR5; T ES O U S; R1 Y R2 SON INDEPENDIENTEMENTE H, ALQUILO, CICLOALQUILO, ENTRE OTROS, O JUNTOS CON EL N AL CUAL ESTAN UNIDOS FORMAN UN HETEROCICLO DE 4 A 8 MIEMBROS CON 1 A 3 HETEROATOMOS DE N OPCIONALMENTE SUSTITUIDOS POR R70 U OPCIONALMENTE FUSIONADO CON ARILO, HETEROARILO, ENTRE OTROS; OPCIONALMENTE SUSTITUIDOS; R10, R20, R30, R40 Y R50 SON INDEPENDIENTEMENTE H, ALQUILO, ENTRE OTROS; W ES -(CR(13)2)n- O UN ENLACE COVALENTE; X ESTA PRESENTE O NO, ES ALQUILO, ARILO TAL COMO, FENILO, AZETIDINO, PIRIDINILO, PIRROLIDINO, PIPERIDINILO, TIENILO, OXAZOLILO, IMIDAZOLILO, ENTRE OTROS; Y ESTA PRESENTE O NO, ES UN ENLACE COVALENTE O -C(R6)2]n-; Z ES H, ARILO O HETEROARILO, TAL COMO FENILO, INDOLILO, BENZOIMIDAZOLILO, PIRAZOLILO, TIENILO, PIRIDINILO, IMIDAZOLILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS POR CIANO, ALCOXI, HALOGENO, ALQUILO, ENTRE OTROS. ESTOS COMPUESTOS SON INHIBIDORES DE LAS MALOPROTEINASAS DE MATRIZ (MMPS), UNA DESINTEGRINA Y METALOPROTEASAS (ADAMs) Y/O A LA ENZIMA CONVERTIDORA DEL FACTOR DE NECROSIS TUMORAL ALFA (TACE) POR LO QUE EVITAN LA LIBERACION DEL FACTOR DE NECROSIS TUMORAL ALFA (TNF-a), POR LO QUE SON UTILES EN EL TRATAMIENTO DE OSTEOARTRITIS Y ARTRITIS REUMATOIDEA Y OTRAS ENFERMEDADES AUTOINMUNES
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DE1123468B (de) | 1955-01-22 | 1962-02-08 | Hermann Leinfelder | Verfahren zur Herstellung wasserloeslicher, poly-N-quaternaerer, die Diffusion in Geweben erhoehender Substanzen |
US5618842A (en) * | 1991-12-31 | 1997-04-08 | Lifegroup S.P.A. | N-acyl derivatives of aminoalcohols with polycarboxylic acids able to modulate mast cells in inflammatory processes having neuroimmunogenic origin |
US6228869B1 (en) * | 1996-10-16 | 2001-05-08 | American Cyanamid Company | Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
FR2762315B1 (fr) * | 1997-04-22 | 1999-05-28 | Logeais Labor Jacques | Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha |
TR200202163T2 (tr) * | 1999-08-18 | 2002-11-21 | Warner-Lambert Company | Matris metaloproteinaz inhibitörleri olarak kullanışlı olan hidroksamik asit bileşikleri |
WO2001021661A1 (en) | 1999-09-20 | 2001-03-29 | Novo Nordisk A/S | BIVALENT INHIBITOR OF FVIIa/TF/FXa COMPLEX |
EP1237862A1 (en) | 1999-12-17 | 2002-09-11 | Versicor, Inc. | Succinate compounds, compositions and methods of use and preparation |
DE60102137T2 (de) * | 2000-03-17 | 2004-10-21 | Bristol Myers Squibb Pharma Co | Beta-aminsäure-derivate zur verwendung als matrix-metalloproteasen- und tna-alpha-inhibitoren |
US6534651B2 (en) * | 2000-04-06 | 2003-03-18 | Inotek Pharmaceuticals Corp. | 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof |
HUP0301802A3 (en) * | 2000-06-28 | 2009-04-28 | Teva Pharma | Process for producing carvedilol, crystalline carvedilol, process for producing it and pharmaceutical composition containing it |
CA2446931A1 (en) | 2001-06-15 | 2002-12-27 | Vicuron Pharmaceuticals Inc. | Pyrrolidine bicyclic compounds |
AU2003214023A1 (en) | 2002-03-12 | 2003-09-22 | Novo Nordisk A/S | Dimeric tf antagonist comprising two factor vii polypeptides |
PT1660471E (pt) | 2003-08-23 | 2011-08-03 | Merck Serono Sa | Derivados de ácido hidroxâmico como inibidores de metaloproteinase |
US20070167426A1 (en) * | 2004-06-02 | 2007-07-19 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
US7638513B2 (en) * | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
PE20060426A1 (es) * | 2004-06-02 | 2006-06-28 | Schering Corp | DERIVADOS DE ACIDO TARTARICO COMO INHIBIDORES DE MMPs, ADAMs, TACE Y TNF-alfa |
US7553864B2 (en) * | 2005-12-01 | 2009-06-30 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
-
2005
- 2005-05-31 PE PE2005000615A patent/PE20060426A1/es not_active Application Discontinuation
- 2005-06-01 JP JP2007515501A patent/JP2008501691A/ja not_active Withdrawn
- 2005-06-01 MX MXPA06014054A patent/MXPA06014054A/es unknown
- 2005-06-01 CA CA002569111A patent/CA2569111A1/en not_active Abandoned
- 2005-06-01 CN CNA2005800261890A patent/CN101027295A/zh active Pending
- 2005-06-01 EP EP05759261A patent/EP1773821A2/en not_active Withdrawn
- 2005-06-01 AU AU2005252201A patent/AU2005252201A1/en not_active Abandoned
- 2005-06-01 KR KR1020067026812A patent/KR20070103671A/ko not_active Application Discontinuation
- 2005-06-01 TW TW094117942A patent/TW200612911A/zh unknown
- 2005-06-01 US US11/142,601 patent/US7652020B2/en not_active Expired - Fee Related
- 2005-06-01 AR ARP050102245A patent/AR051172A1/es not_active Application Discontinuation
- 2005-06-01 WO PCT/US2005/019131 patent/WO2005121130A2/en active Application Filing
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2006
- 2006-11-28 IL IL179674A patent/IL179674A0/en unknown
- 2006-11-30 ZA ZA200610055A patent/ZA200610055B/xx unknown
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2009
- 2009-10-20 US US12/582,341 patent/US8039467B2/en not_active Expired - Fee Related
Also Published As
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TW200612911A (en) | 2006-05-01 |
WO2005121130A3 (en) | 2006-07-20 |
ZA200610055B (en) | 2009-05-27 |
IL179674A0 (en) | 2007-05-15 |
US20100145048A1 (en) | 2010-06-10 |
US7652020B2 (en) | 2010-01-26 |
MXPA06014054A (es) | 2007-01-31 |
KR20070103671A (ko) | 2007-10-24 |
AR051172A1 (es) | 2006-12-27 |
US8039467B2 (en) | 2011-10-18 |
CA2569111A1 (en) | 2005-12-22 |
JP2008501691A (ja) | 2008-01-24 |
WO2005121130A2 (en) | 2005-12-22 |
EP1773821A2 (en) | 2007-04-18 |
CN101027295A (zh) | 2007-08-29 |
AU2005252201A1 (en) | 2005-12-22 |
US20060252778A1 (en) | 2006-11-09 |
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