PL3430141T3 - Oligonukleotydy do obniżenia ekspresji pd-l1 - Google Patents

Oligonukleotydy do obniżenia ekspresji pd-l1

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Publication number
PL3430141T3
PL3430141T3 PL17710874T PL17710874T PL3430141T3 PL 3430141 T3 PL3430141 T3 PL 3430141T3 PL 17710874 T PL17710874 T PL 17710874T PL 17710874 T PL17710874 T PL 17710874T PL 3430141 T3 PL3430141 T3 PL 3430141T3
Authority
PL
Poland
Prior art keywords
oligonucleotides
expression
reduce
Prior art date
Application number
PL17710874T
Other languages
English (en)
Inventor
Lykke PEDERSEN
Hassan JAVANBAKHT
Malene JACKEROTT
Søren OTTOSEN
Souphalone LUANGSAY
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL3430141T3 publication Critical patent/PL3430141T3/pl

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C—CHEMISTRY; METALLURGY
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    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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PL17710874T 2016-03-14 2017-03-14 Oligonukleotydy do obniżenia ekspresji pd-l1 PL3430141T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16160149 2016-03-14
PCT/EP2017/055925 WO2017157899A1 (en) 2016-03-14 2017-03-14 Oligonucleotides for reduction of pd-l1 expression
EP17710874.3A EP3430141B1 (en) 2016-03-14 2017-03-14 Oligonucleotides for reduction of pd-l1 expression

Publications (1)

Publication Number Publication Date
PL3430141T3 true PL3430141T3 (pl) 2022-02-28

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PL17710874T PL3430141T3 (pl) 2016-03-14 2017-03-14 Oligonukleotydy do obniżenia ekspresji pd-l1

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Country Link
US (5) US20170283496A1 (pl)
EP (2) EP3430141B1 (pl)
JP (4) JP6748219B2 (pl)
KR (5) KR102580776B1 (pl)
CN (5) CN114717235A (pl)
AR (2) AR108038A1 (pl)
AU (4) AU2017235278C1 (pl)
CA (2) CA3120687A1 (pl)
CL (4) CL2018002570A1 (pl)
CO (1) CO2018007761A2 (pl)
CR (2) CR20180432A (pl)
DK (1) DK3430141T3 (pl)
ES (1) ES2857702T3 (pl)
HR (1) HRP20210315T1 (pl)
HU (1) HUE053172T2 (pl)
IL (5) IL303077B2 (pl)
LT (1) LT3430141T (pl)
MX (2) MX2018010830A (pl)
MY (1) MY194912A (pl)
PE (3) PE20181892A1 (pl)
PH (1) PH12018501964A1 (pl)
PL (1) PL3430141T3 (pl)
PT (1) PT3430141T (pl)
RS (1) RS61528B1 (pl)
RU (1) RU2747822C2 (pl)
SG (1) SG11201807854SA (pl)
SI (1) SI3430141T1 (pl)
TW (5) TWI840950B (pl)
UA (1) UA127432C2 (pl)
WO (1) WO2017157899A1 (pl)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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IL260759B (en) 2022-03-01
CN114736901A (zh) 2022-07-12
US12552862B2 (en) 2026-02-17
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KR20220100095A (ko) 2022-07-14
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JP2024029180A (ja) 2024-03-05
US11466081B2 (en) 2022-10-11
US10745480B2 (en) 2020-08-18
KR20230136689A (ko) 2023-09-26
AU2017235278B2 (en) 2021-11-11
CL2018002570A1 (es) 2018-12-28
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AU2022202479B2 (en) 2025-03-20
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RS61528B1 (sr) 2021-04-29
JP7447073B2 (ja) 2024-03-11
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CA3120687A1 (en) 2017-09-21
IL317818A (en) 2025-02-01
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CR20200119A (es) 2021-04-19
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