NI200900061A - Composiciones y métodos para la modulación de los receptores c-kit y pdgf. - Google Patents
Composiciones y métodos para la modulación de los receptores c-kit y pdgf.Info
- Publication number
- NI200900061A NI200900061A NI200900061A NI200900061A NI200900061A NI 200900061 A NI200900061 A NI 200900061A NI 200900061 A NI200900061 A NI 200900061A NI 200900061 A NI200900061 A NI 200900061A NI 200900061 A NI200900061 A NI 200900061A
- Authority
- NI
- Nicaragua
- Prior art keywords
- methods
- raf
- kit
- compounds
- pdgf
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Biomedical Technology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
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- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
Abstract
La invención proporciona compuestos y composiciones farmacéuticas, en el que son útiles como inhibidores de la proteína quinasa, así como los métodos para la utilización de dichos compuestos para tratar, aliviar o prevenir una afección asociada con anomalías o desregulación quinasa. En algunas incorporaciones, la invención proporciona métodos para el uso de dichos compuestos para tratar, aliviar o prevenir enfermedades o trastornos que implican la activación anormal de c-kit, PDGFR , PDGFR , CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF , SRC, EGFR, trkB, FGFR3, FLT3, Fes, lck, Syk, RAF, MKK4, MKK6, SAPK2 , BRK, KDR, c-raf o b-raf quinasa, o de formas mutantes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86243006P | 2006-10-20 | 2006-10-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
NI200900061A true NI200900061A (es) | 2010-03-10 |
Family
ID=39027274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI200900061A NI200900061A (es) | 2006-10-20 | 2009-04-20 | Composiciones y métodos para la modulación de los receptores c-kit y pdgf. |
Country Status (25)
Country | Link |
---|---|
US (2) | US7678792B2 (es) |
EP (1) | EP2076513A1 (es) |
JP (1) | JP2010506948A (es) |
KR (1) | KR101079520B1 (es) |
CN (1) | CN101528744A (es) |
AR (1) | AR063343A1 (es) |
AU (1) | AU2007309279B2 (es) |
BR (1) | BRPI0718162A2 (es) |
CA (1) | CA2667010A1 (es) |
CL (1) | CL2007003005A1 (es) |
CO (1) | CO6170361A2 (es) |
CR (1) | CR10717A (es) |
EA (1) | EA200900573A1 (es) |
EC (1) | ECSP099353A (es) |
IL (1) | IL197875A0 (es) |
MA (1) | MA30888B1 (es) |
MX (1) | MX2009004141A (es) |
NI (1) | NI200900061A (es) |
NO (1) | NO20091949L (es) |
PE (1) | PE20081262A1 (es) |
SM (1) | SMP200900027B (es) |
TN (1) | TN2009000145A1 (es) |
TW (1) | TW200825081A (es) |
WO (1) | WO2008051757A1 (es) |
ZA (1) | ZA200902711B (es) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2003220222A1 (en) | 2002-03-13 | 2003-09-29 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
WO2006084033A1 (en) | 2005-02-03 | 2006-08-10 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US7897762B2 (en) | 2006-09-14 | 2011-03-01 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of proliferative diseases |
US8188113B2 (en) * | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
AR063621A1 (es) | 2006-11-09 | 2009-02-04 | Alcon Res Ltd | Matriz polimerica insoluble en agua para la administracion de farmacos |
TWI498115B (zh) * | 2007-12-27 | 2015-09-01 | Daiichi Sankyo Co Ltd | 咪唑羰基化合物 |
BRPI0908849A2 (pt) * | 2008-02-22 | 2015-08-25 | Irm Llc | Composto e composições como c-kit e inibidores de pdgfr quinase |
EP2282735B1 (en) | 2008-04-21 | 2019-01-16 | Signum Biosciences, Inc. | Pp2a modulators for treating alzheimer, parkinson, diabetes |
FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
WO2009152356A2 (en) * | 2008-06-11 | 2009-12-17 | Irm Llc | Compounds and compositions useful for the treatment of malaria |
CA2733010A1 (en) * | 2008-08-05 | 2010-02-11 | George Mason Intellectual Properties, Inc. | Signal pathway alterations and drug target elevations in primary metachronous metastatic colorectal cancer compared to non-metastatic disease |
BRPI0920765A2 (pt) * | 2008-10-29 | 2015-08-18 | Deciphera Pharmaceuticals Llc | Amidas de cilopropano e análogos que exibem atividades anticâncer e antiproliferativas |
AR074776A1 (es) * | 2008-12-18 | 2011-02-09 | Sanofi Aventis | Metodo para tratar la degeneracion macular; modulando el sistema inmunitario del paciente |
US8674095B2 (en) | 2008-12-19 | 2014-03-18 | Afraxis Holdings, Inc. | Compounds for treating neuropsychiatric conditions |
CA2751517A1 (en) * | 2009-02-13 | 2010-08-19 | Fovea Pharmaceuticals | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
US8372970B2 (en) | 2009-10-09 | 2013-02-12 | Afraxis, Inc. | 8-ethyl-6-(aryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders |
NZ600857A (en) | 2010-01-29 | 2014-06-27 | Boehringer Ingelheim Int | Substituted naphthyridines and their use as syk kinase inhibitors |
CN102770426B (zh) * | 2010-02-05 | 2016-03-23 | 诺瓦提斯公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
EP2668210B1 (en) * | 2011-01-26 | 2020-06-17 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
EP2701510B1 (en) | 2011-04-25 | 2017-02-15 | Usher III Initiative | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
CA2843022C (en) | 2011-07-26 | 2019-09-24 | Boehringer Ingelheim International Gmbh | Substituted quinolines and their use as medicaments |
EP2748172B1 (en) * | 2011-09-30 | 2017-12-06 | Kineta, Inc. | Anti-viral compounds |
KR20150008406A (ko) | 2012-05-15 | 2015-01-22 | 노파르티스 아게 | Abl1, abl2 및 bcr-abl1의 활성을 억제하기 위한 벤즈아미드 유도체 |
MX2014013373A (es) | 2012-05-15 | 2015-08-14 | Novartis Ag | Derivados de benzamida para inhibir la actividad de abl1, abl2 y bcr-abl1. |
AP3613A (en) | 2012-05-15 | 2016-02-29 | Novartis Ag | Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1 abl1abl2 bcr-abl1 |
PT2900637T (pt) | 2012-05-15 | 2017-11-15 | Novartis Ag | Derivados de amida de pirimidina, piridina e pirazina substituídos com tiazole ou imidazole e compostos relacionados como inibidores de abl1, abl2 e bcr-abl1 para tratamento do cancro, infecções virais específicas e disturbios do snc específicos |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
ES2663605T3 (es) * | 2012-06-07 | 2018-04-16 | Deciphera Pharmaceuticals, Llc | Dihidronaftiridinas y compuestos relacionados útiles como inhibidores de quinasas para el tratamiento de enfermedades proliferativas |
BR112015001459B1 (pt) | 2012-07-25 | 2023-02-14 | Celldex Therapeutics, Inc | Anticorpo isolado ou fragmento do mesmo, conjugado, usos dos mesmos, composição farmacêutica, polinucleotídeo, vetor, célula hospedeira, célula isolada, kit, método in vitro para inibir atividade da kit, método para produzir um anticorpo |
US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
EP3013341A4 (en) * | 2013-06-26 | 2017-02-08 | Proteostasis Therapeutics, Inc. | Methods of modulating cftr activity |
GB201401886D0 (en) | 2014-02-04 | 2014-03-19 | Lytix Biopharma As | Neurodegenerative therapies |
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CA2942386A1 (en) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
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CN105085489B (zh) * | 2014-11-05 | 2019-03-01 | 益方生物科技(上海)有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
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WO2002028853A1 (fr) | 2000-10-02 | 2002-04-11 | Tanabe Seiyaku Co., Ltd. | Compose de benzylamine, son procede de production et produit intermediaire correspondant |
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2007
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- 2007-10-16 BR BRPI0718162-0A patent/BRPI0718162A2/pt not_active IP Right Cessation
- 2007-10-16 AU AU2007309279A patent/AU2007309279B2/en not_active Ceased
- 2007-10-16 CN CNA2007800390373A patent/CN101528744A/zh active Pending
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- 2007-10-16 MX MX2009004141A patent/MX2009004141A/es active IP Right Grant
- 2007-10-16 KR KR1020097008062A patent/KR101079520B1/ko not_active IP Right Cessation
- 2007-10-16 US US11/873,196 patent/US7678792B2/en not_active Expired - Fee Related
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- 2007-10-19 PE PE2007001422A patent/PE20081262A1/es not_active Application Discontinuation
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- 2009-04-17 CO CO09039151A patent/CO6170361A2/es not_active Application Discontinuation
- 2009-04-17 TN TNP2009000145A patent/TN2009000145A1/fr unknown
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EP2076513A1 (en) | 2009-07-08 |
SMAP200900027A (it) | 2009-07-14 |
AU2007309279A1 (en) | 2008-05-02 |
ECSP099353A (es) | 2009-06-30 |
JP2010506948A (ja) | 2010-03-04 |
KR20090054477A (ko) | 2009-05-29 |
AU2007309279B2 (en) | 2011-03-24 |
ZA200902711B (en) | 2010-05-26 |
US8106068B2 (en) | 2012-01-31 |
PE20081262A1 (es) | 2008-10-29 |
US20080176846A1 (en) | 2008-07-24 |
US20100081656A1 (en) | 2010-04-01 |
BRPI0718162A2 (pt) | 2013-11-26 |
US7678792B2 (en) | 2010-03-16 |
TN2009000145A1 (en) | 2010-10-18 |
SMP200900027B (it) | 2010-01-19 |
CO6170361A2 (es) | 2010-06-18 |
WO2008051757A1 (en) | 2008-05-02 |
NO20091949L (no) | 2009-05-19 |
AR063343A1 (es) | 2009-01-21 |
CN101528744A (zh) | 2009-09-09 |
TW200825081A (en) | 2008-06-16 |
IL197875A0 (en) | 2009-12-24 |
MA30888B1 (fr) | 2009-11-02 |
CL2007003005A1 (es) | 2008-05-23 |
CR10717A (es) | 2009-07-02 |
KR101079520B1 (ko) | 2011-11-03 |
EA200900573A1 (ru) | 2009-10-30 |
CA2667010A1 (en) | 2008-05-02 |
MX2009004141A (es) | 2009-05-01 |
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