BR112013032391A2 - antagonistas de trpv4 - Google Patents

antagonistas de trpv4

Info

Publication number
BR112013032391A2
BR112013032391A2 BR112013032391A BR112013032391A BR112013032391A2 BR 112013032391 A2 BR112013032391 A2 BR 112013032391A2 BR 112013032391 A BR112013032391 A BR 112013032391A BR 112013032391 A BR112013032391 A BR 112013032391A BR 112013032391 A2 BR112013032391 A2 BR 112013032391A2
Authority
BR
Brazil
Prior art keywords
trpv4
compounds
trpv4 antagonists
antagonists
relates
Prior art date
Application number
BR112013032391A
Other languages
English (en)
Other versions
BR112013032391B1 (pt
Inventor
Carl Brooks
Guosen Ye
Hilary Schenck Eidam
Jaclyn R Patterson
Krista B Goodman
Mark A Hilfiker
Marlys Hammond
Mui Cheung
Patrick Stoy
Tram H Hoang
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47558389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013032391(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of BR112013032391A2 publication Critical patent/BR112013032391A2/pt
Publication of BR112013032391B1 publication Critical patent/BR112013032391B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

resumo “antagonistas de trpv4” a presente invenção refere-se a compostos de espirocarbamato da fórmula (i), em que r1, (r2)y, r3, r4, x e a têm os significados indicados no relatório descritivo. a inven-ção fornece ainda composições farmacêuticas contendo os compostos ou sais farmaceuti-camente aceitáveis dos mesmos e refere-se à utilização destes compostos como antagonis-tas de trpv4 no tratamento ou na prevenção de condições associadas com o desequilíbrio de trpv4.
BR112013032391-4A 2011-06-17 2012-06-15 Composto antagonista de trpv4, composiçao farmaceutica que compreende o dito composto e uso do mesmo BR112013032391B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161498110P 2011-06-17 2011-06-17
US61/498,110 2011-06-17
PCT/US2012/042622 WO2013012500A1 (en) 2011-06-17 2012-06-15 Trpv4 antagonists

Publications (2)

Publication Number Publication Date
BR112013032391A2 true BR112013032391A2 (pt) 2016-08-16
BR112013032391B1 BR112013032391B1 (pt) 2020-11-24

Family

ID=47558389

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013032391-4A BR112013032391B1 (pt) 2011-06-17 2012-06-15 Composto antagonista de trpv4, composiçao farmaceutica que compreende o dito composto e uso do mesmo

Country Status (38)

Country Link
US (1) US9187464B2 (pt)
EP (2) EP2721016B1 (pt)
JP (1) JP5969017B2 (pt)
KR (1) KR101870003B1 (pt)
CN (1) CN103732583B (pt)
AR (1) AR086958A1 (pt)
AU (1) AU2012284540B2 (pt)
BR (1) BR112013032391B1 (pt)
CA (1) CA2839743C (pt)
CL (1) CL2013003602A1 (pt)
CO (1) CO6821953A2 (pt)
CR (1) CR20130671A (pt)
CY (1) CY1117792T1 (pt)
DK (1) DK2721016T3 (pt)
DO (1) DOP2013000307A (pt)
EA (1) EA023616B1 (pt)
ES (2) ES2688733T3 (pt)
HK (1) HK1195068A1 (pt)
HR (1) HRP20160539T1 (pt)
HU (1) HUE029594T2 (pt)
IL (1) IL229872A (pt)
JO (1) JO3154B1 (pt)
MA (1) MA35184B1 (pt)
ME (1) ME02416B (pt)
MX (1) MX337440B (pt)
MY (1) MY173521A (pt)
PE (1) PE20141943A1 (pt)
PL (1) PL2721016T3 (pt)
PT (1) PT2721016E (pt)
RS (1) RS54858B1 (pt)
SG (1) SG195106A1 (pt)
SI (1) SI2721016T1 (pt)
SM (1) SMT201600150B (pt)
TW (1) TWI538912B (pt)
UA (1) UA113963C2 (pt)
UY (1) UY34138A (pt)
WO (1) WO2013012500A1 (pt)
ZA (1) ZA201308816B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2720546B1 (en) 2011-06-17 2016-04-06 Glaxosmithkline Intellectual Property (No. 2) Limited Spiro-cyclic trpv4 antagonists
WO2012174340A1 (en) * 2011-06-17 2012-12-20 Glaxosmithkline Llc Trpv4 antagonists
JPWO2013146754A1 (ja) 2012-03-27 2015-12-14 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素５員環誘導体
WO2015046193A1 (ja) 2013-09-25 2015-04-02 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体
BR112018073700A2 (pt) * 2016-05-19 2019-02-26 Glaxosmithkline Intellectual Property (No. antagonista trpv4
US10968209B2 (en) 2016-05-19 2021-04-06 Glaxosmithkline Intellectual Property (No.2) Limited TRPV4 antagonist
WO2018185701A1 (en) 2017-04-06 2018-10-11 Glaxosmithkline Intellectual Property (No.2) Limited Trpv4 antagonists as antitussive agents
PE20201184A1 (es) * 2017-11-01 2020-11-03 Bristol Myers Squibb Co Compuestos espirociclicos como moduladores del receptor farnesoide x
WO2021170811A1 (en) 2020-02-27 2021-09-02 Glaxosmithkline Intellectual Property (No.2) Limited Method of treating eye disease using trpv4 antagonists
CA3180132A1 (en) 2020-04-30 2021-10-30 Raqualia Pharma Inc. Pyrimidin-4(3h)-one derivatives as trpv4 antagonists
CN111704613B (zh) * 2020-06-23 2021-07-06 中国人民解放军军事科学院军事医学研究院 咪唑类衍生物及其作为trpv4抑制剂的用途
WO2022014707A1 (ja) * 2020-07-16 2022-01-20 ラクオリア創薬株式会社 眼疾患の治療薬としてのｔｒｐｖ４阻害薬
WO2024011214A1 (en) 2022-07-08 2024-01-11 Actio Biosciences, Inc. Therapeutic compounds and methods

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JP2007534624A (ja) * 2003-07-16 2007-11-29 ニューロジェン・コーポレーション ビアリールピペラジニル−ピリジン類縁体
CN101346375B (zh) * 2005-11-23 2013-04-10 阿罗斯药物有限责任公司 调节门离子通道用组合物和方法
WO2007067756A2 (en) 2005-12-08 2007-06-14 Amphora Discovery Corporation Certain chemical entities, compositions, and methods for modulating trpv1
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TW200944520A (en) * 2008-01-29 2009-11-01 Glaxo Group Ltd Spiro compounds as NPY Y5 receptor antagonists
EP2312947B1 (en) 2008-07-25 2014-01-01 GlaxoSmithKline LLC Trpv4 antagonists
JP2012006837A (ja) * 2008-09-30 2012-01-12 Mochida Pharmaceut Co Ltd ２−インドールアクリルアミド類縁体
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EP2720546B1 (en) * 2011-06-17 2016-04-06 Glaxosmithkline Intellectual Property (No. 2) Limited Spiro-cyclic trpv4 antagonists
WO2012174340A1 (en) 2011-06-17 2012-12-20 Glaxosmithkline Llc Trpv4 antagonists

Also Published As

Publication number Publication date
KR20140041733A (ko) 2014-04-04
AU2012284540A1 (en) 2013-04-04
CN103732583B (zh) 2015-12-23
BR112013032391B1 (pt) 2020-11-24
CA2839743C (en) 2017-03-28
NZ618221A (en) 2015-02-27
HK1195068A1 (zh) 2014-10-31
EP2721016A4 (en) 2014-10-08
TW201313705A (zh) 2013-04-01
HUE029594T2 (en) 2017-03-28
WO2013012500A1 (en) 2013-01-24
DK2721016T3 (en) 2016-06-06
SI2721016T1 (sl) 2016-06-30
CY1117792T1 (el) 2017-05-17
AU2012284540B2 (en) 2014-08-28
CA2839743A1 (en) 2013-01-24
CL2013003602A1 (es) 2014-07-04
IL229872A (en) 2017-03-30
JP5969017B2 (ja) 2016-08-10
ZA201308816B (en) 2015-02-25
EA023616B1 (ru) 2016-06-30
US20140121206A1 (en) 2014-05-01
US9187464B2 (en) 2015-11-17
UY34138A (es) 2013-01-03
EP3121177A1 (en) 2017-01-25
HRP20160539T1 (hr) 2016-06-17
MA35184B1 (fr) 2014-06-02
MX337440B (es) 2016-03-03
UA113963C2 (xx) 2017-04-10
EP2721016B1 (en) 2016-04-06
JO3154B1 (ar) 2017-09-20
MX2013014898A (es) 2014-03-21
RS54858B1 (sr) 2016-10-31
EA201490037A1 (ru) 2015-12-30
EP2721016A1 (en) 2014-04-23
JP2014518214A (ja) 2014-07-28
TWI538912B (zh) 2016-06-21
AR086958A1 (es) 2014-02-05
CO6821953A2 (es) 2013-12-31
EP3121177B1 (en) 2018-08-01
KR101870003B1 (ko) 2018-06-22
PL2721016T3 (pl) 2017-01-31
DOP2013000307A (es) 2014-06-01
ES2569193T3 (es) 2016-05-09
ES2688733T3 (es) 2018-11-06
PT2721016E (pt) 2016-06-06
CR20130671A (es) 2014-02-04
SG195106A1 (en) 2013-12-30
MY173521A (en) 2020-01-30
ME02416B (me) 2016-09-20
CN103732583A (zh) 2014-04-16
SMT201600150B (it) 2016-07-01
PE20141943A1 (es) 2014-12-28

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
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