CO6170361A2 - Composiciones y metodos para modular receptores de c-kit y pdgfr - Google Patents

Composiciones y metodos para modular receptores de c-kit y pdgfr

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Publication number
CO6170361A2
CO6170361A2 CO09039151A CO09039151A CO6170361A2 CO 6170361 A2 CO6170361 A2 CO 6170361A2 CO 09039151 A CO09039151 A CO 09039151A CO 09039151 A CO09039151 A CO 09039151A CO 6170361 A2 CO6170361 A2 CO 6170361A2
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optionally substituted
nrc
alkyl
alkenyl
alkynyl
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CO09039151A
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English (en)
Inventor
Donatella Chianelli
Christopher Cow
Yun He
Songchun Jiang
Xiaolin Li
Xiaodong Liu
Zuosheng Liu
Jon Loren
Valentina Molteni
Juliet Nabakka
Pingda Ren
Taebo Sim
Xiaojing Wang
Shuli You
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Irm Llc
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Application filed by Irm Llc filed Critical Irm Llc
Publication of CO6170361A2 publication Critical patent/CO6170361A2/es

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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
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Abstract

1.- Un compuesto de Formula (I):o sales farmacéuticamente aceptables del mismo, en donde: Y y Z son independientemente CR o N; L es NR- C(O), C(O)NR, C(O)NRC(O)NR, NRC(O)NR, NRC(O)NRC(O), NRC(S)NRCO, NRS(O)0-2 o NRCONRS(O) 0-2;R1 y R3 son independientemente halo, (CR2) kR6, (CR2) kNR7R8, (CR2) kOR9, (CR2) kSR9, o un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; R2 es (CR2) kR6, (CR2) 1-4OR9, (CR2) 1-4NR7R8, u un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; R4 es (CR2) kR6, (CR2) kOR9, o un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; R5 es H, halo o C1-6 alquilo; R6 es un C3-7 cicloalquilo opcionalmente sustituido, o un arilo, heterociclo o heteroarilo de 5-12 miembros opcionalmente sustituido; R7 y R8 son independientemente H, (CR2) kNR7R8, (CR2)kOR9, (CR2) k-R6, o un C1-6 alquilo,C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; o R7 y R8 junto con N en cada NR7R8 pueden formar un anillo opcionalmente sustituido; R9 es H, (CR2) k- R6, o un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; cada R es H o C1-6alquil con un carbono que es opcionalmente sustituido o reemplazado por N, O, =0, S; o dos grupos alquileno en (CR2) k pueden formar un alquenilo o alquinilo; cada C1-6 o alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido es opcionalmente halogenado u opcionalmente sustituido con N, O ó S;k es 0- 6; y n es 0-2; siempre y cuando L es C(O) NRC(O)NR, NRC(O)NR, NRC(O) NRC(O), NRC(S) NRCO o NRCONRS(O) 0-2 cuando R1 es halo, (CR2) kNR7R8 o C5-8 heterocicloalquilo y R2 es C1-6 alquilo. 2.- El compuesto de la Reivindicación 1, en donde Y es CH. 3.- El compuesto de la Reivindicación 1, en donde Z es N.
CO09039151A 2006-10-20 2009-04-17 Composiciones y metodos para modular receptores de c-kit y pdgfr CO6170361A2 (es)

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Application Number Priority Date Filing Date Title
US86243006P 2006-10-20 2006-10-20

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US (2) US7678792B2 (es)
EP (1) EP2076513A1 (es)
JP (1) JP2010506948A (es)
KR (1) KR101079520B1 (es)
CN (1) CN101528744A (es)
AR (1) AR063343A1 (es)
AU (1) AU2007309279B2 (es)
BR (1) BRPI0718162A2 (es)
CA (1) CA2667010A1 (es)
CL (1) CL2007003005A1 (es)
CO (1) CO6170361A2 (es)
CR (1) CR10717A (es)
EA (1) EA200900573A1 (es)
EC (1) ECSP099353A (es)
IL (1) IL197875A0 (es)
MA (1) MA30888B1 (es)
MX (1) MX2009004141A (es)
NI (1) NI200900061A (es)
NO (1) NO20091949L (es)
PE (1) PE20081262A1 (es)
SM (1) SMP200900027B (es)
TN (1) TN2009000145A1 (es)
TW (1) TW200825081A (es)
WO (1) WO2008051757A1 (es)
ZA (1) ZA200902711B (es)

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