MA41253A - Composés, compositions et procédés pour augmenter l'activité du cftr - Google Patents
Composés, compositions et procédés pour augmenter l'activité du cftrInfo
- Publication number
- MA41253A MA41253A MA041253A MA41253A MA41253A MA 41253 A MA41253 A MA 41253A MA 041253 A MA041253 A MA 041253A MA 41253 A MA41253 A MA 41253A MA 41253 A MA41253 A MA 41253A
- Authority
- MA
- Morocco
- Prior art keywords
- cftr
- compositions
- activity
- compounds
- processes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/42—Oxazoles
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2635581C (fr) | 2005-12-28 | 2017-02-28 | Vertex Pharmaceuticals Incorporated | Formes solides de n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoleine-3-carboxamide |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CA2797118C (fr) | 2010-04-22 | 2021-03-30 | Vertex Pharmaceuticals Incorporated | Procede de production de composes de cycloalkylcarboxamido-indole |
| WO2015138934A1 (fr) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité cftr |
| EP3116501A1 (fr) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité du cftr |
| RS62140B1 (sr) | 2014-04-15 | 2021-08-31 | Vertex Pharma | Farmaceutske kompozicije za lečenje bolesti posredovanih transmembranskim regulatorom provodljivosti cistične fibroze |
| CA2952862A1 (fr) * | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Composes, compositions et procedes pour augmenter l'activite du cftr |
| WO2016054560A1 (fr) | 2014-10-02 | 2016-04-07 | Flatley Discovery Lab | Composés isoxazoles et procédés pour le traitement de la fibrose kystique |
| IL313498A (en) | 2014-10-06 | 2024-08-01 | Vertex Pharma | Modulators of the cystic fibrosis transmembrane conductance regulator |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| CA2971835A1 (fr) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derives de 3-heteroarylisoxazol-5-amide carboxylique utiles dans le traitement, entre autres, d'une fibrose kystique |
| CA2971855A1 (fr) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derives d'amide 5-(hetero)arylpyrazol-3-carboxylique ou d'amide 1-(hetero)aryltriazol-4-carboxylique utiles pour le traitement, entre autres, de la fibrose kystique |
| CA2971850A1 (fr) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derives d'amides 5-phenyl- ou 5-heteroarylthiazol-2-carboxyliques servant au traitement, entre autres, de la fibrose cystique |
| AU2016297886B2 (en) * | 2015-07-24 | 2020-12-10 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing CFTR activity |
| KR20180093882A (ko) | 2015-10-06 | 2018-08-22 | 프로테오스타시스 테라퓨틱스, 인크. | Cftr 조절용 화합물, 조성물, 및 방법 |
| WO2017112853A1 (fr) * | 2015-12-22 | 2017-06-29 | Proteostasis Therapeutics, Inc. | Méthodes de traitement de maladies et troubles pulmonaires |
| EP3436446B1 (fr) | 2016-03-31 | 2023-06-07 | Vertex Pharmaceuticals Incorporated | Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique |
| CN109563047A (zh) | 2016-04-07 | 2019-04-02 | 蛋白质平衡治疗股份有限公司 | 含有硅原子的依伐卡托类似物 |
| ES2954658T3 (es) | 2016-06-21 | 2023-11-23 | Proteostasis Therapeutics Inc | Compuestos, composiciones y procedimientos para aumentar la actividad de CFTR |
| HRP20211683T1 (hr) | 2016-09-30 | 2022-03-04 | Vertex Pharmaceuticals Incorporated | Modulator transmembranskog regulatora provodljivosti cistične fibroze, farmaceutski pripravci, postupci liječenja, i postupak za pripravu modulatora |
| KR101912153B1 (ko) * | 2016-11-24 | 2018-10-26 | 이진호 | 극지항해용 자기 부상선 |
| MX2021013639A (es) | 2016-12-09 | 2022-09-30 | Vertex Pharma | Forma cristalina del compuesto 1, un modulador del regulador de conductancia transmembrana de fibrosis quística, procesos para su preparación, composiciones farmacéuticas del compuesto 1, y su uso en el tratamiento de fibrosis quística. |
| AU2018279646B2 (en) | 2017-06-08 | 2023-04-06 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| US20210069174A1 (en) * | 2017-07-01 | 2021-03-11 | Vertex Pharmaceuticals Incorporated | Compositions and methods for treatment of cystic fibrosis |
| AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| TWI799435B (zh) | 2017-08-02 | 2023-04-21 | 美商維泰克斯製藥公司 | 製備化合物之製程 |
| WO2019079760A1 (fr) | 2017-10-19 | 2019-04-25 | Vertex Pharmaceuticals Incorporated | Formes cristallines et compositions de modulateurs de cftr |
| US11465985B2 (en) | 2017-12-08 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| CN108440455B (zh) * | 2018-04-11 | 2019-06-14 | 上海馨远医药科技有限公司 | 一种3-氧杂环丁烷羧酸的制备方法 |
| WO2019200246A1 (fr) | 2018-04-13 | 2019-10-17 | Alexander Russell Abela | Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur |
| AU2019278935B2 (en) | 2018-05-31 | 2025-02-13 | Celltaxis, Llc | Method of reducing pulmonary exacerbations in respiratory disease patients |
| GB201810071D0 (en) * | 2018-06-19 | 2018-08-08 | Univ Oslo Hf | Compounds |
| JP7551087B2 (ja) | 2018-06-27 | 2024-09-17 | キネタ, インコーポレイテッド | プロテアソーム活性増強化合物 |
| CN115427050B (zh) * | 2020-02-07 | 2025-02-14 | 南佛罗里达大学 | 对tau蛋白病中的β-抑制蛋白寡聚化的抑制 |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| US20240327412A1 (en) * | 2021-02-19 | 2024-10-03 | Kalvista Pharmaceuticals Limited | Factor xiia inhibitors |
| KR20240155228A (ko) | 2022-02-03 | 2024-10-28 | 버텍스 파마슈티칼스 인코포레이티드 | (6a,12a)-17-아미노-12-메틸-6,15-비스(트리플루오로메틸)-13,19-디옥사-3,4,18-트리아자트리시클로[12.3.1.12,5]노나데카-1(18),2,4,14,16-펜타엔-6-올의 결정질 형태를 제조하는 방법 |
| IL314449A (en) | 2022-02-03 | 2024-09-01 | Vertex Pharma | Methods of treatment for cystic fibrosis |
| CN118974059A (zh) | 2022-02-08 | 2024-11-15 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调控因子的调节剂 |
| CN119947720A (zh) | 2022-05-16 | 2025-05-06 | 弗特克斯药品有限公司 | 治疗囊性纤维化的方法 |
| TW202425990A (zh) * | 2022-11-02 | 2024-07-01 | 南韓商日東製藥股份有限公司 | 包含cftr調節劑化合物之點眼用組成物 |
| CN120136817A (zh) * | 2025-05-16 | 2025-06-13 | 安徽泽升科技股份有限公司 | 一种氧杂环丁烷-3-甲醇和氧杂环丁烷-3-甲醛的制备方法 |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3812225A1 (de) * | 1988-04-13 | 1989-10-26 | Basf Ag | Isoxazol(isothiazol)-5-carbonsaeureamide |
| CA2201478A1 (fr) | 1995-08-02 | 1997-02-13 | J. Uriach & Cia S.A. | Nouveaux carboxamides a activite antifongique |
| DE69628705T2 (de) * | 1995-08-24 | 2004-05-13 | Basf Ag | Isoxazole- und Isothiazole-5-carboxamid Derivate, deren Herstellung und deren Verwendung als Herbizide |
| PT957099E (pt) * | 1998-04-15 | 2003-02-28 | Pfizer Prod Inc | Carboxamidas heterociclicas |
| WO2002000651A2 (fr) | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Inhibiteurs du facteur xa |
| CA2484209C (fr) | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Modulateurs de proteine kinase et procedes d'utilisation |
| EP1394159A1 (fr) * | 2002-08-13 | 2004-03-03 | Warner-Lambert Company LLC | Nouveaux dérivés de thiophène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent |
| US7598412B2 (en) | 2003-10-08 | 2009-10-06 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| JP4869072B2 (ja) | 2003-11-14 | 2012-02-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atp結合カセットトランスポーターのモジュレーターとして有用なチアゾールおよびオキサゾール |
| WO2005077345A1 (fr) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Composes pour le traitement de la maladie du reflux gastro-oesophagien |
| WO2005077373A2 (fr) | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Nouveau traitement du reflux gastro-oesophagien pathologique ii |
| WO2006078287A2 (fr) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Inhibiteurs de pde4b |
| SE0401969D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Piperidine derivatives |
| US20060100226A1 (en) | 2004-09-10 | 2006-05-11 | Sikorski James A | 2-Thiopyrimidinones as therapeutic agents |
| DE102004051277A1 (de) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
| JP2006176443A (ja) * | 2004-12-22 | 2006-07-06 | Shionogi & Co Ltd | メラニン凝集ホルモン受容体アンタゴニスト |
| ES2354569T3 (es) | 2005-06-22 | 2011-03-16 | Pfizer Products Inc. | Antagonistas del receptor de histamina-3. |
| JP4822406B2 (ja) | 2005-09-26 | 2011-11-24 | ルネサスエレクトロニクス株式会社 | 表示制御駆動装置および表示システム |
| WO2007075896A2 (fr) | 2005-12-22 | 2007-07-05 | Kemia, Inc. | Inhibiteurs de cytokine heterocycliques |
| KR101394245B1 (ko) | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
| WO2007086584A1 (fr) * | 2006-01-30 | 2007-08-02 | Meiji Seika Kaisha, Ltd. | NOUVEL INHIBITEUR DE FabK ET DE FabI/K |
| TW200815351A (en) * | 2006-05-02 | 2008-04-01 | Astrazeneca Ab | Novel compounds |
| US8193225B2 (en) | 2006-10-13 | 2012-06-05 | The Board Of Regents Of The University Of Texas System | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis |
| WO2008046072A2 (fr) | 2006-10-13 | 2008-04-17 | The Board Of Regents Of The University Of Texas System | Inducteurs chimiques de la neurogénèse |
| EP2076513A1 (fr) | 2006-10-20 | 2009-07-08 | Irm Llc | Compositions et procédés de modulation de récepteurs de c-kit et de facteur de croissance dérivé de plaquettes (pdgfr) |
| WO2008070739A1 (fr) | 2006-12-06 | 2008-06-12 | Cytokinetics, Inc. | Activateurs de ksp |
| ATE539078T1 (de) | 2007-06-29 | 2012-01-15 | Sk Holdings Co Ltd | Isoxazolderivate enthaltende pharmazeutische zusammensetzung zur prävention und behandlung von restenose |
| WO2009011850A2 (fr) * | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Nouveaux composés thérapeutiques |
| CN101796036A (zh) | 2007-08-02 | 2010-08-04 | 欧加农股份有限公司 | 作为trpv1调节剂的5-苯基异噁唑-3-甲酰胺衍生物 |
| AU2008345225A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009131951A2 (fr) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Composés, compositions et procédés comprenant des dérivés isoxazole |
| US20090318429A1 (en) | 2008-04-28 | 2009-12-24 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives |
| US20120095002A1 (en) | 2009-02-04 | 2012-04-19 | N.V. Organon | Isoxazole-5-carboxamide derivatives |
| CN102421784B (zh) | 2009-03-11 | 2015-09-30 | 杏林制药株式会社 | 作为gsk-3抑制剂的7-环烷基氨基喹诺酮 |
| GB0910003D0 (en) * | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| IN2012DN00352A (fr) | 2009-06-16 | 2015-08-21 | Bikam Pharmaceuticals Inc | |
| WO2011008931A2 (fr) | 2009-07-15 | 2011-01-20 | Cystic Fibrosis Foundation Therapeutics, Inc. | Composés arylpyrimidines et thérapie de combinaison comprenant ceux-ci pour traiter une mucoviscidose et des troubles apparentés |
| US9212177B2 (en) | 2009-08-05 | 2015-12-15 | Versitech Limited | Antiviral compounds and methods of making and using thereof |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| US8569899B2 (en) | 2009-12-30 | 2013-10-29 | Stmicroelectronics, Inc. | Device and method for alignment of vertically stacked wafers and die |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| JP5996532B2 (ja) | 2010-07-15 | 2016-09-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 有害生物防除剤としての新規複素環式化合物 |
| HUE038714T2 (hu) | 2011-03-10 | 2018-11-28 | Daiichi Sankyo Co Ltd | Dispiropirrolidin származék |
| CA2736441A1 (fr) * | 2011-04-06 | 2012-10-06 | The Regents Of The University Of California | Pyrazolylthiazoles en tant que correcteurs du regulateur de la conductivite transmembranaire de la proteine .delta.f508 de la fibrose kystique |
| US9428490B2 (en) | 2011-07-29 | 2016-08-30 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US9056867B2 (en) | 2011-09-16 | 2015-06-16 | Novartis Ag | N-substituted heterocyclyl carboxamides |
| EP2755967B1 (fr) | 2011-09-16 | 2015-10-21 | Novartis AG | Composés hétérocycliques destinés au traitement de la mucosviscidose |
| US8623860B2 (en) | 2011-12-30 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Azetidine derivatives, pharmaceutical compositions and uses thereof |
| AU2013221420B2 (en) | 2012-02-16 | 2017-07-13 | Corteva Agriscience Llc | Methods of producing sulfilimine compounds |
| UA110436C2 (en) | 2012-03-06 | 2015-12-25 | Zoetis Llc | Antibacterial phenol compounds |
| WO2013146970A1 (fr) | 2012-03-29 | 2013-10-03 | 第一三共株式会社 | Nouveau dérivé de quinoléine |
| EP3591052B1 (fr) | 2012-09-24 | 2023-08-30 | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. | Restauration de la fonction cftr par modulation de l'épissage |
| EP2922852A4 (fr) | 2012-11-20 | 2016-05-25 | Discoverybiomed Inc | Correcteurs de cftr à petites molécules |
| EP2922853A4 (fr) | 2012-11-20 | 2016-11-23 | Discoverybiomed Inc | Correcteurs de cftr bicycliques et tricycliques à petites molécules |
| US20140371238A1 (en) | 2013-03-13 | 2014-12-18 | Flatley Discovery Lab | Compounds and methods for the treatment of cystic fibrosis |
| EP2968323A4 (fr) | 2013-03-13 | 2016-12-14 | Flatley Discovery Lab | Composés de pyridazinone et procédés pour le traitement de fibrose kystique |
| CA2903103C (fr) | 2013-03-15 | 2020-06-09 | Discoverybiomed, Inc. | Derives de coumarine et leurs methodes d'utilisation dans le traitement de la fibrose kystique, de la bronchopneumopathie chronique obstructive et des troubles lies a des proteine s mal repliees |
| WO2014144860A1 (fr) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Correcteurs agissant par l'intermédiaire de msd1 de la protéine cftr |
| EP2994463B1 (fr) | 2013-05-07 | 2017-10-25 | Galapagos NV | Nouveaux composés et leurs compositions pharmaceutiques pour le traitement de la mucoviscidose |
| WO2014181287A1 (fr) | 2013-05-09 | 2014-11-13 | Piramal Enterprises Limited | Composés hétérocyclyliques et leurs utilisations |
| AU2014302458A1 (en) | 2013-06-26 | 2015-12-24 | Proteostasis Therapeutics, Inc. | Methods of modulating CFTR activity |
| US9920073B2 (en) | 2013-10-04 | 2018-03-20 | Drexel University | Compositions useful for inhibiting HIV-1 infection and methods using same |
| EP3116501A1 (fr) | 2014-03-13 | 2017-01-18 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité du cftr |
| WO2015138934A1 (fr) | 2014-03-13 | 2015-09-17 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité cftr |
| CA2952862A1 (fr) | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Composes, compositions et procedes pour augmenter l'activite du cftr |
| WO2016054560A1 (fr) | 2014-10-02 | 2016-04-07 | Flatley Discovery Lab | Composés isoxazoles et procédés pour le traitement de la fibrose kystique |
| CA2971835A1 (fr) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derives de 3-heteroarylisoxazol-5-amide carboxylique utiles dans le traitement, entre autres, d'une fibrose kystique |
| MA41253A (fr) | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
| CA2971850A1 (fr) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derives d'amides 5-phenyl- ou 5-heteroarylthiazol-2-carboxyliques servant au traitement, entre autres, de la fibrose cystique |
| CA2971855A1 (fr) | 2014-12-23 | 2016-06-30 | Proteostasis Therapeutics, Inc. | Derives d'amide 5-(hetero)arylpyrazol-3-carboxylique ou d'amide 1-(hetero)aryltriazol-4-carboxylique utiles pour le traitement, entre autres, de la fibrose kystique |
| US20180147187A1 (en) | 2015-01-12 | 2018-05-31 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing cftr activity |
| AU2016297886B2 (en) | 2015-07-24 | 2020-12-10 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing CFTR activity |
| WO2017040606A1 (fr) | 2015-08-31 | 2017-03-09 | Proteostasis Therapeutics, Inc. | Dérivés d'isoxazole destinés à être utilisés dans le traitement de maladies et de troubles pulmonaires |
| KR20180093882A (ko) | 2015-10-06 | 2018-08-22 | 프로테오스타시스 테라퓨틱스, 인크. | Cftr 조절용 화합물, 조성물, 및 방법 |
| WO2017112853A1 (fr) | 2015-12-22 | 2017-06-29 | Proteostasis Therapeutics, Inc. | Méthodes de traitement de maladies et troubles pulmonaires |
| ES2954658T3 (es) | 2016-06-21 | 2023-11-23 | Proteostasis Therapeutics Inc | Compuestos, composiciones y procedimientos para aumentar la actividad de CFTR |
-
2015
- 2015-12-22 MA MA041253A patent/MA41253A/fr unknown
- 2015-12-23 CN CN201580074407.1A patent/CN107207487B/zh active Active
- 2015-12-23 AU AU2015371294A patent/AU2015371294B2/en active Active
- 2015-12-23 MX MX2017008380A patent/MX388421B/es unknown
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- 2015-12-23 US US15/539,392 patent/US10392372B2/en active Active
- 2015-12-23 NZ NZ732701A patent/NZ732701A/en unknown
- 2015-12-23 WO PCT/US2015/000212 patent/WO2016105485A2/fr not_active Ceased
- 2015-12-23 ES ES15825647T patent/ES2962673T3/es active Active
- 2015-12-23 SG SG11201704859UA patent/SG11201704859UA/en unknown
- 2015-12-23 RU RU2017126232A patent/RU2767460C2/ru active
- 2015-12-23 EP EP15825647.9A patent/EP3237411B1/fr active Active
- 2015-12-23 BR BR112017013710-0A patent/BR112017013710B1/pt active IP Right Grant
- 2015-12-23 KR KR1020177020139A patent/KR102677444B1/ko active Active
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2017
- 2017-06-18 IL IL252987A patent/IL252987B/en active IP Right Grant
- 2017-06-26 SA SA517381828A patent/SA517381828B1/ar unknown
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2019
- 2019-07-12 US US16/510,406 patent/US11098035B2/en active Active
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2020
- 2020-08-02 IL IL276426A patent/IL276426A/en unknown
- 2020-10-12 AU AU2020256305A patent/AU2020256305A1/en not_active Abandoned
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2022
- 2022-09-06 AU AU2022228100A patent/AU2022228100A1/en not_active Abandoned
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