AR086958A1 - Antagonistas de trpv4 - Google Patents
Antagonistas de trpv4Info
- Publication number
- AR086958A1 AR086958A1 ARP120102143A ARP120102143A AR086958A1 AR 086958 A1 AR086958 A1 AR 086958A1 AR P120102143 A ARP120102143 A AR P120102143A AR P120102143 A ARP120102143 A AR P120102143A AR 086958 A1 AR086958 A1 AR 086958A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- halo
- hydrogen
- independently
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
- C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Abstract
La presente se refiere a análogos de espirocarbamato, a composiciones farmacéuticas que los contienen y a su uso como antagonistas de TRPV4.Reivindicación 1: Un compuesto de fórmula (1), en la que: R1 es hidrógeno, alquilo C1-3, CH2OH, CH2-O-CH3, CH2OCH2Ph, CH2CN, CN, halo o C(O)OCH3; R2 es independientemente hidrógeno, CN, CF3, halo, SO2-alquilo C1-3, alquilo C1-3 o CºCH; R3 es hidrógeno, alquilo C1-2, CF3 u OH; R4 es hidrógeno, halo o alquilo C1-3; X es CR4 o N; A es (CH2)n-Het; o A es (CH2)n-(CRaRb)-(CH2)m-Het; Ra es hidrógeno o alquilo C1-3, en el que el alquilo C1-3 puede estar sustituido adicionalmente con uno o más halos; Rb es alquilo C1-3; o Ra y Rb, junto con el átomo de carbono al que están unidos, forma un grupo cicloalquilo C3-6; uno o más de los átomos de carbono en el grupo cicloalquilo C3-6 formado por Ra y Rb pueden estar reemplazados con oxígeno para formar un oxetano, tetrahidrofurilo o tetrahidropiranilo; uno de los átomos de carbono en el grupo cicloalquilo C3-6 formado por Ra y Rb, puede estar reemplazado con nitrógeno para formar un grupo pirrolidinilo o piperidinilo; Het es seleccionado del grupo de fórmulas (2), en la que Het puede estar sustituido con dos o tres sustituyentes seleccionados entre: halo, alquilo C1-5, CN, CH2F, CHF2, CF3, cicloalquilo C3-6, (CH2)n-O-alquilo C1-3, (CH2)n-fenilo, (CH2)n-piridilo, pirimidinilo, pirazinilo, CH(CH3)-O-alquilo C1-3, CH(OH)-alquilo C1-5, C(CH3)2-R5, C(O)N(CH3)p, N(alquilo C1-3)p, NH2, C(O)NH2, oxetano, oxetano-CH3, tetrahidrofurfurilo, tetrahidropiranilo, morfolinilo o pirazolilo; en la que el sustituyente fenilo, pirazolilo, y piridilo en el Het puede estar adicionalmente sustituido con uno o dos sustituyentes seleccionados entre: halo, CN, OCH3, alquilo C1-3 o CF3; y el sustituyente alquilo C1-5 y cicloalquilo C3-6 en el Het puede estar adicionalmente sustituido con CN u OH; R5 es CN, O-alquilo C1-4, (CH2)m-OH, (CH2)p-O-C(O)-O-alquilo C1-5 ó O-(CH2)p-O-R6; R6 es alquilo C1-4 o P(O)2(CH3)2; n es independientemente 0, 1 ó 2; m es independientemente 0, 1 ó 2; p es independientemente 1 ó 2; e y es 1, 2 ó 3; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498110P | 2011-06-17 | 2011-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086958A1 true AR086958A1 (es) | 2014-02-05 |
Family
ID=47558389
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120102143A AR086958A1 (es) | 2011-06-17 | 2012-06-15 | Antagonistas de trpv4 |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US9187464B2 (es) |
| EP (2) | EP3121177B1 (es) |
| JP (1) | JP5969017B2 (es) |
| KR (1) | KR101870003B1 (es) |
| CN (1) | CN103732583B (es) |
| AR (1) | AR086958A1 (es) |
| AU (1) | AU2012284540B2 (es) |
| BR (1) | BR112013032391B1 (es) |
| CA (1) | CA2839743C (es) |
| CL (1) | CL2013003602A1 (es) |
| CO (1) | CO6821953A2 (es) |
| CR (1) | CR20130671A (es) |
| CY (1) | CY1117792T1 (es) |
| DK (1) | DK2721016T3 (es) |
| DO (1) | DOP2013000307A (es) |
| EA (1) | EA023616B1 (es) |
| ES (2) | ES2569193T3 (es) |
| HK (1) | HK1195068A1 (es) |
| HR (1) | HRP20160539T1 (es) |
| HU (1) | HUE029594T2 (es) |
| IL (1) | IL229872A (es) |
| JO (1) | JO3154B1 (es) |
| MA (1) | MA35184B1 (es) |
| ME (1) | ME02416B (es) |
| MX (1) | MX337440B (es) |
| MY (1) | MY173521A (es) |
| PE (1) | PE20141943A1 (es) |
| PL (1) | PL2721016T3 (es) |
| PT (1) | PT2721016E (es) |
| RS (1) | RS54858B1 (es) |
| SG (1) | SG195106A1 (es) |
| SI (1) | SI2721016T1 (es) |
| SM (1) | SMT201600150B (es) |
| TW (1) | TWI538912B (es) |
| UA (1) | UA113963C2 (es) |
| UY (1) | UY34138A (es) |
| WO (1) | WO2013012500A1 (es) |
| ZA (1) | ZA201308816B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012174340A1 (en) | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
| JP5969016B2 (ja) | 2011-06-17 | 2016-08-10 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | Ｔｒｐｖ４拮抗薬 |
| US9499533B2 (en) | 2012-03-27 | 2016-11-22 | Shionogi & Co., Ltd. | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity |
| JPWO2015046193A1 (ja) | 2013-09-25 | 2017-03-09 | 塩野義製薬株式会社 | Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体 |
| KR20190005877A (ko) * | 2016-05-19 | 2019-01-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Trpv4 길항제 |
| US10968209B2 (en) | 2016-05-19 | 2021-04-06 | Glaxosmithkline Intellectual Property (No.2) Limited | TRPV4 antagonist |
| WO2018185701A1 (en) | 2017-04-06 | 2018-10-11 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists as antitussive agents |
| MX2020004400A (es) * | 2017-11-01 | 2020-08-06 | Bristol Myers Squibb Co | Compuestos espirociclicos como moduladores del receptor farnesoide x. |
| WO2021170811A1 (en) | 2020-02-27 | 2021-09-02 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of treating eye disease using trpv4 antagonists |
| WO2021221169A1 (en) | 2020-04-30 | 2021-11-04 | Raqualia Pharma Inc. | Pyrimidin-4(3h)-one derivatives as trpv4 antagonists |
| CN111704613B (zh) * | 2020-06-23 | 2021-07-06 | 中国人民解放军军事科学院军事医学研究院 | 咪唑类衍生物及其作为trpv4抑制剂的用途 |
| BR112022024553A2 (pt) * | 2020-07-16 | 2023-01-24 | Raqualia Pharma Inc | Composto com atividade inibidora de trpv4 ou um sal farmaceuticamente aceitável do mesmo e seu uso, composição farmacêutica, método para se tratar uma doença da retina acompanhada de distúrbio do fluxo sanguíneo ou distúrbio celular, kit para uso na prevenção ou tratamento das doenças, marcador de doença para uma doença da retina, método para se detectar uma doença da retina, métodos de triagem para uma substância que suprime a expressão do gene de trpv4, uma que reduz o nível de expressão de uma proteína de trpv4 e uma que inibe a atividade de trpv4 e agente para prevenir ou tratar uma doença da retina |
| WO2024011214A1 (en) | 2022-07-08 | 2024-01-11 | Actio Biosciences, Inc. | Therapeutic compounds and methods |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673797B1 (en) * | 1998-05-26 | 2004-01-06 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic indole derivatives and mono- or diazaindole derivatives |
| EP1644358A2 (en) * | 2003-07-16 | 2006-04-12 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| CA2630617C (en) * | 2005-11-23 | 2014-03-25 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| WO2007067756A2 (en) | 2005-12-08 | 2007-06-14 | Amphora Discovery Corporation | Certain chemical entities, compositions, and methods for modulating trpv1 |
| ES2436225T3 (es) * | 2005-12-22 | 2013-12-27 | Hydra Biosciences, Inc. | Inhibidores TRPA1 para tratamiento del dolor |
| TW200819457A (en) * | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| US20100286151A1 (en) * | 2007-02-01 | 2010-11-11 | Jonathan Bentley | 1-OXA-3-Azaspiro[4,5]Decan--2-One Derivatives For The Treatment Of Eating Disorders |
| GB0707934D0 (en) * | 2007-04-24 | 2007-05-30 | Glaxo Group Ltd | Chemical compounds |
| JP2010535812A (ja) * | 2007-08-09 | 2010-11-25 | アボット・ラボラトリーズ | Ｔｒｐｖ１拮抗薬としてのテトラヒドロピリジンカルボキサミド誘導体 |
| TW200944520A (en) * | 2008-01-29 | 2009-11-01 | Glaxo Group Ltd | Spiro compounds as NPY Y5 receptor antagonists |
| EP2312947B1 (en) * | 2008-07-25 | 2014-01-01 | GlaxoSmithKline LLC | Trpv4 antagonists |
| JP2012006837A (ja) * | 2008-09-30 | 2012-01-12 | Mochida Pharmaceut Co Ltd | ２−インドールアクリルアミド類縁体 |
| EP2605658B1 (en) | 2010-08-18 | 2016-03-23 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| JP5969016B2 (ja) | 2011-06-17 | 2016-08-10 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | Ｔｒｐｖ４拮抗薬 |
| WO2012174340A1 (en) | 2011-06-17 | 2012-12-20 | Glaxosmithkline Llc | Trpv4 antagonists |
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2012
- 2012-06-14 JO JOP/2012/0159A patent/JO3154B1/ar active
- 2012-06-15 CN CN201280039690.0A patent/CN103732583B/zh active Active
- 2012-06-15 AU AU2012284540A patent/AU2012284540B2/en active Active
- 2012-06-15 MY MYPI2013702447A patent/MY173521A/en unknown
- 2012-06-15 UA UAA201400152A patent/UA113963C2/uk unknown
- 2012-06-15 US US14/125,378 patent/US9187464B2/en active Active
- 2012-06-15 ES ES12814591T patent/ES2569193T3/es active Active
- 2012-06-15 EA EA201490037A patent/EA023616B1/ru not_active IP Right Cessation
- 2012-06-15 BR BR112013032391-4A patent/BR112013032391B1/pt active IP Right Grant
- 2012-06-15 EP EP16162808.6A patent/EP3121177B1/en active Active
- 2012-06-15 JP JP2014516020A patent/JP5969017B2/ja active Active
- 2012-06-15 KR KR1020147000958A patent/KR101870003B1/ko not_active Application Discontinuation
- 2012-06-15 PE PE2013002807A patent/PE20141943A1/es active IP Right Grant
- 2012-06-15 ES ES16162808T patent/ES2688733T3/es active Active
- 2012-06-15 EP EP12814591.9A patent/EP2721016B1/en active Active
- 2012-06-15 SG SG2013086483A patent/SG195106A1/en unknown
- 2012-06-15 MX MX2013014898A patent/MX337440B/es active IP Right Grant
- 2012-06-15 AR ARP120102143A patent/AR086958A1/es active IP Right Grant
- 2012-06-15 CA CA2839743A patent/CA2839743C/en active Active
- 2012-06-15 SI SI201230564A patent/SI2721016T1/sl unknown
- 2012-06-15 ME MEP-2016-120A patent/ME02416B/me unknown
- 2012-06-15 TW TW101121449A patent/TWI538912B/zh active
- 2012-06-15 PL PL12814591T patent/PL2721016T3/pl unknown
- 2012-06-15 WO PCT/US2012/042622 patent/WO2013012500A1/en active Application Filing
- 2012-06-15 PT PT128145919T patent/PT2721016E/pt unknown
- 2012-06-15 DK DK12814591.9T patent/DK2721016T3/en active
- 2012-06-15 HU HUE12814591A patent/HUE029594T2/en unknown
- 2012-06-15 UY UY0001034138A patent/UY34138A/es not_active Application Discontinuation
- 2012-06-15 RS RS20160417A patent/RS54858B1/sr unknown
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2013
- 2013-11-22 ZA ZA2013/08816A patent/ZA201308816B/en unknown
- 2013-12-09 IL IL229872A patent/IL229872A/en active IP Right Grant
- 2013-12-11 CO CO13290152A patent/CO6821953A2/es active IP Right Grant
- 2013-12-13 MA MA36564A patent/MA35184B1/fr unknown
- 2013-12-16 CL CL2013003602A patent/CL2013003602A1/es unknown
- 2013-12-17 CR CR20130671A patent/CR20130671A/es unknown
- 2013-12-17 DO DO2013000307A patent/DOP2013000307A/es unknown
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2014
- 2014-08-20 HK HK14108527.9A patent/HK1195068A1/zh unknown
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2016
- 2016-05-19 HR HRP20160539TT patent/HRP20160539T1/hr unknown
- 2016-05-31 SM SM201600150T patent/SMT201600150B/it unknown
- 2016-06-21 CY CY20161100556T patent/CY1117792T1/el unknown
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