CA2736441A1 - Pyrazolylthiazoles en tant que correcteurs du regulateur de la conductivite transmembranaire de la proteine .delta.f508 de la fibrose kystique - Google Patents
Pyrazolylthiazoles en tant que correcteurs du regulateur de la conductivite transmembranaire de la proteine .delta.f508 de la fibrose kystique Download PDFInfo
- Publication number
- CA2736441A1 CA2736441A1 CA2736441A CA2736441A CA2736441A1 CA 2736441 A1 CA2736441 A1 CA 2736441A1 CA 2736441 A CA2736441 A CA 2736441A CA 2736441 A CA2736441 A CA 2736441A CA 2736441 A1 CA2736441 A1 CA 2736441A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- aryl
- alkyl
- cftr
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2736441A CA2736441A1 (fr) | 2011-04-06 | 2011-04-06 | Pyrazolylthiazoles en tant que correcteurs du regulateur de la conductivite transmembranaire de la proteine .delta.f508 de la fibrose kystique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2736441A CA2736441A1 (fr) | 2011-04-06 | 2011-04-06 | Pyrazolylthiazoles en tant que correcteurs du regulateur de la conductivite transmembranaire de la proteine .delta.f508 de la fibrose kystique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2736441A1 true CA2736441A1 (fr) | 2012-10-06 |
Family
ID=46964768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2736441A Abandoned CA2736441A1 (fr) | 2011-04-06 | 2011-04-06 | Pyrazolylthiazoles en tant que correcteurs du regulateur de la conductivite transmembranaire de la proteine .delta.f508 de la fibrose kystique |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2736441A1 (fr) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014023367A1 (fr) | 2012-08-09 | 2014-02-13 | Phenex Pharmaceuticals Ag | Hétérocycles à 5 chaînons contenant de l'azote substitués par carboxamide ou sulfonamide en tant que modulateurs pour le récepteur nucléaire orphelin ror gamma |
WO2015196071A1 (fr) * | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité du cftr |
WO2015197187A1 (fr) * | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Carboxamides à base de pyrazolyle v |
US9745292B2 (en) | 2014-03-13 | 2017-08-29 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
US9790219B2 (en) | 2014-03-13 | 2017-10-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
US10344023B2 (en) | 2014-12-23 | 2019-07-09 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
US10392372B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
US10550106B2 (en) | 2015-10-06 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
US10662207B2 (en) | 2016-04-07 | 2020-05-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
US10738011B2 (en) | 2014-12-23 | 2020-08-11 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
US10899751B2 (en) | 2016-06-21 | 2021-01-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
-
2011
- 2011-04-06 CA CA2736441A patent/CA2736441A1/fr not_active Abandoned
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014023367A1 (fr) | 2012-08-09 | 2014-02-13 | Phenex Pharmaceuticals Ag | Hétérocycles à 5 chaînons contenant de l'azote substitués par carboxamide ou sulfonamide en tant que modulateurs pour le récepteur nucléaire orphelin ror gamma |
US9458104B2 (en) | 2012-08-09 | 2016-10-04 | Phenex Pharmaceuticals Ag | Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor RORγ |
EP3118189A1 (fr) | 2012-08-09 | 2017-01-18 | Phenex Pharmaceuticals AG | Azote substitue de carboxamide ou sulfonamide contenant des heterocycles a 5 chainons en tant que modulateurs de recepteur nucleaire orphelin gamma ror |
US9745292B2 (en) | 2014-03-13 | 2017-08-29 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
US9790219B2 (en) | 2014-03-13 | 2017-10-17 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
US10017503B2 (en) | 2014-03-13 | 2018-07-10 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
WO2015196071A1 (fr) * | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Composés, compositions et procédés pour augmenter l'activité du cftr |
US10174014B2 (en) | 2014-06-19 | 2019-01-08 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
US10738040B2 (en) | 2014-06-19 | 2020-08-11 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
WO2015197187A1 (fr) * | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Carboxamides à base de pyrazolyle v |
US10392372B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
US10392378B2 (en) | 2014-12-23 | 2019-08-27 | Proteostasis Therapeutics, Inc. | Derivatives of 5-phenyl- or 5-heteroarylathiazol-2-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
US10738011B2 (en) | 2014-12-23 | 2020-08-11 | Proteostasis Therapeutics, Inc. | Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
US10344023B2 (en) | 2014-12-23 | 2019-07-09 | Proteostasis Therapeutics, Inc. | Derivatives of 3-heteroarylisoxazol-5-carboxylic amide useful for the treatment of inter alia cystic fibrosis |
US11098035B2 (en) | 2014-12-23 | 2021-08-24 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
RU2767460C2 (ru) * | 2014-12-23 | 2022-03-17 | Протеостазис Терапьютикс, Инк. | Соединения, композиции и способы для повышения активности cftr |
US10548878B2 (en) | 2015-07-24 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
US11083709B2 (en) | 2015-07-24 | 2021-08-10 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods of increasing CFTR activity |
US10550106B2 (en) | 2015-10-06 | 2020-02-04 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
US11136313B2 (en) | 2015-10-06 | 2021-10-05 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
US10662207B2 (en) | 2016-04-07 | 2020-05-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
US11248010B2 (en) | 2016-04-07 | 2022-02-15 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for modulating CFTR |
US10899751B2 (en) | 2016-06-21 | 2021-01-26 | Proteostasis Therapeutics, Inc. | Compounds, compositions, and methods for increasing CFTR activity |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20140408 |