WO2015114146A1 - Method for predicting the response to an anti-her2 containing therapy and/or chemotherapy in patients with breast cancer - Google Patents

Abstract

A method for predicting a response and/or survival after anti-HER2 containing therapy and/or chemotherapy in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer, said method comprises the determination of the expression level of at least one of the following 12 genes: CCLS, CD21, CD80, CDBA, CTLA4, CXCL13, CXCL9, FOXP3, ID01, IGKC, PD1, PDL1 in a tumor sample from said patient, wherein said expression levels indicate a) the likelihood of benefit from inclusion of Carboplatin in a chemotherapy regimen; b) the likelihood of response to chemotherapy; c) the likelihood that the tumor is infiltrated with leucocytes; d) the likelihood of benefit from anti-HER2 containing therapy; e) the likelihood of developing metastases after treatment.

Description

Method for predicting the response to an anti-HER2 containing therapy and/or chemotherapy in patients with breast cancer

Technical Field The present invention relates to methods, kits and systems for predicting the response and survival after anti-HER2 containing therapy and/or chemotherapy in breast cancer. More specific, the present invention relates to a method that comprises the measurement of gene expression levels to predict the response to anti-HER2 containing therapy and/or chemotherapeutic agents, in particular to the inclusion of Carboplatin in a chemotherapy regimen.

Background of the Invention

HER2/neu-positive (HER2+) and triple-negative breast cancer (TNBC) patients generally have a poor clinical outcome. Cytotoxic chemotherapy is commonly used in these subgroups to reduce the risk of recurrence. A multitude of chemotherapeutic treatment options are available. Several clinical trials demonstrated that anthracycline and taxane-based treatment strategies improve long-term clinical outcome compared to other treatment strategies (Misset et al., J Clin Oncol., 1996, Henderson et al., J Clin Oncol., 2003).

Chemotherapy can be applied in the neoadjuvant (preoperative) setting in which breast cancer patients receive systemic therapy before the remaining tumor cells are removed by surgery. A complete eradication of cancer cells in the breast and lymph nodes after neoadjuvant treatment is called pathological complete response (pCR). pCR is an appropriate surrogate marker for disease- free survival and a strong indicator of benefit from chemotherapy. Treatment of HER2+ and triple-negative breast cancer with neoadjuvant therapy approaches leads to high pathological response rates. However, resistance may individually occur and still a large proportion of tumors do not respond to the treatment.

The use and combination of different types of anti-HER2 agents such the mon- oclonal antibody trastuzumab or the tyrosin kinase inhibitor lapatinib leads to increased response rates and better disease-free survival and/or time to pro- gression in HER2+ breast cancer. Several molecular mechanisms of action have been described for trastuzumab including immunological mechanisms, in particular antibody-dependent cell-mediated cytotoxicity (ADCC).

For triple-negative breast cancer, the use of platinum-based chemotherapy is currently evaluated as a chemotherapeutic option (v. Minckwitz et al., ASCO, 2013). However, still approximately 50% of the patients do not respond to the treatment. Therefore, to reduce the number of patients suffering from serious side effects associated with Carboplatin-based therapy without having a clini^¬ cal benefit, there is a great need for novel markers predicting Carboplatin effi- cacy. Other therapeutic options should be considered for patients, which were predicted to have a low probability of response to Carboplatin.

Several studies demonstrated that immunological infiltrate is an independent predictor of response to neoadjuvant chemotherapy (Denkert et al., J Clin Oncol., 2010; Ignatiadis et al., J Clin Oncol., 2012). Recently, tumor infiltrat- ing lymphocytes (TIL) have been shown to predict Carboplatin response in the GeparSixto trial (Denkert et al., SABCS, 2013). So far it is not known whether immune markers quantified on the protein and/or RNA level are predictive for Carboplatin benefit in HER2+ and triple negative breast cancer patients. EP 2036 988 Al discloses a method for predicting a response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the pattern of expression level of at least one gene of the group comprising AKR1C1, MLPH, ESR1, PGR, COMP, DCN, IGKC, CCL5, FBN1 and/or UBE2C, or of genes coregulated therewith, in said sample; c) comparing the pattern of expression levels determined in (b) with one or several reference pattern(s) of expression levels; d) identifying at least one marker gene; e) determining a molecular subtype for said sample on the basis of (d); and f) predicting from said molec- ular subtype response of a tumor for a chemotherapeutic agent, wherein the molecular subtype is selected from the group comprising the subtypes basal, stromal-high, stromal-low, luminal A, immune system-high, immune system- low, proliferation-high and/or proliferation-low. WO 2012/153187 A2 relates generally to the field of cancer prognosis and treatment. More particularly, methods and compositions are disclosed that uti^¬ lize a particular panel of gene products ("biomarkers") and their differential expression patterns ("expression signatures"), wherein the expression pat- terns correlate with responsiveness, or lack thereof, to chemotherapy treat^¬ ment. The disclosure is based on the identification of a specific set of bi^¬ omarkers that are differentially expressed in chemotherapy-treated tumors and which are useful in predicting the likelihood of a therapeutic response, in^¬ cluding residual disease persistence and subsequent tumor recurrence in can- cer patients receiving chemotherapy. The gene panel is also useful in design^¬ ing specific adjuvant modalities with improved therapeutic efficiency.; Also disclosed are methods for characterizing tumors according to expression of the biomarkers described herein. WO 2010/076322 Al discloses a method for predicting a response to and/or benefit from chemotherapy in a patient suffering from cancer comprising the steps of (i) classifying a tumor into at least two classes, (ii) determining in a tumor sample the expression of at least one marker gene indicative of a re^¬ sponse to chemotherapy for a tumor in each respective class, (iii) depending on said gene expression, predicting said response and/or benefit; wherein said at least one marker gene comprises a gene selected from the group consisting of TMSL8, ABCC1, EGFR, MVP, ACOX2, HER2/NEU, MYH11, TOB1, AKR1C1, ERBB4, NFKB1A, TOP2A, AKR1C3, ESR1, OLFM1, TOP2B, ALCAM, FRAP1, PGR, TP53, BCL2, GADD45A, PRKABl, TUBAIA, C16orf45, HIFIA, PTPRC, TUBB, CA12, 1GKC, RACGAP1, UBE2C, CD14, 1KBKB, S100A7, VEGFA, CD247, KRT5, SEPT8, YBX1, CD3D, MAPK3, SLC2A1, CDKN1A, MAPT, SLC7A8, CHPT1, MLPH, SPON1, CXCL13, MMP1, STAT1, CXCL9, MMP7, STC2, DCN, MUC1, STMN1 and combinations thereof. WO 2008/154249 A2 concerns markers of resistance of HER2 expressing tu^¬ mors to treatment with HER2 inhibitors, such as HER2 antibodies, including trastuzumab.

Fiona O'Neill, et al., in Molecular Cancer 2013, 12:69 doi: 10.1186/1476-4598- 12-69, report about a gene expression profile indicative of early stage HER2 targeted therapy response. The paper d iscloses that an efficacious application of H ER2-targetting agents req uires the identification of novel predictive bio- markers. Lapatinib, afatinib and neratinib are tyrosine kinase inhibitors (TKIs) of H ER2 and EG FR g rowth factor receptors. A panel of breast cancer cell l ines was treated with these agents, trastuzumab, gefitinib and cytotoxic therapies and the expression pattern of a specific panel of genes using RT- PCR was in^¬ vestigated as a potential marker of early d rug response to H ER2-targeting therapies. The results are summarised by the authors as the treatment of H ER2 TKI-sensitive SKBR3 and BT474 cell lines with lapatinib, afatinib and neratinib induced an increase in the expression of RB1 CC1 , ERBB3, FOX03a and NR3C1 . The response d irectly correlated with the degree of sensitivity. This expression pattern switched from up-reg ulated to down-reg ulated in the H ER2 expressing , H ER2-TKI insensitive cell line M DAM B453. Expression of the CCND1 gene demonstrated an inversely proportional response to drug expo- sure. A similar expression pattern was observed following the treatment with both neratinib and afatinib. These patterns were retained following exposure to traztuzumab and lapatinib plus capecitabine . In contrast, gefitin ib, dasatin ib and epirubicin treatment resulted in a completely d ifferent expression pattern change. The authors concluded that in the investigated H ER2-expressing cel l line models, lapatinib, neratinib, afatinib and trastuzumab treatment gener^¬ ated a characteristic and specific gene expression response, proportionate to the sensitivity of the cel l lines to the H ER2 inhibitor. Characterisation of the induced changes in expression levels of these genes may therefore give a valuable, very early predictor of the likely extent and specificity of tumour H ER2 inhibitor response in patients, potentially g uid ing more specific use of these agents.

Veg ran F, et al . in Br J Cancer. 2009 Oct 20; 101 (8) : 1357-64. doi : 10. 1038/sj . bjc.6605310 report about gene expression profile and response to trastuzumab-docetaxel-based treatment in breast carcinoma . The paper d islcoses that resistance to trastuzumab is often observed in women with hu^¬ man epidermal growth factor receptor 2 ( H ER2)-positive breast cancer and has been shown to involve multiple potential mechanisms. We examined the abil ity of microarray analyses to determine the potential markers of patholog i- cal complete response (pCR) . The authors conducted an analysis of tumours from 38 patients with locally advanced HER2-positive breast cancer who had received trastuzumab combined with docetaxel. Quantitative reverse transcrip^¬ tase (RT)-PCR was used to assess the expression of 30 key genes; microarray analyses were carried out on 25 tumours to identify a prognostic gene expres- sion profile, with 13 blinded samples used to validate the identified profile. The authors found that no gene was found to correlate with response by RT-PCR. The microarray analysis identified a gene expression profile of 28 genes, with 12 upregulated in the pCR group and 16 upregulated in non-pCR. The leave- one-out cross-validation test exhibited 72% accuracy, 86% specificity, and 55% sensitivity. The 28-gene expression profile classified the 13 validation samples with 92% accuracy, 89% specificity, and 100% sensitivity. The au^¬ thors concluded from the results the suggestion that genes not involved in classical cancer pathways such as apoptosis or DNA repair could be involved in responses to a trastuzumab-docetaxel-based regimen. They also describe for the first time a gene expression signature that predicts trastuzumab response. Chemopreventive agents induce programmed death-l-ligand 1 (PD-Ll) sur^¬ face expression in breast cancer cells and promote PD-Ll-mediated T cell apoptosis. Zhang et al. report in Molecular Immunology 45(5): 1470-6. DOI: 10.1016/j.molimm.2007.08.013 about chemopreventive agents induce programmed death-l-ligand 1 (PD-Ll) surface expression in breast cancer cells and promote PD-Ll-mediated T cell apoptosis. they disclose that chemo^¬ therapy has been widely used in cancer treatment. However, the prognosis of the cancer patients following chemotherapy has not been substantially im^¬ proved. Alternative strategies such as immunotherapy and their combinations with chemotherapy are now being considered. Yet, the effects of chemothera^¬ py on the immune responses of cancer cells are not clear. Cancer immunoresistance and immune escape are major obstacles in immunotherapy. In the present studies, we examined the effects of chemopreventive agents, paclitaxel, etoposide and 5-fluorouracil, on the surface expression of pro^¬ grammed death-l-ligand 1 (PD-Ll), a negative regulator of T cell anti-tumor immunity. Interaction of PD-Ll on cancer cells with programmed death receptor 1 (PD-1) on T cells has been reported to inhibit the proliferation of tumor- reactive cytotoxic T cells and induce T cell apoptosis, which could be an im- portant mechanism in the development of cancer immunoresistance. The authors demonstrated that those chemopreventive agents were able to induce PD-Ll surface expression in human breast cancer cells, which then promoted PD-Ll-mediated T cell apoptosis. Their studies reveal a potential link between chemotherapy and cancer immunoresistance.

Qin X, et al. in Cell Mol Biol (Noisy-le-grand), 56 Suppl:OL1366-72 report that Cisplatin induces programmed death-l-ligand l(PD-Ll) over-expression in hepatoma H22 cells via Erk /MAPK signaling pathway. The authors disclose that Cisplatin has been widely used in cancer treatment. However, the prognosis of the cancer patients following chemotherapy has not been substantially improved and several different mechanisms could be involved. Clinically alter^¬ native strategies such as immunotherapy and their combinations with chemo^¬ therapy have being used. Cancer immunoresistance and immune escape are major obstacles in chemotherapy. However, the effects of cisplatin on the im^¬ mune responses of cancer cells are not clear. In the present studies, the au^¬ thors investigate the expression of immunoresistance moleculor PD-Ll (the negative regulator programmed death-l-ligand 1) on cisplatin-induced hepatoma H22 cells, which can interact with PD-1 on T cells to mediate cancer immunoresistance. Hepatoma H22 cells were treated with cisplatin in vivo or in vitro to analysis the expression of PD-Ll by flow cytometry (FACS). Erkl/Erk2 phosphorylation expressions were examined by western blotting. They demonstrated that cisplatin was able to induce H22 cell apoptosis and when the concentration less than IC50 cisplatin could up-regulate PD-Ll ex- pression in hepatoma H22 cells. The optimal concentration of cisplatin for the highest expression of PD-Ll was 0.5 pg/rnl in vitro. Meanwhile, cisplatin could induce the phosphorylation of Erkl/2.The lack of effect during treatment with a specific MAPK pathway inhibitor PD98059, demonstrated that cisplatin- induced PD-Ll expression is dependent of Erkl/2 phosphorylation. The studies reveal a potential link between chemotherapy and cancer immunoresistance. PD-Ll and its signaling pathway appear to be a potential therapeutic target for the cisplatin treatment of hepatoma. Definitions

Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The term "tumor" as used herein, refers to all neoplastic cell growth and proliferation, whether malignant or benign, and all pre-cancerous and cancerous cells and tissues.

The term "cancer" is not limited to any stage, grade, histomorphological feature, or malignancy of an affected tissue or cell aggregation . The term "prediction", as used herein, relates to an individual assessment of the malignancy of a tumor, or to the response to a given therapy, or to the expected survival rate (OS, overall survival or DMFS, distant metastasis-free survival or DFS, disease free survival) of a patient, if the tumor is treated with a given therapy. A "benefit" from a given therapy is an improvement in health or wellbeing that can be observed in patients under said therapy, but isn't observed in patients not receiving this therapy. Non-limiting examples commonly used in oncology to gauge a benefit from therapy are survival, disease-free survival, metastasis free survival, disappearance of metastasis, tumor regression, and tumor re- mission.

A "risk" is understood to be a probability of a subject or a patient to develop or arrive at a certain disease outcome. The term "risk" in the context of the present invention is not meant to carry any positive or negative connotation with regard to a patient's wellbeing but merely refers to a probability or likelihood of an occurrence or development of a given condition.

A "gene" is a set of segments of nucleic acid that contains the information necessary to produce a functional RNA product.

An "mRNA" is the transcribed product of a gene or a part of a gene and shall have the ordinary meaning understood by a person skilled in the art. The term "expression level" refers to a determined level of gene expression. This may be a determined level of gene expression as an absolute value or compared to a reference gene (e.g. a housekeeping gene) or to a computed average expression value (e.g . in DNA chip analysis) or to another informative gene without the use of a reference sample. The expression level of a gene may be measured directly, e.g . by obtaining a signal wherein the signal strength is correlated to the amount of mRNA transcripts of that gene or it may be obtained indirectly at a DNA or protein level, e.g . by immunohisto- chemistry, CISH, ELISA or RIA methods. The expression level may also be ob- tained by way of a competitive reaction to a reference sample. An expression value which is determined by measuring some physical parameter in an assay, e.g . fluorescence emission, may be assigned a numerical value which may be used for further processing of information.

The term "sample", as used herein, refers to a sample obtained from a pa- tient. The sample may be of any biological tissue or fluid. Such samples include, but are not limited to, sputum, blood, serum, plasma, blood cells (e.g ., white cells), tissue, core or fine needle biopsy samples, cell-containing body fluids, free floating nucleic acids, urine, peritoneal fluid, and pleural fluid, or cells there from. Biological samples may also include sections of tissues such as frozen or fixed sections taken for histological purposes or microdissected cells or extracellular parts thereof. A biological sample to be analyzed is tissue material from neoplastic lesion taken by aspiration or punctuation, excision or by any other surgical method leading to biopsy or resected cellular material. Such biological sample may comprise cells obtained from a patient. The cells may be found in a cell "smear" collected, for example, by a nipple aspiration, ductal lavage, fine needle biopsy or from provoked or spontaneous nipple discharge. In another embodiment, the sample is a body fluid. Such fluids include, for example, blood fluids, serum, plasma, lymph, ascitic fluids, gynecological fluids, or urine but not limited to these fluids. A "tumor sample" is a biological sample containing tumor cells, no matter if intact or degraded.

The term "hybridization-based method", as used herein, refers to methods imparting a process of combining complementary, single-stranded nucleic ac- ids or nucleotide analogues into a single double stranded molecule. Nucleotides or nucleotide analogues will bind to their complement under normal conditions, so two perfectly complementary strands will bind to each other readily. In bioanalytics, very often labeled, single stranded probes are in order to find complementary target sequences. If such sequences exist in the sample, the probes will hybridize to said sequences which can then be detected due to the label . Other hybridization based methods comprise microarray and/or bio- chip methods. Therein, probes are immobilized on a solid phase, which is then exposed to a sample. If complementary nucleic acids exist in the sample, the- se will hybridize to the probes and can thus be detected . These approaches are also known as "array based methods". Yet another hybridization based method is PCR, which is described above. When it comes to the determination of expression levels, hybridization based methods may for example be used to determine the amount of mRNA for a given gene. An oligonucleotide capable of specifically binding sequences a gene or fragments thereof relates to an oligonucleotide which specifically hybridizes to a gene or gene product, such as the gene's mRNA or cDNA or to a fragment thereof. To specifically detect the gene or gene product, it is not necessary to detect the entire gene sequence. A fragment of about 20- 150 bases will con- tain enough sequence specific information to allow specific hybridization .

The term "a PCR based method" as used herein refers to methods comprising a polymerase chain reaction (PCR) . This is a method of exponentially amplifying nucleic acids, e.g . DNA by enzymatic replication in vitro. As PCR is an in vitro technique, it can be performed without restrictions on the form of DNA, and it can be extensively modified to perform a wide array of genetic manipulations. When it comes to the determination of expression levels, a PCR based method may for example be used to detect the presence of a given mRNA by ( 1) reverse transcription of the complete mRNA pool (the so called transcriptome) into cDNA with help of a reverse transcriptase enzyme, and (2) detecting the presence of a given cDNA with help of respective primers. This approach is commonly known as reverse transcriptase PCR (rtPCR) . Moreover, PCR-based methods comprise e.g . real time PCR, and, particularly suited for the analysis of expression levels, kinetic or quantitative PCR (q PCR) . The terms "Quantitative PCR" (qPCR)" or "kinetic PCR" refers to any type of a PCR method which allows the quantification of the template in a sample. Quantitative real-time PCR comprise different techniques of performance or product detection as for example the TaqMan technique, the LightCycler tech- nique or the usage of a dye directly staining DNA such as SYBR Green. The TaqMan technique, for examples, uses a dual-labelled fluorogenic probe. The TaqMan real-time PCR measures accumulation of a product via the fluorophore during the exponential stages of the PCR, rather than at the end point as in conventional PCR. The exponential increase of the product is used to deter- mine the threshold cycle, CT, i.e. the number of PCR cycles at which a signifi^¬ cant exponential increase in fluorescence is detected, and which is directly cor^¬ related with the number of copies of DNA template present in the reaction. The set up of the reaction is very similar to a conventional PCR, but is carried out in a real-time thermal cycler that allows measurement of fluorescent mol- ecules in the PCR tubes. Different from regular PCR, in TaqMan real-time PCR a probe is added to the reaction, i.e., a single-stranded oligonucleotide com^¬ plementary to a segment of 20-60 nucleotides within the DNA template and located between the two primers. A fluorescent reporter or fluorophore (e.g., 6-carboxyfluorescein, acronym: FAM, or tetrachlorofluorescein, acronym: TET) and quencher (e.g., tetramethylrhodamine, acronym: TAMRA, of dihydrocyclopyrroloindole tripeptide "minor groove binder", acronym: MGB) are covalently attached to the 5' and 3' ends of the probe, respectively. The close proximity between fluorophore and quencher attached to the probe in^¬ hibits fluorescence from the fluorophore. During PCR, as DNA synthesis com- mences, the 5' to 3' exonuclease activity of the Taq polymerase degrades that proportion of the probe that has annealed to the template (Hence its name: Taq polymerase + TacMan). Degradation of the probe releases the fluorophore from it and breaks the close proximity to the quencher, thus relieving the quenching effect and allowing fluorescence of the fluorophore. Hence, fluores- cence detected in the real-time PCR thermal cycler is directly proportional to the fluorophore released and the amount of DNA template present in the PCR.

By "array" or "matrix" an arrangement of addressable locations or "addresses" on a device is meant. The locations can be arranged in two dimensional ar^¬ rays, three dimensional arrays, or other matrix formats. The number of loca- tions can range from several to at millions. Most importantly, each location represents a totally independent reaction site. Arrays include but are not limited to nucleic acid arrays, protein arrays and antibody arrays. A "nucleic acid array" refers to an array containing nucleic acid probes, such as oligonucleotides, nucleotide analogues, polynucleotides, polymers of nucleotide ana- logues, morpholinos or larger portions of genes. The nucleic acid and/or analogue on the array is preferably single stranded . Arrays wherein the probes are oligonucleotides are referred to as "oligo-nucleotide arrays" or "oligonucleotide chips." A "microarray," herein also refers to a "biochip" or "biological chip", an array of regions having a density of discrete regions of at least about 100/cm2, and preferably at least about 1000/cm2.

The term "regimen" refers to a timely sequential or simultaneous administration of anti-tumor, and/or anti vascular, and/or targeted therapy, and/or immune stimulating, and/or blood cell proliferative agents, and/or radiation therapy, and/or hyperthermia, and/or hypothermia for cancer therapy. The admin- istration of these can be performed in an adjuvant and/or neoadjuvant mode as well in a metastatic setting . The composition of such "protocol" may vary in the dose of the single agent, timeframe of application and frequency of administration within a defined therapy window. Currently various combinations of various drugs and/or physical methods, and various schedules are under in- vestigation .

The term "adjuvant chemotherapy" relates to a postoperative systemic therapy regimen consisting of a panel of hormonal, chemotherapeutic and/or antibody agents, which is aimed to eradicate micrometastasis (tumor cells spread throughout the body), thereby preventing from recurrence and improving sur- vival .

The term "neoadjuvant chemotherapy" relates to a systemic preoperative therapy regimen consisting of a panel of hormonal, chemotherapeutic and/or antibody agents, which is aimed to shrink the primary tumor, thereby rendering local therapy (surgery or radiotherapy) less destructive or more effective, enabling breast conserving surgery and evaluation of responsiveness of tumor sensitivity towards specific agents in vivo, and which is also aimed to eradicate micrometastasis (tumor cells spread throughout the body), thereby preventing from recurrence and improving survival .. The term " measu rement at a protein level" , as used herein, refers to methods which allow for the quantitative and/or qualitative determination of one or more proteins in a sample . These methods include, among others, protein pu^¬ rification, incl uding ultracentrifugation, precipitation and chromatog raphy, as wel l as protein analysis and determination, incl uding immunohistochemistry, immunofluorescence, ELISA (enzyme l inked immunoassay), RIA (rad ioim^¬ munoassay) or the use of protein microarrays, two- hybrid screening, blotting methods incl uding western blot, one- and two dimensional gel electrophoresis, isoelectric focusing as well as methods being based on mass spectrometry like MALDI-TOF and the like.

The term "marker gene" as used herein, refers to a d ifferential ly expressed gene whose expression pattern may be util ized as part of a pred ictive, prog^¬ nostic or d iagnostic process in mal ignant neoplasia or cancer eval uation, or which, alternatively, may be used in methods for identifying compounds usefu l for the treatment or prevention of mal ig nant neoplasia and head and neck, colon or breast cancer in particu lar. A marker gene may also have the characteristics of a target gene.

The term "therapy" refers to a timely seq uential or simultaneous ad ministra^¬ tion of anti-tumor, and/or targeted therapy, and/or anti vascular, and/or anti stroma, and/or immune stimulating or suppressive, and/or blood cell prol ifera^¬ tive agents, and/or rad iation therapy, and/or hyperthermia, and/or hypothermia for cancer therapy. The administration of these can be performed in an adjuvant and/or neoadjuvant mode. The composition of such "protocol" may vary in the dose of each of the single agents, timeframe of application and freq uency of administration within a defined therapy window. Currently various combinations of various d rugs and/or physical methods, and various schedules are under investigation . A "taxane/anthracycl ine-containing chemotherapy" is a therapy modality comprising the ad min istration of taxane and/or anthracycline and therapeutical ly effective derivates thereof. A "carboplatin- containing chemotherapy" is a therapy modal ity comprising the ad ministration of carboplatin and therapeutical ly effective derivates thereof such as for ex^¬ ample cisplatin . An "anti- H ER2 containing therapy" is a therapy modal ity comprising the administration of H ER2-targeting agents such as for example the monoclonal antibody trastuzumab or the tyrosin kinase inhibitor lapatinib and therapeutically effective derivates thereof.

The term "immunohistochemistry" or IHC refers to the process of localizing proteins in cells of a tissue section exploiting the principle of antibodies bind- ing specifically to antigens in biological tissues. Immunohistochemical staining is widely used in the diagnosis and treatment of cancer. Specific molecular markers are characteristic of particular cancer types. IHC is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue.

A "tumor sample" is a sample containing tumor material e.g . tissue material from a neoplastic lesion taken by aspiration or puncture, excision or by any other surgical method leading to biopsy or resected cellular material, including preserved material such as fresh frozen material, formalin fixed material, paraffin embedded material and the like. Such a biological sample may comprise cells obtained from a patient. The cells may be found in a cell "smear" collected, for example, by a nipple aspiration, ductal lavage, fine needle biopsy or from provoked or spontaneous nipple discharge. In another embodiment, the sample is a body fluid. Such fluids include, for example, blood fluids, serum, plasma, lymph, ascitic fluids, gynecological fluids, or urine but not limited to these fluids.

"Primer" and "probes", within the meaning of the invention, shall have the ordinary meaning of this term which is well known to the person skilled in the art of molecular biology. In a preferred embodiment of the invention "primer" and "probes" shall be understood as being polynucleotide molecules having a sequence identical, complementary, homologous, or homologous to the complement of regions of a target polynucleotide which is to be detected or quantified . In yet another embodiment nucleotide analogues and/or morpholinos are also comprised for usage as primers and/or probes. "Individually labeled probes", within the meaning of the invention, shall be understood as being molecular probes comprising a polynucleotide, oligonucleotide or nucleotide analogue and a label, helpful in the detection or quantification of the probe. Preferred labels are fluorescent molecules, luminescent molecules, radioactive molecules, enzymatic molecules and/or quenching molecules. The term "marker" or "biomarker" refers to a biological molecule, e.g ., a nucleic acid, peptide, protein, hormone, etc., whose presence or concentration can be detected and correlated with a known condition, such as a disease state. The term "predictive marker" relates to a marker which can be used to predict the clinical response of a patient towards a given treatment.

"Predicting the response to chemotherapy", within the meaning of the invention, shall be understood to be the act of determining a likely outcome of cytotoxic chemotherapy in a patient affected by cancer. The prediction of a re- sponse is preferably made with reference to probability values for reaching a desired or non-desired outcome of the chemotherapy. The predictive methods of the present invention can be used clinically to make treatment decisions by choosing the most appropriate treatment modalities for any particular patient.

The term "cytotoxic treatment" or "cytotoxic chemotherapy" refers to various treatment modalities affecting cell proliferation and/or survival. The treatment may include administration of alkylating agents, antimetabolites, anthracyclines, plant alkaloids, topoisomerase inhibitors, and other antitumour agents, including monoclonal antibodies and kinase inhibitors. In particular, the cytotoxic treatment may relate to a treatment comprising microtubule- stabilizing drugs such as taxanes or epothilones. Taxanes are plant alkaloids which block cell division by preventing microtubule function. The prototype taxane is the natural product paclitaxel, originally known as Taxol and first derived from the bark of the Pacific Yew tree. Docetaxel is a semi-synthetic analogue of paclitaxel. Taxanes enhance stability of microtubules, preventing the separation of chromosomes during anaphase. To improve pharmacokinetics and cellular uptake taxanes can be bound to delivery vehicles such as for example albumin (abraxane). Epothilones such as for example Ixabepilone stabilize the microtubules, have the same biological effects and target the same binding site at the microtubule as taxol . However, the chemical structure is different. Cisplatin and carboplatin belong to the group of platinum-based antineoplastic agents, and interact with DNA to interfere with DNA repair.

As all measurement results also gene expressions values or combined scores, consisting of a mathematical combination of one or more gene expression val- ues, require to be compared to a "reference-value" to get a meaning in a clinical context. As such an expression value or a combined score exceeding such a "reference-value", by way of example may mean an improved or worsened likelihood of survival for a patient. Such "reference-value" can be a numerical cutoff value, it can be derived from a reference measurement of one or more other genes in the same sample, or one or more other genes and/or the same gene in one other sample or in a plurality of other samples. This is how "reference-value" within the meaning of this invention should be understood .

Object of the Invention It is one object of the present invention to provide an improved method for the prediction of a response of a tumor in a patient suffering from or at risk of developing a neoplastic disease - in particular breast cancer - to at least one given mode of treatment.

It is another object of the present invention to provide an improved method for the prediction of response to Carboplatin-containing chemotherapy and/or anti-HER2 containing therapy in a patient suffering from or at risk of developing a neoplastic disease - in particular breast cancer.

It is another object of the present invention to provide a method for identification of patients, particularly breast cancer patients, who have a benefit from receiving Carboplatin-containing chemotherapy and/or anti-HER2 containing therapy as a part of their therapy.

It is another object of the present invention to avoid unnecessary side-effects of adjuvant and/or neoadjuvant chemotherapy or targeted therapy.

It is another object of the present invention to assess the risk of recurrence in patients receiving anti-HER2 containing therapy and/or chemotherapy treatment.

It is another object of the present invention to offer a more robust and specific diagnostic assay system than conventional immunohistochemistry for clinical routine fixed tissue samples that better helps the physician to select individu- alized treatment modalities. In a more preferred embodiment the disclosed method can be used to select a suitable therapy for a neoplastic disease, particularly breast cancers.

Summary of the Invention

This disclosure focuses on a test that predicts response and survival from anti- HER2 containing therapy and/or chemotherapy and thus will help physicians to decide on selecting tailored treatment regimens. Additionally, the test will help to identify patients who will have a benefit from inclusion of Carboplatin or its therapeutically effective derivates in a chemotherapy regimen.

The present invention relates to a method for predicting a response and/or survival after anti-HER2 containing therapy and/or chemotherapy in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer. Said method comprises the determination of the expression level of at least one of the following 12 genes: CCL5, CD21, CD80, CD8A, CTLA4, CXCL13, CXCL9, FOXP3, IDOl, IGKC, PD1, PDL1 in a tumor sample from said patient, wherein said expression levels indicate a) the likelihood of benefit from inclusion of Carboplatin in a chemotherapy regimen. A high expression level of the said at least one marker gene generally indicates an increased likelihood of benefit from inclusion of Carboplatin in a chemotherapy regimen and a low expression level of the said at least one marker gene indicates a decreased likelihood of benefit from inclusion of Carboplatin in a chemotherapy regimen.

b) the likelihood of response to chemotherapy, a high expression level of the said at least one marker gene generally indicates an increased likelihood of response to chemotherapy and a low expression level of the said at least one marker gene indicates a decreased likelihood of response to chemotherapy.

c) the likelihood that the tumor is infiltrated with leucocytes as evaluated by a pathologist. A high expression level of the said at least one marker gene generally indicates that the tumor is infiltrated with leucocytes and a low expression level of the said at least one marker gene indicates a decreased infiltration with leucocytes.

d) the likelihood of benefit from anti-HER2 containing therapy, a high expression level of the said at least one marker gene generally indicates an increased likelihood of benefit from inclusion of anti-H ER2 containing therapy in a chemotherapy regimen and a low expression level of the said at least one marker gene indicates a decreased likelihood of benefit from inclusion of anti-H ER2 containing therapy in a chemotherapy regi- men .

e) the likelihood of developing metastases after treatment, a high expression level of the said at least one marker gene generally indicates a decreased residual risk of recurrence after anti-H ER2 containing therapy and/or chemotherapy treatment and a low combined score of the said at least one marker gene indicates an increased risk of recurrence after anti-H ER2 containing therapy and/or chemotherapy treatment.

According to an aspect of the invention there is provided a method as described above, wherein said expression level is determined as an mRNA level .

According to an aspect of the invention there is provided a method as de- scribed above, wherein said expression level is determined by at least one of a PCR based method,

a micorarray based method,

a hybridization based method,

a sequencing and/or next generation sequencing approach A preferred form is kinetic or quantitative RT-PCR using e.g . commercially available systems such as Taqman, Lightcycler or others.

According to an aspect of the invention there is provided a method as described above, wherein said determination of expression levels is in a formalin-fixed paraffin-embedded tumor sample or in a fresh-frozen tumor sample. According to an aspect of the invention there is provided a method as described above, wherein the expression level of said marker genes are determined relative to at least one reference gene or to a computed average expression value.

According to an aspect of the invention there is provided a method as de- scribed above, wherein one, two or more thresholds are determined for said expression levels and discriminated into response groups by applying the threshold on the gene expression levels. Accord ing to an aspect of the invention there is provided a method as de^¬ scribed above, wherein said expression levels are mathematically combined to a combined score. The method comprises a step of applying an algorithm to values representative of an expression level of a given gene . Accord ing to an aspect of the invention there is provided a method as de^¬ scribed above, wherein said algorithm is a mathematical combination of said values representative of an expression level of a g iven gene.

Accord ing to an aspect of the invention there is provided a method as de^¬ scribed above, wherein a val ue for a representative of an expression level of a g iven gene is multipl ied with a coefficient.

Accord ing to an aspect of the invention one, two or more thresholds are de^¬ termined for said gene expression and/or combined scores and d iscriminated into ( 1 ) "pred icted benefit" and "pred icted non-benefit", (2) "predicted benefit" and "predicted adverse effect", (3) "predicted benefit", "pred icted indifferent effect" and "pred icted adverse effect", or more grou ps with d ifferent probabili^¬ ties of benefit by applying the threshold on the gene expression levels or the combined scores.

The invention further relates to a kit for performing a method as described above, said kit comprising a set of oligonucleotides capable of specifically bind ing seq uences or to seq uences of fragments of the genes in a combination of genes, wherein said combination comprises a subset of the 12 genes CCL5, CD21 , CD80, CD8A, CTLA4, CXCL13, CXCL9, FOXP3, IDOl , IGKC, PD1 , PDL1 .

The invention further relates to a computer program product capable of processing gene expression val ues and combined scores. Said computer program prod uct may be stored on a data carrier or implemented on a d iagnostic system capable of outputting values representative of an expression level of a given gene or combined scores, such as a real time PCR system .

If the computer prog ram prod uct is stored on a data carrier or running on a computer, operating personal can input the expression val ues obtained for the expression level of the respective genes. The computer program product can then apply algorithms to predict said response and survival after anti-HER2 containing therapy and/or chemotherapy treatment.

According to an aspect of the invention said cancer is breast cancer. The marker genes described in this invention are not breast cancer specific genes, but generally cancer-relevant genes or genes relevant to the therapeutic mechanism of anti-HER2 containing therapy and Carboplatin. It can therefore be expected that the methods of the invention are also predictive in other cancers, in which similar therapy regimens are commonly administered, such as lung cancer, head-and-neck cancer, ovarian cancer, testicular cancer, prostate cancer, and stomach cancer.

Detailed description of the invention

Additional details, features, characteristics and advantages of the object of the invention are disclosed in the sub-claims, and the following description of the respective figures, tables and examples, which, in an exemplary fashion, show preferred embodiments of the present invention. However, these drawings should by no means be understood as to limit the scope of the invention.

A total of 12 immunologically relevant genes (table 1,2), including T-cell markers (CXCL9, CCL5, CD8a), B-cell markers (CD80, CXCL13, IGKC, CD21) and putative immunosuppressive regulators (IDOl, PD-1, PDL1, CTLA4,

Foxp3) were prospectively evaluated in 483 tumor samples from the neoadjuvant GeparSixto trial . In the GeparSixto trial (NCT01426880), patients were treated for 18 weeks with paclitaxel 80mg/m² qlw and non-pegylated- liposomal doxorubicin (NPLD) 20mg/m² q lw (PM). Patients were randomized 1 : 1 to receive simultaneously carboplatin (PMCb) AUC 1.5 (initially 2.0) q lw versus not (PM). Patients with TNBC received simultaneously bevacizumab 15mg/kg q2w. Patients with HER2-positive disease received simultaneously trastuzumab 6(8) mg/kg q3w and lapatinib 750mg daily. As part of the prospectively planned collection of biomaterials, FFPE pretherapeutic core biopsies were collected at the time of randomization, after written informed consent.

Primer and probe sequences for the 12 marker genes are shown in table 3. qRT-PCR was performed in triplicate and relative expression levels of genes of interest (GOI) were calculated as ACt values (ACt = 20 - [CtGOI - Ct(mean of RPL37A, CALM 2, OAZ1)]) in all analyzed 483 tumor samples.

Two combined scores / metagenes were defined:

Metagene A (Meta A) = combined score of CCL5, CXCL13, CXCL9 and IGKC. The ACt values of CCL5, CXCL13, CXCL9 and IGKC were z-transformed. The sum of the transformed values yields the combined score: metagene A (Meta A).

Metagene B (Meta B) = combined score of CXCL13 and CXCL9 C. The ACt val^¬ ues of CXCL13 and CXCL9 were z-transformed. The sum of the transformed values yields the combined score: metagene B (Meta B).

First, all 12 marker genes and both metagenes were evaluated for Carboplatin response. Pathological complete remission (pCR) was defined as the absence of residual invasive or non-invasive tumor cells in breast and lymph nodes (ypTO ypNO) after neoadjuvant chemotherapy/anti-HER2 containing therapy. High expression levels of the immune markers indicated an increased Car^¬ boplatin response in HER2+ and triple-negative tumor samples (Fig. 1, table 4).

All evaluated genes/metagenes were also predictive for increased response to neoadjuvant chemotherapy (table 5). Tumor samples with an increased ex- pression level of one or more marker genes were associated with a higher pathological complete response (pCR) rate.

Fig. 2 depicts gene expression distribution of all 12 immune marker genes and both metagenes in the "LPBC" (high immune infiltration) and "no LPBC" (low immune infiltration) subgroups. All immune markers and metagenes had a significantly higher gene expression level in the "LPBC" group compared to the "no LPBC" subgroup.

All analyzed tumor samples from the GeparSixto trial were divided into two subgroups: "LPBC" and "no LPBC" (Fig. 2) based on pathological assessment of lymphocyte infiltration. "LPBC" tumor samples were infiltrated with lympho^¬ cytes, whereas "no LPBC" tumor samples had no considerable infiltration of lymphocytes. "LPBC" tumor samples had a significantly higher expression level of all 12 marker genes and both metagenes in comparison to "no LPBC" tumor samples (Fig. 2).

The immune markers predicted chemotherapy and anti-HER2 containing ther- apy response in HER2+ breast cancer patients (table 6).

Immune marker genes were also evaluated in centrally HER2+ breast cancer patients (n = 161) from the GeparQuattro study. All patients were treated pre^¬ operative^ with four cycles of epirubicin/cyclophosphamide followed by four cycles of docetaxel with or without capecitabine and trastuzumab 6 mg/kg (with a loading dose of 8 mg/kg) every 3 weeks during all chemotherapy. Im^¬ mune marker genes predicted response to chemotherapy and anti-HER2 con^¬ taining therapy (table 7). The marker genes also predicted risk of recurrence after chemotherapy and anti-HER2 containing therapy (table 8).

Herein disclosed are marker genes which can be used as a new predictive test. Technically, the method of the invention can be practiced using two technolo^¬ gies: 1.) Isolation of total RNA from fresh or fixed tumor tissue and 2.) Quantitative RT-PCR of the isolated nucleic acids. Alternatively, it is contemplated to measure expression levels using alternative technologies, including but not limited to microarray, in particular Affymetrix U-133A arrays, sequencing or by measurement at a protein level. The methods of the invention are based on quantitative determination of RNA species isolated from the tumor in order to obtain expression values and subsequent bioinformatics analysis of said de^¬ termined expression values. RNA species can be isolated from any type of tu^¬ mor sample, e.g. biopsy samples, smear samples, resected tumor material, fresh frozen tumor tissue or from paraffin embedded and formalin fixed tumor tissue. Herein disclosed is a unique panel of genes which can be combined into algo^¬ rithms for the here presented new predictive test.

Table 1 : Affymetrix probeset ID and TaqMan design ID mapping of the marker genes of the present invention.

Table 2 : full names, Entrez Gene ID and chromosomal location of the marker genes of the present invention

Table 3 - qRT-PCR primer and probe sequences

Table 4: Interaction odds-ratio (Carboplatin response) and interaction p-values for the different markers in all analyzed tumor samples. Gene expression levels, response: pCR (ypTO/ypNO) and treatment arms (+/- Car- boplatin) were used for the test for interaction. Almost all marker genes and metagenes had a positive Interaction odds-ratio indicating that a high expression level is associated with Carboplatin response. ypTO ypNO

OR P

CCL5 1.58 0.002

CD21 1.08 0.362

CD80 1.49 0.1

CD8A 1.43 0.011

CTLA4 1.35 0.044

CXCL13 1.14 0.142

CXCL9 1.19 0.085

FOXP3 0.96 0.833

IDOl 1.22 0.024

IGKC 1.09 0.262

PD1 1.44 0.016

PDL1 1.34 0.079

Metagene A 1.15 0.028

Metagene B 1.20 0.103 Table 5 : Logistic regression analysis: All marker genes were significantly associated with pathological complete response (ypNO/ypTO) in all tumor samples. All marker genes and metagenes had a positive OR indicating that a high expression level is associated with chemotherapy response. univariable

CCL5 1.42 1.24 1.63 0

CD21 1.11 1.03 1.21 0.011

CD80 1.60 1.27 2.03 0

CD8A 1.29 1.13 1.48 0

CTLA4 1.38 1.20 1.60 0

CXCL13 1.16 1.06 1.26 0.001

CXCL9 1.26 1.14 1.39 0

FOXP3 1.22 1.00 1.50 0.046

IDOl 1.25 1.15 1.36 0

IGKC 1.15 1.06 1.24 0

PD1 1.44 1.25 1.67 0

PDL1 1.59 1.35 1.87 0

Metagene A 1.16 1.09 1.23 0

Metagene B 1.27 1.14 1.42 0

Table 6 : Logistic reg ression analysis : Al l marker genes were significantly asso^¬ ciated with pathological complete response (ypNO/ypTO) in the H ER2+ sub^¬ g roup . All marker genes and metagenes had a positive OR indicating that a high expression level is associated with chemotherapy response. univariable

CCL5 1.53 1.25 1.9 0

CD21

1.25 1.1 1.43 0.001

CD80 1.4 0.987 2.03 0.065

CD8A

1.4 1.15 1.72 0.001

CTLA4

1.45 1.18 1.82 0.001

CXCL13 1.12 1 1.27 0.053

CXCL9 1.35 1.17 1.58 0

FOXP3 1.61 1.16 2.27 0.005

IDOl 1.32 1.15 1.52 0

IGKC

1.21 1.08 1.38 0.002

PD1

1.68 1.33 2.16 0

PDL1

1.82 1.4 2.4 0

Metagene A

1.19 1.09 1.3 0

Metagene B 1.31 1.12 1.54 0.001

Table 7 : Log istic reg ression analysis : All marker genes were associated with pathological complete response (ypTOis/ypNO) after chemotherapy/ anti- H ER2 containing therapy in H ER2+ breast cancer patients. All marker genes had a positive OR indicating that a hig h expression level is associated with chemo^¬ therapy/ anti-H ER2 containing therapy response. univariable

CCL5 1.19 0.95 1.48 0.13

CXCL13 1.26 1.06 1.49 0.01

CXCL9 1.31 1.08 1.59 0.01

IGKC

1.06 0.94 1.19 0.34 Table 8: Cox regression analysis: All marker genes were associated with clini^¬ cal outcome after chemotherapy/ anti-HER2 containing therapy treatment in HER2+ breast cancer patients. Almost all marker genes had a negative HR indicating that a high expression level is associated a particularly good clinical outcome. univariable

CCL5

0.96 0.78 1.19 0.73

CXCL13 0.79 0.68 0.93 0.00

CXCL9

0.84 0.72 0.99 0.04

IGKC

1.00 0.89 1.12 0.98

LISTING of SEQUENCES

<110> Sividon Diagnostics GmbH

<120> Method for predicting the response to an anti-HER2 containing therapy and/or chemotherapy in patients with breast cancer <130> 143331 O

<160> 48

<170> Patentln version 3.3

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gatacatcca aaaatggtta cgatggtaaa ttttatgtta 5100 tgaatatttt accacaatta aaaaaaaatt taatgctgtt aggcacagaa tcaggagaac 5160 cacaagagct taatgacttt gacagacaca ccaatacatg catagagaaa gaatgaaaat 5220 attaaaccaa agaatgaatg agtgatgaaa tatttaaata aggtgggtac atagcacatc 5280 agaacatatt tgggaataat acttccatct agggaataca tttctttttt tttttaatgt 5340 gatagtaatc acaaaagcaa aggcggaatt tctgtgttgt ttgagacata taattccttt 5400 gttatgctat gtaatcatgt ggcatactgc atgggtcaat aagatttaaa aaataaactt 5460 ctatctgggt gcggtggctc acgtctgtga tccctgtact ttgggaggct gaggcgggtg 5520 gtcatctgag gtcaggagtt caagaacagc ctggccaaca tgatgaaacc ctgtatctac 5580 taaaaataca aaaacattag ctgggcgtgg tggcgcacac ctgtaatccc agctactcag 5640 gaggctgagg caggagaatc gcttgaaccc gggaggcgaa ggttgcagtg agccaagatt 5700 gtgccactgc actccagcct gggcaataag agcaaaacac catctcaaaa ataaaaaata 5760 aaataaactt ctggccaggc atggtggctt acccctgtaa taccagcatt ttagggagat 5820 tgaggcagga ggatggcttg agcccaggaa tttgagacca acctgggcaa cgtggtaaga 5880 gcttgtctct acaaaaataa atttttaaaa attagccaag tgtggtggta tacacctgtg 5940 gtcccagcta ctcaggaggc taaggtggga ggatcacttg agcccaggag gttgaggctg 6000 cagtgagttg tgttcatgtc actacacttc agcctgggtg acagtgagac cctgtctcaa 6060 aaataaaaat aaataaataa acttctggat ggctgcacaa taaatagttg attttcttcc 6120 tatgagaatc tctaaaataa catatccagt atttgaactt aagtaaaatc agtgttcaaa 6180 tttcaaataa taataagaat aatgtgcagg aaaaaatcct aaaggaaaag ccaaaatggg 6240 aaagggtaag taggcaggac tgaccctgaa gtaatgtgtt aattggcagc gctgctagca 6300 aggcccaagg tctcgcacag gtagaatcag tttcccagca gacaggtgag gcaggcagct 6360 ggactgaccc tcatgacccc caacttttac atttccagct ttatcatcaa tgactataga 6420 gataaggcct ctgattctca taggcctcca cattctggct ggttacttgg tgcaagtgct 6480 ttgacattgc cattatctca tggccctcaa ctcccctgag ccacagtgtc tagtaccagg 6540 acttttagtc tcatgttgct ctcatccacc ctaaaggaga agtttcagag cattctagta 6600 acaacacatg aatggtattt ttccaaactt attcatacat attatccttt gagcttcaca 6660 gtaattgtgc aaagaattat ttctatctac atttcagagc ttagcaaata gaagcagagg 6720 ctttaagtga tttgcacaaa atgatcaaac taataaatgg tgaaatgaag actcaaggtc 6780 atgcccatct ttcgttcacc cacccatgca cagatgtatt cacttgttga gtgtgccagg 6840 cactgcgttg tctaaagcca aatcagatgt tcttttaaga acttctcggc caggcgcggt 6900 ggctcatgcc tgtaatccca gcactttggg aggccaaggt gggtgaatca cgaggtcagg 6960 agatcgagac catcctggct aacacagtga aactctgtct ctactaaaaa tacaaaaaat 7020 tagccaggcg tggtgggggg cgcctatagt cccaactact caggaggctg aagcaggaga 7080 atggcgtgaa cccgggaggt ggaacttgca gtgagctgag atcgtgccac tgcactccag 7140 cctgggtgac agtgagactc cgtctcaaag gaaaaaaaaa aagaggccag gcgccgtggc 7200 tcacgcctgt aatcccaaca ctttgggagg ccaaggtggg tggatcacct gaggttagga 7260 gtttgagacc atcctggcca acatggtaaa accccatctt tactaaaaat acaaaaatta 7320 gctgggcatg gtggcgggcg ccagtagtct caactacttg ggagactaag gcaggagaac 7380 cgcttgaacc cgggaggcga aagttgcagt gagctgagat cgtgccactt gcactccagc 7440 ctgggtgaca gagcaagact ccatctcaaa aaataaaaaa aaaaagaact tcttgtctcc 7500 cacttattca atcatgactc agttcttgag ggacacctta ttctctctgc atcttaagca 7560 cccagcacaa ggcctggagc agaggaagtg ctgagaaaag tctagtgatt ggcaggctca 7620 gccctgggct tcaaggctcc gtatcctctt agcttttcag gctacatgca tttgtgtgaa 7680 ggcgattaaa atgcacacaa atttgtttct ggcttggagc cctttgatcc aacagatgag 7740 gaaatgttct ctccttaaaa gccacaaata aaatcttatg gagctccaaa tatgccctac 7800 cccgatatca tcataatttc cctttatacc ttaatccact tcatccccca aactggctgt 7860 cccggtactg acaaggtctc atcctccctc ttcttctcct ctcccacagc tttgtcaccc 7920 gaaagaaccg ccaagtgtgt gccaacccag agaagaaatg ggttcgggag tacatcaact 7980 ctttggagat gagctaggat ggagagtcct tgaacctgaa cttacacaaa tttgcctgtt 8040 tctgcttgct cttgtcctag cttgggaggc ttcccctcac tatcctaccc cacccgctcc 8100 ttgaagggcc cagattctac cacacagcag cagttacaaa aaccttcccc aggctggacg 8160 tggtggctca cgcctgtaat cccagcactt tgggaggcca aggtgggtgg atcacttgag 8220 gtcaggagtt cgagaccagc ctggccaaca tgatgaaacc ccatctctac taaaaataca 8280 aaaaattagc cgggcgtggt agcgggcgcc tgtagtccca gctactcggg aggctgaggc 8340 aggagaatgg cgtgaacccg ggaggcggag cttgcagtga gccgagatcg cgccactgca 8400 ctccagcctg ggcgacagag cgagactccg tctcaaaaaa aaaaaaaaaa aaaaaaatac 8460 aaaaattagc cgggcgtggt ggcccacgcc tgtaatccca gctactcggg aggctaaggc 8520 aggaaaattg tttgaaccca ggaggtggag gctgcagtga gctgagattg tgccacttca 8580 ctccagcctg ggtgacaaag tgagactccg tcacaacaac aacaacaaaa agcttcccca 8640 actaaagcct agaagagctt ctgaggcgct gctttgtcaa aaggaagtct ctaggttctg 8700 agctctggct ttgccttggc tttgccaggg ctctgtgacc aggaaggaag tcagcatgcc 8760 tctagaggca aggaggggag gaacactgca ctcttaagct tccgccgtct caacccctca 8820 caggagctta ctggcaaaca tgaaaaatcg gcttaccatt aaagttctca atgcaaccat 8880 aaa 8883

<400> 38

atttaagggc ccgcctctcc tggctcacag ctgcttgctg ctccagcctt gccctcccag 60 agctgccgga cgctcgcggg tctcggaacg catcccgccg cgggggcttc ggccgtggca 120 tgggcgccgc gggcctgctc ggggttttct tggctctcgt cgcaccgggg gtcctcggtg 180 agctgggagg gggagcacgg aggtggggac gcgtcccggg cagggaaagt ttctgtgccg 240 cgatgcaaag cagggggcca aaagcgagac ggtgggggca gtgctcgacg cgtgtccgcc 300 tcccgctagc tttgagggac cactgcaata aaccgcctgg tcctgattgt ccccactggc 360 ccctccggga gctgggacct ccagaattgg aggctgcgcc acagaggggc gctgtctggt 420 cggcccggtg tggctggcgg cgtgcgggtg ctcgcggtct cctgccgggc tccccgcccc 480 caggattctg caggtgctca tcgctctctg gccggcggtc agcgctaccg ctcgccacgg 540 gaaacctacc cactgcatga ggcaccagct agccacgtga ggctgtttct gtacacccga 600 accgcgctct tgcccagcaa aagcggcaga acctcggctc ccttccctaa ataagagtaa 660 gacctggttc ccaagcatgg gtctcagatt ttctgaactc taatgtgata ttggtagaga 720 tcctaaacat taaccatccg tagttatttt tgagacatgg attaaaacta ttgttttctt 780 cttgttatta acctactgta atggtgtgga cgtccgcaaa ggtctcattc accgtttatt 840 atatcttttt ttcctccaga ttggcttgat tttaaagaaa gattataatt aagattagcg 900 tctcttggct acaggatggg tctaagtttc taattatctc cacggtaccg tgcattccta 960 gtttataaga cgtttactgt gtgcagacct caataactgg gtgacttttg gcaagtcatt 1020 tagctccctg atcttcagtt tcttcatctg taaaatgaaa ctagtgatta actggccttc 1080 cacctcactg agctgccctg agcacagatg aaactaagca aagaaagttg gatgttagtc 1140 gttactacta aatatcagta ataagcctcc tgtacagact tgattttatg gagccagcat 1200 ttaagctaac aagctgggtg tccaattgtt tctatggaca tccagcttat tgaggtgtct 1260 ggaatacagc acatattagt ttattacaac tttttgcttt cctgacattt tactgtctcc 1320 tgacccttaa acctttctcc agaccattat cttcatctct tttctttttc tgcatattaa 1380 ctccctttga acaaatgtat attcacactt tttctaagag cagagtacgt ccctgacttc 1440 tcacctattt ctaaatttca aagaggatat tatcaactga aaatcaaatt cttcaccagt 1500 cctgccaatt cagggccaca gcagcagcat catgtaggtc acttaactgg agccccatga 1560 aataccaggt ctacctatca gccattcaag ctactgtgct tctgttgttt gtccatttct 1620 catttttgta ccagtattcc catcctaagc attataatta cctgtgtaac aacctcatct 1680 cttttaagag attttggttc ttatgattgg aaaggttaaa gagtgaccta taggtcactt 1740 tccaattatg aaaacaaaaa attaagaaat atatatattt tcattatttc actccattgt 1800 tcaaaaatct aaaaggcctc cagtggaaga aaatctggtg tcttcagcct ttctagccct 1860 ttggaatggg atctcaccga agctcacacc ccctgatttc tccagctgcc tgtcttgtat 1920 gcgctgctca tggtcttccc cacctgtctc ccatggctca tgctttgccc actctccact 1980 gctaactttt actgctactg catgctctcc acacatcatc tcttggccag ttcctgcact 2040 tgagtgtgct taataaaata ctaaagtacc tttataaaat gtaggttcct ggttccacct 2100 ccccctccag aggttcatag gtttggagtt agcacaggaa agctgaggtt taacaatcac 2160 tctagaagat tctgcaacaa gtatctatag ggcacactgc tataagcaaa gtcaatggaa 2220 gcaaatttcc tttttagtgt tttcctattt ttccttttgt ctatttgcat aaacagtttc 2280 aaatttccta cacttctaga ttttactcaa gccttcagtg gccacctaac tttatcctat 2340 gctgagaaaa caaaaccatg aaacaagaat gctcccattt tctaatcggc tacaaaccta 2400 ccaacttaca aacttacctc catctagaat cagattttgt tctccactgc agaaaacctg 2460 ctgaggcctt cccgtcacat tagaataaaa cccatacccc ttattctcca gtctgaggcc 2520 ttctgcctct ccctgaaatt ctctgtaccc cactcactct ctctgcccca gccacactgg 2580 ccttctcttt attctttgag cacaattgca ctaggtattc tctcttttga aatgctcttc 2640 ctacaaatta ttctttgcct gtctccttga cattcaaggc tcagccctct gttgtgcttc 2700 tctgactctt gtctgaagta tccatattcc agggtactct ccaatacaaa actgtgttct 2760 attttctaca gaccacctat caccatctaa aaccttcttc cttatttatg tacctgtttg 2820 ttgtttgttc cctcactgga atacaagttc catgagtgca agaccttaat ctgccttatt 2880 tcctgatttg agttcctatc aatagcctgt aatttggaat tcaataaata tgaattgaaa 2940 tcttggtatg tttcctccta taacaatgaa agaagtatcc attctgctga caaattcagc 3000 tccttttcct gtattcatga tcatgttcca taccctcttg cctttgcaag gactttactt 3060 ctgcagatat ctcctacctt gcatcatcaa tgtacctctt tctgtatgat catccccacc 3120 agcatttaag tataccccag gaaatccttt atggaccttc tcatgaccca ctggaactcc 3180 attttcctgt ccctcttctt gttcttctca gcaaaacttt tcattgacta cttactcaaa 3240 tttcgttatc tccttctcca cttcagacag gcttcttccc cacagtctcc tgaagctgtt 3300 tcttgcaatg tcgctactga cccttatgct gataaatcca atggtcattt ttctatgtta 3360 atctttctca gtctttcagc aaaaactgat gacttccttt accttgaaac cattatcatt 3420 ctcatcttcc aaaccaagac actcttacct gttttttcca tacttccctg ttgtctctta 3480 gtcttttttg ttctatctct aaatattaga gggtcttggg gctcagccct gagcctcttc 3540 tttcttcatt tcttcttcct aaaaaacctc aactcatctt gtctcatggc tttgaatact 3600 atttatatgt tgatgactca tatttattat ctatagttct gtcctctctc ctgagctgca 3660 aactgcctac ttggcatctt gatgtggatg cctagtgtgt tagatatacc aagtctgaat 3720 ggaaatgatt ctgaacacaa ttccctacct caaggccaca acacacacac acacacacac 3780 acacacacac acacacacac tcctttttca ggctttccat cctcagaaca gggtaattct 3840 atcaattgtg tagcccaagt cagaagtcta gaagtcagga atcctcccat ttcctcagcc 3900 ccacatgtaa aacaacaaaa aatcttgcca attctatttc taaaatatat ccactgctca 3960 atcctttgcc aagcttcatt tttttttttt tggccctaaa ctgtactctt tgcttctaaa 4020 agtaagcagt tcgatccact ctctacccaa ttgccagaat attcctttaa aaatgtaagt 4080 caggccttgt gattctcctg cttgaactct ccaatgactt ctattcagga taatattcac 4140 atatctgtgg tctaaaaagc ccttcatgat ccctcctgct gagttttctg acttgatcgt 4200 ggaccattct gctttgctca ttgcatccca gccacacttg ccttctgtct gtccctggag 4260 cataccaaat ccattcctcc tgttaggcct ctgcctaaaa tacttgtacc cagcaatttg 4320 cctggctgct tccttcttcc ttcttgtcct tcagtcacaa cttaaatgtt gccttttcac 4380 aggccttcct taaccatcat aactgaagtt gcatgccacc ctgtcccttc tccttccagt 4440 gcattacatt gtgacatatc actctatttc atatttcatg ttcagcacct tcttatttat 4500 ttcctggtat ctatttacag tctgtctctt tctgttggat tataaattct atgagggtgg 4560 gaaccttgtc tctgatgttc acagatacat ctcctgtgct taggactgaa ctttggttaa 4620 tatgcataac tgttgttaaa ctaaataaca aacagggaaa gaccctaaaa aaaaaagata 4680 tttgtttggg aatagaacat tgcaatggga atatgtgtgt gattatgaat tgtgtgtata 4740 ttcaaggaag taaaagaaga caaaggtttt taaaggaaaa atatgaggat tacataattg 4800 ttttagaata attatccttg gctacaaaga ccaataacaa ggatgatgcc agtttgaggt 4860 tatacaggca gatgccggaa ggatgttctt gtagggttgc agtggctttt gtgcacggtt 4920 gtggtttttc agtcttttat gatagtttgg gttaacaggt atacaagcat gagaacccta 4980 ttttcatggc cttccctggc tttctgaagg tgttttttgt tgtttttttt tttattacat 5040 tagtgactct attttgattc tgacaacttt cacatcatca ttcaaaactt gcttatcaaa 5100 taggcaggaa acccagtatt aaggtatttg attatatgaa ttatcagtct caataatgat 5160 tttccctcct acctgctttc tgactaaaat ttcagtttta tttttattat cctatatgtt 5220 tgtttttcat ccatttcaaa tggatttcca agccattcca ggtaaagtcc ctgggcccaa 5280 gtaattaaat atatctctgt tcatttaact cagaaactgc ttcgcctgtt agttttaaac 5340 atggttggaa ggatatgtgt ctgaatgtca agtcaccatc tttgatcttc aatccagtca 5400 tgatctcctc tgagttttac tcctggctac agaaagatgt gaagagggtc cagtgaccct 5460 caagaaaatt tgtattactt gatggcccat ggcttaacct tcccttttct gatatgatct 5520 gccttgtgac ttgggattct ggctttcgtt actaatgagg attgatgttc ccaaaggaag 5580 atagccctta agtctcctta ttggaaatga gaccctccca ttttttatca tccagaaagt 5640 gtgatccgta tctcctttca tcatggaaag ttatgctgtg aagcaccctt ctgcttttgc 5700 tatttctgga tcttcattcc atcttcgtcc atgtcattgc cactgattaa atcgtgtaaa 5760 tttaaattgg ttttccagct tgtggaggat aatttgatat tgtccttatt tacatttgat 5820 aattacagat taagtcactt gactagagtc actagtacaa gtagtatcag gatcatgaag 5880 tttgtcttca ttgaggtcaa accctgatat tccttataga atcttgctat tttgcacaga 5940 gtaagcactt ggagactttt gtagttgtta atggagaaaa ctaaagaaac tgaggaaata 6000 aatagaaggg gacctatagt gatatctggc tcccaataat gatgcctatt cttagaacca 6060 gtctttgtga cttctccagt agtagtttgg ggtcacagct aaggtctggc tgtgttttgg 6120 gagctttgtg tgtgaccttg tgtcagttca tccatgttta tactttgact ttcacccgta 6180 cctgtctcag acctgtttga aaaaggagat tataaatttg atatttaaat acactgctat 6240 tctaggaggg ccttacaact gagtactttc tttttttgcc tggactacca tctgatctgg 6300 aagaagagtt aacttcttgt tttctgcttg tcagtttagg gcgttgaaac ttgagctcgt 6360 tctcatacat agaaaaatga cttttccagc tatatcccta agtgtatcat tgctatagtt 6420 tcttacctat ctcctagaat aacttctgtt ccattattaa taataatatt gttactttaa 6480 gtcacaggaa tctgtgttga aatgactgtc cctttatcta gttcccatca gaaagtattt 6540 actgagttct ctttggtggc atattactct actagattaa cagaataaaa taatgaagaa 6600 taatcaacat attttctcct ctctaggcat taacggttta atagctaaga tagttatgta 6660 aattcattaa agtaattttc aggatcatat gtgtactgag cttttacaag atctcttata 6720 tactttagtt tcttatgcta tcctgggaaa gtttgtattt aaagattttt acctttttgt 6780 cccacaaatt cacaaatagc gtacattagt tatgtgcagt ttttttgtgt ataaataaga 6840 cctcattgaa gctgggaaaa atattaatat ccgctccccc taccaccctt ataaaaaaaa 6900 atcaaaacat atgtaatcat ccttcaaggc ccttgccaca tgcctttcct gttttcccca 6960 gactctgacc tcactgtgaa aaaacaagca aacaaactaa aaccactaat ttttacttgt 7020 aagggtgaag gagatggaac aattctgagg attttctgaa attttatgaa aaattacttt 7080 ctccatctct gaagtctacc ctaaaaattc tctgaacctc tgagcttatt tctgtgtata 7140 ttcaccctta ctgcaatgat atgcattctt cattccataa aatattgccc tattttagac 7200 tttcattcta aagatcaaag ttttcaggat aattggtaac aaggcagaag cagagaagag 7260 gttttagcct ctcttggttt ttatgtttct gtagcctttg tctcaggtcc tcaggtcagg 7320 gtaagtttct gccaaggttt ccttttgcta agcctaaaat tcagagtaac caatcttaag 7380 tttgctgttg agatatcttg caaatacaaa tgctttcttg ggtatatcaa gaggcattct 7440 ttgtcacctc cctagagatc ttcaagtggt cagatgctca gcagttctgt aaaggtgagt 7500 aatcctgtaa tagaggcata tttgggtctg tcgctgtatc tggatgagat aacatgttat 7560 gtttaagata aaagaccagt aaattcacat gtcatctcaa gtgaagaggg ctcctgagtg 7620 ctccatgctt ccttttactc ctaggggcac tgggtatgag ggttaagtca tgatagctgg 7680 ccaaacctat tcatcctgtg atctttatga ctttgatcta tggtatccat actgtgttag 7740 ggtgaggtta gaagttagag acaagagatg ttaatattac ctcatcctca tcccattcaa 7800 ttcaaaaaat acttttaagt aactactaga tactaagctc tagaccagac agtggggcct 7860 gggagtgaca taaaaatgaa tctgatagtc tttgcctttg agaaactcct acactagttg 7920 taaaggccaa ctcttaaata tatattgtac tatgaggtag ttctcttatt taagaagtgc 7980 tatgaggtca tagagaaata aatcataaat gctacctaga agaattagag aactataggc 8040 cctctgagca gaggaaacag catttgcaaa agcataagtg tgcaagaaca tgatgtctct 8100 ggaaaaaatc agtgttgttg gagtataggc tacatagtga ggaatggtag ttgattaaat 8160 ggattggagc ttacttgtaa aaaaatatat gcattttttc cctataaaca gtggtaagtc 8220 atagtaagtt tttaaatgtg cagagtggca tgaccacatt tgtgttttag aaagataaat 8280 gtgcagtagt atagaaggtg taccagccca agggagaaca attagaaaag taaattatgt 8340 cattcagtga tccaatgaga gactactgca atgacaaaat agttggtttg gagagagatt 8400 tctggagtcc agtcactaaa cttcagtaag taattgaatg aagagaagag agtagaggat 8460 gagttagagg atgagttaca aaaaggaaat gatcactgtg agatttttaa ggcagaagac 8520 ttggtagatg atatcataga ttaacagaat atgtataaaa atggaaaatg aagactataa 8580 gttataactg accacaaata aagttggcat ccatgcacag aaatgcagac tgtgtgcatt 8640 aaacaagtag tgttctagag ttgactgatc cgttggaaag ttttgtaaat gtaagaattt 8700 ctgtgagtaa acataagcag gcctgtcagc aagtccagtc aggttgagat ttaatataaa 8760 acacaaaaag tctccaaaaa gtctcctgaa tcccagcctc aaattctgtt tgggttgatt 8820 tggttttctt ttgtagataa atcatgtgtg agtcatagag aactccttta ggactctgtg 8880 attacacaca tgggtattgc atttgggttg acaatgacat attcttgtaa taaagggtga 8940 gttggcagga gacagttcct gggtacatgg ataccagaac agcagttcca accagaaacc 9000 atcactcttc caaaagagat ctgagtaatt gccacatact ttttaaaata aataagcaaa 9060 aaggaatcac ctccctgatc cactccagag acactgcttc aagattacca gctagagagg 9120 atccctagaa gagaaggaag ttttggctgc tctcttccag ttttaagtct ccagtgctac 9180 tgaccaggag cttgaatttc atttggcttt aaattgtatg agtccttaat ctgtcacccc 9240 tgcttgtcat aaatgatatt ctattctctg ctattctttc agtagagaaa gaactaagtt 9300 tttctaaaat gtaagtctag ctgggagatg atcactcttt atttttattt ttattttaag 9360 ttctggggta catgtgcagg atgtgcagtt ttgttacagg gtaaacgtgt gccgcgagat 9420 ttcttatctc tttgtcttta gatatctact ctttggtgac tcatctgcta catgtattat 9480 ctcagacaat attgtaacct gggataatga catgcctttt aatgaatgta agtaaaacaa 9540 tctctttatt gcaccctatt taattcctct tgtccccttc cagagggaaa ttgagcatct 9600 gcacaccaaa gtgagtagcc aggagggttt acacttggtt tgagtagctc taggcacaca 9660 gctatgactt acccatcttc ctcatggccc ccaatcctac cacacgttcc tttgtttact 9720 gtcctttgat tataagttat ttcatagtga gtaaatgctt acatctaaaa cattccagga 9780 gattacacac tgccaacttt attccatgca aaaagtaagc caccctaggt cccttctata 9840 acaatttatc tgtggtctgg ggcggggact ggtgaccagc tcatagcttt tcggttttta 9900 tcagccagtt ccatatatct tttgaccttg ctacttccta tttagaatca tctttgagat 9960 caggatacag aatttcaaca aaataggtaa attgtaggct gagttgcagt ttggattgca 10020 agaatgaaga gaaaattctc agaaagtata atattctctc tttccccacc tactccttaa 10080 aaaggtattc cttgtaagtc actcccagcc atcccccatg ggactttgac agcagcagca 10140 gggagagggg tttgctatga aatcatcagt gccatattgg atgtaatagg gaaaagctgt 10200 ttgacctctt ggatgagaag tcaatgcatt gcaccagcaa agataatcaa gttgatgtct 10260 ggagctctgg agcaaccctc ctcttcagtg tattactctt acttgaatgc tcaattatag 10320 aagttgaaaa tggagttgtg gaatctggat tatgttcatt tttttaaaat gatacatgat 10380 atttaagtgt aagcttggtt ttaccctgaa aggcagcaat gtaatatggt gtcaactaaa 10440 cagcaaacag aatcctctac tgccaaagtg cttcaggggt gagttgggct gaaacttcag 10500 gatctagaaa taaaacaagg tttttctggg aaatagatat atggtaccta tggaaagagc 10560 agaaggaaga tagtatatgt ggttgagttt tctagttaaa gagtttttta ttgttattgt 10620 ttgttttgtg tttctgtttt tgtttttttg agatggagtc tcgctcagtc gcccaggctg 10680 gagtgcaatg gcgtgatctt ggctcactgc aacctccacc tcctgggttc aagcgattct 10740 cctgtctcag cctcccgagt agctgggatt acaggcatcc aacatcatgc ctggctaatt 10800 tttgtatttt tgtagagatg gggtttcacc atgttgacca ggctggtctt gaactcctga 10860 cctcaggtga tccacctgcc tcagcctccc aaagtgctgg gattacagac gtgaaccacc 10920 acaccctgcc tagttaaaga gtttaaaagt aaactttgaa agtaatatct aaatgttgca 10980 gatgtaggac tttttcttct tttgtatttt ggggcagtgc tagatctgtg ttattgtagg 11040 ggaaattaaa agatgctttt ttaaaaaagc agatagcacc aaagtcaatg attagagatt 11100 ttttcataca tatatatata tataattatc acatcttatc cataggtgtg ctttgaacat 11160 atatatgcca ctcttctctg tcttctggaa tgcagaccaa agatgttaaa ttgattcagt 11220 tgagtatata ttatactgca gattctatat gtataaagac aacagttctc gaaagttacc 11280 cttactgaaa ccaagtatag cactgatgtg atgaaacagt ttggctgtat cttcttatgt 11340 cagttttcac tgaagacctc ctcttggagc caaagggaag ttaactgaaa gttctagagg 11400 ttggcaattt tccctttatt ctgagactcc ctcagaaaag gcgtgcataa caaagtaaat 11460 gtaaacaata tccttcatgg ttattaggac aagtaaatga agaatatgag gccattattc 11520 aaaacctctg ttcacttcct gtggcttttt caaagtgttc cagcctcaag tcaggacaaa 11580 tcacctgtac tgaggctcta gcatcttcag cagcaggacc aaaagtggtc atctcagcct 11640 gtacccccag ttgtgtgttt gaagcagcca ttgaataatt agtatgttcc aggtattgta 11700 ctttctctgt tcatgtactt ttagcactgg attctcacta taccttatga agtagtttgc 11760 gttatactat agactaagaa actgaagctt aaagagagta agacttgcct gaggtcacac 11820 agctattgaa tgaccgtggg gagttgaaac taggtccact gagctcaaat ttccctaatc 11880 catggtacct ccccacatgt aactatcatg ccactaatat gttattttca tgtgctgaat 11940 ttgccttttg tttcattatt aaaattgatt agactcagaa cttttggata tattcttttc 12000 attattattg tttggtcaag atgatttatg ttgatctgtt tgctgaggat caagaaaaag 12060 gtaagaattt aggagtttgg gagtaagcag ggaataaata 33Ct3t3C3t atttctaagt 12120 ctgtttctga aaaagttatg tgatctatat ttggatattt tacctacatt tgaatatttt 12180 ctcaccatga tcagtatgcc taccaagttc cttttctact tttcagggat ttcttgtggc 12240 tctcctccgc ctatcctaaa tggccggatt agttattatt ctacccccat tgctgttggt 12300 accgtgataa ggtacagttg ttcaggtacc ttccgcctca ttggagaaaa aagtctatta 12360 tgcataacta aagacaaagt ggatggaacc tgggataaac ctgctcctaa atgtgaatat 12420 ttC3.3-t3-3.3-t attcttcttg ccctgagccc atagtaccag gaggatacaa aattagaggc 12480 tctacaccct acagacatgg tgattctgtg acatttgcct gtaaaaccaa cttctccatg 12540 aacggaaaca agtctgtttg gtgtcaagca aataatatgt gggggccgac acgactacca 12600 acctgtgtaa gtggtgagta tgaaaagaaa gctgggttgg gaggttgggg tcttgccttt 12660 ctgtgcagac cacgttttgt accctcctga aggacaaaca gtgtgaacat gtaatgatga 12720 gggtggaaga aggaaacaag ggaaaaggtg aaagttatgg cttcttcgtg gaggcatata 12780 actgctcgtt C333333C3t caattgagca aaggagttta aagtacatgg aaaaatgtaa 12840 tt333C3C3C ctaataattg agtagggtaa gttttgcaag gatggggtca gagtttgttg 12900 gggatgtggg aatggggtgg ttttcaactg tatatctgtg ttactgttaa aatgagaaga 12960 acggtgggat cttatagcaa 333t3C3CCC aatggatttg aaattaatgt ataagtagct 13020 gctaacacag tctagcacag gtgatatcct gctctctgtg gtctctgtaa acatgttttg 13080 aagttatcca ctatttcccc aagtcatctt ctgagccatc 3C3tttC333 taaatgcctt 13140 tgaaaatagg gacctactgt 333tt3ttC3 ttccttctct tttggtttgg tttatgttgc 13200 tgctgaaata taaatctgaa tttgaattcc 3C33tt3C33 gaaatggcaa tatttgacaa 13260

333tt3t3Ct atcaaattag gtattttctt aataaagaac aatattgaca aattttaagc 13320 agattaaaga gctgacaaaa ctgttaaatt agtataaaat gggattctgt ttattgattg 13380 attgattgat aaatagcctt ggaggaagga gatcttaacg atagttacaa agggcaatgg 13440 ctgctgaaaa cagttaagcc tttgtaacaa tttagacaga catatatgta tggacatgga 13500 aggatatcgt atacatgtcg ctaagtagag gaagtaaggc atagaatatg tattagttgt 13560

3C3C3C3C3C ataatatagg tgtatatatg tatcatgcat aggatcccaa t333Ct3t3t 13620 tgccaatatc taccaggata gcccttgaaa tgatagcatg ctacttttgg aacagagaat 13680 aagcttaagg atagggtgag aatataggtg aaaattgact ttttttggta attgaaattt 13740 ttcacaaggc aaatgtaatt catatagtgt 33Ct33333t gaaaaataag gtactattta 13800 tggctatttg tggcataaaa tggatacact t333CC3C3C ctgtttgatc tttaaaagac 13860 taggttgaaa gttaatacca actggctacc atagatcatg tgtcatttat ttaaatccat 13920 atcctaagtc agcatctcga tcaagcttgt ccaactcgct acccgtggac agcatgtggc 13980 ccaggatggc tttgaatgtg gcccaacaga 33ttC3t333 ctttcttaaa ccattatgag 14040 attttttttt tgcaattttt ttagcttatc agctatcatt agtgttagcg tatattatgt 14100 gtggcccaag acaatttttc ttcttccaat gttgcccagg gaagccaaaa gattggaccc 14160 ccttgattct agattgtgaa ggatgcatca tctgacggct tttttttcct ggtatgtgtg 14220 tgtaaagttt tccctctcga gtgtccagca cttcctatga tccacaatgg 3C3tC3C3C3 14280 agtgagaatg ttggctccat tgctccagga ttgtctgtga cttacagctg tgaatctggt 14340 tacttgcttg ttggagaaaa gatcattaac tgtttgtctt cgggaaaatg gagtgctgtc 14400 ccccccacat gtgaaggtac cctaaattta caatctattt taagaatctg ggctgttctg 14460 ttatttgcca tgcatttctc atctttggtt tgttttttag aggcacgctg taaatctcta 14520 ggacgatttc ccaatgggaa ggtaaaggag cctccaattc tccgggttgg tgtaactgca 14580 aactttttct gtgatgaagg gtgagtgtca ggattattta tgagatttaa ttcatttgtc 14640 ttgtgtgtgc gtggtgtgga ctgtgaaacc tgcagaagtc tcctctgtga ggatctctgg 14700 gcagtctggg gtagggttgt gagaggtaat gctgataaaa ggaacagatg cacactgatt 14760 gaaatgaact tgtcttgaat tgtaagtaga ggctgctgtt cttcagcaca aactgcctaa 14820 tagttctgaa tgacaacctt ctgtctccag gtatcgactg caaggcccac cttctagtcg 14880 gtgtgtaatt gctggacagg gagttgcttg gaccaaaatg ccagtatgtg aaggtaggct 14940 aggcaactat ggtctgacag cactgcattc tcagcttaac taaaagcttt tggttcagtc 15000 attaccttac agactcttac tgaacacaga actcctagag atctttaagg atatgtgctt 15060 caccaaagca tccttatttt ttgtttcctc aagtaaaatg gggttcctag gctttccctc 15120 ctctgaaagc tatgcagacc ttctaagtag gtagaccata tgcataaaga aaatagtgta 15180 tttggtaaaa gaaatcaaag gatcagcaga gtacatatac tcaggaatga agcttgagaa 15240 tcaatcttct aaattatgtt gctttagctg ccttgactga ttcattatag actcggatat 15300 cactgtccta ggatagtggt atcaagcagc atctggggca ttctttgttt tcaatacacc 15360 tatgatcttg tcatttcttt ctgcaattcc cctagaaatt ttttgcccat cacctccccc 15420 tattctcaat ggaagacata taggcaactc actagcaaat gtctcatatg gaagcatagt 15480 cacttacact tgtgacccgg acccagagga aggagtgaac ttcatcctta ttggagagag 15540 cactctccgt tgtacagttg atagtcagaa gactgggacc tggagtggcc ctgccccacg 15600 ctgtgaactt tctacttctg cggttcagtg tccacatccc cagatcctaa gaggccgaat 15660 ggtatctggg cagaaagatc gatataccta taacgacact gtgatatttg cttgcatgtt 15720 tggcttcacc ttgaagggca gcaagcaaat ccgatgcaat gcccaaggca catgggagcc 15780 atctgcacca gtctgtgaaa agggtgagtg ttccggtact cagaaaaggt gcttctgatt 15840 cgtttctgaa aaattagaag aaggggttgt gggctttagg tagggccttg tccagtttat 15900 acttccctca aatctactac 3tct33tC33 tataaatttt gtagagggca ttcttatcac 15960 tagcccccca ccattgtttt attttgtggg aatatgcttg gaaaaaatgt taggaatcac 16020 taagtttctc atttctatag gggaaaaaat gaggagaaaa atgcttgttt gtcttaatag 16080 tgacttctta aaagagaagt cattcaagcc ctcattccta gggatatatc agaatctccc 16140

3t333333C3 tacaagatga ttccttatga agggaagagg caggagagga gttgcagaac 16200 ccagtggaaa gtgaacaaca tctgcagcag cctctgtgca gaaaacaaca 3C33C33C33 16260 caacaaaaga ttgggaaact gtgatctaaa 3tt3CCC333 gctggtctgc aacatatgtt 16320 ctgtatcata cagctgacgc cagagtggaa ttatagcatg 33t3tC33tt tctttggctc 16380 agtttctttc tgtggttgtt tacttaagca gttatgtttt gtttttgtcc tttcatttag 16440 aatgccaggc ccctcctaac atcctcaatg ggcaaaagga agatagacac atggtccgct 16500 ttgaccctgg 33C3tct3t3 aaatatagct gtaaccctgg ctatgtgctg gtgggagaag 16560

33tCC3t3C3 gtgtacctct gagggggtgt ggacaccccc tgtaccccaa tgcaaaggtg 16620 ccaggcctca aatgtagaca ttttgttaac tttaagattg ccttgaatta aattctcatc 16680 16740 16800 16860 16920 16980 17040 17100 17160 17220 17280 17340 17400 17460 17520 17580 17640 17700 17760 17820 17880 17940 18000 18060 18120 18180 18240 18300 18360 18420 18480 18540 18600 18660 18720 18780 18840 18900 18960 19020 19080 19140 19200 19260 19320 19380 19440 19500 19560 19620 19680 19740 19800 19860 19920 19980 20040 20100 20160 20220 20280 20340 20400 20460 20520 20580 20640 20700 20760 20820 20880 20940 21000 21060 21120 21180 21240 21300 tggcagcctt attcctgtcc atgactatct acagcagagg ctgtttggca acggttgtct 21420 ttgaccagca cagtaatctt aagtgaaacc catcttcagt ttaagataaa tagtgagctt 21480 gcgagccaca agaccccctt tgcttcccag caaggcacca gtaacttgag ctgagcagtg 21540 gctgccactt ttagaaggac aggggctctc tgacttgtcg tatctggtgg cttcacttcc 21600 tagctctcgt agacatttga aggtgtaacc atgtctgcta tttaaaggga aaggaaaaga 21660 aaactgttgg ctgatggatt accattgtga actgtatcca ttaatgtttc attatcttat 21720 tttttaacac ttttcttcaa atcatattgg ctatcagtag gaaatgcaga tctccatcca 21780 gtgttgctgg tctgggtgga atgaatgaat gtttttggat accagttagt tggcttgttg 21840 cttctggcct tcctgtatcg ctatcaccca gagatagtgc aggctatgtg ttcctctgtg 21900 ctgagttaaa gaccctttct tattggtgtc taagccttca tagggtgtcc acctccgcct 21960 aagaccccta acgggaacca tactggtgga aacatagctc gattttctcc tggaatgtca 22020 atcctgtaca gctgtgacca aggctacctg ctggtgggag aggcactcct tctttgcaca 22080 catgagggaa cctggagcca acctgcccct cattgtaaag gtgctttgtc tattttttat 22140 tcttattttt atatcaaatt tgtgccaaat agatatattc agttgggtac tttcaactta 22200 aaatagccaa agaaatgaat taactgtctg attacattaa aggctttaat tagattaata 22260 caatcattaa atatctcaaa ataagaaaaa atgtctcagg ctgtagtcta tctggtgaat 22320 gaccacttat gtagtcattt acacatagaa agttggagtt atgtctgtaa attaaacaac 22380 caaagcacag attgtattta cacactgtag ttacagttat gttaagtgtg tatttgataa 22440 agtaccaata aaaagcacag caatcttttg agaatattta ctgagtgttg gtgggattat 22500 gggtacattt ttaataaaag tttcagaaag tcattttcat tgtcataaac agtgcatatg 22560 aaatatgact agtaaattag tgtctagtat tcattgaaca ctttttactc tatgccagac 22620 actgtgcaca gcacctgaca tgcattattt catttagtct tcatgagagc cacatgaggt 22680 tggtgccatg attatccctg ttttatagat gaggtttcag tagcatggag agatttggaa 22740 cttacccaaa gtcacacatc taggaagtac tagagccagg cttcaaatcc aagatctcac 22800 tgtgttaatc cattctcaca ctgctaataa agacatatct gaaactgggt aatttataaa 22860 ggaaagagat ttaatggact cacagtttca catggctggg gaagcctcac aatcatggca 22920 gaaggtgaag gaggagcaaa ggcacatctt acatgatggc aggcaagaga gcgtgtgcag 22980 gagaactgtc ctttataaac catcagatct catgagactt atttactatc acaaaaacaa 23040 cacaggaaac cccaccccca tgatccaatg acctctcacc aggtccctcc catggcgcat 23100 ggggattatg ggagctacaa ttcaacatga gatttgagtg gggacacagc caaaccatat 23160 cactcacact attgatgact acactgaaaa gaagaaagaa atgagaaagc acgcacatgt 23220 atgaagaatt agagagtaaa actagaagca gaaaataaca gtaattcaga atacttcata 23280 atattaccaa ttcggccctc accatttctc caagaagcca ttaaaattat ccatcactgt 23340 ttggatagaa actgaagcaa aaaacacaaa tataatctgg cttaaattac ccagaggtta 23400 ttgagataga gggctgacag taaaagattg tgtctaggat atagtcttat cctatttcag 23460 tgcagctttc cttactgaga gtgaaacagg ttggttttat aaatctttct attaagggaa 23520 atttctgctt tcttggtaaa aggccaaaat atgactgtgc ttgaattaga tttctttaat 23580 ttcagaggta aactgtagct caccagcaga tatggatgga atccagaaag ggctggaacc 23640 aaggaaaatg tatcagtatg gagctgttgt aactctggag tgtgaagatg ggtatatgct 23700 ggaaggcagt ccccagagcc agtgccaatc ggatcaccaa tggaaccctc ccctggcggt 23760 ttgcagatcc cgtaagtacc aagggcttca ccgccgcttg taactggcta acggagagaa 23820 gagagtgaga gtttccctca gcgtggagag tcctgggttt taaattgaca taggtttgtg 23880 accagttgta taattacaga ggaacttgaa gtcagtggtc tattctagaa aaagcacagc 23940 ttggccaggt ccgtgacttc tgcctgtgat accagaattt tgagaggctg aggcaggagg 24000 attgcttgag cctaggagtt taaaaccagt ctgggcaatg tagtgagacc tggtctctac 24060 caaaaaaaaa ataataataa taaccaggca tggaggtgtg cacctgtggc cccagctact 24120 cgggtagctg agataggagg atcacttcag cccaggaggt tgaagctgca gtgaaccatg 24180 attgcaccac cgcactctag cctgggcaac agagtaagac cctatcaaaa aaaaaaaaaa 24240 aaaaaaaaga aagaaagaaa ttaaataaaa taaaaaagaa aaaggaaaag aaaaaacaca 24300 actttcttag gatggggaaa gtgaagaaaa gaaaatagaa acactaattt aaaaggaaca 24360 aaaatgtgaa acaagcaacc tgaaattttg aaaggagttg ctgcatagac caccctacgt 24420 gctgaatctg agttaataag tgcttacaat ttgacaggga actccagaaa taggttaaat 24480 aaatagttgt tacagttaat atttgcattc taacctgaga aatctctgat tataaagttg 24540 agtatattgt ttttgtcatt ggtggactcc cccaatctac ttagagtgaa aaaaaaaggc 24600 cagtgagttg ctacataaga aacaagtgga tataactcaa ggttccaata catctttttt 24660 atctgttgtt ttttgttttt gtttttgttt ttgtttttgt tttaaataga cacaaggtct 24720 cactatgttg cccaggttgg tctcaaactc ctgagctcaa gtgatcttcc caccttggcc 24780 tctcaaagtg ctaggattac aggcatgtgc cactgtgcct ggccccagta catcttttaa 24840 atcgacttgg aagggagcta gagtgttgat ttctgggaca ttaccatgaa acgtggggct 24900 acattgaatt atgacactat actgataatc attttcatga ttttgtacta tttttaggtt 24960 cacttgctcc tgtcctttgt ggtaagtctt cttaaatact tgaagaaaag ctcttataat 25020 attttttaaa aatatgtaat gctagaggtc ctatatccta tctgatgata tatttaactc 25080 atagggaatg ttctcttttt ggtgttttaa agatacttca atgtacatgt cacattacaa 25140 aatgtcactt tggcatagag ttggataaat tatttgaaca gccagctctt tcttcttttt 25200 aaattgatat tttagttttt attaactgtt ggtgtttggc ttgatttggt ctattgaaat 25260 aggcaggctt cttctgctgt agcaaaatac atttcacagc tgagagttaa atgttatgca 25320 aaattataag aacctggtgt cctgtgcacc taatttctat tcttgagatt tctctcttgt 25380 cacctcagtg acaagattgt tactaataaa actaaaagga acagaaaaac tcaatgaaaa 25440 gttgactgga accttgtggt catgtgcttg gtgctttaga ttaaaggtgg actggatcaa 25500 atcagaaaaa ccttaagctc aactatgatt attcaggaat tcagcattta tgtccaagaa 25560 gagttaagta tgagtcacat aacattttcc ccaccactag caataggccc tgcaatcagt 25620 cagaacaatg taggtgatcg tcttctggca tttgatactt gctggatttt tcttctaggt 25680 attgctgcag gtttgatact tcttaccttc ttgattgtca ttaccttata cgtgatatca 25740 aaacacagag cacggtaagt tcaaaggcga atacttgatt gaccaacatg cacaagtggt 25800 ttcggcttct tgtctgaaac taaacacaga agcacaagtt atgtgaaata aatactgcaa 25860 tgtgataact aaatgaagta tctcgtgcta tacaaaagga agccctttct gtaggactta 25920 agagatatca aacacttagc ttattttatt gaatgatgtt tattcagata gtatattgta 25980 aacaaatcta gagaatagga aaaaaatccc agtgggaacg actgcaaata ctttggtgta 26040 ttcgtatctg atctttttcg tatatttttt ctctctttaa actgaaattt tgtcattttc 26100 atcttctgtc ttgatttttt tcatttagac tcatgtttat gtttttatgc tttaagtcat 26160 gttttcagtt actaaatagc atattattct attctgtgta tttatatatg tatttatgtg 26220 ttttaagttc cttccaaatt tactttgata atatataaag ataggagtag cacctctggc 26280 taaacctttt ttcataccca cttatttcct tagaatagat ttctagaatt actaaagata 26340 agtgcatgag catttaatat acttgataac tattgtcaga tgacttgcca ggaagtttgt 26400 tcttagtaat atttaatgta ctgggatatg tcgtgtttct caaccccttt tcctgcttca 26460 ttgatttgcc tgttccatta caaaccactt tgtgtttaat taataccttt atgttattat 26520 atctggtagg gcaagaattc acactacaat tttataggac tttcctctct attctcttct 26580 gtttgttcct ataggtgatt tttagaatca tttataattt caaaaaaaaa ttgtgattac 26640 atttaagtct atagataaat ttgtgagaaa ttggcatctt ttctgtaatg tcttctcatt 26700 cagaaatata ctaggtcttt ccatttgatc aagtaatctt ttctctccct tagtcatttt 26760 catgattact taatattaac tatattacta cgtttctatg ttttggtatg ttatgttttc 26820 ttatccagaa attagatata tttttgcata ttatttttaa ttatttttaa acatcttaat 26880 ccattaggaa tttattttat ggtatggtag ttgaagtaaa cctacttgta ctttttttcc 26940 ctatatattc aattttttca aaacctattt tgagtaaacc atcccttcac cattggtcat 27000 agttttcttt atcagataaa gcacgcctat tcaattcttg tgtacactgg ggcttatgtc 27060 agagatatct gacataaata tgcaagatag attatattcc actgatcggc ctgtctctat 27120 gagccagagc tactctatta ataaatgtag ctttttccga gatgtgttcc ccctcttcaa 27180 aactattttg aaattttctt ctatttattt ttgcagatag gctatagaat tatttgcacc 27240 acgactacac ctcccatacc ctagaaaaat aaaataaaat cttagatcat tgataggaag 27300 tgccttaaac ctatatattt atttgggaag aactgacctc ttcatgatat tcactatttc 27360 cttccagaaa taccagatga ctaattattc agatgttttg ttatatttta gttaaaattt 27420 aatagattac cttatataag ctacatagcc ataaaagtat cttattttta ttgctttata 27480 aatagaatca tttttggtta tgtcttataa gtaattgcaa atgatatcta ggaaagtcta 27540 tctttataca gtcattaatt ctaatagctt ttcagtgagt tacccaatca tctaagtaga 27600 aaactatatt ttctaccaat tattattatt ggtagaaata atttctacct catatctacc 27660 gattatacat tttcatttat ttgtttttgt ctcattttac tgagaagaat tttaaggaaa 27720 atcttcagta atattaggga atattggcat attttaacct ttatttttaa tataaagcct 27780 ctagtgtttt atcactaaaa atgatactgc atcctttttt cttttctata ttacataaag 27840 tgtatttata gtcacaaaag ttgtttttcc ctatttaaaa tcactgaaaa atcttgtttc 27900 ccttctttaa gcatattttt atatcactat aaatatttgc ataaattttt aaaatacaaa 27960 agtaaatatg cttgttgtag caaattagtt tataaagata ctgaatagtc tcttccactg 28020 aacaactgct ggtgccttca agtccaacat attaagttga tggatgtcag caatttgctg 28080 tagatacttt catatgttgc tctatctagt atatacatgc atggctttta aaacatttga 28140 gcagtaatgt tagagaaata gaagtcatgc gaaaagagga atgaccacgt ccatccattc 28200 ttttcttata caacaatggc tgagtgccta ctatgcctta gcactatact aggctagaat 28260 cacaaagcct agtagcatat ggcctctgtc atcaaggagg tcacagcctg gtaaaggagg 28320 acaagcatgt cgctaaacaa gtaccataaa ataacgtcgc catggtggat tatatgatat 28380 ttggtgagga tgcaaagcaa atggtcaata tttgggagtt ttaatcagga aaagtttcag 28440 cgtggaagag atgtttcagg tgagcctcaa gagagtgtag acaagaagag aaaggcattc 28500 cagacagaaa gagcagtttg aataaaggcc cagaggcttg gctttccatc atgtgttgtg 28560 agaactacat aacccatttg aaatggctgg gaaatagtgt gtgtgtgatg gtgattgaag 28620 gcgaaagtgg catagcttta ggtggagaca tgccattaaa gaaaaaaaaa aaaaaccctg 28680 acacgtaaat cttgtggaag ctacagaata ctaatatgtg caaaggatac atttttaaca 28740 aagcataccg tcaggtgttg gcctcggatg ttatgtgtgc ataggttcgt gagtctttgt 28800 acatgctagt gttagggcgg ataatccaat gaagtcttac caactctcag gtagctccga 28860 gtggggagat gaccaagtca tgccacctaa aacatgtcac caaaaagctc cagcaaaatt 28920 tctttcacgt gccaagtccc ctgcatctat catttaccct gccaccagtg ccatctgatg 28980 ccatggctca gttatgtaat tcctagaata ggctcagaca tgaaggggtt gcactgaaac 29040 tatgtactga gggtatctac gaacctgggc agtttgttct aggctggagg cgggagggtg 29100 agggctgcct atggggttct ggctgtcctg tacagttagc gtgtacttag agtgtagagt 29160 ttaccagagt gtgtaccaca caaccctgct ttcatgaatg acttcagaaa aaaagggtgt 29220 tctatggcaa ataagatttg gacatactgc acactgtttt tttttcttgt ggagaatcac 29280 aaggaccatg agaatattta ataagaggtt ttttgctatc aagaggacag gatttccagg 29340 acttggtgac atgctggatg tggggagaag gaggcacata gaatggctca catgaaggcg 29400 atgaggtgga ccccctgact cactaaaaga ggagaggggc aggatttgtg ggggaagatg 29460 aggagttcgg ttctgacctg gtactttgag gtactcatga tttagggctt gggagaaggg 29520 tctggactcg ggtgggtgac acttaaatca caatgaaagc tgtggaacca aaaagaacag 29580 aacagataaa aattgggatg agaacagccc tcagaagaac agtaatgttc aaaaggcaga 29640 aagtgaagga agagaggcag ggggaaaact agcagagagt agcgtcacag aattcaagga 29700 gaaaagggtc tcaaaaaaaa ttagggatgt catttgcagg gccttcctca taggaagtca 29760 caagataatt tcagccaaga ggcattagaa atgtaaatac atagaaaata cagtctctat 29820 ctctttcctt catgctactg agtttgctat cagagcactg catgtgtata aaaatttgca 29880 aatttgggga atgcttacaa gtgcaaataa tttataatat tccagtctaa ttattgttta 29940 ttaatatgat tatatcatgt actatactta agtgcctcaa ctgatatgaa gcaaacatac 30000 ctgtttaacc agattcctag ttgccattca tttatttcca tttgctaacc cacttcaatt 30060 gattttccaa taattgataa agacacttga atggcctgaa atgctttttt aaatgagatg 30120 agtaatcatt taaaaatgaa tgtctagtga caatattaaa tattttgaaa agccatctaa 30180 acacttgaaa gacactatgc tattcttttc tagtcatcta agatattgta acaaagctta 30240 aatctcacat tgacctaaaa attactgttt tataatcttc ttaacatatc tcctgtacac 30300 ggaactcttc aatattctag tgagtgacat gctgtcagtg tctttagcag tattctttct 30360 tccccagtaa ttttgtatta tgttatttta gagctttaca tggtagtata atcacatttt 30420 attgtctttt agtaattctg gcaaagtggt tttagaagca caatgaaata tgtgtacttt 30480 caaagaagga aagtaaaaac attctcttca aactcgttta aagcttttaa gtcagactag 30540 aacattgagt cccaaaaggg taaagttatg atctaaaata agaacttatt tttgcttctt 30600 ttcttcaatt tggaagttgt agttgttagt cattaagcgt cctggatcct agggtaaagc 30660 tgcttagtgt cagcctctga cttgaacact tacaagccta gatcattcat tttttatgtg 30720 cctttccaaa aaatggagtt acagtgttta cacttcatag gataaaaaca ataaaaatga 30780

3-3.tC3.tC3.C3. gaaaaccaaa caccgtatgt tctcacttgt aaatgaaagt tgaacaatga 30840 gaacatgtgg gcacagggag ggaaacatca tacactggga cctttcacag ggttgggggt 30900 taggggaggg atagtattag gagaaatacc taatgtagat gacgggttgt tgggtgcagc 30960 aaaccaccgt ggcacatgta tacctatgta acaaacctgc acattctgca catgtatccc 31020 agaacttaaa gtataattta 333333tC]^~33 atcatccaca aaagtactta ccatgtgttg 31080 ggaattatgg aaagcaaaca actgctacat tgaaacatgg tcaatgagta aagatattac 31140 atttttcttt cttcttctgt ttagcaatta ttatacagat acaagccaga aagaagcttt 31200 tcatttagaa gcacgagaag tatattctgt tgatccatac aacccagcca gctgatcaga 31260 agacaaactg gtggtatgta atgaaatgga 3t3tt3tt33 tttacatata aaatttcctt 31320 caacttgtat tt3tC33t33 gcgtagcatt cacggtgtat atacatgctt cttactattg 31380 cacaagtctt cagtaatcat gcatagcaat tgttcattta cctacttcat tttgccaact 31440 aatgttccaa ttttttaatc cattcatcca ttC33C333t 3tt333Ct33 atagcaaaac 31500 aactaagaat 3333tC33t3 agatgataag cattatatag agacataata aagcaggcaa 31560 gggggataaa gagaacaggg tggtcgcaag ggaagctctt actaagagaa tgtcatttga 31620 gaaaaaactc aagggaagta aagagccagg gccggccttg gtggctcacg cctgtaatcc 31680 cagcactttg ggaggctgag gcaggcagat catttgaggt caagagttcg agaccactct 31740 gttcaacatg gtaaaaccct gtctctacta 3333t3C333 aattagccaa gcgtggtggt 31800 gtgcacctgt ggtcccagct actcgggagg ctgaggcagg agaatcactt gagcctagga 31860 ggcggaggtt gcagtgagcc aagactgcgc cactgtaccc cagcctggac aacagagcaa 31920 gactgcatct C333333333 3333333333 aaaaaaagcc agccatgtgg ccatatgagg 31980 gaggaggatt ccagaaagaa cagtaggtgc aaaggccata aggcagtgtg tgccagctgt 32040 gttggcggca cagcaaggag gccagtgtgg cctacagttg tagagatgaa gtcacagaga 32100 tgggggtggg atgtgggcga gaggatgatc gtacaaagtc tgctatgtca ttgtaatggg 32160 atggtgggca ggagaggatg attgtataaa gtgtgctagg tcatggtaaa gagattggtt 32220 tttatttgga agcttttaag gagaggagca acacattcac cttaactgct gtgttaagaa 32280 cagactgtag gaagccatgg gtggaagatg ggagtcaatg aggaggctgc tgcaatcatc 32340 caggcaagaa attgtcagtg gctaccacca ggttgtaaga agaggccaga ttctgcatgc 32400 aattttaaga cagtgacagt aggattcgtg gatagtttgt atcagaatat gagaggaaga 32460 gagctgtcaa taatgacacg agggcttttg cctaagcaac tggaaggata gaactgccat 32520 taattacatg attgagattg caaagagcag gactggggag aaaaatcagg agttccactg 32580 tggagatgtt aaatgtggat gtctaataga cttggcaaga agacagctga tgtacaagtc 32640 tgtattttgg gcaattggtc caggctggag 3t33333ttt gggctttgtc atcatgtggt 32700 tgtacataac aaggagactg aataagatct ccgagaagtg aaagaggcta gcaaaaagaa 32760 aaggtccaag tactgagccc tggatcctcc aacattagaa gtcatggagt gagaaggcac 32820 ccactaagaa gtgaaggagc agcctctgat actatccaga gaagaacctt aaagtcaggc 32880 aaagaaagaa ttttagggag gagggagtga tcaactctgt ccagtgttgc tggtaggcca 32940 aaaaaatgag ccctgaaaac tgaccattga aattcagtag cacaattttt ttgctgttgt 33000 tgtttgagac agggtctcac tctgtcgccc aggctggagt gcagtggtgt gatctcagct 33060 cactgcagcc tctacttcct aggttcaagt gattctcatg cctcagtctc ctgagtagct 33120 gggattatag gcaagcagca caaaatttgc tgctgaactt gacaagacag tttttgaaga 33180 gaggaaggag gcaggagcct gactggacgg agcttaagag agaatgaaag gagagaaatt 33240 gcagctatca aatacagaca actctttcta ggtttttttc tataaaaagg agcaaataag 33300 taaagtgcta gtaagagtaa aacataaagt caacagaaat attttttaag attggagaaa 33360 tagcagttat gccctattcc tacatgatga tgggaataat ttagtagaaa gggaaagagt 33420 gatggcagaa agagagagaa gaattgctcg aacaaggtct gggtaagcta ggaggaacag 33480 attaagcaga ggagctccta gctgcgtggg cttagtaaca ggagggaggg cagaatctgc 33540 aggtgcagat gaaggcaggt tgggagctgt gatggggagt gaacgtgtgg aagttctctt 33600 ccgatgattc agtcttctca gtgaatagaa agcaaattat tcaggtgaga gtgaggctca 33660 gaaaggaggt attagagagt taagaagaaa aaggaaggca ttaaatcatc aactaagaac 33720 tgaagactga attataggga gtacagaaag gccgacaggc cacatgagat gtgcacctga 33780 gtttcccatg agaaagtggg gatgaacatt tgaaggttta ctctgtccgg ggattatgtg 33840 acagtctttc atgccttctc ttacttagcc atcagtacca ctttgaaagg tgggtgttct 33900 cccaagataa tatcaagatg aagaaataat atccaagaaa accttgggca aggtctcagg 33960 gtcaatcatt ggcaaaggtg gaatgcaagc tcatgcctga gtttaaactg ctttctccta 34020 cataatctag 3333t333C]^~3 taccagccag gagtggtggc tcacgtctgt aaacccagca 34080 ctttgggagg ccaaggcagg cagatcacga gttcaggaga tcgagaacat cttggccaac 34140 atggtgaaac cccgtctcta Ct33333t3C aaaaattagc tgggtttgat ggcacgtgcc 34200 tgtaatccca gctactcggg aggctgaggc aggagaattg cttgaaccag ggagttggag 34260 gttgcagtga gctgagatca cgccactgca ctccagcctg ctgacagagc gagactccat 34320

CtC3333t33 33t3333t33 3333t3t3CC acctctgtcc tcttggaact tattttaata 34380 agataaataa gacccataaa tatcataggt 33t33t3C3t 3CC3t333C3 aggtatagaa 34440 aatctgtgat ggcagttgag gaagaaaagg taacctgctg ctggtgagtc ctgacagggg 34500 gaccatacta gtgacctcta 33tCC333CC agttgaggta cagagtacac ctagctcata 34560 aatatttgtt gaatgagttt atgaatgaga aagattagta ctttcatttc tcatttagtt 34620 taattcatgt ttatatgaat gtatataaaa tgtagttatt tgttccagag catgttatat 34680 gaagaaaggc ctttcaatag aatgatatct tctaatagac ttgatgcttt gttggttata 34740 ccagctgtaa ctggtatgta aagagaatgt tagcattatt taaacttcga gttgcaccgc 34800 tgctattcat gctgcctcct aaacagaaat gatctatttc agtgtgcctc attgcttgga 34860 attcagcgga atattgatta gaaagaaact gctctaatat cagcaagtct ctttatatgg 34920 cctcaagatc aatgaaatga tgtcataagc gatcacttcc tatatgcact tattctcaag 34980 aagaacatct ttatggtaaa gatgggagcc cagtttcact gccatatact cttcaaggac 35040 tttctgaagc ctcacttatg agatgcctga agccaggcca tggctataaa caattacatg 35100 gctctaaaaa gttttgccct ttttaaggaa ggcactaaaa agagctgtcc tggtatctag 35160 acccatcttc tttttgaaat cagcatactc aatgttacta tctgcttttg gttataatgt 35220 gtttttaatt atctaaagta tgaagcattt tctggggtta tgatggcttt acctttatta 35280 ggaagtatgg ttttattttg atagtagctt cctcctctgg tggtgttaat catttcattt 35340 ttacccttac ttggtttgag tttctctcac attactgtat atactttgcc tttccataat 35400 cactcagtga ttgcaatttg cacaagtttt tttaaattat gggaatcaag atttaatcct 35460 agagatttgg tgtacaattc aggctttgga tgtttcttta gcagttttgt gataagttct 35520 agttgcttgt 3333tttC3C ttaataatgt gtacattagt C3ttC33t33 attgtaattg 35580 taaagaaaac 313C33 35596

<400> 39

gacaagtact gagtgaactc aaaccctctg taaagtaaca gaagttagaa ggggaaatgt 60 cgcctctctg aagattaccc aaagaaaaag tgatttgtca ttgctttata gactgtaaga 120 agagaacatc tcagaagtgg agtcttaccc tgaaatcaaa ggatttaaag aaaaagtgga 180 atttttcttc agcaagtaag tacatttact attatcttac tatgggatag cttggtagaa 240 ctagttacca gcaacctcac tgctttttaa 3C333C33t3 cctctgctac cacctcctgg 300 atccaggctt gccctcaaag gaacccttag ggtctcattc ccacaggagg ctgtggcttc 360 ccgacatatt tggagcatca tagtgagaat tgtggcccat t3tttt3333 tatcctagat 420 cctagcaaat attgtttttg tgggccgtat ttgaatttct caagccagta aaattctagt 480 gaaagtggga aaatcgcttg agctcgggag gttgagactg tggtgagcta tggtcacgcc 540 actgcactct agcctgtgtg acagagcaag attctatctt 33C]^"33333C3 aattctggtg 600 aataagtctc ttttaactaa tcctgtctaa aatggatgat ggctaataaa acaatatggc 660 gtggctggaa ctctagctct agggtggtct ccaaagagga cactcaagca ttctctgagc 720 agcacggggc tgtgtcctgg tagcagcctg aaggggtgac agtggagcac agtgtttatt 780 ttcatttctc aattttgaca tatttactgg 33333tt33t ccctagccac ctcacatgac 840 agtacataat tttttttttt tttttttttg agatggagtc tcactctgtc gcctaggctg 900 gagtgcagtg ttgcaatcat cttggctcac tgcagcctcc acctcctgga ttcaagcaat 960 tctcgtgcct cagcctccca agtggctggg attacaggca cccaccacca cacctggcta 1020 atttttgtat ttttggtaga aatggggttt tgccatgttg gccaggctgg tctggaactc 1080 ctggcctcaa gtaatccgcc cacctcagcc tcccaaagtg ctgggattac aggcgtgagc 1140 caccacgcct ggccctggag tacataattt tgataagtaa cgtctgcagt gtcttttttt 1200 ccctcccttt ttatggatag acttttctgg ttattgagat ctcatacccc tttatgatat 1260 attatttgag tagagggttt aaagaattga gatacttgtt ttcttatgtt aatatgtcaa 1320 gaaagaagtt gtttcataac ttaggtcctg ccttggacaa aatacaccct tactgtctgc 1380 tctatgtttc ttggtatgtt cagaagagga tttgaacttt tgcaggttgg ctaacagata 1440 tggagggtcc ttagagctct cctgtttcta accaaatctt caccccacct attaagtaga 1500 aagccttttc atggaagggc tgtggttggt tcttggaact ggtcccctca cagaatttcc 1560 attcgctttt cctcagggtc acgccctgct ttagaggttg cttaggttaa gctctccaat 1620 taattttagc aggcaactcg agagttttgc aactcaaagt aggcacacct tccttcctga 1680 atgactttta tttgttcctt tttcaggctg tgaaactaaa tccacaacct ttggagaccc 1740 aggaacaccc tccaatctct gtgtgttttg t333C3tC3C tggagggtct tctacgtgag 1800 caattggatt gtcatcagcc ctgcctgttt tgcacctggg aagtgccctg gtcttacttg 1860 ggtccaaatt gttggctttc acttttgacc ctaagcatct gaagccatgg gccacacacg 1920 gaggcaggga acatcaccat ccaagtgtcc atacctcaat ttctttcagc tcttggtgct 1980 ggctggtctt tctcacttct gttcaggtaa gcaactttca ggaacttaac tgagtcaact 2040 gctacagggt taagagaaag gacatggggt tctctgagct gctcccttct attatcctat 2100 aagctggaag gaaccttcag ggtgttttca gaagatttta aagattagaa gactgtggtc 2160 caaagaggtt aaaggacctg cctatcatca cacagcaagt tagcaaccaa gttaactcaa 2220 gaacccaggc cttcaaggaa gcgtggaagg gacagtgtta tttt33C333 accatacagc 2280 cgattcataa tggtctcttc catgaatatt agatgctcat ttacattttg tgatgtgccg 2340 atactggcct cggagtctag tcccaaacta tgttttcatg atacagctca gcgaaagtgt 2400 cctgcttcta aaattgaaca atggtgatct tctttccaat ctgaaggcgg gagagtagtt 2460 gaggacaatt cctcttaatg acattcatct tcttaacctt cttaagttcc tcttaataca 2520 ttaatcttat ttgttctgct ttggatgctg agatcttttt tcaacattgg catctgactt 2580 taagtggtat cagatttaac 3C3333tt3t gtttttagtt atttttaatc tgccacatag 2640 gtattacata tatgtcctga aagtaataat ttgacttcta gaggcttttg ttcctgctca 2700 ggtgatctta agagtgctga acttttggga ctgtcaagaa gggtgaggct tgtccctgct 2760 ggcaggatgg ttctgatttt tttttttaag tcagaaaaca aaagatctgt tttctagtga 2820 gcagcatact tcccagtttc CC33333C33 agaagtttgg gctccagcat gatttgccag 2880 tctgcaaaga cccgactatt aagggtcctt gtcttaaaaa cttctcacat aaagtactgc 2940 ctagaatatc agaggtgtga gagagaggta gagggaagag aagaggagtt gggggcccac 3000 agattacttg actgcgatgg tggtcattta aaattttctg tccagagcta ttttacattg 3060 tttcagaacc aagagaaaca tggcctacat ttcacaattt acacctcagg ttttttatat 3120 atttgacagt tacattacat ttccaacagt tacaatttcc ttctggggag ctggggaagc 3180 attcccaaac tagtcttctg gggagtacag aggagtttaa aatatataga aggaaatttg 3240 tacaggcttc ccagaaataa ggggggcagg gagggggaga gacagaaaga gggagaacaa 3300 taaaaaaagt aaaagaggac 3t3333t333 33tt3333CC cagactttag aaattgtaca 3360 aggaaaatta gggtcagagg taagtggaaa gagatctttg agctaaagaa agatgtttag 3420 gaaagcacct tgttctctag ctacatcctg gttttactgc tgctgtgact gagtcaatga 3480 agcacctact gtgtgccagg tgggccataa aagttgaggc taggattcct gcactcaaag 3540 aggtctgcat atgttagttg cggaaatgca aagctaaccc atgtagaaca agcaaagagc 3600 aatgaaatgc tttgccctga ttgtaggagc ccaagatctg ggaaagtggg taacagactg 3660 ggctgcagga aggagggcag gctttacaga ggcagatgga tgatggagag agaattctgg 3720 tcagggcaac agcctggaca aaggcacaaa ggtaaggatg aggctggcac aggtgttcat 3780 tcttttgttt aatcatttat t3.3-ttC3-3.C3- aacatgagca tctcctaaaa ccaagagact 3840 tttcttggtc ctggggacat ggctcttgca tttgtgaaat ttactatcat tggaaagagg 3900 aaaagtaatc caatagccac tcaaatgaat gtgttaaagt gtggccaaca aacaaagcca 3960 cgtgctttga aggcagggca caggcactgc ctgaggaagt gctgtcttcc tctgccagca 4020 agaaggggca gtgagctggg aagtagcaga ggagggactg gcccagtgag caagaaccgg 4080 accctgcagc acttgtgagt tataatcatg aatccgcatg ttattcagga agctggaagg 4140 gctttaccca ggagagtggc gtggtctacc ccagctctgt tcactcttta C3C3t3CC33 4200 tagcctgggg gttttgctaa attgcagttt ctagcacagg gaatttttta gagaagtgaa 4260 tctattttgc ataatactgt aatgatagat ataagtcatt ataaatttgc ccaaatccat 4320 agaatatgca ataccaggag tgacccctat cgtgaactct agatttgggg tggtaatgat 4380 gtgttaatgt aggttcattg attgtaacaa gtgtactgcc ctggcgcagg atgtagacag 4440 tggcggaagc tgtgaatatg tggggagggg gttactttac attcaatttt tcgatgaacc 4500 taaagcagct ctaaaaaata aagtctatat agttttttaa atgctgtttc tgcttaggtg 4560 ggtctgggat ggggcctgag attctgcatt tctaagaagc acctaggtga tgctgatgct 4620 gctccaccat acactttgag tttcagtagt aaaggtgtaa ataactttaa aaggaaaaaa 4680 gtgttactga agaacagagt ggcttgtagg gcagccacag tgactgtgca aaacctatta 4740 ggaggttatt tcagtaactt acagtaactg atgatgtctt taatgaaaag aattggatca 4800 gaaggaagtt gatgggttgg agagtgtgta ccatgtaaaa ttagtgagga ctgctcaacg 4860 ggagtgtagg tgtgagtgtg catggtctgt gggaggtgag attcagtgaa tacagtggag 4920 taggattata gagggcttta ttcagggcag agatttgcca cactaggcct tcctctcctg 4980 ccacaccatg gcagaggtgt tccccctctc ctcctgccca gccactgatg cccaggggaa 5040 gggactcctc tttcatgcac agggtggaac cagccaggct cctctccccc tctaggcctg 5100 caggcactgt ctatggaggc agaaacgcct gactttatag tccagcaact ggtggcagta 5160 aggcagaggc tctaacaggg cagccctcag agggaccaat gtgggcagct tttccttcag 5220 agctggagtc ctttaagaga gggtcaggtc taaggagagg ggaaaggcct cctgtaggag 5280 gaggcaagag atgtaggaaa agcattgcct ataagtttat agtctgagaa ctcagagcta 5340 ggagaaaaga gaatacccca aagtgccacc attcacagaa cacatcctcc tctccctgca 5400 acacacaccg ctatgctgct ggcccagggg tcccatgagc agtgattgtt gccatcatca 5460 ccctgacaac agctgttcaa gtccctgtgc attttaagga tataaatact gtttagaaag 5520 agaaaaagta aggatcagat ggtacagagt atatgagcag ggtctaaaca gggggaaaag 5580 tcaggaacag tgtgaacacg aggagacaca ggtctcaagc ctgtggctgc cagaggcagc 5640 tctgcctgtc tcctttgtgt ggctagcacc tagcccaggg ctgacaccag ccctgtcggt 5700 gctagttcac ctaatcaaac atttagaggg gggtcactcc tgttggaaga gtgtgcacaa 5760 accaggaacg gtaaaatctc caggtggtga gacaataggt gactttcacg cttttctata 5820 tcttccattc tttctaagaa tgtttatttc atagtcaggg aaaatgttta tttaaaaagc 5880 acacttgtgt ttccagggag atcatgtatg tcccgtcatt tggtgagtta aaagatgttg 5940 tgtcaactgc ttctctccct tctccactag cagtggtgat gcagctccca gacccctgcg 6000 agggcagcct ctctaacggc tgctgaggtt gaactccctg ggaggggcac tgcagactgg 6060 ccactgcatc ctccaggcct ccaggctgca cggagagggt ggggaagact caggtcttcc 6120 tagtatggat tcttcttttc ccttcatgtt ttatttgcaa tgacataaaa ttcaacgttt 6180 taaagtatac aattcagcca ggcacggtgg ctcactcctg caatcccagc attttgggag 6240 gccgagatgg gtggatcacc tgaggtcagg agtttgagac cagcctggcc aacatggtaa 6300 aaccctgtct ctactaaaaa tgcaaaaatt aaccacacaa ggtggcccgt gcctttaatc 6360 ctagctactc aggaggctga ggcaggagaa tcttttgaac cctggaggcg ggggttgctg 6420 tgagccaaga tcatgccact gcactccagc atgggcaaca gagcgagact ctgcctcagt 6480 aaataaataa ataaataaat aaataaataa ataaataaat aaataaataa agtgtacaat 6540 tcagtgggtt ttagtatatt tgcaatgttg tgaaaccacc atcactatcg aattccagaa 6600 ggaaatgttc tggatgatga tggaaatcat catcccagaa agaaacctgc gcctatttgc 6660 agctactcct cattcccctg taccccatct cctcgtaacc actaatttac tctctgtctc 6720 tatgaatttg cctgttctag acatttcttt tctcttcctt tttttccaga atccaggtaa 6780 gaaagaatat tctggacatt tcttacaata tgtggcgttt cgtgactatt ttctttcact 6840 gagcattatg tctttcaggt tcatccatgt tgcgtatgtc ttagtactcc attcgctttt 6900 acggccaaat aatattctga aataatattc tgttgtagat tgagatctat tttttctttt 6960 tgtagcgatg gggtttttgc tatgttgcct aggctggtct cgatttcctg ggctcaagca 7020 atccacccgc cttggccagc tcccaaagtg ctgggattac gggtgcctgg cctagattga 7080 gcccttgaga ggtccttttt tttttttttt tttttttttt tgagacagag tcttgctctg 7140 tcgcccaagc tggagtgcag tggcacaatc tctggctcac agcaagctcc gcctcccggc 7200 ttcacgccat tctcctgcct cagcctcccg agtagctggg actacagctc gtaaaagtcc 7260 tccacacaaa aatcagcccg ccaccacgcc tggctaattt attttttttg tatttttagt 7320 agagacgggg tttcaccgta ttagccagga tgatcttcga gctcctgatc cgcctgcctc 7380 ggcctcccaa agtgctggga ttacaggcgt gagccaccac gcccggccga gaggtccatt 7440 atttgtctaa aattcttggt ctctactctt gttggcaaat agcttcctct cctgtgtggc 7500 tagcagtcca gagttgaagt ggtcagagca ggagggtggc caaggggtca ggagaggcag 7560 aggctgaggc cagcagtgtt gagtgtccct attgtgccct acaggtgggc agtttccatg 7620 cattcgccag aaggcgagca gcgttgccgt ccatctctgc cttctctccg cctcctttca 7680 cagcctctgg ccctttctga ctgctgctgg gtagaggtgc aggaggggct ccccatgcca 7740 gctatgggca ctgaactcag ttcaagaatc agccagttac catggtgatg ctggtcctat 7800 gggggtgtgg ttcagcaaag caggctgttg tgcatgagaa agaacagccc catttaaaat 7860 ctgtagagca ttctaaagtt aagaaagcac tttacatctg gtatcctgtg atcgctgtga 7920 taattatgtg aagcagggaa gatagttatc tcggtctggt ttgtgctgct ataacagaat 7980 acctgacatt gggtaattta gaaagaacag agatttattt cttactgttc tggaggctgg 8040 gaagtccaag gtcaaggggc tcacatctga tgaggacctt cttgctgcat catcccatgg 8100 cagaggatag aaaggcagga gagcacgccc aaggcagagt aggaaggagg ccaaaaccat 8160 cctttataag gaagccactc ctgctgtagt gaacccactc ccaaaaaaat ggcattaatc 8220 catccatgat ggcagagtct ccatgaccta atcacctttt aacagtccca attctcaaca 8280 ctgttgcacc cggaattaaa tttccaacac aaaaccttta ggggacacat tcaaatcata 8340 gcaatagtat tatgactgtt ttacagagat ggaacctgaa gcccagagag gttacccagc 8400 ttgctcaagg ttatgattct aatacacagt ggatggagcc agacctcatt tcctcatgcc 8460 tagacatgca ttcagcaagt atttactgag cacctactat gggccaggcc ctgttctaga 8520 cactgcagat atggcagtga acaaaggagg aagcctctgc tccatagctc catacgtaat 8580 tatgtatcac atatacctgt aaatatacat cacagttgta aaaatatata tcagctggag 8640 acaagcctga agagaaacaa atcaggcaaa gagactaaag agtagcagga tggagggggg 8700 cagggaggat ggcgctgttc aaggagagtc agggaaggcc tctttgacaa ggggccacga 8760 gagtagatgt gagcaaagtg ggacctgaac tgtgtggatc tctggggaag acactggctc 8820 cctctaatgt cctaggtact gtggaggact tttatgagca gtatctcatt ttgaatcctt 8880 gcacccactg ggttgggtag gtgttacaat gcccattcaa aaatggcaaa gcaagctcag 8940 aagttcaacc aggtttgaga cagtaatatt gagatttcca ggtgctgact ttccccgcca 9000 gtcactgaag cagacaaaat cgttagagac atttccgttt caactgcttt ttgtccgtgt 9060 gtgatggagt ccctaaaaca gacaaaactg atataaattt gggcaaattt ataatgactg 9120 ttttctgtct ctgtgtggtg gaatcccgaa aactgggttc ccgtgtgaat ttccaaattg 9180 ttcggaagat tttgggttcc tctttttagt cctgttcttc ttcactcttc tcctcagaag 9240 gctggacaaa aactcctcag aagccatcac caaaattaga tagtctctct ttcagctatg 9300 ctttcacttt tgctaacatc accacatacc aaaatcagtg agaaatattg gattcttttt 9360 ggctgggaat gaatagttcg gtggggaaag accctattat tgggaggccc agacaagtga 9420 gttgctgtct gtctggccca tagcaagacc agagtgctat atatctgaca taacccttga 9480 gtgaaatgaa aggtaagagt tggcagtggg aggagggaga aagaaaaatg gaaactctta 9540 cagaagacct gctatgtcct tgggactttt tatttatatc atttaattga actgaatttt 9600 ccagtgatcc caaggggtag gtgtcatacc tatttagaga tgaagaaaca gatgaaacag 9660 caagtggctg agctgggact agaatccaag tcaatggaga tggatagccc atgttccttc 9720 tacgtctcat tttgctttcc ttgcaacact aggagtgtct gggttgtcat ttgatcttta 9780 gctaatatag cttcactttg aaatatgctc ccttcaagta tgtcttttta tttcttcctt 9840 tctttcagtt atattcccta aagcagggac tggcaacatt ccacacaatt gctgaagagg 9900 tgcctggacc tttctgcatt acctcacttt gctatgcaaa tacccaccat cacaaaactc 9960 tcttgttcag tgctgtggtg gggccgtatc cagtctgaca gaggcctgag aatggctggt 10020 gagatggaaa ggtgctagtg ccccatgatc ctgctatcta agaaaagaga gggcttggaa 10080 atgaagtccc tagacatggg tctccctaag gggatctgtg tggctccagg ggatacaggg 10140 cccagaaggc acagtacgac agcactgggc agggggcgct ggggccttag agggatgctg 10200 cttttaggtc ctacaagagc ctaggaagaa tgaccatgcc ttctaaacca aaaatcagaa 10260 aatacagcct gctaaggaat tttggtgcta ttgacacaga gactagttta gatattgata 10320 tgctgatatt tcttggctat gtggatggag aaatgaacag aatattttaa ataaaaactc 10380 ttttagcaaa tccaggctgg agggtaattg tatggcatgg actgcagata gccaaagaga 10440 taaaggcagg atataggatc catttagggt acctgaagat ggtagaaata gtccaaaggt 10500 ataagcatgg gagtcatttc agcctggaac catgggatca atcaggcctg gaaagaaagg 10560 gactctgttt cttatttatt tatttattta tttattttga gacggagtct cactctgtca 10620 cccaagctgg agtgcagtgg tgtgatcttg gctcactgca acctctgcct cccaggttca 10680 agtgattctc ctgcctcagc ctcctaagta gctgggatta caggtgtgtc ccaacatgcc 10740 cggctaattt ttttgtattt ttagtagaga tggggtttca ccatgttgac caggctggtc 10800 tcaaactcct gacctcgtga tctgcccacc tcagcctccc aaagtgctgg gattacaggc 10860 ttgagccatg atgcccggcc tgggactctg tttcttatag caaaagggct cagtggtagg 10920 gctggattgg ggtgggtggg gacagtgttg gcttaactta ctgactgtgg cctaaaactg 10980 aagaaatcgg taaacaagaa gaatggccct aaaagcctgg gccagaaaga aaaaaatgtg 11040 taaaactggg gcagtttctt ttcctcagct cagtttcctc atttgtaaga taaggccacg 11100 agaatgaatg atcatggaag tcccttccag atctcacatt ccttactatg actttcatat 11160 cccctggggc tgagcacatc gtttaaccca tggttggcac ttatattcag gtcttctcag 11220 gggaccagtg gactttctca ctcactaggg atccctgtct ctgtccccaa ctcctggccc 11280 ataggcatct ggctatatac ataagacaag caggtgcctt tccatatttc tgaatgctca 11340 cgatgtctca tcatgctagg cgtggtggct cacacttgta atcccagcat tttgggaggc 11400 tgaggtggga ggatcacctg agatcaggag tttgagacca gcctggcaaa catggtggaa 11460 accctgtctc tactaaaaat acaaaaatta gctgggcatg atggcgggcg cctgtaatcc 11520 cagctactca ggaggctgag gcaggagaac tgcttgaacc tgggggtgga ggttgcagtg 11580 agctgagatc gcgccacttc actccagcct gggcaaaaga acaagactcc gtctcaaaaa 11640 aaaaaagaaa aagaaaaaag aaagaaagat gtgtcgtctt atggagattc agggaagggg 11700 aagattctgg ataactcttg aaagataacg tcactggaag agctttaccc atttggtggg 11760 gtgttgaact ggatgtagga gcagcacaca gtggtatgta taggtggaaa aataaggcaa 11820 tttgcttgtc agtatatcaa tagttatatc aaaggtgtaa ggtggctgct aatatattga 11880 attcaacttt aggctgcaaa catagattta ggtaaaggaa gtgacaaccc ggttctactc 11940 tgagccaatc acacagtgga tgtctggaat gctagattta gtgacttcgc tctctcaaaa 12000 aaatatacac acaaatcaaa ctgtgtagtg aggaaagtga gggtactcac tttcagtaca 12060 tcaataagga acaggggcag atgggaacct gcagaactgt ctgagagagg atataagtat 12120 cctcagatat ctgcaagtct tgttacataa gaagaatgag atgtgttttg taatgcatgt 12180 agaagctaga gggaaacaga cttcaacata aagcaaagca aaacttcctc agtcaaattg 12240 tccaaagacg aaatcaaaag ccttagaggt tggtaaattc cccaccccct tggagaaagg 12300 agaatgggat tcatatttgg tgtgggtcta ggcattgaat tacagtatgt gcttgccata 12360 aattatctca tttaatcttc ataataacca atgtgaagac tggggttcag agaagtaaag 12420 taagttgctt aaggtcacac aactactgtg gattttattg aatgaaaaaa gcccatgttc 12480 tttctatacc aacaaccagg agcctctagg caaggatgtt agcagggtgc acttagtcat 12540 ggttgccttt aaggtaggta gggaagtagg cagtcctgag agctttaaat cctaagtcac 12600 tcaagtgaaa aggggaggaa tcaggatgtg tattaaggtg acagatgaag gttttattcc 12660 tgtgccacgc cactgaagtc acatgaaatg gattgtcttt agctcactta atctggataa 12720 aatttattct tagatttttc ccacggttaa atgcagttct gtagtttaaa tgaatgcgtg 12780 tacatgtgca tatctgtgtg tgtgtgtgtg tgtgtgtgtt gttgcatcac gtgattgtgg 12840 ggagaggggc tgtaggagaa acgcaaggga aaaggcagtg agcatcagag actaggtctt 12900 tacagtgaaa ttcttcctta tttctcaagg cagtagtagc tgaaaattac ctaatcaagt 12960 gaccaggcaa cagatccaag aaggaggcct tctgtaagtg agaattcatg aataatgaag 13020 attgattata ttccctacct atttaaagta tggccctctt ttttcttctt agttgacctc 13080 atctccctcc cttattcttc gtcatgactg cagaatcata ggcccttgga atctcaggct 13140 gacctgccct gtcctagact tcctgaacct ctcaatctct cagttgtctc agctgcaaaa 13200 tggggaaaat aatacatatc ttgtggggtt gttgggggat taaatgacat agcacctgtc 13260 ccctccatag agccaccaca gaggaagcaa aaaaaggaaa tagtatgaag agtaattcaa 13320 tataggctat ctagacagag gtgggcaaca gcaccttgcc ctcctccacc accactgtac 13380 ccagaacctt agtcaggact gacttctctt gggggtggta ttgtgttagg taaaccaaat 13440 aagaagtaat aggactaaaa attgcctgct gtgagagaag gctcatatgc tcctaaatct 13500 tgcatgtcat tggaaaattc tcaagaaaaa ggaaggggat aggttatgtt ataatgattg 13560 gtccatgagt ctgattttag tgatttgtct tcattgtttt caaaaccaaa tttgtttttt 13620 atgcaatcac atttagtttt tctagatagt gacttccaaa acctttaaca agcattgcgg 13680 gtgcaactgc tatagaaaac actattgagg ttcctcagaa aattaaaaat agaactacca 13740 tatgacccca aaattccata tatccataag aattgaaagc agggtcttga agagatattt 13800 gcacacccat gttcatagca gcacagtagc caggaggtgg gaagcaagcc aaatgtccat 13860 ctacagatga atgggcaaac aaaatgtggg ggggggtgtg tgtgtaatat tattcattat 13920 ccttatgatc atatcattac cattccaaag gaaggaaatc ctatcatatg ctacaacgtg 13980 aatgaacctt gagtgcatca tgctaagtga aataagccaa tcataaacag gctgttactg 14040 tatgattcta tttctatgag atatttaaag tagccaaatt catacaaaca aacagaatgg 14100 caattgccag aggctgaggg gagaggggga aaggggagtt gtttaatggg catagagttt 14160 cagatttgca aaatgaaaat ttctagagat ctgtttcaca acaatgtgaa tatacttaac 14220 attactgaac tgtacactta aaaatcaata agatgataaa ttttatgtta tgtgtttgtt 14280 tgtttgtttg tttgtttgga gatggagttt tgctcttgtt gcccaggctg gggtgcaatc 14340 tcagcttact gcaacctccg cctcctgggt tcaagtgatt ctcctgcctc agcctcccga 14400 gtagctggga ttactacacc cgccaccaca cccggctaat tttttgtatt tttagtagag 14460 acagagtttc accatgttgg cccggctggt ctcgaactcc tgacctcaag tgatctgcct 14520 gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc accacgccca gcctgttgtg 14580 ttttttacca caatttttaa aaaatgaaga gaaaaaaagc attggggacc ccaaaaatca 14640 aactggattg atacttagtc actagacaca acaccctaag ttctgttact gccgactttg 14700 gattcctgac catgcaggaa tctgtattta ataaatatac aatcttgttc tgtttgcctc 14760 tccataggtg ttatccacgt gaccaaggaa gtgaaagaag tggcaacgct gtcctgtggt 14820 cacaatgttt ctgttgaaga gctggcacaa actcgcatct actggcaaaa ggagaagaaa 14880 atggtgctga ctatgatgtc tggggacatg aatatatggc ccgagtacaa gaaccggacc 14940 atctttgata tcactaataa cctctccatt gtgatcctgg ctctgcgccc atctgacgag 15000 ggcacatacg agtgtgttgt tctgaagtat gaaaaagacg ctttcaagcg ggaacacctg 15060 gctgaagtga cgttatcagt caaaggttgg tgggattttc tgattttact ctaggccggc 15120 agattcttaa tgcccttaaa gacacatggc tattgattta ggtgaaaatt ttaccaaaga 15180 gggatgtatc tcacttcatt tcttggagtt aagtctctag ttgtacaata aactctaact 15240 ggtttctaaa gatgtcctgg aaatatctgt taatgtgcat ttcttgttct ttgacaatcc 15300 aagttcatga caatcatcct ggggcactat aatgacctaa agagcctctc aatcaccaag 15360 gggcatcttt gatttgatgt agccttgcta ctaactgcac ttgacccagc aatatatgcc 15420 tgtgaaagta tgctgaaaag gtaacggggc tgggtatggt ggcttatgcc tgtaatctca 15480 gcactttggg aggccaaggc aggcggatca cttgaggtca tgagttcaag accagcctgg 15540 ccaacatagc gaaactccgt ccctactaaa aatacaaaaa ctagccagat gtggtggcgc 15600 attcctgtaa tcccagctac tctggaggct gaggcagaga atcgcttgaa cctgggaggc 15660 ggaggttgca atgagctgag attgcaccac tgcactccag cctgggtgac atagcaagac 15720 tccatctcaa aaaaaaaaaa aaaaaaagaa caatggaggc ataaatcttt ttcaggtagt 15780 atgtgaacgt ctattactat ggctatctta ctattatatt ctaatatttt caaagtgata 15840 atttacttat tgcatatttg aagctctaat ctagcagtca gtcctgaaaa attagatgtt 15900 agagaattgg gccaggtgcg gtggctcagc actttgggag gccaaggtgg gtggatggct 15960 tgagctcagg agtttgagac cagcctgccc aacatggtga aaccccatct ctactaaaaa 16020 tacaaaaatt agccagggac gtgttggcta ctcaggaggc tgaggcagga gaatcacttg 16080 aacctgggag gcggaggttg cagtgagcag agatggtgcc actgcactcc agccttggtg 16140 acagagcaaa gactgtttca aaaaaaaaaa aagtagacta cagaggaggg tgagcatttc 16200 cctactggta gagactctgt cttaaaaaaa aaaaaaagtt agagaattgg atgcataatt 16260 aattcctgcc acaaggaaaa aaactaattt atgaatcaaa gccctgttta tgtacctact 16320 gtggaaggca agcatttctg gtctcggaaa gaaaggaccc ttgcttttgt aaccacccaa 16380 gaggtttacc tcgcctgctg cgtagataga gccaattcat caagacaggg gaattgcaat 16440 agagagagta atttacgcac aactggctgt gcgggagacc ggagttttat cattactcaa 16500 atcagtctct ccaagcatct ggggagcaga gtttttaagg ataactaggt gggtcggggg 16560 aagccagtga gctgggagtg ctgattggtc agggatgata ccatagggag ttgaagctgt 16620 cttcttgcac tgggttgggg ggccacaaga tcagatgagt cagtttattg atctgggtgg 16680 tgccagctga tccatcaagt gcaggggctg caaaatagct caagcactga tcttaggagc 16740 agtttaggga gggtcagaat ctcatagcat ccagctttat gactcctaaa ccataatttc 16800 taatcttgtg gctaatgtta gtcctacaaa ggcaatctac tccccaggca agaaggaggt 16860 ctgctttggg aaagggctgt taccatcttt gtttaaacta taaactataa actaagtttc 16920 taccaaagtt agttcagcct acacccagga gtgaacaaag atagcttgga ggttagaagc 16980 aagatggagt cagttaagtt agatctcttt cactgtctca gtcataattt tgcaaagggg 17040 gtttcacttt aattacagta taacagagga tactgaagga gccagagccc tttttgagaa 17100 attatatccc tgagccattt tctcacagtt gaaatttgaa catatttctt tttcccctgg 17160 gacttgagcc tctagtgaaa accaaacttc ttacttaata aaacataatg attaaccttg 17220 ataatagata acttcagcag atccgtagtg aattccttac tgttctttgt tttaatcatt 17280 agctatgaat ctttacttgt gacatccaga tcacacctaa agttgtgggg agtaagccaa 17340 agttacatgg aactatctta aacttcactc agtgttttct ctgctcttgg atagaataaa 17400 ttattatatg gtgatgtgat ttgaggggta ctaagaagcc tacctcttcc acgattttca 17460 cctgcattga ctcctgaaat tctcatcatc atagccattc ctgctagttt ctccattttc 17520 ctcctaaaag atccctgtta aaatgaaaat gtgtttcctg gggtgggggg tggggggtgg 17580 caccacaaat atattagcct gtattagtta attacattag gtacgtagtc ctctaatgga 17640 ctaccgagag agaagtagac tcaggtcagg tgaatttgga tagaaagata aagaagaaaa 17700 tccaagagtg agaaaaggaa acatttcaag gggggcaggc cctattagca gattaccgta 17760 agagaccaag gacagctaag gggacaatgt gagatttctg gggtactcag aaccgagggt 17820 gtgtgggtgg acaaaatcca gtaaagggaa gacaaaaagg tcactcgctt aattttgctg 17880 agaagcattc tgaattttcc aattgagtca aagcagtgtt tctcaaatgc ttataagcct 17940 atgagtcatt tgagggtctt gttaaaaatg cagatttaag ttcagtaggt ctggggtttg 18000 gatctgagat tctgcacctc taacaagctc tcaggtgatg cctgtgctgc tgtggaggac 18060 cacaatttga gaagcaagga attaagctct catttggcta gagtgaccag gtatcctctt 18120 tgctcagaac caaagggttt atttggggca caagattttt ggtgctaaaa ctgggaaagt 18180 ctcaggcaaa taggacacgt tggttaccct atatttgtct aagattgcaa aatggtaata 18240 taatatcagc atagccatat gaaaacctcc attaactggc atgtttgaga actagctaca 18300 ttcgttaaca gcttaactag gttaatggat ttttcctcct aaaacatgtg cacctattcc 18360 tttccttgta agacattcct accctttcct attaagagtg gtaaaaattg ggttaactaa 18420 ttaaaatgag atacaaaggt tacagtctta caacgtcttt gattgttcac aatctcacaa 18480 gacctcagga gtagttaccc taaacagatc accttagaaa aaaggtggga gatggagttt 18540 aggctgttct aagccaagaa agattttgaa actttttttt tttttgagat ggagtctctt 18600 actctgtcac ccaggctaga gtgcagtggc gtgatctcgg gtctctgcag cctctgcctc 18660 ctgggttcaa gcgattctcc tgtctcagcc tccaaactag ctgggactac aggcatgtgc 18720 catcatgcct ggctaatttt ttatttttag tagagacaag gtttcactat gttgtccagg 18780 gtggtctcaa actcctgacc tcaagcgatc ctcctgcctt gacctcccaa agtgctagga 18840 ttacaggcat gagccagcac acctggcctt gaaaagattt ttaatacagt tcctggtatg 18900 agtggcattc ctgtagttta tttcccagaa aagcagagca cagaaatgaa catgaatcat 18960 attaataatt taggatatga gtttttggat ttattattcc tagttataac acaaaacata 19020 ttgatgttat aagaaacaca gaatattcta gatatcagct gcctgtgtca tgagtcgatc 19080 ttataggata aattaataag tgggaaataa caatgccaac taaaagtggc tcaggaacat 19140 atcaaacttc atttagggac agggttcatt gaaacaaaca aaaaaaaaag gtaacttcac 19200 ctccaaccaa atccaacttt tcctctttcc tggcaattat catcatttgt catggcttcc 19260 ctttatcctc attattgtag gtgccacaag gcattcctgg aagtgtttgc ctggcaacct 19320 gatttaaatg agggggctta cctaagagag gataaattca agacccactt aaatatagct 19380 atcattggct gggtgtggtg gctcacgcct gtaatcccag cactttggga ggccgaggct 19440 ggtggatcac gaggtcagga gactgagacc atcctggcta acacagtgaa accccatctc 19500 tattaaaaat acaagaaatt agatggtagt ggtgggctcc tgtagtccca gctactctgg 19560 aggctgaggc aggagaatca cttgaacccg gaggttgcag taagccaaga tggtgccact 19620 gcactccagc ctgggcaaca gagtgagact atttagtttc ctgtgtgtca ggctctgtgc 19680 taagtgattt ctatgaacga tgtcatttaa ttcttacaac cctgggtatt agtgtcccta 19740 tcttatagat gagcaaacta agactaaagg tgggtaagtt attgacccag ggtcacaagg 19800 cagaactggt tttaaaacct gcttttgatg accatatgct acatgacatc tctgtggggc 19860 tcagaattct gaaaagaaag ctaactctat gaggagattg aatccctaca ttcatgctaa 19920 gaagctaatc tctttatgtg taagaataag tgacgaagcc gctaggtatc tttctcctat 19980 gttctctgca tttattttcc tgtactttgt acttcagaat cttatgggga tcaaatatat 20040 aaatgaaaca gtgcctcaag ggtcttggag gaatgctagg aaggccttcc tgtcccttta 20100 aggcatatca aaatagtaag aaaaacaata aagtgtggtg aatgaggtta taggctcaat 20160 gttgtagttt ggatataggt ttttctgagt aaaagactac tttttttttt tttaatttca 20220 accaggtatt taattggtct ggcaactgca caatatacaa atttctgaaa ggcatctcct 20280 gtttgaaagc tagcatagct tcatcccagt aattaattcg gacaaatata tagaacacca 20340 agaagtcata aattatgcat ggaagactcc caaaccaatt aacaactaaa ctcagtctat 20400 acagctttct atttttcagg cttccatatg cacattaaat aaataaacag catgtctact 20460 atcaaaataa ttaaaaaatt caaatgaatt caaataaatt tattcaaata catttcaatg 20520 atattttcaa atgaaaacat tactgatgtg gttcagagtt tttcttctca cctaaaataa 20580 agagctttgc ccatggtctc atgaggacag aataaagagg ggaaaaccca tccagaaata 20640 aatatgcaaa ttaaaaaata ctggtcatgg gtgttttttt ggggtatggg gtgttggtga 20700 gactcagtag aagcaaaagc tcatgactat agttcaatgc ctgcccccca ctcacacgca 20760 cacaatgccc cctcaaaagg caggtcacag gtttgtaaat taggcagcat tttcctttct 20820 ccaagatctc ctctccttga ccagatttat gttttctctc tccccatcta gaccctttcc 20880 aacgaaagtt ctatgttagg caaagccttc tctatttatg tattgagttt aggtagccag 20940 aaagaaaagg gaaacacaac ttcatggagc ccttacctgt aacagactta agagtcaatg 21000 ttcaaaggat aaggccagaa aggaggacat gagaaaccat tctcaagagc aaaggggtag 21060 gcccctcatg taaaagacga ccttttaaaa agcaaggaaa tgctaaccac aaatttagga 21120 tagtgatagt gattacctta ggtaagggaa agagagggac aggataggtg acatcatacc 21180 agcagattta cctaagttac tgtcagtgtt tttggtctca agttggatgg tgggttttca 21240 ggcgttcgct atagtttagt aaataaatag ataacataga agaaagccac ttgcgtactt 21300 caagcatcag gaagaaaaga agagaagaga agaaagggaa aggaaagaaa gaaaggcaag 21360 gtcaagaaaa gataggctct ggtgtcagac agatttgaat tctgccatta ctggttagtt 21420 ataatttctc taaacctcag tttgattact tataaaatgg aaattatatt aggttaaatc 21480 atatgaaatt actgatcttt gaccttttta gatctacaac ctacctctct agggtttctg 21540 tgaggacaaa atgaggtaag gtccagacct aacaaacaag agttcagtaa acgttgtcta 21600 ttattcttct cttcatctct tacaattgca agtactctgg caacatttat tcacacgaac 21660 ctacttctcc tttctgtaat aagtgccctc ctatctccat caaaagtggc aaagaattga 21720 tataaccaat tcaaatcaaa gttagtcttt ggattataca taactattaa tgagtaatgg 21780 gaagttgcaa attatatctc attttatcat tcttgttttg ttttgttgtt tttgagatga 21840 agccttgctc ttttgcccag gctggagtga agtcgtacga tctcggctaa ctgcaatctc 21900 caccctctgg gttcaagcca ttctcttgcc ttagcctccc gagtagctgg gattataggc 21960 gcctgccacc acgcctggtt aatttatgta tttttggtag agatggggtt ttgccatgtt 22020 agccaggctg gtctcaaact cctgacctca ggtgttccac ctgcctcggc ctcccaaagt 22080 gctgggatta caggagtgag ccactgcacc tggcctttat caattcttat taaagctaga 22140 aaattattta aaaataaacc tctacacaca taggtttgta actatacgta attatatatt 22200 cttgttcttt ctttagctga cttccctaca cctagtatat ctgactttga aattccaact 22260 tctaatatta gaaggataat ttgctcaacc tctggaggtt ttccagagcc tcacctctcc 22320 tggttggaaa atggagaaga attaaatgcc atcaacacaa cagtttccca agatcctgaa 22380 actgagctct atgctgttag cagcaaactg gatttcaata tgacaaccaa ccacagcttc 22440 atgtgtctca tcaagtatgg acatttaaga gtgaatcaga ccttcaactg gaatacaagt 22500 aagtgacatt gttctgggga gtttctacta tatcgaatct aaaaagacaa tatagtcgtg 22560 tcatttaatg atgtggatac attttgagaa atgcatcatt aggcaattct gtcattgtct 22620 gaacatcaga gtgtatttac ataaacctag atggtacagc ctactgcaca cctaggctac 22680 atggtacagc ccagtgctct gaggctacac acctgtacag catgttacca tactgaacac 22740 ataggcagtt gtaacacaat aagtatttgt gtatctaagc gtatgtaaac ataggaaagg 22800 tacagtaaaa atacggtatt ataattttat gggactacca tcatatatgc agaatgccat 22860 tgaaaatgtt acatggcaca ttactgtaac tcagccagat acattttaga attgtcgtat 22920 ttattttgat agtgttttat agtgttttta gatatacaaa tgacatgtgc tattatgact 22980 tattaaagtc actgtgagac tgggcacagt ggctcatgcc tgtaatccca gcactttggg 23040 aggctgaagt gggaggatca cttgagccca ggagttcaag accagctggg aagcatgaga 23100 ctctgactct acagaacatt gccaggcttg gtgacacaca tgtgtagtcc 23160 taggtacttg ggagggtaag gtgggtggct tacttgagcc caggtgttca aagttgcagt 23220 gagctatgat catgccacta gactccagcc tgggcaacag agtgagaccc tgtctctaaa 23280 agaaataaat aaagtcactg tgcaaggtgt 23340 gataatgtta ctaattttct ttttatttat ttatttattt ttttgagaca gtgtctcgcc 23400 ctgttgccca ggctggagtg cagtggcaca atctcagctc actgcaacct ccaccttcca 23460 ggttcaagca attcttctgc ctcagcctcc cgaatagctg ggattacagg cgccagccac 23520 caccctcggc taattttttc tatctttagt ggagatgggg tttcaccatg ttggtcaggc 23580 tggtctcgaa ctcctgacct cgtgatccgc ccgcctcagc ctcccaaagt gctgggatta 23640 caggtgtgag ccactgcacc cggccttatt ttcttgtaat 23700 ccattatcca tcaagcattc gtttttgtaa caatagtatt 23760 attgaaagca ttaaaatttg ccctttggaa ctgcccttag ggatttggtg ctttctttta 23820 gggcatgcca cccacacggt tccatggtgc ttttttgtgg gcgaatgtgc 23880 tttttaagaa ctactggttc attctgaacc aagtctggga aaggtgagtg acaaactcct 23940 tgaagacaac gcctgaaaag aggtcatttt ggagcaaata ttttacccta ctggtagtaa 24000 actcagagaa ttctctttcc ccaagaggtg aaatcatttg atgaaaacga 24060 tgggtttata tgaatatata catcttaggc ctataatggc ttaagatggc ttacaaggtg 24120 aactgagatg taatacttgt ttaaattgta cggctgatca tacagaggac 24180 cacaggtctc tctccctacc cctagcccca ctcccaagga taggttttgt gactgtatag 24240 taagaaacaa aacactgagt ttgataatac agttgcacat aagtatatag 24300 actatatggc atgtcttaat tcttcatgtc tttacttgta gttgcgaagt ggataattta 24360 ttttagatgg tctagtaatt catgctagtg tatgatttac tctagatctt tcagtgttac 24420 agcagatttt tttttttttt tttgagacgg agtctcgctc tgtcacccag gctggagtgc 24480 agtggcgtga tcttggctca ctgtaacctc cgcctcccag gttgaagcaa ttctcctgtc 24540 tcagcctcct gtgtagctgg gactacaggt gccagccacc acacacagat aatttttgta 24600 tttttagtag agatggagtt tcaccacgtt ggtcaggctg gtcttgaact ctcgacctta 24660 ggtgatctgc ccgcctcagc ctcccaaagt gtggagatta caggcatgag ccaccatgcc 24720 cggctacagc agattcttta ttttcctcaa tgagacaaaa tttcctggga aaattagttc 24780 caaactttga catgactatt gatactccaa acttaccagt ctcagtcatc 24840 ttttatgtgt tgtaaaaatt gaggcttcaa tcatatagtt tattaagtct 24900 ctatttttac tttcttgtta tagcattatt taaccaattt tacattattc tgattgaagg 24960 cagaaaacag tagagtactg cagtaatact agcttggatt gcattttgat 25020 ttggacatta tttatattgg aatatggata tatgtgacat tctaagacag gggttggcaa 25080 atttttttct gaatagagcc agatagtaaa tattttaagc tttgcagtca cagtctctgt 25140 tgcaacaact caattctgct ggttgtagca caaaagcagc cacagacaag acataaatga 25200 atgacatggc tatgttccaa caaaattttt cttttttttt tctttttctt tttttttttt 25260 ttgagacaga gtttcactct tgttgcccag gctggagtgc aatggtgtgg tctcggctca 25320 ctgcaacctc tgcctcccag gttcaaacga ttctcctgcc tcagcctccc aagtagctgg 25380 gattacaggt gcctgcctcc acaactggct aatttatgta ttttcttagt ggagatgggg 25440 tttcaccatg ttggtcaggc tggtctcgaa ctcctgatct caggtgatcc atctgcctca 25500 gcctctcaaa gcgctgtgat tacaggtgtg agccactaca cccagccaca aaatttcatt 25560 ggtgcaggac aggtttggcc catgtgctat agtttgctaa cttaaggttt 25620 ttgtctttgt ggctggagag ctttagggta taaatgtctc aaatctcatt aattggactg 25680 tgtggggatt ctttagaata agattcaaaa gcaaataatg catttatagg aggtcaaggg 25740 ctgactgcac acattaagtg tatagtacat agaaatgtta caggtcaggg 25800 tgagtaaagc tttgaggtga aaatgtatta gtcccttttc atgctgctga taaagacata 25860 cccgagactg ggcaacttac ggtttaatta gactcacagt tccacgtggc 25920 tggggaggcc tggcagaagg caaggaggag caagtcatgt cttatgtgga 25980 tggcagcagc caaaaagaga gcttgttata aggaaactcc tgtttttaaa ctatcagatc 26040 tcgtgagact cattaactat cacaaggaca gtgcaggaaa gactcgcccc cataattcag 26100 tcacctccca ctgggttcct cccatgacat gtggcaactg tgggagttat aattcaagat 26160 gagatttggg tggggacaca gccaaaccat atcagtaaat aactgatttg 26220 aaaagcccaa atgtattaat taagcggatt gcgcatatga ttctttttag tgtagtctca 26280 ccaaatttgt tttcccttga taaactggaa ggagatacat ctgagagagt catactcatg 26340 gtatctaata agctacatgt gcagatgccc tcacaccgct ctgtaccttg gattctgggt 26400 ctgcccctgt gggatgttac caggtttcta acaggtgtca caatagacct ggcttgctgc 26460 tactgaggcc tccctctttc cctcacacac atactctctc taggttgaat gaggcttgtg 26520 gatgggtgtg gagtggaagc caggaatgag ctgaagcctg tgaaacttct agactcccag 26580 gataacagca atggcttgtt attttttgtg tcattctaat ctgtagaggt caactctggt 26640 aatcacttga tgtctccatt caatctggtg ttttagagaa ccaactatcc 26700 tgtctttaag tggtaggtac actatgatta aataggtgtt tcagaatgat tactgtgaca 26760 gcaatgtgca ggagttatta gagcctagga aacctgaggc aaagagaccg gtttgcaggc 26820 tactaggtgg gagatgagaa aaatctcagc taaggcagtt gctgcaagag atttgggaaa 26880 aagcagtaag ttccagagat attctgaata tagaacagaa aatacatggg agcctactgg 26940 gaagtgagca caaagaaaat accacactct tatttgggta actaaatggt attgttattc 27000 actgaaatgg gagaatacag ctggtagata tgatttggaa agcaggtagt aaattcagtt 27060 ttaatcaggt ggagatgctg gcatccatcc tttagaaatc agatggcact 27120 tctttttttt ttttttcttt gtctttttct gagatagatt ctcactctgt cacccaggct 27180 ggagtgcaat cttggctcat tgcaacctct gtctccctgg ttcaagcaat tctcttgctt 27240 cagcctcctg agtacctggg attggtactc gccaccgata attttttgta cttttagtag 27300 agacagggtt tcactatgtt ggccaggctg gtctcgaact cctgacctca ggtgatctgc 27360 ccaccttggc ctcccaaagt gccagaatta caggtgtgag ccactgtgcc cagcctcaga 27420 tggcatttca aatctcaggt gtggaggata ttacccagga agactggggc cagtaagggc 27480 aaaatgggac cacaaacaga accatgggaa tagaggacaa gaagaggaag 27540 aaaagccttc agagaaaacg gagtgcaaca aacagaaaca gaaggatgtg gtgtcacaga 27600 agtccaagaa ggagaagatt ccaactggct aaatgctgat gagaagtcca ataagcaaaa 27660 gaataaaact aggccaggcg cagtggctca tgcctgtaat cccagcactg tgggaggcca 27720 agacaggaga atcacctgag gtcaggagtt cgagaccagt ctggccaaca tggggaaacc 27780 ccatctctac tgaaaataca aaaattagct gggtgtggtg gcacgcccct gtaatcccag 27840 ctactcggga ggctgaggca ggagaattcc ttgaactegg gaggcagaga ttgcagtgag 27900 ctgagatcac atcactgcac tccagcctgg cctgggaaac acagtgaaag teegtcttaa 27960

3t333t333t 333t333t33 3t3333Ctt3 ccactgggtt tggtaatcag 3333C]^~t3333 28020 acagggatct tggactccct ggaccctctc tccagcccag ccttgctagc tccgcctgtg 28080 gtgcatgctc ctgcctccga ctcaatggtt tgcaggaaaa atttagatag cacaacagtg 28140 gcaattcaca atgaagagat etactgeaaa tcctactatg gaaagaaata tgggacaaaa 28200 ggctatggtt atggccaggg tgctggcacg cttaacatgg cgagaggctg ggcatcaagc 28260 cagagagtgt tcagcctcac aggectacaa gaaatccaaa tgcttctaaa tttgetcaga 28320 aatatggagg tgctgagaaa tgttccagat gtggggattc tgtatatget gecgagaaga 28380 taattggagc tggaaagccc tggcacaaaa actgtttctg atgtgcaaag tgtgggaaga 28440 gtcttgaatc aacaactctg actgaaaaag aaggtgaaat ctattgtaat ggtgctatgc 28500 aaagaacttt gggcccaagg gatttggcta tggccaagga gcaggggctc ttgttcatgc 28560 ccagtaaggt gtaaacccag aactaagcat cacacattga gaatctcttc ataatctagg 28620 cacagataat ctttaacact aaactactgt gaaattctac cagcattgag tactgtatat 28680 taccctgtac ttggataggc tggctaactc atagtgagag agcactgtgt cgtatccttt 28740 tgctttattc actagcattt tgggggaaca tttcttttat gttttaaata aaacttcagc 28800 atgaagaaaa 333C]^~t33333 caataagtta gtaaatattc atttatttgt aagecattte 28860 agagaaacca gaaaatgagc tgctataatt tgtgtccctg ccgtttttcc agatgttgct 28920 aatgattcct caaagcagct gaagaataaa tactgeaget gctgctcctg atctggaggg 28980 atggacccgc agcaccatat ccaccaacac ctttctcctc cccaccctca tttccttgtg 29040 tacttcttgt gctctctgtg ggactgaaac tacagctgat aaccttcagt gctctcttct 29100 aggatggtcc cacctaatac caagecatat ccacacttag ttctttgeca gacttgttct 29160 gtgtttccag tagctagagg gtgaaaaacc tgtatccgaa agtgaatgca aagtggctcc 29220 tgtagcttta gggcagctac tgtgaggtaa gggtgtgtgt gatgtgtatg tgttgagaga 29280 gaatatggta ggagaaaggg agaaggcacg acagagctag agaaggaaaa ataaagtata 29340 cctagaacac agttagtagt aacacatagt tataatcagc tataaaagtg 29400 agatactgca agatggcttg taaaagattt ccttagaatc ttccttatgt caacttaact 29460 cagtaaatgc agacattcaa agtatctttt tcacttttaa tatgtgacat ctgactatta 29520 gttgcccaca agtatgtgcc tgattgaaga attatgeaag aaaaatgeta geagctgeat 29580 actggagagc tgaccaggca aagaatactc cacagttgea tcaatagaaa aggcacagaa 29640 tgagtatcag gcagtaggaa 3t3C3^~tt3C3 gctgacatta ttcttttccc tccatagcca 29700 agcaagagca ttttcctgat aacctgctcc catcctgggc cattacctta atctcagtaa 29760 atggaatttt tgtgatatgc tgcctgacct actgtaagta ctatcatacc atcatcctga 29820 tctcaattct ggaagatcaa actttattac catggttcgg catctctctg aggttttagc 29880 ctattcgctt ctcatgttta cagcaagcct atggaaacat gagcatctcc tttacttgtc 29940 tcaacaagtt ctgttcattc actggacatt ttccggacac ctcctacgtg tgtggcactc 30000 tactaggcac tggaattaca atgacaagaa gtcactgccc tcaagacaca ttctagttta 30060 gtctgtttat tttttccctg actttatata tttttggaga ctggggtttg ctaactaatt 30120 tgaaaacgtt tctgatgcta aatgatattc taattttttt ttaagggcta gtcgatttgg 30180 caggtgagtt gttacacact ccttagtgaa ttccaacttc catggccacc atectgetga 30240 tattctaatt ttgatttgga gttagagaaa aggcaaattg acaaattttg gtgccaagaa 30300 tcattttctt ggaggagggc aagatgeact aatacagttg agaaactaca tggctacagg 30360 tgatctcacc aattctcagt tcttgggctg ggtggggtgg ctcatgcctg taatcccagc 30420 actttgggag gecaaggcag gtggatcact taaggtcagg agttcgagac cggcctggcc 30480 aacatggtga aactctgtct Ct3Ct33333 t3C33333^~tt agecaggcat ggtggcgtgc 30540 acctgtagtc ctagctactc aggaggctga agcaggagaa ttgettgaac ccaggaaccc 30600 aggaggcgga gaetgeagtg agecaagate atgccattgc actccagcct gggtgacaga 30660 gtgagactcc 3^~tctC3333C 3C333CC33t tcttagttct tttttttttt tgagatggag 30720 tctcactctg ccacccaggc tggagtgtat gccccgatct cagctcactg cacctccgcc 30780 tcccaggttc aagcaattat ccggcctcag cctcctgagt agctgggact acaggtgcgt 30840 gctgccacgc ctgactaatt tttttttgta tttttagtag agaeggggtt tcaccatgtt 30900 ggccaggatg gtcttgatct cctgacctcg tgatccgcct gecttggett cccaaagtgc 30960 tgggacttct tgtctttgga attccagtgc ctagtagagt gccacacaca taggtgtctg 31020 gaaaatgtcc attttctcag ttctttagaa tacatttttg gatgaaagat caggagtggc 31080 tgatgaaaga agagatttct aagatatttt accctatgaa tttacacttt gggtgttaga 31140 catatgctgc cctcaatctc tatgattaaa tgaagaggaa ctgctagttc tatggtccga 31200 aataaggcca taatcactat gaaggggtac caacccttct ttgagtagaa atcatgtaca 31260 ctgatcaaat aaaatcggaa gatcaacatc tgctgatttt cccaggcttt agcaccaaaa 31320 aaacccaaag ctcagtgaat tctttagaga gtatgtgctg ttaacaactt atcccaaggg 31380 taggataaag aggtctggtg ggctcaagga tgtttctaat accaactatc cagtgttacc 31440 cctttaattc aggggctctc atcctcaaca ttattggcat tttgggcaag ataattcttt 31500 gttttggagt gctgttctgt gcactgtagg atgtttagca gcttccttag cctctactca 31560 ctacatgcca gtagcacccc ttgcccgttg cgacaatcaa aaatatcccc aagcattgee 31620 aaatgtcccc ttggcaaaga ggtaaagagg gagcattgta aatcacccct ggtataagaa 31680 caactgctcc agttctaagc cagtctgaag ecttgetaaa gtaaatatta acatatgggc 31740 acaattcaag ggaaacttac ttatcatttt tattgtttgt tcttgtctcc aaggctttgc 31800 cccaagatgc agagagagaa ggaggaatga gagattgaga agggaaagtg tacgccctgt 31860 ataacagtgt ccgcagaagc aaggggctga aaagatctga aggtagcetc cgtcatctct 31920 tctgggatac atggatcgtg gggatcatga ggcattcttc CCtt33C333 tttaagctgt 31980 tttacccact acctcacctt Ctt33333CC tctttcagat taagctgaac agttacaaga 32040 tggctggcat ccctctcctt tctccccata tgcaatttgc ttaatgtaac ctcttctttt 32100 gccatgtttc cattctgcca tcttgaattg tcttgtcagc caattcatta tctattaaac 32160 actaatttga gttcatcttg aatattcctg tggtaacttc ttattctgat cattcatttt 32220 tccctctatc tctcagtatt gatggacatg ggttggggtc actttgtatt aacaeggtaa 32280 cattttcatt ggtttctctg cctcttacta acagactcat cctactgacg aatcatggag 32340 ccaaatttca caaagaatta ctctgtcatg tcattttccc 3CtC33333C tcagaagaga 32400 ccccactgcc tacagaaaaa gcttcaaagc tttttaactt tccacattcc agctgatctc 32460 ttcagtctaa atacccttga gttctgtcaa ttgttcctca catggcatgg tttccagtgc 32520 ctcacatgaa tggggtaaac ggaacccaag actttagatt tggtcttaat gactctacat 32580 acaatgagat aattattatc tggggtctgg aatgtccatc ctgttaagag agcctaacac 32640 agcactagct ttagtgagtc acaaatcccc aggtattttc atgcaagaga aacttacatg 32700 ggacattaga atccaagaga ctgatatcag gtcccaggta gttataagcc tccctaaaca 32760 gttcagcttt gacttgtgaa ggttagagta acaccagtat aggaattagt Ct3C3333tt 32820

3tcttt3333 ataaaggaaa gcaagaattg tcctgggcag gagggggaaa tataaagaaa 32880 aatgaaaaat aatacctgac gcttatacaa caggttgttt tgcaaaaaca ctatttcatc 32940 ttagtcttat 33333tctct atgagcaaga tctatttcca tgttatggga gagaaaccag 33000 aggctcccag aggttaagag atttgcttga ggtacggtca tacagatgaa gaataaaacc 33060 aagattcaaa ctggacatca agttcaggct cctttcccta caacctggca gcctacacat 33120 attttccccc aaggcagtgt ctcaacttcc tatcctgttt tttcatttcc actgaatgct 33180 tgctcactcc tcagaatgtc ttttccagga tgttgctctg gctcagttct gtcattatct 33240 acaattttct tgactttcta tctaaaaagt cttctgctca gtctgctgat 3CttC3333t 33300 gaagccgtgt acccaatctt ctacacaagg ccttctgtgg tcatcttgtc tagctcaagc 33360 agttccacct ctatagcaca tctcatacca ccagcatagg ttgattttca tgtaccacat 33420 cttccttcta tcctttactg gactgtatgt aggtttattg agaaaagcaa ccatgcctga 33480 gagccccaca catagaagag tggcttgatc aagcatttgg tcgtttggta atagctggta 33540

3t33Ct333C atttgcctga tcgatatttc atgtgacaaa aattgccaga gtagttttaa 33600 gttctctcat aattcagctt tcccttcata ttcttcagct atcaaggtta ctgtgtacaa 33660 gctgggaata cccttgatct tgagattaaa atgtaaatta agagattaaa attaagatct 33720 t3t3ttt333 3t3t3t3t3t 3t3C3t3t3t 33tt333tt3 t3t3t3C3t3 t3t3C3t3t3 33780 t33ttt3333 attatatatg t3t33ttt33 t3t3t333t3 aatttaagat gttttcctcc 33840 tttgccaata tagggtttga tgtaatcatt tctttgtttt ctcaggtccc acctccattt 33900 gcaattgacc tcttctggga acttcctcag atggacaaga ttaccccacc ttgcccttta 33960 cgtatctgct cttaggtgct tcttcacttc agttgctttg caggaagtgt ctagaggaat 34020 atggtgggca cagaagtagc tctggtgacc ttgatcaagg tgttttgaaa tgcagaattc 34080 ttgagttctg gaagggactt tagagaatac cagtgttatt aatgacaaag gcactgaggc 34140 ccagggaggt gacccgaatt ataaaggcca gcgccagaac ccagatttcc taactctggt 34200 gctctttccc tttatcagtt tgactgtggc ctgttaactg gtatatacat atatatgtca 34260 ggcaaagtgc tgctggaagt agaatttgtc caataacagg tcaacttcag agactatctg 34320 atttcctaat gtcagagtag aagattttat gctgctgttt acaaaagccc aatgtaatgc 34380 ataggaagta tggcatgaac atctttagga gactaatgga aatattattg gtgtttaccc 34440 agtattccat ttttttcatt gtgttctcta ttgctgctct ctcactcccc catgaggtac 34500 agcagaaagg agaactatcc 3333Ct33tt tcctctgaca tgtaagacga atgatttagg 34560 tacgtcaaag cagtagtcaa ggaggaaagg gatagtccaa agacttaact ggttcatatt 34620 ggactgataa tctctttaaa tggctttatg ctagtttgac ctcatttgta 333t3ttt3t 34680 gagaaagttc tC3ttt3333 tgagatcgtt gtttacagtg tatgtactaa gcagtaagct 34740 atcttcaaat gtctaaggta gtaactttcc atagggcctc cttagatccc taagatggct 34800 ttttctcctt ggtatttctg ggtctttctg acatcagcag agaactggaa agacatagcc 34860 aactgctgtt catgttactc atgactcctt tctctaaaac tgccttccac aattcactag 34920 accagaagtg gacgcaactt aagctgggat 33tC3C3tt3 tcatctgaaa atctggagtt 34980 gaacagcaaa agaagacaac atttctcaaa tgcacatctc atggcagcta agccacatgg 35040 ctgggattta aagcctttag agccagccca tggctttagc tacctcacta tgctgcttca 35100 caaaccttgc tcctgtgtaa aactatattc tcagtgtagg gcagagaggt Ct33C3CC33 35160 cataaggtac tagcagtgtt tcccgtattg acaggaatac ttaactcaat aattcttttc 35220 ttttccattt agtaacagtt gtgatgacta tgtttctatt ctaagtaatt cctgtattct 35280 acagcagata ctttgtcagc aatactaagg gaagaaacaa agttgaaccg tttctttaat 35340 aa 35342

<400> 40

ctctgtaaaa taaatgcgct gggccggatc ttttctgagt tctcttctcc cctacgaatt 60 ctagatccct cctctgtcct ccctgcgcca gggaccttcg ggcgaccctt ccctgtaccc 120 ccaccccacc ctctctggac cccgtttctg cctcagtacg gcgcgctgag ctctgccccc 180 tgcccaggcc ctgaccccct caggagccgc ggtttcctgg ggtaacagtg ggaaacgtgt 240 cggccgtctc cgctcaggcg cttgctgtgt acagaaaggt gaattcatgg gaaaggtggc 300 ggagggatcc aggttctggt ggacgcttta cggctccacc aaggctggcc ccgagatttg 360 cgcagaatga gcggctgagg atggaagggc tgcaagatcc accgccttac ttagctggga 420 cccggcccca cctcctctac agcagaccct gtctccaccg gtgcggttgg tgctaggttc 480

CC333C3C3C tgctgccgtt tcttgtctga catcgcggcc ctgctcctgc ctgccttcag 540 cctgggctag ccccccgccc ttcccccagc tccctgcccc tgcgcccacc acactcctcc 600 tccgtctcct ttaggctgat tcaggcacac cggctctcgt cgccttggtg gccctcccca 660 gccctcctcc gcgcctgctc cgggtggcgc tccgctgggc tcctcgtgcg cctgtccgcg 720 accgcaccca cctcatcctg gcacccccat cgtggcatca cgtgttccct catctgtcct 780 catggctggc gtgcccctct gcggtgagac ctgcagaaca ggaattggtg ccgggtcagc 840 agccggcgat gaagccggac gaagcctgca aaccccaccc atacgccagc ttcacatagc 900 tcctatccat tgcacagcag cgtggggaag caccgttctc taccctccaa gtaagaagct 960 gattgttggg gcacagggga gatcctatag catggctctg cttatgggca cgcgcagaaa 1020 cattcccaaa tgaatttttt tgttgtttgt tttgttttgt ttcttgtttg ttttaagaga 1080 cagggtcttg ttctatcgcc caggctggag tgcagtggtg caatcacggc tcactacagc 1140 ctcgacttcc gggctcaagc gatcccccca cctcagcctc ccaagtagct tggaccatgg 1200 acccgcgcca gcacgctggc tttttttttt attttatttt attttatttt ttgagagaac 1260 ctgatttcct tccaaccaat tgtgctctcc caattccaac aaccaaatga agcttcaacg 1320 cttctttttg ttcagaggcc tcctgagtcc tgtcctactc acagtaaagg ctctggcaaa 1380

33C33333C3 3333C3tC3t ggggcaaaat aaactgcatc ttaaaaaggc tcatttctct 1440 ctaggtctct ctccaatttg ttatcttgaa acgatttacc caaaatagaa 3Cttt33333 1500 agtagtggaa aattttcttt ttgcacaaga tggttaattc ttttgggtgc tggcctggga 1560 tccatgaaat aacctacact ccaccataaa gcttttcact cccatgtttt gcaaactgac 1620 gaccttgctg ggggcaagct ccccgtgtga ctttacgagg gaatttgagt ggtgcaagcc 1680 ggaggatggg gcctcactat gtggcccagg ccggtctcca actcctgggc tcaagtgatg 1740 ctcccctcac ggcctcccaa agtgctggga ttagatgcgt gagccaacgt gccccgccca 1800 aagggcagtt gacctcagcg tctgaggtgt ggagggagca gctcgttcct ctttttcctg 1860 ctctactggg aaggtacaaa ccatactaag aaatcctctt cagtctgtcc ccacaaaaag 1920 agaaagagga gttgctgcag gccaaggaca aggaggaagg gaggagagag cccttgactt 1980 ctcccacttc ttgactttcc ttgccgtggt ctttccttcc tttttccagg tccacacctc 2040 tccttctata gtcctagaaa tgggtcaccc cctacaggag tcagagcctt cgcccagccc 2100 tcatgctctg agggtaagtg ggtggaaaca gacgccttcc ctctcgcaat gtttccatca 2160 ctgcgtcctc caccttgcac cactcagatc ccctcggaaa gtcacacggg gggcttgcca 2220 ccaacaaggt catcaccgtt tgcataacgt gggagtgaaa agttttatgg tcgagttgag 2280 gttatttcat ggatcccagg ccagcactca aaagaattaa ccaacttatg caaaaagaaa 2340 agtttccact ggctttgtaa ggtttctatt ttgggtaaac tgttttaaga taacaaattg 2400 tcacatacac attttgttgt gacaattgtc acaacaagag aaaaagaaaa agaaagagag 2460 agagagaaag aaagaaaaag aaacgagcct tttttggatg cagtgtattt ttccccttta 2520 tttacttatt tatttatttt gccacagcct ttactgtgag taggacagga ctcaggaggg 2580 ctctgaacaa aaagaagagt tgaagcttca tttggttgtt ggaattagga gagcacaatt 2640 ggttggaagg aaatcaggtt ctctaagcat caaaaaaatt cgtattttaa gtgatgtgag 2700 ttatggaagg cagagagttc ttggtatatg gaagttactg aaacagagca gtggacaaac 2760 gggcagtctg cagaagagga aagctgaata gccagcaaac atggggccag atgctcggtc 2820 tcaaccttaa caagagaagt caggtttaaa caacgagata ccatcacacc ctatgagatt 2880 ggcagaattg aaaagactga caaaaccaga aataacaaag ctcgtgggta aatgaaaact 2940 cctccacagc tggtgtgagt gtggactgga accatgactt cggagaaaaa tgtatcaaaa 3000 gctatgggac acatctttcg aatcagtcat ttctcacaag gttgccatac tcctcaagtc 3060 attccttttc caggaaaaca ccctagagaa aatcttgtac ttggactcta gggaatgtgt 3120 acaaggatgt ccattgtagt ttagcttata acagcaaaac ccagcccaaa agtacatcaa 3180 caaaggaatg aataaatgaa agtggcagtt gtcattaaac ctttttcctt ttcttgtatc 3240 accccaaagt atgaaagact atggactcct tcactcatta aaaaaaaaaa tttaggccag 3300 gtgtggtggc tcatgcctgt aatcccaaca cttaggaagg cttaggcagg tggatcactt 3360 gaggtcagga gttcgagacc agtctggcca acatggcaaa actctgtctc tactacaaat 3420 acaaaaatta gccaggcatg gtggcgtgtg cctgtaatcc cagctactca ggaagctgaa 3480 gtaggaaaat catttaagcc caggaggtgg agcttgcagc gagctgagat cgcaccactg 3540 cactccagcc tgggtgacag agcgagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaaa 3600 aagatttagc aaggaacagt gaatggctca cccctgtaat ctcagcactt tgggaggctg 3660 aggcaggagg actgcttgag gccaggagtt gggggctcaa gagttggagg ctgcagtgag 3720 ctgttatcac accaatgcac tcaacctggt tgacagagct agactctgtc tctaaaaaaa 3780 ataataatac taatttattg tggcaaaata cacataacaa tcttaccatt ttaacattta 3840 agtgtacagt tcagtggtat taagttcatg cacattgttg tgcaaccttc accaccatcc 3900 ttctctctaa ctcttttcat ctagaaaaac taaaactcta taaccgttaa acataactcc 3960 cactcctccc tctccccagc ctgtcccaac caccattcta ctttctgtct ctattatttt 4020 gactacttta aatacctcaa atacatagaa tcatacagta tttggttttt tgtgactggc 4080 ttaattcact tagcataata tcctcaagat tcatccatat tgtggcatgt gtcagaactt 4140 cctttttaag gctgaataat attccactct atgtatatac cacattttgt ttgtttaaat 4200 aaattttatt gtgtatatat aaggtatata caacatcatg gtataagaca cacatattta 4260 gtagaatgga tactatagtg aaacaaattg acttatgcat catctcactt agttacccat 4320 ttatttcctc ctgtagcaaa agcaactatg ctcatctagc aaaaatcctg gaataatatg 4380 ctattattaa ttgtagtctt catattgtac tttatttgac ttgttcatcc tatatgtttg 4440 ctacttcgta tccttaggcc tacatctgcc catttcctct ctcctactcc aatcttgata 4500 accactgttt tattctctat atatttgacc tttttaaaag attccacagg ccaggcatgg 4560 tagctcacac ctgtaatccc agcactttgg gaggccaagg caggtggatc atctgaggtc 4620 aggagtttga gaccagcctg gccaacatgg caaaacccca tatctactaa aaatacaatt 4680 agccaggtgt ggtggcaggt gcctgtagtc ccagctactc aggaggctga ggcaggagaa 4740 ttacttgaac ccaggaggca gaggttgcgg tgagccaaaa ttgcgccact gcactccagc 4800 gtgggcaaca gagtgagact ccgtctaaga aaataaataa ataaaagatt ccacatacag 4860 gtaagatcgt gcaatatttt ttttctgtgt ctggcttctt tcatttagca taatgtcctc 4920 caggcccgtc taggttatgg caaatgctat ctcctccttt tttaaggctg aattcccttg 4980 tatatatccg taccacaatt tcttaaacca ttcgtccatt gatggttgtc taggttgtct 5040 ccatatcttg gttattatga ataatgctac aataaacaca ggagtacaga taccttggtg 5100 aggtggtgat ttcatttcct ttgggtatga gcccagaaga gagatgcctg agtccacatt 5160 ttgtttatct attcatccag taataaacac ttgggttgct accacatttt agctactgtg 5220 aaaaatgctg ttataaaatg aatgtacttc tttactcact tttaacttga catcaaacat 5280 ttttcatcac tataaaggac ataatttcca aagtaaatgt tgatttttaa aaaagaaaac 5340 cttattcttt ttaattattt ctaatagcac ataaataata tatcaatttt gtttcaaccg 5400 tcactcattt ttaaaataca agaaaaagtt cttaactttt ggaaattttt catcactcct 5460 ttttctcctt aaacttatga attctaggcc aggcgcgatg gttcacacct gtaatcccag 5520 cattttggga agccaaggca ggcagatcac ttgaggccaa gagttcaaga ccaacctggc 5580 caaaggggtg aaatcccatc tctactaaaa atacaaaaat tagtcgggtg tggtggtgca 5640 cacctgagta gcaatcccag ctactcaggt ggctgagaca cgagaatcac ttgaaccaag 5700 gaggcagagg ttgcagtgag tggagattgt gccactgcgg tccagcctgg gcggcagagt 5760 gagactctgt ctcaaaaaaa taaagagtaa aaacaaatgg acttatgaat tctattctac 5820 ttcctccata aaagtttaat aggtgcatat gcttaaggac cttatattga tcaatatttc 5880 atacttctct gccaaaaaag cacatgagat gaatttttaa tttcctgcaa ccataagttt 5940 ctaaatatta aaagtcttag attatgtcat cattgcgact attaatagtg cacaattgtc 6000 ctttatagca taaataaact gcaagtcttc aaaattaatg aacattaaaa gtaacctttg 6060 gccaggcatg gtggctcaca cctgtaatcc cagcactttg ggaggccgag gcaggcagat 6120 tactagagtt caggagtttg agaccagcct ggctaacatg gtgaaatcct gtctctacta 6180 aaaatacaaa aattagccag acatgatggc gggtgcctgt aatcccagct actagggagg 6240 ctgaagcaag agactcactt gaatccagga ggcggaggtt gcagtgggcc cagatcacac 6300 cactgcactc cagcctgggc aacagaagaa tgctctgtct ctaaaaataa ataaataaat 6360 ataaaagtaa cctttgttag gggaaactgg gtgaagggta tggaattctc tgtacccttt 6420 cttgtatgtg catgtcaatc tacaattatc tcaaaaaaag ctttttaaaa cataattttg 6480 ggggaaaatt cagctcttaa tgaaatggac cccccacaaa tgaattttgt ggtccaatta 6540 attaatgaac ccataaaata acaggattta ttttatttat tgattgctag aatgagacag 6600 agttcagtat taattttgtt ttgcttttgt ttgtcataca atgtaagtac tgagaaattt 6660 tgtctccata aataaatagt tggctttgtt acagcagaat cactaaatct tttaactttt 6720 tccttttttt ttcaaaaaga caaaagcatg aaccaggtgc agtggctcac gtctgtaatc 6780 ccagcatttt ggaggccaag gtggatggat ggattccttg agtccaggag ttcaagacca 6840 gcctgggcaa catggtgaac ccccatctct acaaaaattt agccaggtat gatggtgtgc 6900 acccatagtc ccagctactt gggaggctga ggtgggagga ctgtttgagc ccaggaggtt 6960 gaggctgcag tgactccact gcactccagc ctgggcgaaa gtgcaagacc ctttctccaa 7020 gggagaaaga gagagagaga gagaaaggga gaaagggaaa aagagagaga gaaagagagc 7080 gggaaggagg gaaggaagga aggaagggag ggaggcaggg agggagggag acaatgttat 7140 ctatcatcaa aaattaattt taatgatcta ttagttgctg tattagtttg ccagggctgt 7200 tttaacaaag taccacaaac taggtggctt caacaaaaga aatttattgc ctcacagttc 7260 tagaagctag aagttcagga tcaaggtgtc agctgggtgt gttccttctg agggctacag 7320 aaggaatttg ttccatgctt ctcacctagc ttctagtcag ttgctggcaa tctttggcat 7380 tccttgactt gtagaaacat caccccatct ctgccttgtt ttcagatgat gttctctgtg 7440 tgtgtgtcct gattgcccct ttccacaagg acaccagtta tattggatta ggacccatcc 7500 tattggcctc atttgaactt gattacctct gtaaggacct tgtctccaaa taaggtcaca 7560 ttctgagatg ctagagtata agacttcaac aaatatactt ggggggacac aattcaacct 7620 gtgatagttg ccaaatctag aaggccttct tccaattttg ttgaaagcaa acacttggga 7680 accactgacc tgcacatggg tttgttacca tttttagatt tattcacttt cttgggtttt 7740 ggaagcccta aactaggttt taccgaagcc taccaagtag ccatcaatga catcattctt 7800 ctttcactta aaaacgattg ctgaaattga ttaacttgga aagtgttggg gtattagaaa 7860 tatttttaat ttaatttcaa gacaaattcc aatacaaaca atattgtgat ataatgtttt 7920 tatctttttt tttctttctt tttttttttt tctgtcgccc aggctggagt gcagtggtgt 7980 gatctcggct cactgctacc tccacctcct gggttcaagc aattctcctg cctcagcctc 8040 ctgagtagct gggattacag gcgcttgcca ccatgcccga ctaaattttc tttgtatttt 8100 tagtagagac ggggtttcac catgttggcc aggctagtct caaactcctg accttgtgat 8160 ccacccactg cggcctccca gagtgctggg attacaggca tgagccaccg cacctggcca 8220 aaatgctttt atcttatcat agattttaaa cttgttaaaa gtgttttctt ttctttcttt 8280 ttctaagctg tttctttagc gctaaacttg attctcatca aaaccttgga gctaaagatt 8340 tagctcacta gattcaagga aagttaaaat actgccatta acctcattgg caaagctggt 8400 cttcaatgtc aaaccaatta acaactcaga cttaatttct gttaaaaaaa aaaaaaagaa 8460 ttctgattcc ttttgtaatc ataatgaaca cgttaatatg catcctcata atgactgtct 8520 cacctctgaa ttctagctcg atgatagaga gctgagtaga gggatgaggc cccaaagcct 8580 gctgtgaggc actctgcctc ctgcatccct cccagatgac tcttttcttt cttttttttt 8640 tgagacagag tctcgctctg tcgcccaggc tggagtgcag tggtgtgatc ttggctcact 8700 ggaagctcca cttcccgggt tcaagccatt ctcctgccgc agcctcccga gtcgctggga 8760 ctacaggcgc ccgccaccgt gcccggctaa ttttttgtat ttttggtaga gatggggttt 8820 caccgtgtta gccaggatgg tctcgatctc ctgacttcgt gatccgccca cctcggcctt 8880 ccaaagtgct gggattacaa gcgtgagcca ccgtgcccgg cccccagatg actctacctg 8940 gatactgggg actctgctca ggagaaatgc attctttggc aatttctaac ggatggaaat 9000 tacatgaaaa atgtttggat ttgtcttttt attggtggcc cagaggatta cgtgcccacc 9060 tctggagcat agtaaggaac aggagggcgg gaagtttgcc tttcagtttt aaagtgggaa 9120 ataaaataat catgaaagaa taggccagaa aggagaacga gcacaaagcc taaacacagg 9180 gacttgttct tgggcaggtc cattttatga gaagagaacc aatgggagtt gagaatctgg 9240 aaaacaattt ccttaaaatt atgtgtatcc ccaaggacag cctccatata cttccagaga 9300 gatgaacact ctggttcaag aaccactgaa catgaaactg tggcacattc acaggataat 9360 acaccacaca gcatttaaaa taaatctata tgtatcaaca tagctcaaag acacacaata 9420 tgatgacatt tctgtatttt gaaactctca gaaaataaaa ttatatagca tttatagata 9480 tatatacaca tatacatgta tacatatcta gtaaacattt caaaacagag aaggggaagt 9540 tgaaagtaaa tggatagaaa aagatacatt atgcaggctg ggcacagtgg ttcatgcctg 9600 taatcccagc actttggaag gccaggtggg cagattgcct gaggtcagga gttcaaaacc 9660 agcctggcca acatagtgaa accccatctc tactaaaaat ataaaaatta gctgggcatg 9720 gtgccgtgca cctgtagtcc tagctactca ggaggctgag acaggagaat tgcttgaacc 9780 ctggaggcaa aggttgcagt gagatgagat cgcaccactg cactgcagcc tgggcaacag 9840 agctagactc tgcctcaaaa aaaaaaaaga aaaaggaaaa gatacattat gcaaacggga 9900 agcataagaa agttgtgttt ctggccgggc acagtggctc atgcctgtaa tcccagcact 9960 ttgggaggct gaggcaggtg gatcacctga ggttgggagt tcgagaccag cctgaccaac 10020 atggagaaac cctgtctcta ctaaaaatac aaaattagcc ggacgtggtg gtgcatgcct 10080 gtaatcccag ctactcggga ggctgaggca ggagaatagc ttgaacctgg gaggtggagg 10140 ttgcggtgag ccaacatcgt gccattgcac tccaacctga gcaacaagag ggaaactcca 10200 tctcaaaaaa aaaaaaaaga aagaaagctc tgttccttat gaataaaagg tagacttcac 10260 aacaaagtat taccagaggc agaggtaaag acgaacattt cataatgata aaagagtgaa 10320 ttcatccaga aggcacaatt ctaaatgtgt atgcacctaa taacaaagct tcaaaatata 10380 ggagacaaaa tatgaactga attaaaagga gaaatagaca aatccacact cattggacat 10440 tcggcatcct tctctctcag ctccatagga aaggttaaca gattaaaaat taaaaaactt 10500 accatctttc tgtcataatt aatgaacaaa actccaaatt tagcttttca tgagaaggcg 10560 ggtggggtgg tacttgggag ggtacagttt tatctgtaat gttcatgtga aggaaatgcg 10620 acaaaatgct aacacttata aagagtgggc attttatatt atttgacata ttgttctatg 10680 ttaaaatgtt ttcaaaactt ttttttaaaa aagtgaatag cagaaatatt taaatgagtg 10740 aataatgaat gaagttcaga agtcaacatc acttcatctg acattgccct ccacaagtcc 10800 ccatgctgcc cctaccctcc cttgttggcc tttctcctgt gagtcctcct catcttatca 10860 tccaccaatg gcaaacatgt gggacatcct catgtgggtc aggggcagac atgagcttac 10920 aatctctacc tgccacaggc tttgatgtcc tctctgtgct tctcttatag cccaaacctc 10980 ccctgtgaag ttcttccacc ttctcaagcc ccattctgaa tttcctgcac tacctggatt 11040 ccttgccaat gttttatttc ctgctcttca atacgagcct tccctgaagg ttccatatac 11100 tcttctgtat gttctttcca caccacctcc ctttgcaatg acacccactc tcacaactta 11160 tcacctcctt cccaaggcta catccccagc cctgacccct cttctgaact caaatcctgg 11220 ctctccagtt gcattcagaa cgcttctgtt tcagtgttac tgagattaaa gatccaaaac 11280 aattttgtta ccgaaacacc gggggatcca tctaggtcct tctgctcacc tcacagaaag 11340 ccaatcactg agacaacaag tattgccaag gaagaagaat ttagtcaggt gctgcagcca 11400 aggagatagg agatcagtct caaatccatc cctctgacct gactaaaatt aaggggttta 11460 tatagcaggg aagacatgta atcatgtgtg ggaaaacagg aagttgggag gagtaaggaa 11520 aaggagttgg acaacaggaa acaggaggtt agttaggcca tcataccagg tgaagagtct 11580 gacgtcttat tgttcataat aagtgatctg gtgagtttca gctcattgct accatctggg 11640 aggcctgata gttggtttcc ctagaaagga actcagataa gacaaatgta actttctcag 11700 gttttaagaa ggcaaggatc aatttatatg tttattcaaa gaaaccacaa acatcaactc 11760 tatgggatca ttggatcagt tttacagtaa gcatgtgtca gcaccaaggg aggggatgac 11820 agagagtcaa tgcaaggtgt aaccaaaatg tgtatatttt tccccattac agttcagctt 11880 cttaccctct ctgcccaatc caaactgcaa caaggattct cccaattata tttcaaacat 11940 cctagcttcc tgggatgccc tcttctcttt actcttgatg tttataattc accttgatat 12000 gtgcaaagat gtatatgttt ttatacttgg cactaagagt atttttgatc tgagaatgtt 12060 tgtctttaat tgtgaaaaat tttcagccat gctttcttcc catatttctt ctccacattc 12120 cctttgttct cccctttctg aaatcctatt 333C3CttC3 ccatgctaat atacatctca 12180 acagcttttt caaactgctt ctgtcttcat ctccctgtgt tgcattctct atgaatttct 12240 caatgctagc ttccaattca ttaattatcc cttcaactat gtccaaccta gagtatatcc 12300 ttgtttaata tgtagagtgt tcatttccag tatgctcagt atttatcatc ttcaactgtt 12360 cttctttaat ttctgcattt tctacatttg ttgttctctt tgttttaaac atttttcaaa 12420 ttgttcaata atttgcctct ttttggaagt gaattcacat tccacttgtt gagtcttttt 12480 tatgtatact ttgaatttcg agtgtgtgtg cagggttatc ttgaatagaa atttttgaaa 12540 atctcttcct ctctttactc tctcttttcc tgagtttttt aaagtagcct ctgactttcc 12600 agggcccaca gtcagaacta ggccttacat gggtggctgt gggctctctt tcaatcaaga 12660 gaaaatcaga tccaaatccc tgtttcaagc agagagcctg gctccagcct tcctctatag 12720 gcaaagcact gtgaaactct gttagctgaa ggagtcaaac tcttggtgcc tctacactaa 12780 gaacagaccc tcaagaccca ggcccaagaa tggtttgcta agaacagatc ccagcaagcc 12840 agcccctgat tccagccatt gtcctgcaac tacatccttg aagacgttta tcttgctttt 12900 gagtacatct gccttctccc cttcctcctc ttcttttgtt tttaactata ccattgctat 12960 atgttaaagc atggtatcag ctgatcttga tcagacatat caaatgcctc 3ttct333C3 13020 acctctctcc taattcttcc tttatcttca 33CCC33Ct3 tatgtgaagc ctttcctgac 13080 cactcttact tggaatgaac tatctaagcc tcctctggtc tgctgtaccc tacttctacc 13140 ttcctttagc ttttactgag caagaatttc ttgagtgtgt gccactcaag tgtgtgccaa 13200 gccctctgtt tggcaccctg gtgtaaacat gagagggaca aggctccttc ctcaagggac 13260 caagggtttg gttgtcaagc tggacaggca 33C333CC3t tgtgctccag tctgcagata 13320 cccaaggtcc gggtgacaca gagaagagaa ggatgtggtc tgtactgtct gggagtggga 13380 gggggaagga gctaaacccc acaggaagga gatgcttgag ctgggtctta agggagagga 13440 gtttggtaag cagagagcag aggtgagaac attcttggct gagggaatag catgtttaat 13500 ggctctgaag tggaaaggac tagggtccgc ttgagaaatg agagatgcgg aacctaggag 13560 gagtgaagaa ggtgacagac aagaggacag agactatgaa accaagtgtg cagggcctca 13620 caggcaacat tagggatccc cgacattcta ctagggacac caggaagtcc tttcaggttg 13680 aagcaggggg ttggcatgat gagattttct ctagaaggga ccagagcaga aatggggttg 13740 gccagttaag aggccattgc aaaagtccag gaaagaagga cagcagctag atgaacttgg 13800 ggaactcggg gtggaggaaa agaaaggtga cagaagtgag gccaaattga ttggtatttc 13860 caattaagat aaaacaagcc ctgataactc tagagtttct agccctggac aagctaactc 13920 cttccaagaa cagtaacatc tccatagacc tgaattggcg atggggacac agcaggcaat 13980 ttcccagcca tgattccaag ttgtccctgc agttcatgtc ttaggagcag tggcacagaa 14040 ccctgatgga tttcctacca ctgctctgcc cggttttgca ttttgaatat gtctttaatc 14100 tacattaaag ttttccattt ccatggacca gtttaaatca gcatagaaac tggttactat 14160 cttactctat ctacttctgg atattttttt aaataagggg cttgcttaaa ggagtgcagt 14220 cattcacatt tcttcatgcc atcccaagtc agtgctacag tgtggggttt gggaacttac 14280 ctggcagtga tggacaggcc caacccagcc ctctgcacac ctggtctaca gaaagtttct 14340 ccagaacttg tgcaattgca tctgttctgc cactgcaagg cggatgtcat tgtggtcaca 14400 tcgaaaatcc accacgttct gcaaaaaata tcactggggt cacaaagcct ccttgatggg 14460 tttgacatgt tgccttatcc tccccacccc aacccccatg gtgctctgta caaaggggct 14520 gccaccccac tggctgacac ttttctgagc tgcagggcta gaaggccccc aagctgattt 14580 ccgtgagact aagatggaac tagtctattt taaagcagta cacccccaaa tctggccatc 14640 atcacactca ggggcctgat tctcaagatc caaataggtg gaggttgact ctggccccct 14700 cagtgcttcc accactgggc aagtgcagtt tcgtgtctag ccatcttcct taccaccctg 14760 ttgattgtag cctttggcca gcagggccat ttgacactcc tgatacagtg ctggtggtgc 14820 tgagcaaaat ggcaaactac catctacagc aagaattgat gtgttggtgg cctgtctgga 14880 cttgattgct tccttgtctc cctcattcat gtgagttgag ggacagcact gtgtctacac 14940 agcgagggac cctcatacca tgcacacaca cacacacatg catacatcga taggccagtt 15000

3-t3.3-CC3.tC3. ttgtaaaggt gttttcttcc ccaactccct catctcccat ttgaaaaagc 15060 tgcaggtact ggtgcaagcc ctcagtgata cagatacatt atatctacca cagccttgct 15120 agtgttgcaa taatgagaaa tcgcctaaat gtccactaac agcagaatta aattatggaa 15180 cacccatata taatgcaccc atttataaga atggggtgga tcttcatctg ctgaacgctc 15240 tccttctact gtgaaacaag ataggttgca 333333t3tt tatctcatac aatcccatgt 15300 gtctaagatg atgtataaac atctgtttat gtacagataa tatctaaggg 3C3C3ttC33 15360 ctgtaacagt ggttttctgt ggggagcagg tgacagtgag gagagttgag acagggaact 15420 ttgtgtttgt tttcgtacaa gaatatattg cactgttgtc acttaaaaga catttttaaa 15480 aatttctgaa tataaaatgt tacatgttcc atgctagaat aagcatcttg gatgctttga 15540 gggagctgga aggaggtact gaaatcaaaa t33tt33333 3333333333 agcccatcca 15600 ggccctgata tggtggctca cacctgtaat ctcaacactt tggaggccaa ggcggggcaa 15660 agcgcctgac ctcgggcatt ggagaccagc ctgggcaaca tggtgaaacc ccatctctac 15720 caaaaataca aaaaattagc tgggcatggt ggtgtgctcc tgtggtccca gctacttggg 15780 aggctgaggt ggaaggatca cttgagcctg ggaggtagag gctgcagtga gccgaggtgg 15840 tgccacactg cactccagcc tgggcaacac agccagaccc catctcaaaa aaaaaaatag 15900 caacaacgac aaagaaccca tccaacactt aagtttgtac ttcacaagga caaggagaat 15960 gcagttcaac aagcacagct cagcccatgc tgtgtttctg gggatggagg acacatcatg 16020 aagtctcggc atggtcctcg cccagcagaa ctaatgggtg gggcagacac atggaacaca 16080 gaatgccagg tgtcttgtct ctaggatcaa gcagtagcaa tgtgaggtgc agccactatg 16140 ggattcaaag tggaaagact cagaaaccct gaagaaatgg gaagagggca tgccactgga 16200 gctggaaggt ttcaggacag caacagtcaa aaaggaaaga tgagcctgta gtcccagcta 16260 ctcagggggc tggggtggga ggatcactgg agctcaggag tcccaaggcc agcctgagca 16320 aaacagcgag actccagtct tttttatttt attttatttt ttaaagaaac aaaaaggaag 16380 gggacacaca tgtgttaggg acagaaaaga gaaaaccgcc tctacccaag cattcaccca 16440 catcacccac acctccctgc agagcaccca gagctggggg tgaaagaaat gaggtccaaa 16500 tgagacagca caggagctgc ctccagggct taaacagacc agcattccag gccgagggac 16560 cgcaagtgca agggcgtgaa agcacagagc gcaggggttg aatgacttca agcctgtgaa 16620 gctgcagctg caggtgtatg ggaaaggcag ggcagggggc tgtgcggagg ctgggaggag 16680 ccagcaccca agggctggtc aaccaagctg ggggttgaat ttccatccag caatgcaggc 16740 catgggaggc tgcagcagtg acgctgtcag atcccctttg tgagaataat aatttttata 16800 acaacgtggc tggaggactg atcaggagag agactggtgt gaattgaagg ctgttgcaat 16860 ggctccaaga agagatgagg ctgtgtggtg agtttagccg ctggatgaaa ggccggaaga 16920 atgaggtcag cagcgcactg acaccgacac ccaaagcttc ggctgctgcc gctctcatgg 16980 aaatctcctg ggggaaggga gagggtcctt cctcggtgaa aactggggct gctctagcga 17040 gttcctcaga agcgggcagg tcgctagttc ctcttccttt tcagccctca gtgcccattt 17100 tgccaataaa aagtcccaag gtgacagtac aagagacgcc tttagtgaag gcaaaggaag 17160 ggacactccc ctcctttgct gcctactctc gccctcactt cttgaaatct ttggtctccc 17220 ttcacccact ctgtcactct cacaagacaa ccatttccaa ggactatttc caagcccttt 17280 tcctcatccc caaacccgca gttttcagct gcccccagtt gcctggccag gctgcctcga 17340 cggccctatt cacgggcccc agcctcctcg ccgggctgga aggcgacaac cgcgaaaagg 17400 agggtgactc tcctcggcgg gggcttcggg tgacatcaca tcctccaaat gcgaaatcag 17460 gctccgggcc ggccgaaggg cgcaactttc ccccctcggc gccccaccgg ctcccgcgcg 17520 cctcccctcg cgcccgagct tcgagccaag cagcgtcctg gggagcgcgt catggcctta 17580 ccagtgaccg ccttgctcct gccgctggcc ttgctgctcc gtgagtttga gacgcccggg 17640 aaggcagggg atggggcggg cggggggcgg ggggcgcggg actgcgggct cagcctcgct 17700 gcttgccgcc tgcagacgcc gccaggccga gccagttccg ggtgtcgccg ctggatcgga 17760 cctggaacct gggcgagaca gtggagctga agtgccaggt gctgctgtcc aacccgacgt 17820 cgggctgctc gtggctcttc cagccgcgcg gcgccgccgc cagtcccacc ttcctcctat 17880 acctctccca aaacaagccc aaggcggccg aggggctgga cacccagcgg ttctcgggca 17940 agaggttggg ggacaccttc gtcctcaccc tgagcgactt ccgccgagag aacgagggct 18000 actatttctg ctcggccctg agcaactcca tcatgtactt cagccacttc gtgccggtct 18060 tcctgccagg tccgcgcgcc gggttgcggc acctctccgc gtggggcttg gggttcacct 18120 caacctgttt tccacacctg ggccctgctt tcaagcctct tagcgcacct ggaagcgact 18180 tagatactgt tcccatttca cagacacagc aaactgaggc taacgcgagg ctgagtaggg 18240 actggggatg gctttttacg tccggccgat ctggactcga gttcggattc ttgtgtgatt 18300 ctgggcaaat gacttaaatt atctgcgcct ccgtttgctc gtgggtaaaa tgcggacagc 18360 aatcaacccg cgctccaggg ttgctggttc agcccgggag agaggccagg tgcaggggag 18420 ctggctcctg cgctccggct ctgggcgccg ggtgcgctgg gctgagccga ggcccgagca 18480 caggggtccg cgcgcatccc ggggtcccca tcctgtctcc tctgctatcc cttctcccag 18540 gaaaaccggg gggaggcgtc cccgtgggga aaggtgcgcg aggccggggc tggggcgcct 18600 ccataacccc agcctggccc ccaaccacgc tctgttgctc ttgcagcgaa gcccaccacg 18660 acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg 18720 cgcccagagg cgtgccggcc agcggcgggg ggcgcaggtg aggcgtgcgg gggcccgggg 18780 cgggggcggc acgcaccgcg gggagagccc atgccaggga cagccctgat actgtaggta 18840 gagtcaaggg ctgtccaagt ggtgggaaac cgagatctga ggcggagaga cgttcccggg 18900 acggtggggc ggttgggagg tcccgggccc tctcctaaat gtcggcgtct ttggtgtcgt 18960 cagtgcacac gagggggctg gacttcgcct gtgatatcta catctgggcg cccttggccg 19020 ggacttgtgg ggtccttctc ctgtcactgg ttatcaccct ttactgcaac cacagtaagt 19080 cccgaggaat cgcggcggga aggagtcggc cccgctcctg cccttggctc tgctagctcc 19140 aggcggacct tgcgaggggg gagcttgggg ttgagttttc tgggactccc gagctgcccc 19200 gcaggtacag gcacttcttt ctgggagata gaatgcgaga aagcccttcc cgctccttgc 19260 gctctcggag aggttttggg agacaaagcc gcgttcccag agccgctgca gcgggtgtgt 19320 tccgtcgacg aagcccgcag cgcgcgcgca catgtctgga cacatgacaa acgcccgccg 19380 ggagggggcc gctgtggccg agtcaagtgc ccaggagggt tagtcaaaac caccatcagt 19440 ttgaggttcg tccttggccc tcttcggcga accgcccacc ctgctttggg tcccatgcaa 19500 gagaggtgcc ggatcaggtc tgcaggctcc ccgctttcgc ccgcgtctgt agttgcaatt 19560 ttttttaatt gatgcttgag acgaaggatg gataagaagc ccttacccgg ctctcaagag 19620 ttataatcct caaagaaata ggggaaagga aggagaattc gtagaggcaa ttccctattt 19680 gcctcatcca atttcagccc atgatcgttc tgaaatgatt ttttgtaaaa ccaaaaaaca 19740 gcagcaacaa caacagcaac aacaaaaaat acactgtctt tggggactat tgatggatag 19800 gggcactcac tttttccctt ctttttcctt atccagggaa ccgaagacgt gtttgcaaat 19860 gtccccggtg agtctctttt gaactcagcc tgctcacctt ggccagccct ggggtggggt 19920 cctggtttcc ccagcagcaa atagtgggaa cttttcccag agagaggtca tggccgtgaa 19980 atcctggggc agggagtcag ccagttcctg agcaaagaga ggccaaggct ggcatctggc 20040 ctgtgtcttt gagaaaaagg aggcccgggt taggcgggtg ccaacagcag tgtgactcca 20100 gtaaatctcc atcttatttg acctggcact tccaaaaaaa aaaaaaaaaa acctgaggga 20160 ttcccccaat ttatcctagc tcctcgtagg acctgacctc ctctttattc tgattattcc 20220 atctgggttt tgttgttttc ttaagaaaac aatttttttt cctacttggc tggtctagtt 20280 ttttgaggga gagccaatct tttatcagct gaaccaaaat aataatggct ttggttgcta 20340 acttctctgt gtcatgtagg accttggttt gctgccaagg actggagtag aaaaaagggg 20400 aacgagatgc agggacaatt ggctatctgg cagctcaagt gactgcctca tccagtttca 20460 gcccatgatc acacacacac acacacacac acacacactc tctctctctc tccctctctg 20520 ttaaaaacct ctctccaccc gttggctgag gcatccctgt ggtagcatct aacaagtgcc 20580 tgctctagtc aggcactgtg ataggggtaa tactccccat ctctcttaat cctcacagca 20640 actttgtgcc atctcatggc tcagggatta gtaaagtggc aaaggcacat taaactcaga 20700 ttatcaatag taataaccat ttgatgaaag cctacaacgc acgttacttg ctttatagat 20760 tttttttaat tttaagtttt atgacaactt ttaaagtagt catgattacc tgcattttac 20820 agataaggaa actgaggctt agaacattta gtgatttgtc caaggtcata ctgcccggga 20880 gctgcaactt ccatccaaag ctcagacacc ttccccatgg ctgcaggctg aagtgttaag 20940 gataaccgac tgtgtacacc agttcttttc agtagatgaa atattttaca ttttatacct 21000 ggagtttgca ttttatactc ctttacattt ttctgaggga atccaagttc aggactttac 21060 acattgttgt ttttagcaat ggaaatgcaa tggatttcca atgcatatgt tacaggtgat 21120 ataccaaggg gataaagact ttgaaaatga gccgggtatt gtggtgcatg cctataatcc 21180 gggctactca ggaggctgag gcaggagaat cgcttgaacg tgggaggcgg aggttgcagt 21240 gagctgagat cgtaccactg cactccagcc tgggtaacag agcaagattc catctcacaa 21300 aaaaaaaaaa aaaaagtggg gggggaagtt tttagctttt cttttctttt cttttctttt 21360 tttttttttt tttttttgag acggagtctc gctatgtcgc ccaggcttga gtgcagtggt 21420 gcgatctcgg ctcactgcaa gctccgcctc ccgggttcac gccattctcc tgcctcaacc 21480 tcccaagtag ctgggactac aggcacccgc cacaacaccc ggctaatttt ttgtattttt 21540 agtagagacg gggtttcacc gtgttagcca ggatggtctc gatctcctga cctcgtgatc 21600 cgcccgcctt ggcctcccaa agtgctggga ttataggcgt gagctaccgc acccggccag 21660 tttttagcat ttttattatt cagggtgcac tttggaactt ttgcagaagg accatccctt 21720 ttctcgatct tttctgaaaa ctctcatttt gagatgaata actgagaata aagttctgcc 21780 ttaaaataca aagctataca gattaaacac acctgggaaa ttccaacacc cgagttaata 21840 tactcagtga tgatggtggg ccgctcagct tcaacagaga ggttttagag ggctgagagt 21900 gcagacatga cgctcatgat gaattagcat gtttacaagg tgctagcctg gtgctgaatt 21960 aacacgtttt tagcgtaaca tcatttggct gatggtggtg atttgctcac atcctcctct 22020 ctccctgtca tcctccgggg ctgagaatca ggtcagctaa tgactttggt tatcagtctc 22080 actctcacac ctctgtggag accttgacag gggctccagg aagctagact aactcggttt 22140 agatcctggc tcagccacct cctagatgtg tgaccttggg caagtttaac ttctcaatct 22200 cagtgcccac ccttaaggct gctgtgagga ttacatgaga tggtgcaagt aaggcattta 22260 gcacgggtgc tgtgctgacg tcattcaccc agtcccatgc tggtgcccca ggaacaggtt 22320 ctcagacctt tcaaaggctg ggggattggg aggctggacg tggctggatg gatgctgcac 22380 tggcggggtt ctggctacaa tgatggtcgc tttcctctct ttcaggcctg tggtcaaatc 22440 gggagacaag cccagccttt cggcgagata cgtctaaccc tgtgcaacag ccactacatt 22500 acttcaaact gagatccttc cttttgaggg agcaagtcct tccctttcat tttttccagt 22560 cttcctccct gtgtattcat tctcatgatt attattttag tgggggcggg gtgggaaaga 22620 ttactttttc tttatgtgtt tgacgggaaa caaaactagg taaaatctac agtacaccac 22680 aagggtcaca atactgttgt gcgcacatcg cggtagggcg tggaaagggg caggccagag 22740 ctacccgcag agttctcaga atcatgctga gagagctgga ggcacccatg ccatctcaac 22800 ctcttccccg cccgttttac aaagggggag gctaaagccc agagacagct tgatcaaagg 22860 cacacagcaa gtcagggttg gagcagtagc tggagggacc ttgtctccca gctcagggct 22920 ctttcctcca caccattcag gtctttcttt ccgaggcccc tgtctcaggg tgaggtgctt 22980 gagtctccaa cggcaaggga acaagtactt cttgatacct gggatactgt gcccagagcc 23040 tcgaggaggt aatgaattaa agaagagaac tgcctttggc agagttctat aatgtaaaca 23100 atatcagact tttttttttt ataatcaagc ctaaaattgt atagacctaa aataaaatga 23160 agtggtgagc ttaaccctgg aaaatgaatc cctctatctc taaagaaaat ctctgtgaaa 23220 cccctatgtg gaggcggaat tgctctccca gcccttgcat tgcagagggg cccatgaaag 23280 aggacaggct acccctttac aaatagaatt tgagcatcag tgaggttaaa ctaaggccct 23340 cttgaatctc tgaatttgag atacaaacat gttcctggga tcactgatga ctttttatac 23400 tttgtaaaga caattgttgg agagcccctc acacagccct ggcctctgct caactagcag 23460 atacagggat gaggcagacc tgactctctt aaggaggctg agagcccaaa ctgctgtccc 23520 aaacatgcac ttccttgctt aaggtatggt acaagcaatg cctgcccatt ggagagaaaa 23580 aacttaagta gataaggaaa taagaaccac tcataattct tcaccttagg aataatctcc 23640 tgttaatatg gtgtacattc ttcctgatta ttttctacac atacatgtaa aatatgtctt 23700 tcttttttaa atagggttgt actatgctgt tatgagtggc tttaatgaat aaacatttgt 23760 agcatcctct ttaatgggta aacagcatcc ga 23792

<400> 41

cttctgtgtg tgcacatgtg taatacatat ctgggatcaa agctatctat ataaagtcct 60 tgattctgtg tgggttcaaa cacatttcaa agcttcagga tcctgaaagg ttttgctcta 120 cttcctgaag acctgaacac cgctcccata aagccatggc ttgccttgga tttcagcggc 180 acaaggctca gctgaacctg gctaccagga cctggccctg cactctcctg ttttttcttc 240 tcttcatccc tgtcttctgc aaaggtgagt gagacttttg gagcatgaag atggaggagg 300 tgtttctcct acctgggttt catttgtttc agcagtcaaa ggcagtgatt tatagcaaag 360 ccagaagtta aaggtaaaac tccaatctgg cttggctggc tctgtattcc agggccagca 420 gggagcagtt gggcggcagc aaataaggca aagagatagc tcagaacaga gcgccaggta 480 tttagtaggg gcttcatgaa tgcatgtgag ttggtttagt agagagacac aggcaatttc 540 agacccttct atgagactgg aagtgattta agagggaaag gatagccata gtcctgaata 600 catttgagct gggtttcagg atgagctcac aagttccttt aaaaaaaatt gacttaagca 660 aatcctggga agagtttttt tgctatacaa ttcaaggttt taaggtcctc ggattcatat 720 actttataaa tgaattagcc agcttgttta aaatgtaggg aaattgtggg aagaatgcct 780 tctttactta attcaaggtt ttaaggttct cttaatcaat tctactagct aattagccaa 840 ttatttaaaa ataaaagttt gaaattgcca aaaaaaaaag acaaggaaaa ggaaagaaag 900 aaagccacca gtctgtttgg catacaatac ttaattgttg cctgacctac gtgtgggttt 960 cagatgcaga tcctcagttt tcagctcttc agagactgac accaggtttg ttacacggct 1020 taaaatgatg agtatatcca ttgaatctca accttatctc tctctagacc ttcttggtta 1080 agaaaccatg tagtttgtat gaagtaggta ctcaaaagat atttgatgat ttaattttta 1140 ctggagaaga aatattcata tatgttttct tatttttaca tgttttaaat atgtaaagat 1200 taaataaaca ctcttagaag tatttaaatt tcctaaagta aatttatctc aaccagtaac 1260 aggaccctcc caatactgga aagttgagtg tgaccgcatt tagtggtgat gagtgtgagc 1320 ttgcttgggg agagggcagg acatttagga tttcttaagc ttagagtcaa tacaataaag 1380 attattgagt gctcacttgg gtgggctata atcactgctc acaggagttc atgaaccaca 1440 agtaaaagag tgaggagata tgattagctc acaaataact ttaatacaga gcagaaagta 1500 atgaactact gcaatggagt tatcacagtg ctaaggatgc tcagagggca tctctgatag 1560 gcagaggtga gggttaggga aggaagctgt agtctagcta gctagagctg ctggaataga 1620 catgacaatg gctgctgcca aactgttttc tcttctgagg acagatgtcc cgtgcaagtg 1680 gcttggtgga agggactagt gtctctaata tagggtgatt tataagcagg aaagtgtgtc 1740 ctagaaattc agaccagagt gatagattgg aattggatca tgggggactc attgaatgtt 1800 atttattgta tttgtttttg cgatcagtgt tagtaaagtg tcaaagggat tgagcagatg 1860 agtgacatca tgcaacacaa gttttgagtt tcacttgtca gactgactgg agaggggcct 1920 ggttagttac aggaaggtaa tttggcatgc agccactatt tttgagttga tgcaagcctc 1980 tctgtatgga gagctggtct cctttatcct gtgggaaaag agaacaaagg agcatgggag 2040 tgttcaaggg aaggagaaat aaagggcaga gaggcagcgg tggtgtcagg ggaagcccac 2100 aggagttaac agcagggttg cctcaaccta gagaggaagc gacctggtgc cctcggctct 2160 gtggcttcct tcatctaaca acatcttcca ctctacaaca atgccaggga aggcggaggc 2220 tggtacagtg catcaagaca cagctactcc tgggtgacag aggttcaggg ccagctcact 2280 aagtaggcag aagtttttga catatacttt gagagataaa gcaagattct gtacctcaac 2340 cttcagaatt tcccctacca ctcattatag ttccggagct atatagctcc tatcattcta 2400 tcataacctt agaataccag agaacatatc atctcatcta attatctctt actatatgtg 2460 aaaaaaatga aggacatggg ggaagtgtga cttgccccaa atcacatatt tcatggtaga 2520 gccaggtctt ctgtttgtca tatcagtgtt cttcctgcca caaccatctt gaagaatcta 2580 tttctcagta agaaaatatc tttatggaga gtagctggaa aacagttgag agatggaggg 2640 gaggctgggg gtgtggagag gggaaggggt aagtgataga ttcgttgaag gggggagaaa 2700 aggccgtggg gatgaagcta gaaggcagaa gggcttgcct gggcttggcc atgaaggagc 2760 atgagttcac tgagttccct ttggcttttc catgctagca atgcacgtgg cccagcctgc 2820 tgtggtactg gccagcagcc gaggcatcgc cagctttgtg tgtgagtatg catctccagg 2880 caaagccact gaggtccggg tgacagtgct tcggcaggct gacagccagg tgactgaagt 2940 ctgtgcggca acctacatga tggggaatga gttgaccttc ctagatgatt ccatctgcac 3000 gggcacctcc agtggaaatc aagtgaacct cactatccaa ggactgaggg ccatggacac 3060 gggactctac atctgcaagg tggagctcat gtacccaccg ccatactacc tgggcatagg 3120 caacggaacc cagatttatg taattggtga gcaaagccat ttcactgagt tgacacctgt 3180 tgcattgcag tcttctatgc acaaaaacag ttttgttcct taatttcagg aggtttactt 3240 ttaggactgt ggacattctc tttaagagtt ctgtaccaca tggtagcctt gcttattgtg 3300 ggtggcaacc ttaatagcat tctgactgta aaataaaatg atttggggaa gttggggctc 3360 tcgctctgga gtgctaacca tcatgacgtt tgatctgtac ttttgatatg atatgatgct 3420 cctggggaag tagtcccaaa tagccaaacc tattggtggg ctacccatgc aatttagggg 3480 tggacctcaa ggcctggaag ctctaatgtc cttttttcac caatgttggg gagtagagcc 3540 ctagagttta aaactgtctc agggaggctc tgctttgttt tctgttgcag atccagaacc 3600 gtgcccagat tctgacttcc tcctctggat ccttgcagca gttagttcgg ggttgttttt 3660 ttatagcttt ctcctcacag ctgtttcttt gagcaaaatg gtgagtgtgg tgctgatggt 3720 gcaccatgtc tgatggggat acctttagtg gtatcaactg gccaaaagat gatgttgagt 3780 ttagtgttct tgagatgaga tgaggcaata aatgaagagg aaggacagtg gtaaagaacg 3840 cactagaacc gtaggcattg gcatttgagg tttcagaatg actaatattt tagatgaatt 3900 tgtttgacat tgaatgttca tgtgcttctg agcagggttt caatttgagt aaccgttgca 3960 ataacatggg gcagctgttt tgctctttgt cttcatgaca actgtactta agctaacagc 4020 cctgaaacat gagattaggc tgggcagaat gctgctagag aggaccactt ggatggtctt 4080 tattctcctt ctccatgtcc ctctccatca cctggaagtc acctctgggt gccactctgg 4140 tgccttcctt gtcgaagctg tagctgctca catgacacct atccctgtta tccagtttgc 4200 ttgactggga cgttttgcct tccccttcag ccaggaagtg aaagtcccag tttttattta 4260 tcacaggtgt tggtattggt ggtagaagag gtagaattat ggaatcaggc ctcctgtcag 4320 gatttctttt tgacagtccc tctcagacac ctctgcctaa ggccagcttt gccattacaa 4380 actctccctt ctccctctct cccttcttct cttcctcttc cttcttctcg ctctttctct 4440 ctctctcttt ctccctctct gtctcttata cacatacaca aagatatact ctattccaac 4500 atcctctacc caacctgaca gagatgtcct ttgctgtagg ttcagcagtg gggatgagaa 4560 atacagctct caaacaggat aactaaagct tattatctta tcaagcttgt tcccttgcag 4620 acaagattga tcaattatca taggctttct gggtgttctt tctgaagctt tctcaaagtc 4680 tctttctcct atcttccatt caaggcaaat gattgccatt taacatcaaa atcacagtta 4740 tttatctaaa ataaatttta atagctgaat caagaaaatc tcctgaggtt tataattctg 4800 tatgctgtga acattcattt ttaaccagct agggacccaa tatgtgttga gttctattat 4860 ggttagaagt ggcttccgta ttcctcagta gtaattactg tttctttttg tgtttgacag 4920 ctaaagaaaa gaagccctct tacaacaggg gtctatgtga aaatgccccc aacagagcca 4980 gaatgtgaaa agcaatttca gccttatttt attcccatca attgagaaac cattatgaag 5040 aagagagtcc atatttcaat ttccaagagc tgaggcaatt ctaacttttt tgctatccag 5100 ctatttttat ttgtttgtgc atttgggggg aattcatctc tctttaatat aaagttggat 5160 gcggaaccca aattacgtgt actacaattt aaagcaaagg agtagaaaga cagagctggg 5220 atgtttctgt cacatcagct ccactttcag tgaaagcatc acttgggatt aatatgggga 5280 tgcagcatta tgatgtgggt caaggaatta agttagggaa tggcacagcc caaagaagga 5340 aaaggcaggg agcgagggag aagactatat tgtacacacc ttatatttac gtatgagacg 5400 tttatagccg aaatgatctt ttcaagttaa attttatgcc ttttatttct taaacaaatg 5460 tatgattaca tcaaggcttc aaaaatactc acatggctat gttttagcca gtgatgctaa 5520 aggttgtatt gcatatatac atatatatat atatatatat atatatatat atatatatat 5580 atatatatat atatatttta atttgatagt attgtgcata gagccacgta tgtttttgtg 5640 tatttgttaa tggtttgaat ataaacacta tatggcagtg tctttccacc ttgggtccca 5700 gggaagtttt gtggaggagc tcaggacact aatacaccag gtagaacaca aggtcatttg 5760 ctaactagct tggaaactgg atgaggtcat agcagtgctt gattgcgtgg aattgtgctg 5820 agttggtgtt gacatgtgct ttggggcttt tacaccagtt cctttcaatg gtttgcaagg 5880 aagccacagc tggtggtatc tgagttgact tgacagaaca ctgtcttgaa gacaatggct 5940 tactccagga gacccacagg tatgaccttc taggaagctc cagttcgatg ggcccaattc 6000 ttacaaacat gtggttaatg ccatggacag aagaaggcag caggtggcag aatggggtgc 6060 atgaaggttt ctgaaaatta acactgcttg tgtttttaac tcaatatttt ccatgaaaat 6120 gcaacaacat gtataatatt tttaattaaa taaaaatctg tggtggtcgt ttt 6173 <400> 42

gagaagatgt ttgaaaaaac tgactctgct aatgaggtga gaggttgaat atgtcaaccc 60 taccaattct ccagtggctg ggtaacttcc agagttaatg tctatcattc tttttgaact 120 ggggcagccc tcatctggaa tttgtttcca agttatacta aggaatgtgt atgttctatt 180 tgttctgagt ctcaaatcaa gggtttggaa gcccccagaa tcattgttgg agcactgtgc 240 catggagcac cttgaagatc cacttccagg taatggagag aggccttggt tgtatagtct 300 gttcagagga ctaaccgttc agaacatttt tctttgatcg aaactttaaa gctcattcga 360 cttaaactgt gaatctgatt tttacttcca tattattcaa tgagaaacag ggaaactaat 420 tagcctgctt gctgcctctt taattcttgt tttctcatta gattcatcct gaccatctct 480 cagtttagtg tagttacagc attaaataaa tttagtggca aaatttgtag ttaattttat 540 agaagtcagg aaatgcagag tatcaaagag taaatttatg taattctatc atcacatgtt 600 gctgctatta ctacttctat tagtttgcta gagcttccat agcacagtaa cacatactga 660 gtgggttgaa taataaagta attgtctatc catcctggag gctagaaatc caagatcagg 720 atgtcagcat ggttggtttc ttctgatgct tccctctttg gcttgtaaat ggctgtcttc 780 tcccttgctc ttcatagggc cttttctctg tgtgtctgtg tccaaatttt ctcttcttat 840 aaggacacca gtcatattgg attagggccc atcctgatga tctcatttta acttaattgc 900 ctctttaaaa accctgtctc caaatacagt attattctaa gatactagag gttaggactt 960 gaacagatga tttgggtggt ggaaggacac aatttaaccc agaacattac tttagtgtat 1020 attttttgtt attgttatta ttatacttta agttctgggg tacatgtgca caatgtgcag 1080 gtttcataca taggtataca tgtgccgtgt tggtgtgctg cacccattaa ctcatcattt 1140 acgttaggta tttctcctaa tgctatacct caccactccc ccaaccccac gacaggcccc 1200 agtttgtgat gttccccatc ctgtgtccaa gtgttctcat agtttaattc ccacctatga 1260 gtgagaacat gtggtgtttg gttttctgtc ctcgtgatag tttgctgaga atgatggttt 1320 ccaccttcac ccatgtccct gaaaaggaca tgaactcatc cttttttatg gctattccat 1380 atacaccatg gtattccatg gtgtatatgt gccacatttt cttaattcag tctatcactg 1440 atggacattt gggtcggttc caagtctttg ctattgtgaa cagtgccaca ataaagcatg 1500 tgtctttata gtagcctgat ttataatcct ttgggcatat acccagtgat gggatcgctg 1560 ggtctaatgg tatttctagt tctagattct tgaggaattg ccacactgtc ttccacaatg 1620 gttgaactaa tttacactcc caccaacagt gtaaaagcat tcctatttct ccacatcctc 1680 tccagcatct gttgtttcct gacttttttt tttttttgag acggagtctc actctattgc 1740 ccaggctgga gtgcagtggc acaatctcag cccactccaa gctccgcctc ctgggttcac 1800 aggattctcc tgcctcagcc tcctgagtag ctgggactac aggtgcccac caccaggcca 1860 agctaatttt attgtctttt tagtagagtc ggggttttac catgttagcc aggatggcct 1920 ccatctcctg accttgtgat ccacccaact cagcctccca aaatgctggg attacaggca 1980 tgagccacca cacctggcct gtttcctgac tttttaacta tttccattct aactggtgtg 2040 agatggtatc tctttttttt ttttttttat actttaagtt ttagggtaca tgtgcacaat 2100 gtgcaggtta gttacatatg tatacatgtg acatactggt gtgctgcaac cactaactcg 2160 tcatctagca ttaggtatat ctcccagtgc tatcgctccc cactaccccc accccacaac 2220 agtccccaga gtgtgatgtt ccccttcctg tgtccatgtg ttctcattgt tcaattccca 2280 cctatgagcg agaatatgtg gtgtttggtt ttttgttctt gcaatagttt actgagaatg 2340 atgatttcca atttcatcca tgtccctaca aaggacatga actcatcatt ttttatggct 2400 gcatagtatt ccatggtgta tatgtgccac attttcttaa tccagtctgt cattgttgga 2460 catttgggtt ggttccaagt ctttgctatt gtgaatagtg ctgcaataaa catatgtgtg 2520 catgtgtctt tatagcagca tgatttatag tcctttgggt atatacccag taatgggatg 2580 gctgggtcaa atggtatttc tagttctaga tccctgagga atcaccacac tgacttccac 2640 aatggttgaa ctagtttaca gtcccaccaa cagtgtaaaa gtgttcctat ttctccacat 2700 cctctccagc acctgttgtt tcctgacttt ttaatgattg ccattctaac tggtgtgaga 2760 tgatatctca ttgtggtttt gatttgcatt tctctgatgg ccagtgatgg tgagcatttt 2820 ttcatgtgtt ttttggctgc ataaatgtct tcttttgaga agtgtctgtt catgtccttc 2880 gcccactttt tgatggggtt gtttgttttt ttcttgtaaa tttgtttgag ttcattgtag 2940 attctggata ttagcccttt gtcagatgag taagttgcga aaattttctc ccattttgtg 3000 ggatgcctgt tcactctgat ggtagtttct tttgctgtgc agaagctctt tagtttaatt 3060 agatcccatt tgtcaatttt ggcttttgtt gccattgctt ttggtgtttt agacatgaag 3120 tccttacccg tgcctatgtc ctgaatggta atgtctaggt tttcttctag gatttttatg 3180 gttttaggtc taacgtttaa gtctttaatc catcttgaat tgatttttgt ataaggtgta 3240 aggaagggat ccagtttcag ctttctacat atggctagcc agttttccca gcaccattta 3300 ttaaataggg aatcctttcc ccattgcttg tttttgtcag gtttgtcaaa gatcagatgg 3360 ttgtagatat gcggagttat ttctgagggc tctgttctgt tccattgatc tatatctctg 3420 ttttagtacc agtgccatgc tgttttggtt actgtagcct tgtagtatag tttgaagtca 3480 ggtagcgtga tgcctccagc tttgttcttt tggcttagga ttgacatggc gatgtgggct 3540 cttttttggt tccatatgaa ctttaaagta gttttttcca attctgtgaa gaaagtcatt 3600 ggtagcttga tggggatggc attgaatcta taaattacct tgggcagtat ggccattttc 3660 acgatattga ttcttcctac ccatgagcat ggaaggttct ttcatttgtt tgtatcctct 3720 tttatttcat tgagcagtgg tttgtagttc tccttgagga ggtccttcac atcccttata 3780 aggtggattc ctaggtattt tattctcttt gaagcaattg tgaatgggag ttcactcatg 3840 atttggctct ctgtttgtct gttattggtg tataagaatg cttgtgattt ttgcacattg 3900 attttgtatc ctgagacttt gctgaagttg cttatcagct taagaagatt ttgggctgag 3960 acattgggat tttctagata taccatcatg tcatctgcca acagggacaa tttgacttcc 4020 tcttttccta actgaatacc ctttatttcc ttctcctgac taattgccct ggccagaact 4080 tccaacacta tgttgaatgg gagtggtgag agagggcatc tctgtcttgc accagttttc 4140 aaagggaatg cttccagttt ttgcacattc agtatgatat tgactgtggg tttgtcatag 4200 atagctctta ttgttttgag atatgtccct tgagtaccta atttattgag agtttttagc 4260 gtgaagtgct gttgaatttt gtcaaaggcc ttttctgcat ctattgagat aatcatgtgg 4320 ttttcgtctt tggttctgtt tatatgctgg attacattta ttgatttgca tatatcgaac 4380 cagacttgca tcccagagat gaagcccact tgatcatggt ggataagctt tttgatgtgc 4440 tgctggattc agtttgccag ttttttattg aggatttttg catcaatgtt catcaaggat 4500 attggtctaa aattctcttt tttggttgtg tctctgcccg gctttggtgt caggatgatg 4560 ctggcctcat aaatgagtta gggaggattc cctctttttc tattgattgg aatagtttca 4620 gaaggaatgg taccagttcc tccttgtacc tctggtagaa ttcggctgtg aatccatctg 4680 gtcctggact ccttttagtg ggtaagctat tgattattgc cacaatttca gctcctgtta 4740 ttggtctatt cagagattca acttcttcct ggtttagtct tgggagagtg tatgtgtgga 4800 ggaatttatc catttcttct agattttcta gtttatttgc atagaggtgt ttgtagtatt 4860 ctctgatggt agtttgtatt tctgtgggat cagtggtgat atccccttta tcatttttta 4920 ttgtgtctat ttgattcttc tctctttttt ttctttatta gtctagctag tggtctatca 4980 attttgttga tccattcaaa aaaccagctc ctggattcat taattttttg aagggttttt 5040 gtgtctctat ttccttcagt tctgctctga tcttagttat ttcttacctt ctgctagctt 5100 ttgaatgtgt ttgcacttgc ttttctactt cttttaattt gatgttaggg tgtcaatttt 5160 ggatctttcc tgctttctct tgtgggcatt tagtgctata aatttccctc tacacactgc 5220 tttgaatgtg tcccagagat tctggtatct tgtgtctttg ttctcgttgg tttcaaagaa 5280 catctttatt tctgccttca ttttgttatg tacccagtag tcattcagga gcaggttgtt 5340 cattttccat atagttgagt ggttttgagt gagtttctta atcctgagtt ctagtttgat 5400 tgcactgtgg tctgagagat agtttgttat aatgtctgtt cttttacatt tgctgaggag 5460 agctttactt ccaactatgt ggtcaatttt ggaataggtg tggtgtggtg ctgaaaaaaa 5520 tgtatattct gttgatttga ggtggagagt tctgtagatg tctgttaggt ccacttggtg 5580 cagagctgag ttcaattcct gggtatcctt gttgactttc tgtctcattg atctgtctaa 5640 tgttgacagt ggggtgttaa agtctcccat tattaatgtg tgggagtcta agtctctttg 5700 taggtcactc agggcttgct ttatgaatct gggtgctcct gtattgggtg catatatatt 5760 taggatagtt agttcttctt gttgaattga tccctttacc actatgtaat ggccttcttt 5820 gtctcttttg atctttgttg gtttaaagtc tgttttacca gagactagga ttgcagcccc 5880 tgcctttttt tgttttccat ttgcttggta gatcttcctc catcccttta ttttgagcct 5940 atgtgtgtct ctgcatgtga gatgggtttc ccgaatacaa cacactgatg ggtcttgact 6000 ctttatccaa tttgccagtc tgtgtctttt aattggagca ttgagtccat ttacatttaa 6060 agttaatatt gttatgtgtg aatttgaacc agtcattatg atgtcagctg gttattttgc 6120 tcgtcagttg atgcagtttc tttttagtct caatggtctt tacattttgg catgattttg 6180 cagcggctgg taccggttgt tcctttccac gtttagtgct tccttcagga gctctttaag 6240 ggcaggcctg gtggtgacat ttgcttgtct gtaaaggatt ttatttctcc ttcatttatg 6300 aagcttagtt tggctggaga tgaaattctg ggttgaaaat tcttttcttt aagaatggtg 6360 aatattggcc cccactctct tctggcttgt agagtttctg ctgagagatc cgctgttagt 6420 ctgatgggct tccctttgtg ggtaacccga cctttctctc tggctgccct taacattttt 6480 tccttcattt caactttggt aaatctgaca attctgtgtc ttggagttgc tgttctggag 6540 gagtatcttt gtggcgttct ctgtatttcc ctaatctgaa tgttggcctg ccttgctaga 6600 ttggggaagt tctcctggat aatatcctgc agagtgtttt ccaacttggt tccattctcc 6660 ctgtcacttt caggtacacc aatgagatgt agatttggtc ttttcacata gtcccatatt 6720 tcttggaggc tttgttcatt tctttttatt cttttttctc taaacttccc ttcttgcttc 6780 atttcattca tttcatcttc cattgctgat accctttctt ccagttgatc gcatcagctc 6840 ctgaggcttc tgcattcttc acgtcgttct cgagccttgg ctttcagctt catcagctcc 6900 tttaagcact tctctatatt ggttattcta gttatacatt cgtctaaatt tttttctaag 6960 tttttaactt ctttgccttt ggtttgaatt tcctcctgta gctcatagtt tgattgtctg 7020 aagccttctt ctctcaactc ttcaaagtca ttctccatcc agctttgttc cattgctggt 7080 gaggaactgc gatcctttgg agaaggagag gtgctctgct ttttagagtt tccagtgttt 7140 ctgctctgtt ttttccccat ctttgtggtt ttatctagtt ttggactttg atgatggtga 7200 tgtacagata ggtttttggt gtggatgtcc tttctgtttg ttagttttcc ttctaacaga 7260 gaggaccctc agctgcaagt ctgttggagt ttgctagagg tccactccag atcctgtttg 7320 cctgggtatc agcagcggtg tctgcagagc agtggttttt tgtgaaccgt gaatgctgct 7380 gtctgatcgt tcctctggaa gttttgtctc agaggagtac ctggccatgt gaggtgtcag 7440 tctgccccta ctgggggatg cctcccagtt aggctgctca ggggtcaggg gtcagggacc 7500 cacttgaggc agtctgcccg ttctcagatc tccagctgcg tgctgggaga accactgttc 7560 tcttcaaagc tcagatggaa atgcagaaat cacccgtctt ctgcgtcact cacgctggga 7620 gctgtagacc ggagctgttc ctattcggcc atcttggctc ctcccccatg agatggtatc 7680 tcattgtggt ttgatgtgca tttctctgat gaccagtgat gatgagcatt ttttcatgtg 7740 tctgttggct gcataaatgt cctcttttga gaagtgtctg ttcatatcct ttgcctactt 7800 tttgatgggg ttgttttttt ctcatgaatt tgtttgagtt ctttgtagat tctggatatt 7860 agccctttgt cagatgggtc aattgcaaaa gttttctccc attctgtagg ttgcctgttc 7920 actgtgatgg tagtttcttt tgctgtgcag aagatcttta gtttaattag atctcatttg 7980 tcaattttgg cttttgttgt cattgctttt ggtgttttag acatcaagtc cttgcccatg 8040 cctatgtcct gaatggtatt gcctaggttt tcttctagga tttttatgat tttaggtcta 8100 acatttaagt ctttaatcca tcttgaatta attttcgtat aaggtgtaag gaagggatcc 8160 agtttcagct ttctacatat ggctagccag ttttcccagc accatttatt aaatagggaa 8220 tgctttctcc atttcttgtt tttgtcaggt ttgtcaaaga tcagatggtt gtagatgtgt 8280 ggtgttattt ctgagggctc tgttctgttc cattggtcta tatctctgtt ttggtaccag 8340 taccatgctg ttttggatac tgtagccttg tagtatagtt tgaggtcagg tagcgtgatg 8400 cctccagctt cattcttttg gcttaggatt gtcttggcaa tgcgggctct tttttggttc 8460 catatgaact ttaaagtagt tttttccaat tctgtgaaga aagtcattgg tagcttgatg 8520 gggatggcat tgaacctata aattaccttg ggcaatatga ccattttcaa gatattgatt 8580 cttcctaccc atgagcatgg aatgttcttc catttgtttg tgtcctcttt tatttccttg 8640 agcagtggtt tgtagttctc cttgaagagg tccttcacat cccttgtaag ttggattcct 8700 aggtactgta ttctttttgc agcaattgtg aatgggagtt cactcatcat ttggctctct 8760 gtttgtctgc tattggtgta tagaaatgct tgtgattttt gcacattgat tttgtatcct 8820 gagactttgc tgaagttgct tatcagctta aggagatttt gggctgagac aatggggttt 8880 tctaaatata caatcatatc atcctcaaac agggacaatg tgacttcctc ttttcctaat 8940 tgaatacact ttatttcttt ctcttgcctg attgtcctgg ccagaacttc caacattatg 9000 ttgaatagga gtggtgagag agggcatctc tgtcttgtgc cagttttcaa agagaatgct 9060 tccagttttt gcccattcag tatgatattg gttgtgagtt tgtcataaat agctcttatt 9120 attttgagat gtgttccatc aatatctagt ttattgagag tttttaagaa aaagtgctgt 9180 cgaattttct tgaaggcctt ttctgcatcc attgagataa tcatgtggtt ttttgtcact 9240 ggttctgtgt atgtgatgga ttatgtttat tgatttgcgt atgttgaacc agccttgcat 9300 cccagggatg aagccaactt gatcgtgttg ggtaagattt ttgatgtgct gctggatttg 9360 gtttgccagt attttattga ggattttcac acgggtgttc atcagggata ttggactaaa 9420 attctctttt tttgttgtgt ctctgccagg ctttggtatc aggatgatgc tggcctcata 9480 aatgagttag ggaggactcc ctctttttct attgattgta atgattccag aaggaatggt 9540 accagctcct ctttgtacct ctggtagaat tcagctgtga atccatctgg tcctggactt 9600 tttttggttg gtaggctatt aattattgcc tcaatttcag agactgttat tggtctattc 9660 agagattcaa cttcttcctg gtttagtctt gggagggtgt atgtgtccag gaatttatcc 9720 atttcttcta agttttctgg tttatttgtg tagaggtgtt tatagtattc tctgatggta 9780 gtttgtattt ctgtgggatc ggtggtgata tcccctttat cattttttat tgtgtctatt 9840 tgtttcttct ttcttttctc tttattagtc ttgctagtgg tttctcaatt ttgttgatct 9900 tttaaaaaaa acagctcctg gattcattga ttttttgaag ggtatttttg tctctctttc 9960 aattcttctc tgatcttagt tatttcttgc cttctgctag cttttgaatt tgtttgctct 10020 tgcttctcta gtttttttaa ttgtgatgtt aggatgtcaa ttttagatct ttccagcttt 10080 ctcttgtggg catttagtgc tataaatttt cctctacaca ctgctttaaa tgtgtcccag 10140 agattctggt acattttgtc tttgttctta tggtttcaaa gaacatcttt atttctgcct 10200 tcattttgtt atttacccag tagtcattca ggaacaggtt gttcagtttc catgtagttg 10260 tgcagttttg agtgaatttc ttaatcctga gttctaattt gattgcactg tggtctgaga 10320 gatggtttgt tgtgatttct gttctttcac atttgctgag gagtgcttta cttccaacta 10380 tgtggtcaat tttggtataa gggcaatgtg gtgctgagaa gaaagtgttt tctgttgatt 10440 tggggtggag agttctgtag atgtctatta ggtctgcttg gtgcagagcc gagttcaatt 10500 cctggatatc tgtctaatat tgacagtggg gtgttaaagt cttccatcat tattttgtgg 10560 gagtctaagt ctctttgtag gtctctaagg acttgcttta tgaatctggg tgctcctgta 10620 ttgggtgcat atatatattt gggatattta gctcttcttg ttgaattgat cccttatcca 10680 ttatgtaatg gccttctttg tctcttttgc tctttatttg tttaaagtct gttttatcag 10740 agactaggac tgcaacccct gctttttttt tttttttttt tttttttttt ttgctttcca 10800 tttgcttgct agatcttcct ccaatccttt atttttgagc ttatgtgtgt ctctgcatgt 10860 gagatgggtc tgctgaatac agcacactaa tgggtcttgt ttctttatcc aatttatcag 10920 tttgtgtgtt ttaattgggg catttagccc atttagattt aaggttaata ttgttatgtg 10980 tgaatttgat cctgtcatta tgatgttagc tggctatttt gcccgtttat tgatacaatt 11040 tcttcatagc atcgatggtc tttactattt ggcatgattt gcagtggctt ctaccagttg 11100 tttctttaca tgtttagtgc ttccttcagg aactcttgta aggcaggcct ggtggtgaca 11160 aaatctctca gcatttgctt atctgtaaag gattttattt ctcctttgct tatgaatctt 11220 agtttggctg gatattaaat tctaggttga aaattctttt ctttaagaat gttgaatatt 11280 ggcccccact ctcttctggc ttgtagagtt tctgctgaga gatcaactgt tagtctgatg 11340 ggcttccctt tgtgggtaac ccgacctttc tctctggctg cccttaacat tttttccatc 11400 atttcaacct tggtgaatct gacaattatt tgtcttgggg ttgcttttct caaggaatat 11460 ctttgtggtg ttgtctgtat ttcaggaatt tgaatgttgg cctgccttgc tatgttgggg 11520 aagttctcct ggataatatc ctgaagagtg ttttccaact tggttccatt ctcccgatca 11580 ctttcaggta caccaatcaa atgtagattt ggtcttttca tagagtcgca tatttcttgg 11640 aggcttcgtt catttctttt tactcttttt ttctctaacc ttgtcttctc actttatttc 11700 attaatttga tcttcagtga ctgatactct ttcttccact tgatcaaatc agctactgaa 11760 gcttgtgcat gcatcacgaa gttctcgtgc catggttttc agctccatca ggtcatttaa 11820 tgtcttctct acactgttta ttctacttag ccatttgtct aacttttttc acggttttca 11880 gcttccttgt gatgggttag aacatgctcc tttagcttgg agaagtttgt tattaccgat 11940 ttctgaagcc tacttctgtc aactcatcaa agtcattctc tgtccagctt tgttccattg 12000 ctggcaagga cctgcaaacc tttggaggag aagaggtcct ctggttttta gaattttcag 12060 cttttctgct ctggtttctc cccatctttg tggctttacc taccttggtc tttgatgttg 12120 gtgacctaca gatggggttt tggtgtagat gtccttttgt tgatgttgat gctattcctt 12180 tctgtttgtt agttttcctt ctaacagtca ggtccctcag ctgcagatct gttggagttt 12240 gctggaggtc cactccagac cctgttttcc tgggtatctc cagtggaggc tgcagaacag 12300 caaatattgc agaacagcaa atattgctgc ctgatccttc ctctggaagc tttatcccag 12360 aggggcacct gcctatatga ggtgtcagtt ggctcctact gggagatgtc tcccagttag 12420 gctacatggg gttcagggac ccacttgagg aggtagtctg tccattctca gagctcaaat 12480 gccatgctgg gagaacccct tctctcttca gagaaggcag accaggatgt ttaagtctgc 12540 agaagtttct gctgcctttt gttcagctat cccctgccta cagaggtgga gtctatagag 12600 gcagtaggcc ttgctgagct gtggtgggct ccacccaggt cgagcttccc agccactttg 12660 tttacctact caagcctcag caatggcaga tgcccctctc ccagccaggc tgccacctca 12720 cagttcgatc tcaggctgtt gcactttctc catgggcatg ggacctgcca agccaggcat 12780 gggagagaat cttcttgtct gccggtggct aagacctcgg gaaaagttca gtatttgggc 12840 tggagtgtcc tgttattcca ggtacagtct gttgcagctt cccttggcta ggaaagggaa 12900 atcccctgtc cccttgcact tcccgggtga ggctatgtcc caccctgctt cagctcaccc 12960 tctgtgggct gcatccactg tccaaccagt cccagtgaga tgaaccaggt acctcagttg 13020 gaaatgcaga agtcccctgt cttctgcatt gatagtgctg ggagctgcag actggagctg 13080 ttcctattca gccatcttgg aacagagcac cactttagtg tatattctta tatacctcaa 13140 tcatacacaa atatttttac tttacaaaat tagaccatgc atcagattat gctatggttt 13200 gaatgtatat gacaaaattc acatgttgga agcttaatcc ccaatgcaac agtgttgggt 13260 ggtgaggcct aataagtggt gaatggatta gtgtagttat cacaggagtg ggtcagttat 13320 ctctagagca gcactctctc ccccatgtgc tctcttctgc cttccattat aggatgatgc 13380 agcacaaagg cttttctctg atgctggcca catgttcttg gacttcccag cctccagaac 13440 13500 13560 13620 13680 13740 13800 13860 13920 13980 14040 14100 14160 14220 14280 14340 14400 14460 14520 14580 14640 14700 14760 14820 14880 14940 15000 15060 15120 15180 15240 15300 15360 15420 15480 15540 15600 15660 15720 15780 15840 15900 15960 16020 16080 16140 16200 16260 16320 16380 16440 16500 16560 16620 16680 16740 16800 16860 16920 16980 17040 17100 17160 17220 17280 17340 17400 17460 17520 17580 17640 17700 17760 17820 17880 17940 18000 18060 18120 tctagttttc acccattcag tatgatattg gttgtgagtt tgtcataaat agctctcatt 18180 attttgagat acgctccatc 33t3CCt33t ttattgagag tttttagcat gaagcgttgt 18240 tgaattttgt caaaggcctt tcttgcatct attgagataa tcatatggtt tttgtcattg 18300 gttcttttta tatgctggat tacgtttatt gatttgcata tgttgaacca gccttgcatc 18360 ccaggaatga agcccacttg atcatggtgg ataagcttct tgatgtgctt ctggattcag 18420 tttgccagta ttttattgag gatttttgca tcgatgttca tcagggatat tggtctaaaa 18480 ttctcttttt ttgttgtgtc tctgccaggc tttggtgtca ggatgatgct ggcttcataa 18540 aatgagttaa ggaggattcc ctctttttct attgattgga atagtttcgg aaggaatggt 18600 accagctcct ccttgtacct ctggtagaac tcggctgtga atccatctgg tcctggactt 18660 tttttggttg gtaagctatt aattattgca tcaatttcag agcctgttat tgtctattca 18720 gagattcaat ttcttcctgg tttagtcttg tgagggtgta tgtgttcagg aatttatcca 18780 tttcgtctag attttctagt ttatttcata gaggtgttta tagtattctc tgatggtagt 18840 ttgtatttct gtgggattgg tggtgatatc ccctttaaca ttttttattg catctatttg 18900 attcttctct cttttcttct ttattagtat tgctaatggt ctgtcagttt tgttgatctt 18960 ttC3.3.SSSSC cagctcctgg attcattgat tttttgaagg gttttttgtg tctctatttc 19020 cttcagttct gctctgatct tagttatttc ttgccttctg ctagcttttg tatgtgtttg 19080 ttcttgcttc tctagttctt ttaattgtga tgttagggtg tcaattttgg atctttcctg 19140 ctttctcttg tgggcattta gtgctataaa tttccctcta cacactgctt tgaatgtgtc 19200 ccagagattc tggtatcttg tgtctttgtt ctcgttggtt tcaaagaaca tccttatttc 19260 tgccttcatt tcgttatgta cccagtagtc attcaggagc aatttgttca gtttccatgt 19320 atttgagtgt ttttgagtga gtttctttat tattattatt attattatta ttattattat 19380 cattattata ctttaagttt tagggtacat gtgcacaacg tgctggtttg ttacatatgt 19440 atacatgtgc caagttggtg tgctgcaccc attaactcat cttttagcat taggtatatc 19500 tcctaatgct atccctcccc cctcccccca ccccactaca gtccctggtg tgtagtgttc 19560 cccttcctgt gtccatgtgt tctcattgtt caattcctgt gagtgagaac atgcggtgtt 19620 tggtgggttc tagtttgatt gcactgtggt ctgagagaca gtttgttata atttctgttc 19680 ttctacattt gctgaggagt gctttacttc caactatatg ctcaattttg gaataggtgt 19740 ggtgtgatgc tgaaaagaat gtatattctg ttgatttggg atggagagtt ctgtaggtgt 19800 ctattaggtc cacttggtgc agagctgaga tcaattcctg gatatccttg ttaactttct 19860 gtctcattga tctgtctaat ggtgacagtg gggtattaaa gtctcccatt attattgtgt 19920 gggagtctaa gtctctttct aggtctctaa ggacttgctt tgtgaatctg ggtgctcctg 19980 tattgggtga atatatattt aggatagtta gctcttcttg ttgaattgat ccctttacca 20040 ttatgtaatg gccttctttg tctcttttga tctttgttgg tttaaagtct gttttaccag 20100 agactaggat tgcaacccct gccttttttg ttttccattt gcttggtaga tcttcctcca 20160 tccctttatt ttgagcctat gtgtgtctct ggtacgtgag atgggtttcc tgaatacagc 20220 acactgacgc gtcttgactc tttatccaat ttgccagtct gtgtctttta attggagcat 20280 ttagcccatt tacatttaag gttaatattg ttatgtgtga atttgatgct atcattatga 20340 tgttagctgg ttattttgct tgttagttga tgcagtttct tcctagcctc aatggtcttt 20400 acaatttggc atgtttttgc agtggctggt accagttgtt cctttccatg tttagtgctt 20460 ccttcagtag ctcttttagg gcaggcctgg tggtgacaaa atctctcagc atttgcttgt 20520 ctgtaaagta ttttatttct ccttcactta tgaagcttag tttggctgga gatgaaattc 20580 tgagttgaaa attcttttct ttaagaatgt tgaatattgg ccccactctc ttctggctta 20640 tagaatttct gccgagaaat cagctgttag tctgatgggc ttccctttgt gggtaacctg 20700 acctttctct ctggctgccc ttaacatttt ttccttcatt tcaactttgg tgaatctgac 20760 aattctgtat cttggagttg ctgttctcga ggagtatctt tgtggcgttc tccgtatttc 20820 ctgaatttga atgttggcct gccttgctag attggggaaa ttctcctgga taatatcctg 20880 tagagtgttt tccaacttgg ttccattctc cccgtcactt tcaggtacac caatcagacg 20940 tagatttgat cttttcacgt agtcccatat ttcttggatg ctttgttcat ttctttttat 21000 tcttttttct ctgaacttct cttttggctt catttcactc atttcatctt ccatcactga 21060 taccctttct tccagtcaat caagtcggct actgaggctt gtgtattcat catgtagttc 21120 tcatgccttg gttttcagct cctttaagga gttctctgca ttgattattc tagtttgcca 21180 ttcatctaat ttttttttag gtttttaact tctttgccat gggtttgaac ttcctccttt 21240 agctcagagt agtttgatcg tctgaagtct tcttctctca aatcatcatg gtcattctcc 21300 atccagcttt gctccatttc tggtgaggag ctgtgttcct ttggaggagg agaggtgctc 21360 tgatttttag tttccagttt ttctgctctg ttttttcccc atctttgtgg ttttatctac 21420 ctttggtctt tgatgatggt gaagtacaga tggggttttg gtgtggatgt cctttgtgtt 21480 tgttagtttt ccttctaaca gtcaggaccc tcagctgcag gtctgttgga gtttgctgga 21540 ggtctacgcc agaccctgtt tgcctgggta tcagcagcag aggctgcaca acagcagata 21600 ttggtgaaca gcagatgttg ctgcctgatc gttcctctgg aagttttgtc tcagaggagt 21660 acccggccat gtgaggtgtc agtctgcccc tactgggagg tgcctcccag ttaggctact 21720 caggggtcag ggacccactt gaggaggcag tctgtccatt ctcagatgtc cagctccatg 21780 ctgggagaac cactactgtc ttcaaggcta tcagacaggg acatttaagt ctgtagagga 21840 ttctgctgcc ttttgtttgg ctgtgccctg cccccagagg tggagtctat agcggtaggc 21900 aggcctcctt gagctgtggt gggctccact cagttcgagc taccaggccg ctttgtttac 21960 ctactcaagc ctcagcaatg gcgggcaccc ctcccccagc ctcgctgcca ccttgcagtt 22020 tgatctcaga ctgctgtgct agccatgagc aagggcccat gggcatagga ccctctgagc 22080 catgcacggg atataatctc ctggtgtgcc atttgctaag acctttggaa aagtgcagta 22140 ttagggtgag agtgacccaa ttttccaagt gccatctgtc acccctttct ttgattagga 22200 aagggaattc cctgacccct tgcacttccc aggtgaggca atgtgctgcc ctgctttggc 22260 tcatgcttgg tgcactgcac cctctgtcct gcacccactt tccgacactc cccagtgaga 22320 tgaacctggt acctcagttg gaaatgcaga aatcacccgt cttctgcgtt gctcatgctg 22380 ggagctgtag actggagttg ttcctattcg accatcttgg ttccacctgg cagtttctta 22440

3-3-3-3-03-3-3-3-3- caaaagacat gcaactacca tatgacctag caattgcact cctgggcatt 22500 catcccacat gaacactatg ttC3C3C333 aacctgcaca tggatgtttc taatagcttc 22560 atttgtaaca gtacaaacct ggaaacaatc cagttgttct ttaactgatg aatggctaaa 22620 caatggcaca tcatacatga aatactaccc 3C]^~333t3333 cgaccaaatt attgatatac 22680 tcaacaacct ggataaatct ccagagaatt atgctgagtg 333t333C33 tttaaacatc 22740 ttacatattg tgtgattcca cttatgtgtc attgggagaa acagtgaaat gcacatgaga 22800 tctcttaata ctttcttaat aattgtcaga tctctttctg ggtattattt cagttgaata 22860 tgaatctaca atgatctaaa aataaagttt 33tttt3333 tacacctctg agaacagtgt 22920 ttgtgttggg atcaatttca aacaggtgat acacagcaga agtccattta gtgcaggcct 22980 caggtgtgcc acttaatctc tcatctcctg ccttcacacc tgcaaaatgt tggggttgga 23040 ccataaagaa gcttcaggac ctcctctttg cttctacaat tccatgacct tactgagcta 23100 tacacatttg tggaaccttt gttttggcct tatatttatc agagaccctc tgaaaatctt 23160 tatggaaaca gcagtaacta cctttctggc 3tt3C33C33 aagaagtaaa ttctgccttc 23220 caccctcctg aaaactgctt tgcatgctac agcaagatta ctggaattac aaaaggagaa 23280 acaccaagca tggctttttc atggctaaaa tgatccccaa attcacagtg tcctcacaat 23340 gtcctcttcc acaaagaagg aacttcttcc agacacacac aatttgatca agttaatagt 23400 ttctt3.3-3.3-3- tattcagatc tcttttttag aaactggggg aagaactggg ggcctttagg 23460 aactctgttt tgcattcaat attcaatcat tcattcattc atttatactg taagccctgg 23520 aggtgccctc agttgtgaca tacttctttc ttgacatttt tataaattct tcaatgtatt 23580 ccttccctta taggcgtacc ctttccagtt gagccatgct tgtatataca aacttagtcc 23640 tcaaatctca atcttgcgac ccattgtatt ttccaaagat gactgcaaaa tcattctcat 23700 cccacatgct gttcttacaa tgcaactttg acattcttac catgaagtga tggagactat 23760 gtttcctccc cttgaatctg agcagagcta atagcacatg ttggaagtga catatgcaac 23820 ttccaaagat agggcataaa aattccatgt gcatccacct gcttcttggt gatactcact 23880 attggaaccc agctgccatg ctacgaggaa gcccaaactc acccaattta ccaaggtaag 23940 gaggctacat ggagaggcta gccatagatg ttttgaccaa ccactcagct gaagtctcag 24000

CC33C333t3 actagatcag ctgatagaca ttcaagtgaa tgtgccttta gataacttca 24060 gctcccagat gtaaagccac cttcagcatt tgagtgccag ataagattct aaacattgta 24120 gagacaagcc atcctcacta tgctgtctga attcctgtcc cacaaaagtt gggtgtggaa 24180 ttgatcataa t3333tt3tt attttatacc 3Ct333ttt3 gaatactttg ttgagcagta 24240 atagataact atgattatac ttgatagaat 333C3CCCt3 acctcactcc cctccctctc 24300 tcaatcttct gctggtgctc cccattggcc 333CCC33Ct ggaatccaga aagaaaggaa 24360 gcccagtgat gtaacccata taagtcagct tttgggggca ggaaatagag tggagtgtgg 24420 agctggcaaa actggcagat atccagtgta gtttacactc tgccttattt cattgacgat 24480 gtaaagtaga tggcatgaaa gttgaaatgc ctaaattttg atcattatgg 33t333t33t 24540

333t3CC33t catttaatca tccttttcag ataaatctgt gaaatgaggt gttccgaagc 24600 atagttaact tttaacttcc cttttgggtg tggctccatc atgaagaaga agcagagttt 24660 aatcactaag agtataggtt ctggagccag tctgcctggg ttcaaatcct ggctctgcta 24720 ccaaccagct gtataaattt gggtagctcc cttatcctct ctgtgtttca cttccctcat 24780 ctgtaaggag ggataaaaat attgcctccc ttataaattt gttgtggaga tcaaattagt 24840 taataaagat 3333C3ttt3 gcatggtgct gggtaagagt 333t3CtCC3 taagcattag 24900 ccattattat aacacctaga agaagattac aaggtgcaaa gtgtggcaaa gaaacaagag 24960 gaaaagtggc 3333t3tctt tctttttggc tttattttct tctgaaaaat agcaatagct 25020 gattcaacta tctctgatgc ttagaaattc tttaaaaaga atgactttat caggatagaa 25080 aaaggttcaa gagtgagtac agtaggtaag aaggaaaaaa agctatctca tttttttatg 25140 aactagaggt gtgatctgtt gagttctcat gaaccagtga gacattatta gagcatatta 25200 tctttgaagt aggtctatta ctttggtctt ctcttcccag cttccattca 33333tt333 25260 atccaagaca atggttctat 333C33CCtC tagataaata ctattagtag caatgacatt 25320 caaggagaaa ataaaagaca tattcaaatt gtgttatgaa gagtttatta aacggaatat 25380 tt3t33333C atgagcaagg cataaagaaa gaaactgcaa gggatagttt attactctgg 25440 gactggcagc tataagagta ctactgcaac ccctagacct gaaggtacaa gagtacagag 25500 tcattggcta aacctggagg gaaagctgta tgaacacgac tgcagagagg agctgtgtgt 25560 ggcattagtt gtagagatgc agctgattca cataaggagc aagccagggg 333tC33t3t 25620 cccaacctac ctctccatca cacctccagc ttgttgtcag agctccctat tggggaaacc 25680 taaagaagcc agagagaaca aaagtggtta ttgaactcca tacagggtac agagcaaagc 25740 agagaatagg tctggagggg caatggaaga tatagtgagg agcatgcttc agtaatgtgt 25800 tggataacag tcatccatcc ccatgggctt ggttagaaga ttccaagtat ttagctaagt 25860 tctaaaatgt tttctattac agagtgtgta atggatagca attttgtttg gttttgtttt 25920 actgtgttcc atgtcccagc atccatttga ggtttttgtg catgtgtgat aatagcactc 25980 cagttttcct ttgcataatg actcttcctc cattcttaac ccatgcagtt gttgtgggtc 26040 tgactccact ctatggatcc tagggtagac atgtgattca atttggccaa cccaagcatt 26100 ttctcctctg tctagaggga tgaactcttg 3tCC333tC3 acccagtgag cttcagtcct 26160 gaagctattg cttcagaaaa gggtatcttt ctttctgttg cagtttctaa gcttatagaa 26220 tctaagccca aagttagagc catctctgcc cccagagagt aagaatctga gaacacagac 26280 aacagagagg gaagcagaga tcagtgatgg agaaactgag tcccagagtc ccagtggaat 26340 tgatggaaca ccttgaaccc actgtgccta aaaccaagat acctctggat attttagttg 26400 tctttttcct acctcagcaa tgagaagtct ttgggttgca atgagagagg aggcaggaag 26460 gtgcctcagt tcatgactac ataggctact ctggaagctt tcacaaaaag agactgcctc 26520 agagctctgt ttctgctcag tctcatgaaa gagttgtggt ttttttttgt ttgttttggt 26580 ttggtttttt ttttaatcag tgaagaatga ctcattattt atcttgaggg tgtaacaatg 26640 aattgttgta agatttattc aatgtcttgt cttttttttt ttttttttcc tacagctgtg 26700 gactcttcca ggaaagaaga aatcagaaaa catcaccttt tctccacacc caccctcaac 26760 ttccacttct gtactataga agcaaaattg attaggctgg ctaatttgaa gagaaaaaga 26820 tgataggggc tttgtgcttt agaggtagaa gagggtaata gtcaggttca ctctgacaaa 26880 gcccactaga gatggtagac ccactggtag aaatggctac ctggataccc aaggagagca 26940 ttaatcatcc catctcatat ctgagctcag tactggggga ggggataatc aggtctcacc 27000 aaacctggca gccttccact gtacgtgtgg gcaaagacca acagcagtgg tgttggtggt 27060 ggaagttatc caagtcacat ggcaacaaga tatgttatcg gcagccaatc catttgggtc 27120 tgtagcaacc tcaattcttg tctcctcaga ggaatgaatt tgaggggcat aaggcagaaa 27180 gagctctagg caagttttag aacaagagtg aaagtttatt aagctttaga gcaggaatga 27240 aagtgtactt ggaagagggc caagtggaca gcttgaaaga ctagtgcaca gtttgaccta 27300 atttgacctt tttttttttt ttttcctttt gaaatggagt ctagctctgt cgcccaggct 27360 ggagggcagt ggcgtgatct cagctcactg caacctctgc ctcctggctc aagcatttct 27420 cctgccttag tctactgagt aactgggatt acaggcatgc acccagagtt agggtatcct 27480 ggctcccagt gaagggactg gccaattaat tttagtcata aaaactacac acccagctaa 27540 ttttttgtat ttttaataga gacaggggtt tgccactttg gccaggctgg tctcaaactc 27600 ctgacctcaa gtgatccgcc catcttggcc tcccaaagtg ctgggatcac aagcatgagc 27660 cactgcacct ggccccagtt tgaccttttg acttgaggtt ttatacatta gtgtacttcc 27720 aaggtcctgc atcccttctc ctctaattct tcccttgggg tgggctgtcc gcatggcagt 27780 ggcctgctag cacttgggag aatgcacagt gtgtttactg gagttgtaca catgctcact 27840 tgaggcattc ttcttttacc agttgaatgt ccctggaagg tcatatgcca gttaaactcc 27900 accattttaa tgtgcttgct tgaacccgct cacccaattc ctgagatctt tttgggaagc 27960 tgctgatcac cagtttcagg tgtttatatt tattagggga ttgccgttcc ctggtgccag 28020 ctgcaaccaa ttattatttc agcgagacag ttaacaaccg ccttaccatc acctgatggc 28080 tgcctgacat tcctggtgtg tgtggtgggg gtaggggggg aatccctatc ctgctcagct 28140 cctatctgac tagctaccta ctgtaatagt ggcatccaaa agtgactcaa aaccaagagt 28200 ctctattatt gtccttgacc attgggtcag aagggccata aaaacaggga gatgctgaca 28260 gttgtatcaa tcttgatgaa ggaagaaatt aacttcatat aattattttt agaaaaatag 28320 acacgatatt ttttatgttc agtattatag attgattatc tctgttaact ttatgtaatt 28380 tatatgccag atacctaagg tatctaataa tagtacaaga tagaaaaaat ttttatacac 28440 ttcatgaggg ttctgcaaga cctaactgtg gtatttacaa gaaatatgcc ataaatacat 28500 tttttaataa tttcaacttt tattttggat tcagagagta catgtgcagg tttgttaccc 28560 tggtatatgg catgatgttg agttttgggg tatgattgat cccatcatgc aggtactgag 28620 catagtaccc aatagttaat ttttcaactg ctgcctccct gcctccttcc tccttcctct 28680 agtactcccc aatgtctgtt gtttccatct ttacgtccat gagtacccag tgtttagctc 28740 ccacttgtaa gaagtgacag catgtggtat ctggtttgct gttcctgtgt taatctactt 28800 aggataatgg cctccagctc tatgcatgtt gctgcaaagg ccacaatgtc tttcttttta 28860 tggctgtgta gtactctatg gtgtatatat accatatttt cttcatacat tctgccactg 28920 atggacacct aggctgattc tatgcctgct attgtgaata gttctgtgat gaacatgcaa 28980 gtgcgtgtgg ttttttggta taaaaattta ttttcttttg gaagtaatag ggttgctggg 29040 tcaaacagta gttccttttt aagttctttg agaagtctct aaactgcttt ccacagaggc 29100 tgcactaatt tacattccca ccaacagtgt agaagccttc ccttttctcc acagcatcac 29160 catctgttag tttttgactt ttaatagcag ccattctgac tggtgtgaga tggtatctca 29220 atgtggtttt gatttgcatt tctctgatga tgtgatgttg aacatttttt tcatacgttt 29280 gttggctgct tgtatgttgt cttttgagaa gtgtctgttc gtgtcttttg cccattctta 29340 atggggttat tttctttttg cttgttcaat tgtttaagtt ccttatagat tctgtatatt 29400 agacctttgt tggatgcaca gtttgtgaat atttctctca ttctgtaggt tgtctgttta 29460 ctctgttgtt agtttctttt gctgtgcaga agctctttag ttcatttagg tcccagttgt 29520 caatttttat ttttgtttca attgccttgg aggacttagt cataagttat ttcccaaggc 29580 tgatgtccag aatggtggtt cctaggtttt cttccaggat tcttaatttg gggtcttaca 29640 tttaaatctt taatccatgt ttctttctta tgcatatggc tagccagcta tcccagcacc 29700 atttattgaa taggaagtcc tttccacatt gcttattttt gtcgactttg ttgaagatca 29760 gatggctgta ggcgtatggc tttatttctg ggttctatat tctgttccat tggtctatgt 29820 gtctgttttt gtaccagtac catgttgttt tggttactgt agccttattg tgtagtttga 29880 agtcaggtag tgtgatggct ctggcttttt tctttttgct taggattgct ttggcaattc 29940 aggcttttgt tattgttgtt ccaaatgaag tttagagtag ttttttctag ttctgtgaaa 30000 aattaaattg gtagcttaat atgaatacca ttgaatctgt acattgcttt gtgtggtatg 30060 gccattttaa tgatattgat tccaatcatg agcatggaat gtttttccat ttgtttatga 30120 catctatgat tactttcagg cggtgttttc tagttctcct tgtagagatc tttcacctac 30180 ttggttagat tattcctagg tgggtttttt tgtggctatt gtgaatggga ttgtgttctt 30240 gatttggttc tcagcttgaa tactatttgt gtatagaaat gccacagatt tctgtatatt 30300 ggcttttgta tcctgagatt ttactgaggt catttatcag ctccaggagc cttttgaagg 30360 agtctttagg attttctagg tatagaatca tatcatcaga gaagacagat agtttgactt 30420 cttcttttcc tgtttagatg gcttacattt tttctcttgt ctgattgctc tggcttagac 30480 ttttggaact atgttgaata ggtgtgatga gagtaggtat acttgtctta tgccagttct 30540 caaggggaat gcttccagtt tttgcttttt cagtataatg ttggctacgg gtttgtcata 30600 gatgactctt attattttga ggtatattcc tttgatacca agtttgttta aggtttctac 30660 tctgaaggga tttttggtct aattgagagt tttttctgtg tctattgaaa tgagtgcaag 30720 gtgtcttagt ctgttctcat attgctatag cagtaccaag gggaaaatcc actctcatga 30780 tccaatcacc ttccaccagg ccccatctcc aatactgggg attacaattc tacaagagat 30840 ttgggtgggg acacagatgc aaacaatatc atgtggtttt tgcttttaat tctgtttacg 30900 tggtgaatca catttattga tttgcatgtg tggcacaaat cttgcatccc aggaatgaag 30960 cctacttgat catggtgaac taactttttt aagtgctact ggattcagtt tgctggtatt 31020 tacttgagga tttttgcatc catgttaatc agggatattg gcctatagtt ttctttcttt 31080 gttgtgcctt tgccaggttt tggtatcagg gtgatgctag ctttgtagaa ttagttagga 31140 aggaatctct ccttaatttt ttgggaatag tttcagtggg attggtagca gcttttcttt 31200 ttaggtatgg tagaatttgg ccatggaccc atttggtcta gggcttttct cagttggtag 31260 gttttttatt actgattgta ttttggaact caatattagt ctgttcaggg tttcaatttc 31320 tgcctgattc aatcttggga gattgtgtgt ttctgggaat ttacacattt cttccatatt 31380 ttctagtctg tatgcataga ggtgttcata atagtctcta agggcttttt gtatttctgt 31440 gagattggtt gtaaggtcac ttttgtcatt tctggttgtg cttatttttc ctgttttttt 31500 cattttttat taatgtagtc tagtgtctat caatcttgtt gatcctttca aaaaaactgc 31560 ttttggtttc attgattctt tgtatggatt tttggatctc aatcattcag tactgctctg 31620 agtttagttc ttttcttctg ctagctttgg ggttagctca ttcttgtttt tattattctt 31680 atagtgtgct gttagatagg taatttgaga tctttccaac tttttgacat aggcatttag 31740 cactattaac tttcctctta acattgcttt tgctgtatcc cagagatttt cattgtgtct 31800 ctgtccatct ttatttattt cagagaattt ttgaatttct gtcttacttt tgttgtttac 31860 ccaaaagtca tataggagca acttgtttaa ttttcatgta attgtgtgat ttgaaaagat 31920 catcttggta tttatttcta tttttattcc aatatggtct gagaaaatgg ttgttatgat 31980 ttccattttt tattttattt tttaaattat tatactttaa tttctagggc acatgtgcac 32040 aatgtgcagg tttgttacat atgtatacat gtgccatgtt ggtgtgctgc acccactaac 32100 tcgtcattta cattaggtat ttctcctaat gctatacctc accactcccc caaccccatg 32160 acaggtcccg gtgtgtgatg ttccccaccc tgtgtccaaa tgttctcatt gtttaattcc 32220 cacctatgag tgagaacata tggtgtttgg ttttctgtcc ttgcgatatt ttgcgagaat 32280 gatggtttcc agcttcatcc atgtccctac aaaggacatg aactcatcct tttttatggc 32340 tgcatagtat tccatggagt acatgtgcaa cattttctta atccagtcta tcattgatag 32400 acatttgggt tggttccaag tctttgctat tgggaatagt gccgcaataa acgtatgtgt 32460 gcatgtgtct ttatagtagc atggtttata atcctttggg C3t3t3CC33 gtaatgggat 32520 ggctgggtca aatggtattt ctagttctag attcttgagg 33tC3CC3C3 ctgtcttcca 32580 caatggttga actagtttag actcccacca acagtgtaaa agtgttccta tttctccaca 32640 tcctctccag cacctgctgt ttcctgactt tttaatgatc actattctaa ctggtgtgag 32700 atggtatctc attgtggttt tgatttgcat ttctctgatg accagtgatg atgagcattt 32760 tttctgtgtc tgtaggctgc ataaatgtgt tcttctgaga agtgtctgtt catattcttt 32820 gcccactttt tgatggggtt gtttgatttt ttcttgtaaa tttgtttgag ttctttgtag 32880 attctggata ttagcccttt gtcagatggg tagattgcaa aaattttctc ccattctgta 32940 ggttgcctgt tcactctgat ggtagtttct tttgctgttc agaagctctt tagtttaatt 33000 agatctcatt tgtcaatttt ggcttttgtt gccattgctt ttggtatttt agtcatgaag 33060 tccttgtcca tgcctatgtc ctgaatggta ttgcctaggt tttcttctag ggtttttatg 33120 gttttaggtc taacatgcaa gtctttaatc catcttgaat taatttttgt ataaggggta 33180 aggaagggat ccagcttcag ctttctacat atggctaggc agtttttcca gcaccattta 33240 ttaaataggg aatcctttcc ccatttcttg tttttgtcag atttgtcaaa gatctgatgg 33300 ttgtagatgt gtggtattac ttctgagggc tctcttctgt ttcactggtc tatatctctg 33360 ttttggtaat agtactatgc tgttttggtt actgtagcct tgtaatatag tttgaagtca 33420 ggtagggtga tgcctccagc tttgttcttt tggcttagga ctgtcttggc aatgcgggct 33480 cttttttggt tccatatgaa ctttaaagta gttttttcta attctgtgaa ggaagtcatt 33540 ggtagcttga tggggatggc attgaatctg taaattacct tggacagtat ggccattttc 33600 atgatattga ttcttcctac ccatgagcat ggaatgttct tccatttgat tgtgtcctct 33660 tttatttcct tgagcagtgg tttgtagttc tccttgaaga ggtccttcac atcccttata 33720 aggtggattc ctaggtattt tattctcttt gaagcaattg tgaatgggag ttcactcacg 33780 atttggctct ctgtttgtct gctattagtg tataggaatg cttgtgagtt ttgcacattg 33840 attttgtatc ctgagacttt gctgaagttg cttatcagct taaggagatt ttgggctgag 33900 atgacggggt tttctaaata t3.C3-3-tC3.C3- tcatctgcaa acagagacaa tttgacttcc 33960 tcttttccta attgaatacc ctttatttct ttctcctgcc tgattgccct ggccagaact 34020 tccaacacta tgttgaatag gagtggtgag agagggcatc cctgtcttgt gacagttttc 34080 aaagggaatg cttccagttt ttgtccattc agtatgatat tggctgtgca tttgtcataa 34140 atacctctta ttattttgag atacatccca tcagtaccta gtttattgag agtttttaga 34200 gcgaagggct gttgaatttt gttgtaggtc ttttctgcct ctattgagat catgatgtgg 34260 tttttgtcat tggttctgtt tatatgatgg attacattta ttgatttgca tatgttaaac 34320 cagccttgca tcccagggat gaagccaact tgatcgtgtt ggataggctt tttgatgtgc 34380 tgctggattt ggcttgccac tatcttactg aggatttttg catcaatgtt catcactgat 34440 attggtctaa aattctcttt ttttgttgtg tctctgccag gctttgttat caggatgatg 34500 ctggcctcat aaaatgagtt aaggaggatg ccctcttttt ctattgattg gaatagtttc 34560 agaagtaatg gtaccagctc ttctttgtac ctctggtaga attcggctgt gaatctgcct 34620 ggtcctggac ttttttggtt ggtaggctat taattatcac ctcaatttca cagcctgtta 34680 ttggtctatt cagggattca acttcttcct ggtttagtct tgggagggtg tatgtgtcca 34740 ggaatttgtc catttcttcc agattttcta gtttatttgt gtagagttgt gtatagtatt 34800 ctctgatggt agtttgtatt tctgtgggat cagtggtgat atccccttta tcatttttat 34860 tgcatctatt tgattcttct ctattttctt tattagtctt gctagcggtc tattttgttg 34920 atcttttcaa aaaaccagct cctggattca ttgatgtttt ggagagattt tgtgtctctt 34980 atctccttca gttctgctct gatctttgtt attccttgcc ttctgctagc ttttgaatgt 35040 gtttgctctt gcttctctag ttcttttaat tgtgatgtta gggtgttgat tttagatctt 35100 tcctgctttc tcttatgggc atttagtgct ataaatttcc ctctacatac tgctttacat 35160 gtgtcccaga gattctggtg cattgtgtgt ttgttctcat tagtttcaaa gaagatcttt 35220 atttctgcct tcatttcatt atgtacccag tagtcattca ggagcagatt gttcagtttc 35280 catgtagttg tgcagttttg agtgagtttc ttaatcccaa gtactaattt gattgcactg 35340 tggtctgaga gacagtttgt tgtgattgct gttcttttac atttgctgag gagtgcttta 35400 cttccaccta tgtggtcaat tttggtataa gtgcactgtg gtgctgagaa gaatgtataa 35460 tctgttggag cattctgtag atgtctgtta ggtctgcttg gtgcagagct gagttcaatt 35520 cctggatatc cttgttaatt ttctgtctca ttgatctgtc taatgttgac agtggggtgt 35580 ttacatatca cattattatt gtgtgggagt ctaagtctct ttctaggtct ctaaggactt 35640 gctttatgaa tctggatgct cctgtattgg gtgcatatat atagttagga tagttagctc 35700 ttcttgttga attggtccct ttaccattat gtaatgacct tctttgtctc ttttgatctt 35760 tgttggttta aagtctgttt tatcagagac taggattgca acccctgctt tttttttgtt 35820 ttccattttc ttggtagatc ttcctccatc cctttatttt gagcttatgt gtgtctgtgc 35880 acttgagatg ggtttcctga atacagcaca ctgatgggtc ttgactcttt atccaatttg 35940 ccagtctgtg tgtttaaatt gggcatttag tccatttaca tttaagatta atattattat 36000 gtgtgaattt gaccctgtca ttatgatgtt agctggttat tttgctcatc agttgatgca 36060 gtttcttcct agcattgatg gtctttacaa tttggtatgt ttttgcagtg gctggtacag 36120 gtttttcctt tccatggtta gtgcttcctt caggagctct tgtaaggcag gcctggtggt 36180 gacaaaattt ctcagcattt gcttgtctgt acaggatttt atatctcatt tgtttatgaa 36240 gcttagtttg gctggatatg aaattctggg ttgaaaaaaa atttttttta aggactagaa 36300 tagtgtttaa tatcaatttc tgagaaatca catttatata 333C]^~333t33 aacaggccag 36360 cagaagtcca aaaaagattc agcttacatt attgcacttg gatgaaatat gctatttaga 36420 gtagcataat attcaggcca ggccaggagg agaaagagac aaatggagag gacaaacctc 36480 caggtagtat ttattctgga ttccaaactc tcctgcggcc taaacagtat ttagtctatt 36540 ggaaacattc agcaaggtct tt3C33333t gactgcagta tcttcaacac atttgagttg 36600 cactcatact ttgttccagt catgtgcaag tttaatgcac agctctacct cacaaaatgg 36660 gacatctatg acaccagaac ttccctgtgc ccaaggtcat ggacaggagg ggaaggcagt 36720 gaatttctac tttatgcata ttttagggag caatactgtg gctatcattt acccttttga 36780 gcaatcttga ttttggtcat ttataattag tacatgagaa aaagtgacag tgaatacaag 36840 tgagtactaa ccgaattcct cggctggtac tagaaaataa tcttttcgtt aagaatgtgg 36900 aatattggcc cccattctct tctggcttgt agagcttctg ctgagagatc cactgttaat 36960 ctgatgggct tccctttgtg ggtaacccga cctttctctc tggctgccct taacattttt 37020 tccttcattt caaccttggt gaatctgaca attatgtgtc ttggagttgc ccttctcaag 37080 gagtatcttt gtggtgttct ctgtatttcc tgaatttgaa tgttagcctg cattgctagg 37140 ttggggaagg tctcctgggt gatatcctga agagtgtttt ccaacttggt tccattctcc 37200 tcatcacttt caggtatacc aatcaaatgt agatttggtc ttttcacata gtcccatatt 37260 tcttggatgc tttgttcatt tctttttact ctttttttct ctaaacttct cttctcactt 37320 catttcatac atttgatctt caatcactga tatcctttct tccactggat cgaatcagct 37380 actgaagctt gtgcatgtgt cacgtagttc tcgtgccacg gttttcagct ccgtcaggtc 37440 atttaaggtc ttctctatgc tgcttatcct agttagccat tcttctaatc ttttttcaag 37500 gcctttagct tcctttcaat gagttagaat atgttccttt agctcggaga agtttattac 37560 caatcttctg aagcctagtt ctgtcaactc atcaaagtca tcctccatcc agctttgttc 37620 cattgctggc aaagagctgc catcctttgg aggagaagag gtgctctggt ttttagaatt 37680 ttcagctttt ctgttctggt ttctccccat ctttgtggtt ttatctacct ttggtctttg 37740 atgatggtga cctacagatg gggttttggt gtggatgttc ttttgttgat gttggtgcta 37800 ttcctttctg tttgttagtt ttacttctaa cagtcaggac cctcagctgc agttcttttg 37860 gagtttgctg gaggtccact tgagcccctg tttgcctggg tatcaccagc agaggctgca 37920 gaacagcaaa tgttactgcc tgatccttcc tctggaagct tcatctcaga ggggcaccca 37980 gctgtatgag gtgtcagtca gtccctactg ggagatgtct cccagttagg ctacttgggg 38040 gtcagaaacc cacttgagga ggcagtctgt ctgttctcag atctcaaact ccatgctggg 38100 agaaccactg ctctcttcaa agctgtcaga ctgggacgtt taagtctgca gaagtttctg 38160 ttgcctttta ttcagctatg ccctgccccc agaggtggag tctacagagg caggcagacc 38220 tccttgagct gtggtgggct ccacccagtt caagcttcct agctgctttg tttacttagt 38280 caagcctcag caatggcgga cacccctctc ccagccttgc tgctgcctca cagttcaatc 38340 tcaaactgct gtgctagcag tgagcaaggc tctgttggca tgggatctgc tgagccaggc 38400 acagggtata atctcctagt gtgccacttg ctaagaccat tggaaaggca tgttattagg 38460 gcaggagtgt cctggttttc caggtatggt ctgtcatggc tttccttggc taggaaaggg 38520 aattccccaa ccccttttgc ttcttgggtg agatgatgcc ccaccctgct tcatcttaca 38580 ctcagtgggc tgctcccact gtccagccag tcccaatgag acgaacccag tatcccagtt 38640 ggaaatgcag aaatcatctg tcttctgcat cactcctgct gggagctgta gacgggagct 38700 gtagactgga gctgttccta ttcagccatc tgggaacaat cccaatttcc ctttttttaa 38760 acttactgag ccttgttttg tggccaagca tgtggttgat ttaagaatat gttctatttg 38820 cagatgagaa aaatatataa tctgtagttg atgggaggag tattctgtag atgtcctagg 38880 tccaattgat caaatgttga agttcacaat ttctccgtta gttttctgcc ttgatgattt 38940 gtctgatgct gtcagtaggg tgttaaaatt ccccaatatt attgtgtcta tgtctaagtc 39000 ttttcatagg tctagaacta cttgttttat gaatctgggt gctccaatgt tgggtgtgta 39060 tatatttagg atagttaagt cttgttgaat tgaatctttt atcattatgt catacccttc 39120 tttgtccttt tttactgttg ttgttttaaa gtgtttatct aatatctaaa gtattatcta 39180 atataagaat agtaacactt gccctttttt gttctgttta cataacaaat ctttctctga 39240 catttacttt gagctttggg gtttccttat gtgtgagata gatctcttga agacagcaga 39300 cacttgggtc ctgtattttt attcaacttg ccaccctgtg ccttttaagt ggggcattta 39360 gaccatttac attcaaagtt aacattgata tgtgaagttt tcatcctatc atgaagttag 39420 ctcgttgctt tgtagtttcc attgtgtggt tggtttatag gttctgtggg ctatgtactt 39480 tagtgtgttt tgtggcagca ggtatcatta ttttgtttcc atgtttaaaa ttcctttgag 39540 gctctcttga aggttggtct agtggtaaca aattccctta atgcttgctt gtctggaaaa 39600 ggattttatt tctccttcac ttatgaagct tagtttggtg ggataagaaa ttgttggctg 39660 caatttcttt tctttaagaa tcctgaaaat aggccaccaa tctctcctgg cttgtaaggt 39720 ttctgctggg aagtctgctg ttagcctttg tacatgatct gagcttttcc tctagctgcc 39780 tttaagtctt ttctttagta ttgaccttgg acagtctggt gactacatgc cttgatgaca 39840 ctcgttttgt atagtatgtt gcaagtgttt tctagaatgt ctacctctct agcaagataa 39900 gggaaatgtt cttgaattgt tccctgaaat acgtttattt tctttttttc catttctctc 39960 aggaatgtca ataattcata agcttggttg ctatacataa tcccatgttt ctcaaagact 40020 ttgtttattt tttaaattct tttttctgta tttttgtctt actgagttag ttcaaaagac 40080 tagtcttcaa gctctgaaat tttttcttct acttggtcca gtctattgct aaagctttcc 40140 attgtatttt gaaattcctt aagtgagttt ttcaattcca gaagctctgg ttgatttctt 40200 tttaaaatat ttatctcttc cttcatttcc tggattccct ttgaagtttc tttgtgttga 40260 ttttcaacct tatcttgtat ctcattgaac ttcctaacaa tctatccttt gaattattta 40320 tctgtcattt ctgagtttcc attttggtta gggtccttcg ctggagaggt agtgtgatac 40380 tttggtgtca ctacattcag atttttcatt gtgccagaat tcttgtgtca gttccttctt 40440 acctagagat gctagcactt ctaatatttg taattatttt catgtgggta ggattttttg 40500 tttttctttc tttccctata ataataacat ttttttccct ttcctttccc cgacttccta 40560 gggaatgtga ctgtagagaa tcctaggtag ggtcctttgg ctttgcttct atagtcctgt 40620 gcatttctgt cagcaggttt tattttactc tgtgcagttc aaactacaag ccatagatgg 40680 cacttatggg taagagccag ctgtggccag tacagctggg tatatgtgtg atccttgttt 40740 actgagagaa gctctctgtt gcctcaggaa atgggcttat ttatggggtt cacagtggtc 40800 tgagctccct ccttacccct ggagaggcag ggggcaagat gtgtggggct ggaccaggca 40860 ggtctggacc tacaggtccc ctgatggcag acacaagcac cagcactgag gggagaatcc 40920 agtggccagc caccaagccc tcagagatat gcctaggcat gaagctggga agcctcctca 40980 accccaagtt ctctgcatgg ggatggcgat ggcctaaact tctgatccaa cagagtgcat 41040 gctgcaggtg cctggagatc tgcctggggg taaaacagag agggtcccac tgcaccataa 41100 tctacgtaca ggaagcatga ggtggctgag gctgttgatc caggccaggg ggtactctga 41160 atacctaggg atctgcatgg gcgtggagca gagaaggccc cgctgcacca ccatctatgc 41220 ccatgaagag tgcggctgct caggctgctg gtccaggcaa ggggatggta ctctgattgc 41280 ctgaattttg gcttgggggt ggagtggaaa ggggccctac tgcatcacgg tcttagggta 41340 gcagattggt gtacccagca atgacacata cacacctatt ccaggtcacc agctggccct 41400 agctgtaaga ttcgttgtct gagagaaact atagctgtag cagctctctt cctgctccag 41460 gtctgtgatg ggggagagca aaattccagc acctactgct gaggtacttt tcacagttct 41520 ggctgtggaa gcttctaccc aactccagag catgtgctcc aatctgtggc ccaggactga 41580 agttcctgag cagccatgct gctgggttgc caaagaatgg cagactttgt atgtgcctgg 41640 gttaaaaatg gtgtcctgcc ctcagttcca ggtctggaaa aatgcttaca gcttttctca 41700 gtgtctttcc ctcatagcac cttcaagcct ttccccagta tagctccagg gcctgggaaa 41760 acaaagtgct ctcccttggc ctgaattgct tggatcccca gtggaaaggt gagtcacaga 41820 gataggctct ctgcctctct tgtgtactgg tgcttcactc actttaatca gccccatgtc 41880 atcacagggg ctgtttgccc accccttctc ctccctggga tctggggttt cctttgtgat 41940 tctagtggat tcccattttc cttcttgaaa tgaagctcaa agagttgatc tttgtgtact 42000 acctcgctgt ttccgagtgg atgaggcatg ctgaaagcct ctaatccacc atcttggaaa 42060 aaataaattt ttttttaaaa agcaaaatcc aaatatgtag gataaacaaa ttgaaatatc 42120 tagtgtacaa tgtaaggact atagttaata gcgtattgta tttgggattt tgctaaatga 42180 gtagactatg gctgatgcca catggaagag gaataggtaa ctatgtgaga tgatagaaat 42240 gttcatttgc tccactgtag taaccatttt acaatatata tgtattttat aatatcgtgt 42300 tgtatacctt aaatatacac aataaaattt atttttttaa agaaaccaac cagaacagtt 42360 ccccagattt actcatgaag ttattctctt tctccaccac caaccaacag cattccctca 42420 tcaattgtgt gctctatttt tttggcagcc aatgcatgag tagtgagatt attattatat 42480 aataaaataa tatgttcaaa tttttaaaaa acagatagtt taaagaaaaa gggaaaatta 42540 ttatagcttg taaacattta ccttaagaaa actagagtga tgtttcagga caagaaataa 42600 tactagagat aaagagaaat gtcttatgat gataacagag tatttaatca agaatgcctc 42660 ataaatgtgc atgtatctaa ttacagagct tcaaatatac atgaagcaaa agctgacaaa 42720 agagaaataa gcccacagta atacttggga atttcaaatc tcttctctca gtagttggta 42780 aaacagaaaa ctcagtaaga atatagaaga atggaatagc agtatcaacc aacttgatct 42840 agatatttac agaacaacat ttctaggatg ctccatggaa caacaataac atatacatta 42900 ttttcagatg cacatggaac actcatcaag gcaacatata tgcaggatta tagtctaaac 42960 aaatttaaag cactaaaaca atatagactg tgtcctctga ctacaaaaga atcaattaga 43020 aattaataac agatattgaa aaatccacaa atgtttggag attaaacatc tctaatcatg 43080 tattatagat catatcacaa agaatatgag gatatatttt tacctaaata ataattaaaa 43140 tacaatacat cataatttgt aggatacagc tgaagcagtg attgggggaa atttagagct 43200 ttaaatgctt acattagaaa ggaataaaag tctaaaatta atgatacaaa attttacatt 43260 aagaagctaa aaaaacagaa gaacaaattg aacccaaagt aagtaagtag aaggtaagaa 43320 ataaaaatat gaataaaata aatgaaattt gaaaatattt aattaacagg aaaaaaacca 43380 atgaaaccaa aagcagattc tttgaaaaat tgttgtttct aattagacca agaaaaaaag 43440 gatatgagtt actaaattca ggaatgaaag aggagacatc actgcaggca ttaaaaagat 43500 aaaagtggac tattatgaac aaatgcatgc aacaaattga ataacttaga ggaaatgggc 43560 aaatttattg aaagacataa gctaccaaaa ttaacataaa aagaaacagg gaaacctaat 43620 agcactgtat ttattaaaga aatttaatgt gccaaagtaa ttaaaagtag aaaagatttt 43680 tcattaaata gtgcttgaac cactggatgc ctatgtgaaa aaagcatgaa cttcaactct 43740 tacctcacag taaatgcaag actaattata aatagaatag agacctaaat gtaaaaataa 43800 aaattataaa atgtttacaa caaaacatag gaaaatgtct tcttaaacct ggagcagaca 43860 aagatttctt agatatcaca taaaatatga aagaataata ttaaacattc catatttcaa 43920 aagtcacctt taaaaaataa aacaagcccc aacagatttg ttgtttgtgt tacttttatc 43980 tgatgaaaga cctgtatcca gaatatataa agaacattta caacttgata atgaagacaa 44040 cacagtttta aaattgggta agtcatttga cattttaaaa agatgagaat gatcaatata 44100 tgcatagaaa gatgttcaac attttcagcc ataaagttaa agccacattg atatattttt 44160 acatacccat agaatggcta aaaataaaac caaataactg agaatgtcat gggtgaggtt 44220 atggagccac tgaaactctc tcatatattg ctgagacaaa tgtagaatgg tacaaccact 44280 ttagaaaaca gttgaacagt tccttactta tttacactgc catgtatctg tcaattctat 44340 tcctacatat ataccaatga gaaataaaaa catacatcca ttcagagact tatacacaaa 44400 tgctcatagt agctttattc ataatatcct aaaactagaa acaacccaaa tgtccataaa 44460 caaatgaatg gttaaacaaa ttgtggtata tcattacaat agaagactat ttcataataa 44520 aagacaacag actattgata tacagagtgt ggatctcaaa aacaatgctg agtgaaggaa 44580 gccagacaca aaagaataca tgctgcataa ttccttttat gtgatatttt agaaaaagga 44640 aaactaaccc atagtgacag aaaataggtc agtagttact tgtgtctggt ggttgggggt 44700 ggtattgaca ataaagaggc ctaaaagaac ttttcaggat aatggaaatg tcctatagct 44760 tgatcggggt ggtaggtgca caaatgtata catgtgtcaa aactcaaact gtatatttaa 44820 aatgtacaca ttgtatgtat attaaacctc attaagattg atttatatat cattgtgata 44880 atcttacaaa atactaaaat ataaagttta agaaatggtt tatattttca aaatataaaa 44940 tatgagaaaa attcaaagat gaatccagaa tattaggtcc acaatccaag aaaatgggaa 45000 acaagattgg gcacagtggc tcacacctgt aatcccagca caagcccctg aagtccgggg 45060 tttatgccca gcctgggaaa catagaggag cttgtccgta caaaaaaaat taaaatatca 45120 gccaggcgtg ggggcacaca cctgtattcc cagccactca ggaggccgag aggaagatca 45180 cttaagccca ggagttcgag gctgcagtga tttatgatcg tgccactgcc ctccagcctg 45240 ggctgcagag tgagacccaa aagactgtct ctaaaaaata aaagagagag agagagagaa 45300 aagaaaaatg ggaaacaagg agagaaagga agaaacaaaa caaacaaaat cccattattt 45360 tcctgagtat aaagaaaaca gaaatcttca gtttcaaatg ttgttgattt attcattgaa 45420 ttcattgatt acttggttct cttatacttc cattgtatta ataacagggc cacaacgatg 45480 tttcaggtct ctaagtacca attttaactc agtctccttt ccttagttca catttgtttg 45540 tgtaaatggc ctgtggaaag gctaggggaa tcatcccagt gtacacttgc aaggctgctg 45600 cagggggcct ggaacctggc cttttcatcc atctttggcc tctggaaact ggacaatgga 45660 tcatgactat atattgaaga aactgccgtc aacctcccaa tcaggcatcc ttgatttatt 45720 ttactcatgt agatggaatc atacccttct tggctgccct tctagttttt cctcagggac 45780 actgttttct attaatcagc tccacaattc tctgcaagtc agatccattc attacatttt 45840 gtccttgcat taagataatt gccattacct ggcttctgat gagtaagaac caccacctgt 45900 tttctattgt gtgcattgag cggggcaggt cctgttatca gtaagcccag gtctttagtg 45960 gcattttcta ctgacagcct ggcctgctga ggagtgctgg cactgaactt cttactgatg 46020 ctggagcttc tcacaccagg aaaattctta ttgcttcagt aacacagatg gctagtgggc 46080 tttccagcct tacacagcat actcaccctg gtatgtgtac ttctctgagc cttttattct 46140 tttctaccat ctaccttggc aactctggta tttaccttac tgagtgtgag ctattgacct 46200 ttccatgcct ctaagagcca tcttaggggt gtgtttgcac catctctttg tgtccttgct 46260 agaatttcaa gtcgcatacc ctagaagagt ctcccaaact gctaaattct cttttcaaac 46320 aacatgctct gacaccttga tccagaaccc ttagaaacca atactatcta tactcttcta 46380 gttcttgttt ataaaaaatg gctaggtcct gaagttcctt tatcacttct aagatgcctc 46440 tggctgtttt tgcagcaact taaccctagg tataggccca tggccaagta tgtaggtggc 46500 ccttgatcct gagatgggca cctgttatct tgaaaaggaa aagcttctgc attgcctttg 46560 agcaagggga gagggctaac ccttactagg gaggagtgaa ctacttctaa tttttttttt 46620 taaggagtct ccctgtgtca cccagattgg actacagtgg agcaatctca gctcactgca 46680 acctctgcct cccaaattca agcaattctc ccacttcagc ctcccaagta actgggacta 46740 caggtgtaag tcaccatact tggctagttt ttgtattttt agtagagatg aggtttcacc 46800 atgttggcca ggctgatttc aaactcctga cctcaggtga tctgcccgcc ttggccttcc 46860 aaagtgctgg aattacagga atgcgccacc gcactcagct ggagtaaacc acttctgtag 46920 gaatcagagg aaaatgaaga ttcaagatat ggggggcatc aactgcaatg ttcccatacc 46980 acgtgtcagg gtcttatttt t3CtC33C33 aggccctgac cctggcatag caggtctgcc 47040 tatgttatga gttgaacctc ctttgggatt cattactctt attttctggg cttgatcctc 47100 aacttttttg gaccttctgt gaaggaaaca agagcttctt cttatgctac taaggagaac 47160 tctgcctttc acccctagct tatcttttta ttcaaggcct taattgagct tggtgaagcc 47220 acccgattct attgcctctc tagttagtat tttcctcatt atttctccaa tgtcagatat 47280 cagcattttc ttccaccagt ataccatcca acttcatcaa ctgtgattgt tttaacaact 47340

333C33CC3t ctcacgctgg gattgtatgt cctctgccta ccaccagcag taccttctgc 47400 cacagattgg actctctagg aagcagactc tagataaaga ctatcatata gaaggtttat 47460 caggaggttc ccttggctcc aacacctggg gaagaaaggg gactgagggg agagagggga 47520 aagaaggaga ctgggcagag gaagaaattg agatatgatg cagactaaat aaagcttcag 47580 ttgacccttt ggccatttct gaaaatggaa tgacccttca gagatattcc taattggggt 47640 gagaaggctg agcctttata ctcccatgtt aaacagtcat tggatgtgga cgaccttgag 47700 aagggtggct gtcttcacct ggaggcactc ccagtagctg gggcaatagc ttcttcattc 47760 tggggagagt ttgaacacat tacagctatc gcacagcaac catccacctc tttcttccat 47820 tcaaggacta aatatgccgt gtgtgtgtgt gtgtgtgtga ttgaaagtaa agtaaaacct 47880 gacactctgg ccaggcgcag tggctcacac ctgtaatccc agtattttgg gaggccgagg 47940 caggcagatc acgaggtcag gagatcgaga ccaccctggc taacattgtg aaaccccgtc 48000 tctsctssss 3t3C333333 ttagtcgggc atggtggcgg gtgcctgtag tcccagctac 48060 tcaggaggct gaggcaggag actggcgtga acctgggaca cggagcttgc agtgagcaga 48120 gatggcacca atgcactcca gcctgggtga gagagcgaga ctccatcaca 3333333333 48180

33333333CC tgacgctcaa tgtgctttcc aaatatcttg gagctccagt gaccccttca 48240 cttcctagaa cttcctagtc 3t333C3Ctt ctgtgaccac agcaatgagg ttgttttctt 48300 tctttttctt ttttttgttg gtctttcttt tttgttttgg atatgttaat acttactatt 48360 t3.tC3-3-3.C3-t ttactatgag ccaggccctg tgcaagggta tatatatgga taatctttca 48420 tgaatgatct catttaatca tcacttcaat tctattttgt aaacttgagt aagcctttag 48480 taagaaaata gagattgagg ttgaattgtg tttccaagtc acgctactag ttcttattgg 48540 aatctgtgtg gaacccagat ctgactccaa agtcaatctt agtaatgaca ctgcaattgg 48600 ccacctgctt ctttatctcc aactgcctca gccaaaggtc aacaggtaca ctgtaggcca 48660 ctgttcttga tcaagccctg ttccctgcag catacattcc taaacaatgc cttttgaggt 48720

3C33Ctt3t3 gaatcatttt attaaagttc tgatcttttt tctatacatt cccactgtgt 48780 tC333CCt33 gactcagctg tcctcccagg ctcaattgaa gtctcctttc tagctgtact 48840 tttcttaggt attccagacc agaatagcct cccagtgcct aacaaagctt tcccaccagt 48900 gagaaggatt tagccacatt tttactgctt agtatcttca tatatgtttc tgttcccttc 48960 aacagattgt aaacatcacg cacggtcttt cacaccacta ccctatataa tgtattgtac 49020 ataggagaca tttagaagca gattacatta attttgtatt aatgtcatga attacttagt 49080 gatatgccct tgggctctct tctgtttcct cattctctaa taatgatata atttttatat 49140 tttcttaggt ttcccatgat gctgaaatcc ttatctatcc tatatatttg tcactctgca 49200 cttcctctct tgcatagctc tgtcctggga accccaggca gttaagttta ttagtgatga 49260 ttaacacaag ctggttatgt tccatttaag gctaacagtt ctcatggtta t33tt333Ct 49320 ttttctgttt taggtacaat t333CCC3C3 gattaaacct tatattttcc agggaaaata 49380 ttgtatgatc tattgtacct agtgactaaa gtgaaatttt agaatggttt gaaaccttgc 49440 tgcaaaaagt gtggtccatg gaccaggaac agcagtgtta cctggaggcc tgttagaaat 49500 gtagaaaatt gtcccccacc cagatatgca ggatcagaat ctgcattcta acaagatctg 49560 caggtaattc ctatcaatat ttaagtttga gaagttctac ttt333333t aatttaatgg 49620 cagctctata taaaagtggt tctccattag tgcctaccat gggccagcca catgtttgat 49680 gcttcataca gttctaatta tcccaacagt cctgaaggtg ctatttctgt ttacagatga 49740 aaaacctgat acttagaggc taacttagcc aagatcgttc tgcttataat cagtagtgct 49800 gatcttggag tgtagcacca tctgcttcga agactatctt tcaggctttc tgttgcagat 49860 gcagcagatg ctctcagagc ctgcctatat gtccctgccc cttagcattc cagagtgcag 49920 gggctggact ggtccttgcc tcccctgcag cagtgagagg tgatggtgtg ctggcagccc 49980 ttgcagccct tgcccactct cagcacctcc ttggcctcgg tgcacactct ggcagcactt 50040 gaagagccct tcagcccacc actgcactgt gggagcccct ctctgggctg gccgaggctg 50100 gagctggctc cctctgcttg tggggtgatg tggagggaaa ggcgcaggtg ggaacctggg 50160 ctgcgcccag tgcttgtggg ccagcacaag ttctgggtgg gtgtgggctt ggtgggccct 50220 gcacttggag cggcaagcag tgaggagctt agcacctggg ccagcagctg cggagggtgc 50280 gccgggtccc ccagcagtgc tggcccacca gggctgcgct cgaattctcg cggggcctca 50340 gctgcctccc tgtggggaag gcctcaggac ctgcagccct cccggcacaa gccttcccac 50400 cccctgccca ccgctgcccc caccccccca tcactgcagc cccccgcccc gcctacagcc 50460 accccaaccc ccaccccacc atgggctcct gcgaggcctg agcctccctg acgggcaacg 50520 ccccctgctc tgctgcgctg ggtcccatcg actgcccaag ggctgaggag tgcgggcaca 50580 aggcacggga ttggcaggaa gctccacctg caccggggtg caggatccac caggtgaagc 50640 cagctgggct cctgagtcta gtggggacgt ggagaacctt tatgtctagc taagggattg 50700 tagacacacc aatcagtact ctgtgtctag ctcaaggttt gtgaatgcac caatcagcat 50760 tctgtatctg gctaatctgg tggggacttg aagaactttt atttctagct aagggattgt 50820

333t3C3CC3 atcagcactc tgtgtctagc tcaaggtttg t333C3C3CC aatcagcact 50880 ctgtatctag ctaatctggt ggggacttgg agaaccttta tgtctagcta aaggattgta 50940 aacataccaa tcagcaccct gtgtctagct caaggtttgt aaatgcacca atcagtgatc 51000 cgtgtctagc taatctagtg gggatttgga gaacttttgt gtctagctca gggattgtaa 51060 acgcatcaat cagcactctg tcaaaacgga ccaatcagct ctctgtaaaa cacaccaatc 51120 agctctctgt aaaatggatc aatcagcagg atgtgggtgg ggccagataa gggaataaaa 51180 gcaggctgcc agagccagca gtggcaaccc ccatgggtcc ccttccacac tgtggaagct 51240 ttgttctttc actcttttca ataaatcttg ctgcttctca ctctttgggt ccgcactgcc 51300 tttatgagct gtaacactca ccacgaaggt ctgtagcttc actcctgagg ccagtgagac 51360 tagaaaccca ccagaaggaa gaagctccaa acacgtcaga acatcagaag gaacaaactc 51420 cggacgcccc tttaagaact gtaacgctca ccgggagggt ccgcagcctc attcttgaag 51480 tcagtgagac caagaaccca ccaattccag acacagcagt tctcaagcaa agaccgatga 51540 gagttagtgt ctaaattccc tggctccctt ggcgctcagg tgagataatt ttgtgctgtg 51600 tttacactac agcttacagt ttccctgcga gattaatgtc caatgtacta atctggaagc 51660 tggcttaata atgcaccttt tattaatccc acctcatctc tacttccctg catttcttag 51720 acaccataat taaatcctta tctcaggctc cacttctggg gagaccagca ttaagatagc 51780 agaagagtaa ccttggctgc tatgagaaat tcctcatacc acaagaaaag aagcactgaa 51840 aagtgaacaa ttaacttctc ttgaatacaa tgagtataac actctcaaga atagtgggat 51900 cttcttatga gactgctgac agatgaaaga tgagattcta tgacgtttat taaaatgaag 51960 aattacaggg gaatatacag aaaaacagag ttaacttctt cctcatagga attctcctcc 52020 tcattgttag aatatattgt cttttttata taactgtctt ctatgggagg aatgaacagg 52080 tgtctttggg acatacatac tttctatgcc tcaaatcttc atgtataaaa gtgagggaaa 52140 actcgttgtg taaatgaagt atctcatcct gtctgtggca taaagttttt ccatatgctg 52200 atgtttgtac tcagggccag tttcgagggc atgtgacaga cggccctgca cttggtttga 52260 tactctgctg tcactacctt gaaattctta ataattgtga acaagacacc ccacattttt 52320 attttgcacc agatcctgga aattatgaac ccggtcccat ttgtattaat taaaaactct 52380 ttgaagtacg aattttcatg atacaagcaa gagaagtcag gttaaaagaa tggtaagagg 52440 aagagcaaag tagctttcag gaaaactaga tccaacaaaa gctggagttt ctagaaactt 52500 ctggcagtta tgaaagattt gctgcagaga gagtgggagg aaagccgtgg tatcaggacg 52560 ttctgtacta cttctgaaat gtacatatgc agaggagcag gcacagatgg gatggctaag 52620 acagcaagtt tgacttggag ccagcaggga aagttcaagt gacccaggaa attagaagca 52680 aaaagaatga gccacttgaa ctagctgttc tgcattaggc aaacaaacag attctgttcc 52740 tgattgttcc tgatgatatc cagcatttac caaacattta ctctgtacct ggaactgtta 52800 aaaagggact tatagtcatc tcatttaatc tgacaacaac cctttaaggc atgtgctatt 52860 attgttccta taccaccagt gaagaaagct aggacaaaat aagattaaat cattgcccag 52920 ggcacctagc aagtgctgga gcctggactt taaccctgac agactgtgga gcccaaactc 52980 ttaattatga catatagctc ccctaccaag taaaatggct ctccactcta aaaggcatga 53040 tggagcagat attgtgcgga aaggacccca gtggagaagt gaaaagagaa aggctgtgtc 53100 cctgtggtgc aatcctttgt ggagcaaagt tccccatttc ttcaggggta ggggttaggg 53160 tgggggcaac caaacataaa catccacaga ccttggggag cccacacggg gttttcctgg 53220 acccattttg cttcacaagc acattttcca tggattttca ttaggctgtg tcagagtgtc 53280 agtggtcttc aaactgttct actgatccct tggttcaact tttgtagctc aactgtcttc 53340 cacaatgaga gggaactgaa tggaggggct caggctcctg cttcacttgc acagcttccc 53400 tttcacttat tttcatctga atatagggat tatggataaa aatttgtttg caaaaagaag 53460 atgaggttct acagctaaaa atacactata aaaaccattg ctctgggcag tcacttcaac 53520 tgggagaaga cgaataagct gtaggcagat cacagggctc ttgcacacac attcctccct 53580 ctcctccccc aaacacaact cagattcaac ctgggtcagt gaagaaaggc taatactggt 53640 atttggtgtt tgtagaatct tgggcagaaa gtatttgaat cttctctatg ccacagactt 53700 gttcactaac tgtgagtttg tttctcactt aagaacagtt tttaaacata cagtgttttc 53760 atcaggaaaa tatatatata tatttgcagg gtcaattcag acgcctttac aataatagtg 53820 gttctgacct tcctttcagg taggagccag aattaattgt tctttcctct gctttcctgc 53880 agcaaccaac aattatttga atatctatca agtgtaaaac agggtgatcc tgccctcaaa 53940 ggactcaccg tctagtagta aaaggaccta aataattcct gtgcctgtca tgacgatggt 54000 cactttctac ctcatgttac agaggcaata ggaagtgcag acagctgaag gacatggaaa 54060 aaaaaattga tggaagaatg gcagccaggt ttggccttaa agaaactgca tttccctagg 54120 tggatgtgta attagttttc caagagaaga tgatataata gctacacaaa ggtagcaata 54180 gcataaacaa atcctacaaa ccttgaaaag tcacctttga ggataggaac ctggttttct 54240 aatatttccc ttgaggcctc tctcatctca catgctcttc aaaatctgga cctatgcgtc 54300 aagtttcata gactaatgat tcagatgatc ctctgtataa ttcagttcaa gtttggtgat 54360 gaaggcacac cttcctatac atataattct aataaaagta tgtgtcagca ggaagtgttg 54420 gtgaacagac aaatttcttc cgtcccgctt cagcaaatgg ccttatggga taaactaaag 54480 cctaactaga aaatacacat ttaaaatttt ctaaaacatc caggattaga aacgtgtgtt 54540 cctacctctt gtttaccagt tcattcaggg gttaagaaca taactgttac taaagcaaac 54600 cattgcacaa aactttgact tgctaattgg caacattcct tcagattata ggaactagaa 54660 aagaaacaaa gtgtaattta agacatttca gctctaaaac tgttgctatg tttttatctc 54720 ttggaccata catttttttc tccttttaaa aattggatta tagcaataaa atttacataa 54780 cataaacttt accatcaaac ctgttttaaa tttaaaaaaa aaaatccttg aggtgcaaaa 54840 tgtgagtatt gaggctcttg aaatttcctt ttcaatttgt agcttttgtt tctcttagta 54900 agacataaaa tactaggcta tttcagagcc tcctgtcccc tcacccccta atattagagt 54960 gcatttcctt ggccctttta atcctaaatt accctcttta tagcaaggag taaaacttat 55020 taaccaatca ctacaaaacg taacaacaca accttaagaa tggttttaga tatccaacca 55080 gttgtacttc ttgagttagg ttacaaatta tgttatttaa ggtaattttg ggtgtcgggc 55140 ctctgagccc aagctaagcc atcatatccc ctgtgacctg cacctataca tccagatggc 55200 ctgaagcaac tgaagattca caaatgaagt gaaaatagcc agttcctgcc ttaactgatg 55260 acatcccacc attgcgattt gttcctgcct caccctaact gatcaattga ctttgtgaca 55320 atacaccctc tccacccttg agaagttact ttgtaaaatc ctccccaccc aatcaagaag 55380 gtactttgta atatcctccc cacccttgag aatgtacttt gtaagatcca ccccctgccc 55440 acaaaaaaat tgctcctaac tccaccgcct atcccaaacc tataagaact aatgataatc 55500 ccaccaccct ttgctgactc tcttttcaga ctcagcccac ttgcacccag gtgattaaaa 55560 agttttactg ctcacacaat gcctatttgg tggtctcttc acatggacgc gcacaacatt 55620 gggattccaa gacatgtccc aaatcttcat ttaaagttaa gagtggcaac tctccacaca 55680 aatacttact ggcattgttc aaagtccagt cagagacttt tcacaaaggg aaggaagatg 55740 ttgcccctac gtgaggaact ctgttaacaa ctaaagcagc atgaggtcaa gacaggagtt 55800 tggcaggctt ggttttacaa ggtacaggtc agaaagaacc ctctgataaa acaagatgca 55860 gtaaaaaaag ctggccaaaa CCC3CC3333 ccaagatggt ggcaaaagtg acctctggtc 55920 atcctcactg cttatctgct aattatagta tattaccatg ctaaaagaca ctcccaccag 55980 caccatgaca gtgtataaat gccatgggaa tgttcagaag ctactctgta tggtctaaag 56040 aggggaggaa ccctcagttc ctggaattcc ccaccccttt cccagaaaac tcatgaaaat 56100 ccaccccttg tttagcatat gttcaaaaat 33CC3t3333 atagccaacc agcagccctc 56160 agggctactc tgcctatgga gtagccattc ttttattcct ttactttcct ttactttctt 56220 aataaacttg ttttcacttt actctgtcca cttgcccttg gctcttgaat tccttccttc 56280 atgaagccaa taaccccaat ggactcccag gctgaacccc aattctggag ttaaccctgt 56340 gacatcattt ctggtaacac aaagggacaa tggagacctc cccttggact ccaaattaag 56400 actgatcagc accattcaga cctgacagat gggcatgtct ccttttgtcc agattcaact 56460 cactatcctt ttttatcttc tattttggct cctctgtcct ttcctgtatt ctttattttg 56520 gacagatgga gaagtggcca cgagacttct agcttgatag cctgtttgca gtctcccatt 56580 gtctgggtgc cccatagcag cacacctggc caaccatgtt ctttataacc ccctttgtca 56640 cctcttctct ccaaccgttt ctctttagtt tctaacaacc agccatttta cttttctcct 56700 ctcagtgcca aaatgcttgc ttatgctcat gtcattgtgg catttattgt cttcttttgc 56760 tatttgggca attgtttaag gaaggatgct ttcttgtgag aggtccccca ttctattgac 56820 cctaggatgc gagagtcatg ttgttctgtg gccccagttg tgttaggtct cgtgcctctg 56880 gtgtttgctg ttggccaccc tggagatgct ctagggtttt tggcatttgg tgtgaggatc 56940 ttcactggct gatacttggg tattttgggc ttttcggcat ttggttctgt ttactgcccc 57000 cgaaatgctc tgtggtgttt ggcattggca ttctctctag gattgtgggt tacagtccca 57060 ccctagggga atcttagttt tgcctttcct tgttttctac cctaaagttt tcatttttct 57120 gtaacagtat tttcttttct tattgtctct ttatttaatg ctttgctata ggaggtgaaa 57180 atttgcaggg gaaaatagct gggttcttga aagacttaga 3333Cttct3 tatctagcag 57240 agatccttgt tagacatggg gacaatggtg aatcccaaag gacttgtcac taaggtgcct 57300 tttaagcaat tggagcaaat tcaaatgaga aacaagttta gctaggtact gaaggaacat 57360

3.CCtC3.3.3.3.t aatgagacat ctatgacaaa cccacagcca acattatact gaatgggtaa 57420 aagctggaag cattcacctt gaaaacctgt acaagacaag gataccttct ctcaccactt 57480 ctatttgaca cagtattgga agtcttggcc agagcaatca ggcaagagag agaaataaag 57540 ggcatccaaa taggaagaga ggaagtcaaa ctatccctgt ttgcagatga catgatccta 57600 tacctagaaa 3-CC3.C3.t3.3-t ctcagcccaa aagcttcttg agctgataaa caacttcagg 57660 aaagacacag gttaccaaat caatgtgcaa aaatcactag cattcctata ctccaacaac 57720 tgtcaaacca aaagccaaat caggaatgta atcccattcc caactgccac 3C3C3C3C3t 57780

3Ct3C3C3C3 cagtacctag gaatacagct aaccaggaag gtgaaagatt tctacaagga 57840 gacctacaag atactgctca gagaaatcag aggtcacaca aacaaatgga aacacatttc 57900 aggctcacgg ataggaagaa tcaatatcgt taaaatggtc atactgccca aagcaattga 57960 tagattcaat gctattccta ttaaactacc aaggacattc ttcacagaac tagaaaaaac 58020 ttctaaaatt catatggaac C3333333C]^"3 gtccaaatag ccaaggcaat CCt333C333 58080 gtgaaaaaac ctggaggcat catgttaccc 33CttC333C tatactacag ggctacagta 58140 accaaaacag catggtactg gtacaaaaac agacacatag gccaatggaa cagaatagag 58200 aagcaagaaa taaggcagca tgcctacaac tatctgatct tC33C3333C tgacaaaaac 58260 aagcaatgga aaaaggactc cctattcaat aaatggtact gggataactg gtaagccata 58320 tgcagaagac tgaaactgga ccccttcctt acaccttata 333333Ct33 ttcaacatgg 58380 attaaagact tcaatgtaaa actcaaagct 3t33333CCt ggaagaaaat acaagcaata 58440 ccattctgga atggacaagg atttcatgtt gaagatgcca aaagcaattg caacaaaagc 58500 aaaaattgac aagtgggatc t33Ct333Ct aaagagcttc agcacagcaa aagaaactat 58560 caacagagta aacagacagc ctacataatg ggagaaaatt tttgcaatct atgcctctga 58620 caaaggtcta atatccagca tct3t33t33 acttacaaga 333333CC33 acaatcccac 58680 taaaaagtgg gcaaagggct aggcatggtg gctcatgcct gtaatcccag tgagaggtga 58740 cagcatgctg gcagtcctca gagccctcac ttgctctcgg cgcctcctct gcctgggttc 58800 ccactttggc agcacttgag gagcccttca gcccactgct gcaccgtggg agcccctttc 58860 tgggctggcc aaggccagag ccggctccct cagtttgcag ggaggtgtgg agggagaggc 58920 gcgagcagga actggggctg cgcgcagcgc ttgtgggcca gctggagttc tgggtgggcg 58980 tgggcttggt ggtcctatag tcagagcggt cggccggccc tgccggccct gggcagtgag 59040 gggcttagca cccgggccag cagctgcaga gggtgtactg gatccccaag cagtgccagc 59100 ccaccggtgc tgcgctcgat ttctcaccgg gccttagctg ccttcccatg gggcaggcct 59160 cgggactgca gcccgccatg cctgggcctt cctctgcctc cgtgggttcc tgtgcagccc 59220 gagactccct gacgaatgcc gctccctgct ccacggtgcc cagtcccatc ggccacccaa 59280 ggcctgagga gtgtgagcgc atggcgcggg actggcaggc agctccatct gcagccccgg 59340 tgtgggatcc actgggtgaa gccagctggg ctcctgagtc tggtggggat gcggagagtc 59400 tttatatcta gctcagggat tgtaaacaca ccaatcagca ccctgtgttt agctcaagat 59460 ttgtgaatgc gccagtcaac actctgtatc tagctgctct ggtggggaca tggagagtct 59520 ttatgtctag ctcagggatt gtaaatacac caatcagcac cctgtgttta gctcaaggtt 59580 tgtgagtgca ccaatcgaca ctctgtatct agctgctctg gtggggatgt ggagaacctt 59640 tatgtctagc tcagggattg t333t3C3CC aatcggcact ctgtatctag ctcaaggttt 59700 gtaaacacac caatcagcac cctgtgttta gctcaaggtt tgtgaatgca ccaatcgaca 59760 ctctgtatct agctgctctg gtggggcctt ggagaacctg tgtgtcgaaa ctgtgtatct 59820 aactaatctg atggggacgt ggagaacctt tgtatctagc tcagggattg taaatgcacc 59880 aatcagtgcc ccgacaaaac aagccactgg gctctaccaa tcagcaggat gtgggtgggg 59940 ccagataaga gaataaaagc aggctgccgg agccagcagt ggcaacccgc tccagtcccc 60000 ttccacactg tggaagcttt gttcttttgc tctttgcaat aaatcttgct actgcttagt 60060 ctttgggtcc acgctgcttt tatgagctgt aacactcacc gcgaagatct gcagcttcac 60120 tcctgagccc tgcgagccca cgagcccacc aggaggaatg 33C33CtCC3 gatgtgctgc 60180 cttaagagct gtaacactca ctgcgaaggt ctgcagcttc actcctgagc cagcaagacc 60240 acgaacccac cagaagaaag aaactccgaa cacatctgaa catcagaagg gacagactcc 60300 agacgcgcca cattaagagc tgtaacactc accgcgaggg tccgcggctt cattcttgaa 60360 gtcagtgaga ccaagaaccc accaattccg gacacaccag cactttggga ggctgaggtg 60420 ggtggatcac ctgaggtcag gagttcaaga ccagtctggc caacaaggtg aaattccatc 60480 tcccctaaaa atgtaaaaat tagccaggag tggtggcaca tgcctgtaat cccagctact 60540 caggaagctg aggcatgaga agcatttgaa cctgggaggt ggaggttgca gtgagccaag 60600 actttgccac tgcactccag cctgggtgac agagtgagac cctgtctcaa 60660 aatagtggac aaaggacatg aacagacact tttcaaaaga agacatacat gtggtcaaca 60720 atcgtatgaa aaaaagctca acatcactga tcattagaga actgcaaatc 60780 tgagatagca tctcacacca gtcagaatgg ctattattaa gaagtcaaaa aaaaatagat 60840 gttcgtgagg ttgcaaagaa aaaggaatgt ttataaagtg ttgttaggat aaattagttc 60900 aaccattgtg gaagacagtg aagtgatacc ttaaagactt aaaaacagag ataccatttg 60960 acccagcaat ttcattacta tgtgtatacc aaagggaata taaattgttc tattataaag 61020 acacatgcac acatatattc attgcagcac tattcacaat agcaaaggta gggaatcaac 61080 ctaaatgctc atcagtggta gattggataa agaaaatgtg gtaaatatac accatggaat 61140 actatgcagc cataaaaaag aatgagaaca tgtcctttgc aggaacatgg atgaagctgg 61200 aggtcattat cctcagcaaa ctaacacagg tgaataccac atgttctcac 61260 ttataagtgg gagctaaatg atgagaacac atggacacgt agagggaaac aaccgacact 61320 agtgcctatc agagaatgga gggtgggaga aggaagacaa tcaggaaaaa taactaatgg 61380 gtactagact taatacctgg atgttgaaat aatctgtaca gcaaacccct atgacacaag 61440 tttacctatg gcacatgtac ctctgaactt 61500 ttttctaaga gaaataattt gaatccactt atattttatg aaatagtttg 61560 tgttactatc tcaagactag agttccaaga aaaaaagcta ttgggtcttt tgtgtgtgtg 61620 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtctaaatg tgttttatgt 61680 gtatttacat tatgtcatat attgtatcta cagagtgcca aattggctta taaataagtg 61740 ttaaagaagt ccaagcattt ttcaagttca catgacttaa gttcactaaa 61800 atttaaggtt catttgtaat tctgtatata aaatatgcca aagaagatat 61860 tcttttattt tggccaattc agatgttatt taaagtatgg 61920 ggatttagga ggcactcact tcatgctata gctcagtagc taaggctttg 61980 ctttttcatg atggtggcct gggttcaatt cctggcttag ggaatgaatt ctttctggtt 62040 tgatacctgt gggactttta caatttattt attcttttcc cctccatgga tagcttctga 62100 tttcctgact tgaattttct tttctttgag ggacattagg ggtgattcta ggtcttgtga 62160 aaaccatgtg ccatctgttt agagacacct tgtgcatcca tggttaagtc 62220 ggcttattgg cttcaattag ttgaggaaaa caaagggctt gcttaaaagc 62280 cagaggtgtt ggctgtttgt cctagctaga gtctggtaat tagagatata aaaggatttt 62340 tttaagaggc gtatggttaa aagtcatctt aaaaatggat aaaaagtttt atgctttttc 62400 tcttcttggc tcttgttttt tgttgtttgt ttgtttttct tttcagtcaa ctggattatt 62460 tccccaatct gtcttcttat caccttcaat gtcccatgag aggacctatt ataatttctg 62520 acagcctaga actccttggg ataaacagag aaggtgccac agaccccatt ttggggaaaa 62580 cctgttttct tcatggaacc acagtaattg aaagtggaca ggtctgtctc aaaatctacg 62640 gccgtcctat attttgtatc atgttacctc acctttttga cttttggggg tatcagaaat 62700 tactttgcat tatgagacaa cttttagcct tggtgtgtaa tagctaggta gaacatatac 62760 tttcagggat ggctaatagc agttgcttac agtgagtcat tattaccaca ggccaatatt 62820 tctttcttct tttatttaaa ggtgctattg ggcacctaaa agacagaaaa 62880 tggagatggg ctgattatag aatgagctga ttggctttgg gttggccact agtcttggag 62940 gaacattctt gcaatgaaaa atctgatggc tactgggttt tcttctgcct gtctgtgtag 63000 ttagatatcc gttgtgtgtg tgatgtctat aacaaggagc tctaattaat ggacttaaag 63060 aagaataagt gcttggatca aatatttttt aaagggaaga taaaagctgt ggtacccttt 63120 aagttcatgt aactttaatc tttgagaaat aaaaacagcc ttaaagatta ttggcaatgt 63180 agatgttgtc aaaatgtaaa tatttaccta gggctaaagg gttgttttga attagaaaag 63240 ataatgctga aagttcaaac aagttgtgaa aatattgtaa aaattagctt gcaaaagaaa 63300 ttctgtgtgt gaacatatta aaaggttatt gtatagtttt cctgtaaatt 63360 aagcattgaa agggtactct taaggcacta atcagctctt aagcaaaatt 63420 tgtaaagggt tataaaatgt ttttgctttt ttaaaatttc tgagtcatca ttttggcaaa 63480 gtaaataatt taaggaaatc cggaattcta tcaagtgttt taaacctcca 63540 acttttttat ttttttatta taatacttta agttctaggt tacatgtaca caacatgcag 63600 gtttgctaca taggtatcta tcccatgttg atttgctgca cccatcaact catcatttac 63660 attaggtagt tctcctaacg ctatccctcc cccagccccc tacccctcaa caggccctga 63720 tgtgtgatgt tcccctccct gtgtccatgt gttctcattg ttcaactccc agttatgagt 63780 gagaacatgt ggtgtttggt tttctgtcca tgtgatattt tgctgagaat gatggtttcc 63840 tgcttcatcc atgtccctgc aaaggacatg aatgcatctt tttttatggc tgcatagtat 63900 tccatgtaaa cctccaacat ttaacaggct tcccagaatc aaacttcagt 63960 gctttactga cacctagctt tttaatgcta cagagggccc ctagagcatt cagaagagag 64020 gtaaacagga ttacctggca tgtttaggta catgggattg ccaaaatgat gttcaatttt 64080 ctttaggtta tattttagtg acatatattc caaaattgta tggggtttct 64140 tgtctgagta tatgctattg aggttgttat gttaagttat 64200 tgtaaaccac agagataacc aaatttcttt gtcaattatg ttactggctg taactaccct 64260 ggacattttg ctactcacag aaaattgtac tgttttgatc ctctgcaaaa gatggtttat 64320 aatcagctac agaactttga caggtactct caaatgcagg tttctgataa ttttggagat 64380 tatgacgttg gaataaagga aaaatgtaca ggactcatga agagctgaaa tgtttacaaa 64440 tatcaagcaa aactagagtt aactggatgg actgaaccaa tagaaaactg aagtaatgtt 64500 ttttgctttt gcttggaaca ttgctgatcc ttgctttgtt cttcagagtc aaggaaactt 64560 attttgagct atttatggcc tttaataatt gagtaagtta tactcctgtg 64620 ggggcatatt tgtctctctc tgcctggctt ctccagaatt tggaaactac ttgcaagtat 64680 tcttaactta tggcaatata attgtttgca tcagtgcaac aagaatccac tttcttgcaa 64740 agctgataaa agccccttgg gaaaattggc ctcatacctt gtttacacca tccttgtcca 64800 gggttcctga cctgtggtaa gtgaaaaatg tcactttctg acaggtccag gagctccagg 64860 tttatcttgg gaccttaaga ggagaggatt acccagctca taggtatttg atggcaaaaa 64920 cccatggatg ggctcagctt taaaaagtcc tatctgagat tccttgtgaa acagagttcc 64980 atcaaagtca atctaaaagg cttatgtaaa sstssttstt cttgctgcac tgtacacaaa 65040 taatcaggcc aagtataaga ettataagee taaagtctat tttgeaaaca actccgtcct 65100 atcatgattt gtttttagca gaaatgagga ctggagagag agaaattatg tttccaaact 65160 tatcatacat ttgtcattaa attccagact cattagttgt tttaaagttt ttgectacat 65220 cttagactaa ccctgcttat tcccgtgaac aatccagtga cctctgactg cagctcagaa 65280 ggaacaaaag catagatagc ttttatgggt aatgtaaaaa tctggatcaa tattctaatt 65340 ctgagcaatt atectgeaaa tettgecagg tgatgggaaa aaataggatg accatcacct 65400 ggaggttttc tttttgggag gtaagagcaa ggaagctaac caaagecaag catcatgcac 65460 ccaaatctta gcaagcctcc ttaaccatag ccaccagtta tctgggtgtg tcacaggttg 65520 tcctttaacc tgccttgttg gaggagaact caattccata gcttcacctt agcatttgga 65580 ttataataag gagttcatcc aacccccacc aagacacatt tttggtccca aactcaattc 65640 taagctttga gttgaagece taagaaagaa aactagatct gaggggtccg gaggcagaca 65700 ataatggaag ttaaaaggca cagtgcaggt gagtgtgact aattcctgcc aattaagcca 65760 agcttcccat ttcatggata aaggtcatgc tagtatccat ggcataaatg aggtctagga 65820 aatgcaaata ctattgacag cagtggaggt aggaegtaca tgggtcagag tggatattcc 65880 caccacctag gcctttccat taatatgagt gaaagecact ttgatgecca tgagtagcaa 65940 gcaccctgta atggtcactg ggactcaggg atataagaac agaagaaaga aagaggaata 66000 tctcactttc tctccctcat gtacctcggg tatttgetag gaagagaagg gaaccaggga 66060 gacctgctcc cttctttcta gatgagtagc tattcacctt cagactttac ccctttcgga 66120 tgcatcctga acccctggga ctcctttgaa aaaacctcct tttttccttc ttcctcctct 66180 gtcctcactt cactgatagg taatcatgtc tccatactat gcgacactcc cctcagatgc 66240 atcctccaaa ctgggaaaac tcaatttccc sssccttsss ctggttggct taggattggg 66300 cctggggaat ggaacccaga agactgacat cctggcaaaa gggtaaaagt ccttttttac 66360 cagtcaggat tttggcctcc ctctccctgt gcaaactggt aaaaggcetc aggattcttg 66420 agctgacttt atccaccccc cttgttttat tttgatatat gtttcctaat aacctggttt 66480 gtctattctc acctttagac tatcaaactc caaacagtca tgcaactgga gecacagatg 66540 atggccctgt ttgccaggga cccttagata gccctctgag ggagctctga cttctgcctt 66600 cccaaaacag cgccccctgt cagcaggaag cagttaagat cagccttcat tcttatcctt 66660 atctttgttc taatagcagt taagtgtact tctttaggca gggaatgata gatgcaggag 66720 gcagataagg ggaagggtcc ctggagaatc tctgagccac ctgtgcactg ggagaatggg 66780 gtggagccac gagaatttca tgccttctgt agggggaaag agtctgacct cttcaggtca 66840 tgtgtggtgg cctggaatca atctgtgagg tgggggcctg ttagcaggac accctctcac 66900 tgtactgaga gtttttcttt tttctttttc tctcctaata agttcaaccc tacccaccct 66960 tcaatgtgtc catgtgccta atctttcctg gttgtgtgac aagaacccag ttttagctga 67020 actaaggagc aaaaattctg caacagcatt cttattctct ggtctctgea gcataatcac 67080 acccccaaat tttacctggt atagaatcat gtagaataaa gctgatggtt tccaacctct 67140 cctgcaactg aatatggctt gataactaca tctggccagt aagatgtaag cagaagtgtc 67200 gcatagcagt ttctgagacc gaaggtgcat tttgaacttc cttcatcatc ttttctttga 67260 tcctgcccca gcaaatgaga acttgaggct ggaactccag ccactgcaag ggctacactc 67320 tgaggatggc agagcagtga ggccataggg ccttgagtgc ctggattgtg gagaagagct 67380 gccatcagct gtggatggtc tccaaactga catttgttgg gaaatgcccc actgtctcac 67440 tgaaggcacc cacattttgg ccctcagcta ctcatccaat tctaactaat gtcaatttat 67500 tgcttgcttt ccccccaacc cccagaggct cttaaggagt caatctctgg 67560 gtggaatttt ggaaagctga ataaggacca ttttcctgat gaggaagtgt tgctgctgtt 67620 gctcacccca etaaggatge aggccgtttg cctcccaaag gttgtccttt ssttcsstts 67680 cagcctcaac actttgtgaa gtgaccctct ccagactgaa ttatattcta attagaaagt 67740 taaggttttc tcaatgtatt atgctattgg agtccccaga agtctagtaa tccctattag 67800 ctatgtgtct gactcatact gcatatttta cagacactcc tctactctgt ggttttacta 67860 agttgtgtct ccctggcatg ctgttaagga ccttttattt tttttaattc 67920 tgatgagtgc caagccctag aaattagacc tgctacccct ttaaaaatga tgtactcagc 67980 tacctgaaaa tgetctgett etttgeagag aaggttttag atcaatctct ttagtacaag 68040 cssstssccc caaatgtgtt agegctaage actcagggag ccttagatta ttctgctttt 68100 ttgcctgtta tgagcaatgc tggtgactag aaccaacgac ttactcaagg gtaacatcct 68160 gaaaaatagc tatgecaate cagggtgata tttatcattc ctaaccacag gecaggcata 68220 gacacagaga gtcagatcag accttggctg tgtaaaccac tgatatagee aaactgtaca 68280 aaccagctga ctatcagcca ggtgcaggtt gattattaaa actaagggct cttgacttgg 68340 aatggcaaga aagtgggaag gggatgaatg gtgagaaatt atttaatggg tscssttscs 68400 ttatttgagt gatagataca ctaaaagccc tgacttgact gecatgeaat etatgeatgt 68460 sscssssttt cacttttaaa cctacaattt tstscsssts ssttttssss taaagaatat 68520 agaatatata ttttttaaaa agacaagttt tctttctttt tttttttttt tttttttttt 68580 tttttttttt tttgagatgg agtctctctc tttcaccagg ctggagtgca gtggtgcaat 68640 cttggctcac tgcaacctct gcctcccggg ttcaagcaat tcttctgcct cagcctccca 68700 agtagctggg actacaggca cccaccacca cgcacagcta atttttgtat ttttagtaga 68760 gacggggttt caccatgtta gcctggatgg tttccatctc ttgacctcat gatccgcctc 68820 catcagcccc teaaagtget gggattacag gtgtgagcca ccatgcccag ccgggctctt 68880 ataaagcett caggatttat ttctggcttt tcctttcctt tatttctgga ggatggtttt 68940 tagectagae accctctcct cccctcccct cccctccccc tctcctcccc tgtcttcccc 69000 tcccctcctc tccctccttc ccctctcctg ccctcctctc cccttctcct tccctcccct 69060 ctccctctct tctcctcccc tcctcctttc ccctctccct tttcctctcc tcttctcctg 69120 tgatgagacc ccctggcctt ccctttcact gagattaaaa tccctccaaa tttttcacat 69180 tctcacttct ttacttgaaa scssssscss ssssssscct atcccctaag tgaaatatgc 69240 cagtcacaga agactacatt ttacacaatt tcattcaaat aaaatacaga ataagcaaat 69300 gtatagagaa cgtaggttag tggttgcttg gggttggggg agtgaggaaa taggggagtg 69360 atagctaaag aacccccagg tttctttttg aggtgatgaa aattttttaa atgctctgtg 69420 gtgatggtta cacatatctg gaaatttcta aaagcagttg aattgtacac tttaaatggg 69480 tgaattgtat ttgtaaatta tststcssts aaactgttaa atgccattca agcaagtatg 69540 atctagagaa atatgtgcta aaatacaagt taccaagtgg ttgccaattg actgaatatt 69600 ggctattttg ttggattaac gttgtttaaa acagttgtca aagtttaaaa ataaagaaat 69660 ctcccacaaa aatccagctt tttgccatca gaatctctgg tatcaatggc tctatattcc 69720 tgcatgggga gaagtgcctg gctcaaggga tcttgggatc ccttcaaatg agacctgagt 69780 tcttccagga accacctctt gctaagattt gacttaatta ttatactatt actccccata 69840 agagttagca tcctccaaac tagatccttt ttaattcaac aaatacgtat tgagtatgta 69900 ttaggtgcca tgtaccttct ctctttcctc ctatctgagg acaaaaacct cccaaacctc 69960 tacaatcttt tcccactatc ctctccccca ttagcctata gaccttttct ggtctttctt 70020 atcataaaaa ttgtcagcca attaaacaat cttctgttga atccgctgct ttctgaagtc 70080 agctgtctca tctcttgcat tcatttcaag cataatctat gttcactggc atttctttgc 70140 ctcctactcg ttgaactggt tgcaattttg gtttctatta ctctactgaa actcttctat 70200 taaagttcac taaaggagag tagtgagtca tcaaatccag tgcccttttc ctcagttctc 70260 actttcctca atgctttgcc ttttttcggc ctggaaaaca tagaaaaaaa tggaaagaaa 70320 aaaaacatca ttctattctc ctaatataaa aatttaaaaa gtcggtggaa agtggatttt 70380 ctcttgtttt tcccagacag agctcttctg atcttttgta gatctccctc aaggatgaat 70440 accccctccc tctatacatt ggagctgacc cactcattca ataaagctgg gccctgtgga 70500 caaacaaagc ctctgtcctc atggagtcta tagtctggtg gcatattgga tgaatatata 70560 attactaact gggcagcact ccaagagaga cagtatgatt cttaagagac catgcaataa 70620 caaaggaagg tgacctagat cgggtaggca gtgggatcag gggagacatt cctggggaat 70680 ttatgtttgt ccagttcatt tctactcatc ctttgctttt cttctcatag aaagtgagga 70740 gagagagagc aagagcaagg gcaagagagt aaattccagg cagaaaaata aaaccagcgt 70800 gggggaagct tgacgtagga actaagagaa tacagaaggg gagagtggtg aaagatgagt 70860 ctagataaat cagacgggat cttgcaggtc atggtaagag gtttgttatc ctaaagccaa 70920 tagtaagaca tggaaagtta aaagcaaggg agataacatg attacttcaa catatttttt 70980 aaaaatgctt ctgctgcaat atgaagaatt ggtgcagggg gccagggaag agacagggat 71040 tctaattagt aagttattga cagagggtag gtaagagttg gtggttgtta ccagattcca 71100 acatatgtag acaatgaaat caacagaagg aatgtggact tttggaacac caaccaaact 71160 cagaaaattt caaggctttc ctccattccc tccaaattca agaagaaggt actcataact 71220 aggtcatggc tgaagatgcc attataatag tcatgctgtt actggggttg aagcttttaa 71280 tgtaagcaac aaagccttga aatgcttcct tctagacaaa ctgaataatc taactgtgac 71340 atgtgccctc ctcagctctt ccttaggtca gagagccaag gaagaaccac agttagatta 71400 aggtggccat tgggaaagct tctactttaa tccctgggct agaaattgct cttagggctt 71460 attttttgtc catctggacc acttgaataa atttaggccc aacctctttc catgggaatg 71520 aaacagggat caatatagcc aaggtatgca gcttggtagg gatgcaaaat ccctgagtga 71580 tgccttccat ccttcatctc ccaacacagt tctcttcttg ctcccttact cctgccactc 71640 tcatgttttg aaagccagac tcaagcatga ccactgtgta agccactgcc tccaatagag 71700 aaggaaagaa aggagagtaa gggttggaga acaattttcc tgaacatact cttcaaccat 71760 ttcagaatgt atcactcctt cctcttcact tccttctgca cgtcaatgtg ggccttcttg 71820 tgcagtgcct tttgtgcacc tcagggtact gagttctcct ttcccttgat cccagaggca 71880 gctgcaataa gaatacaaat ggctatgggg ctttgttgtc acttcaccaa tgaaacagca 71940 cacaaattct tatttgcatt gaccgggtcc tctgactggc agagaaagct ctaggtgctt 72000 atctccatca aggtcctttc taggccgtta taagtggcac ctgttagcaa tgaaggataa 72060 ccatcgatct ataaggtact cttcatgggc taggtgagtt tgttattatt tgctttgttt 72120 tctttgtttg ttttgttgtt tgttgctgtt tgggatttca gtgagcccat gcagggaact 72180 acatgggaca ctctttccct ctaaatccca cttacttccc tttaaaacta agaaagtggc 72240 agacaggcaa ggtaagaccc agtggaaatg ggctaaggat gccactgaga ttgttctcaa 72300 aaatgaaggg gcaacaggag tctatggtgg aggtccattc catgccattg atttaggaca 72360 ttgcattcaa gtgtagggcc aaagcacaga ccaataacat gattccatgg cctagatagt 72420 ctttaaatat cattcctcaa agactatggt ggccacaata gatggctatt caagatttgt 72480 atcccaacca ctgatgagca cgcaccttcc caactcctct cacatcacag ttctgttctt 72540 attgccttgg tctattcacc attcccccaa catgccctaa gtccatcagc atgccttgtc 72600 ttcattagac agttgatggg actcatgtgg gttgagaaca gggaagaaga tcattcaggt 72660 aaaatatttc attgatgttg ttctaatatg caaaaaatac aaaaagtaac actctttcct 72720 cagctgctac cagaaatgaa aataatctca acatttgaca gaaagtaaaa ttagattgtt 72780 tcaaagtctt ctaaaaatct gagttctcct tagaagagac atttttaaca gtttggagac 72840 actggataga agccatggct gaatttgagt ttctagggca caggaaatgc tgaggagtga 72900 gctgagttgg gagaaggagc atgatgatca gcccagaaga tccagtgcct tgactgtttg 72960 ggaaagctgg ggtcaggaag aaattgcctg gaaaaaagct ggaaagtcca gtcaagggct 73020 tctgcccctc aggcgagtgc tgggagaaaa gttgggaatg ccaatctgct ttttctcctc 73080 taggtttttt tcactaatgg caaaaggaag gagaaatact aggcatcaca atccaagaat 73140 ataagattca attaccccaa ccctaaggcc actttcatga caaatatgac ttacacttgt 73200 ctagagccca atatatgctc taaagatttt ttcttcttta aagacttcaa atgaagtgtg 73260 ctcatggctg gctgagcaca tcatgttgcc atgagctcat gactacttgc aagctttcct 73320 gaagtagagc tccaaatcac acacgtctgg ccaccatctt acagcatgac tgcatcctgg 73380 aatcccatca ggccactgga aacaggcttt atcaaagctg ttttctgaaa cctggcttta 73440 aaaattggga gaaaggcttc tttattcaat aaaaatcttg atcttagcat tctggttatt 73500 taaaacctct cttcaggtat ggatgcacag gagcaggggg acttggttaa tgtgaatcag 73560 gaattttaat ttaatgaaaa attattgcaa acgatgttta tttaaatcat gattaaatct 73620 caaggtctgc agagcaggtt gcggctgatg tcattggctg ccatttactg tccagaaagc 73680 tgcactactg attcctaaac gtcctcagcc acatcgtgtg agtctttctc ataacatgca 73740 caaaaacgag aactagcagt ctgggtaaca aagcctttga cctgctgatg ggtgaaagct 73800 gccgttagct ctgtgcttgc ttcagagctg ccactccttt cctttcctac accagtctca 73860 gagagacgct gtgtcaccca gtggacacta aagtgatggc tttttaaacc taatcaatga 73920 ctaatgatag gtcaccatag tctcttgaag aatattttct tagaactaga cttttgtggt 73980 aaaacacctg gttatctatg ctttgggtac ttcaaaatat ttgagaagct ataataggcc 74040 ccaaagcagc tgagtgatca tctttctgct tccatagggc acgcggcagg cctcatcatg 74100 agggatgaaa tctacacttg ctggttctcc tgtggacttg gaatttacca tcacaaagat 74160 aattcagacc tagcacttcc cagaggttga gccccagtac attgattgag gaactgtcaa 74220 aacaggcttg caaaaatata gtatattttg agtgtttaca tttaataaat taacacttgt 74280 gaaacactat aaacaatgca acataattgt gtgatgactt gtaaaaatta attcaggctg 74340 tgcagtttta taatggggta attgtatagt tgcatgagaa aaaagtcctt ttcacattta 74400 tcctgaatct cagtgaccat atgcataacc tcgtttgaag ttaaggtgaa agtctaaatt 74460 tgacatattt tgtgaataag aggcctggac caatgccatc ctagataagc tacttgttct 74520 ccctgttctc aaagggacac aatgaaatca catgtaaaaa atatttttga gtaacaagat 74580 aattgaattt ggtgagagag tgctgttctt aaaatcggta tgttggcagg atggttcttt 74640 ccatctttgc tgaagtttgc tatatctccg gtcctaacgt ttttgagcaa agtttactgc 74700 atatctcttg ccaggtcagc tgaatatgaa cttaaaggga cctaacaaaa caggcagtat 74760 gcatcgatga tttagaattc cactgtgccc acgaggacaa gtaagagcaa gcgccttggg 74820 caaaggacat gggtattacc tccataacat gctgtgctag gctgcatatt caggacagga 74880 tctctgacag tggagaaata acgactttct gatggactgc tagggtgcca gcatggattt 74940 tcctggcttc agtggaataa ctcatttttc catctgtaaa tagagtactg agacattatc 75000 ttcatatatg cttgatgtta gtcaggggca cttcggggta caattttgaa gctctaggga 75060 aattttatag caaaggttaa agtccagaga ggaaaagagt ctagatagca attgaaaatt 75120 gggcacaaat gaagtatagt ttgaccccca catctcctgc ctacaaactg cagacccagc 75180 tgcagtaggt ggtagtgaaa taagggaagt tctagggggg actccgtcct cttcagcaag 75240 tgacagatgg tgtgaaacca cacggtagct tggcagtatg gggcggctgc tgcttagtca 75300 ctcctaactc aggaacctag tattgaaact tgaacagcct tccctgtctg gctataatgc 75360 agcccagaca tcccttgtca acaagttagt caacagtgct ctgaacaata tccggtaagt 75420 ctgatgtctt acttgccgaa ccagtcaaaa caagaaaagt gggctctgtt ggaacattcc 75480 ctttggttaa ctgaagatct ctagtttcat ttctccccac caccatcccc tttgttcatt 75540 cacttgtgca ttcagtcagc agaggagcca gggggatatg acgaactttc actggttata 75600 tactatgtgc tggttacagt ttaaggaata cgaagctgta aggtttgctc tctttctgca 75660 ggaagctcac agtccagcta aggagacacg tgcaaaaata aacaatggtg atccttaggg 75720 gtagatacaa tactggaggt ggtacttggt acaatggtgg ctcataggag ggagagacag 75780 aattgcttaa ttggatcctt cacaaaaact gatattcatc atgattcaac ttccactgta 75840 tgccaggtac agtaccaaat attttacctg ttttatctca tttaattctc cattgactac 75900 catttcaaag attattaaaa caaagctcca ggaaaacaag taacataccc aaggccatga 75960 aactagtaag aggaagagcc aggattcaag tcgaagtcag tctgtctttt cagttctctg 76020 atgctcctca ccgagtaatc cgttgcaagg ataacgagcg tgaaactgtc tggtacgtta 76080 ccctgcgaag cagggtcata taagggaatg gcggccatgg gggctggctt gagccagaaa 76140 caactcctgc tcctggctgc agagggaact ggatggggag gcagccctca caagtgacca 76200 gcacttgtca ctaccctgtc cttgcctgct tctttcaagg gatgcaggtt cccacctact 76260 cagcctcatc cacactcttg aagggtgctg atgtagggca ccagtatcca tggccaaggg 76320 gattttgatc tggcttcctt tgcatatctt gaattttttt cttttctgac cctacaaagg 76380 attaaaaaag gaaatgcctc tttcattaaa tattatgaca cctacctgaa ttttcctgga 76440 gggccatccc cccgttctca ccatttagtc ttcttagaaa aagttctagt gaacaatcaa 76500 atgtgattga gaatttgggt acatactttc taccatttct taaccccatt actgcccctg 76560 aggcataaga taaactatga ctagaaagag tggccacggt tggggtaggc ggggaagttg 76620 attggtcctg acccccaggg attcaggtgt gacacctgtc cacctttgag gatcactatt 76680 ctggcagttc agtgtcattg ctgccttcat atctgtgtca gcttagttgt tcctctttgt 76740 agcacatcac tgacaatgct tggagcctgc taagagagca cagcagaaga attattttta 76800 aatatgtaat tttttcttat ttgtccttgg catgtgtatt tgtcaacagt ggagcttctc 76860 tccacaacta cctacctagc taatattctg tcttttggat actcagttct ctctagcctg 76920 agacatgaat ctggctctat cttcattctc ttgatccatc tcacagatcc tctttctctg 76980 gttcttttcc tggattaatt tcttgggctc tgaccacttc caaccctccc ttctcaagca 77040 tagataaacg agaacaaagc tgaactctcc catagcaatc actgctcact actattaaaa 77100 ccactacatg tagtaatgga ggtgaatcaa actcaggaag actaggatag aaaatttcct 77160 tttatgacta ccagaaatga aaattacccc catggttgaa gcagtttcct cttagccact 77220 tctattttca ctctgtctag atttctattt taggccgatg tggttggaaa ggcttataga 77280 acatatacct tttgcaattt atagaaatgc ttacaagagc cttcctttga tattgggcag 77340 agttgaggaa attgtccaga gttacagtag tccaccctta tcaacagttt cgcattccgc 77400 agtttgttat ccacagccaa tcacagtctg aaattattaa aaggaaaatt acagaaataa 77460 ttcataagtt ttaaattgtg cactgttcta agttgtgtgg taaaatctca tgccatcctg 77520 cttcatccca tctgggacac taatcatccc tttgtccagc acatccacac catctatgta 77580 tccagccctt tgtcacttag tagccttctt ggttattaga gctactgtct cggtatcaca 77640 gtgcttgtgt tcaagtcacc cttactttac ttaaaaatgg ccataaagct caagagtagt 77700 gatgctggca tattgttata attgttctgt tttgttacta ttaatctctt accgtgccta 77760 atttatacat taaactttat tgtaggcagg tatgtatgta tcagaaaaaa aaaacctagt 77820 acatataggg ttctgtatta tccccagttt tagacatcca ttaggagtct tggaacatac 77880 accccacgaa taaggtgggg ggactactat ctaccaaagt tctactttct gacctcaggg 77940 ctgaacacca agtgcttgac acagagttgg catttgttaa gtgtttgaga gatattatat 78000 gcttttctgg agacatggac attgacagat actcatgttt tcaactggcc caagctgtct 78060 agtgcttctt tcgcatcaat tagacagagg aaattaggaa gaggttcatt ccattcaaca 78120 gacaacacac tgaaacactg cctgtgttac catcagaata gtaattccac ttttctctcc 78180 ttttttaatt atcccaaaca cctacatata cattccccat attcgcatct cccatatgcc 78240 gcaagtacgt ggcccaggta aatgctctat aaatattgat gattgaagcc tattgatcat 78300 ttttattaac ataggattac agcctcttgg aatatgtaga ggagttccaa ggtagtcaga 78360 gacgtttgta ctgcgtggct ccgggaaaag gtaagatata tttttaattc agaagaggat 78420 aatatcctaa atttatatat aaattgctaa ccacctacca cacatgtcag aaatgtcatt 78480 ttagggaatg tctcttctgt ctttagaaac cagtttccat aggaggaaaa agcagcctaa 78540 ggtaaaagtc tttctcttcc cagcagcgta ataagtgagc caaggtcaaa agtcaccatc 78600 ctacttcaaa gaagctgaca gctgtggggg attcacagag gcagtttaca ggaagtttga 78660 tattccagtt ctttcagcta atgcaagtat tatttctttt ttaaaataaa tgattttcaa 78720 cagaattgca tgtggcataa ttcagtaaag tgaaacacag tatcaaaata tgaatcataa 78780 acttacctgg aaaaacgctc aagaacaggt tttccatgga cataagtcac atggccattc 78840 cttctttttc tgctcctgta tagaaaaccg aatagtcaac acaatgtcca ttggcatgac 78900 agtagcccat gaattattcg ctctcctgtg gagatgtcac acactcattc tgtgagcagg 78960 attacaatag tcttataaat tcaaatgggt ttggcacatg tgtagttctt tgctccaggc 79020 cccagtacag ggccagtatt tttattttgt gaccagaatg ggcatgttaa atgctatttt 79080 atgccatgca aagtttatta ataagaaatg ttacctgtct catactattt atttgtttat 79140 ttattgagat ggagtctcac tctgtcaccc agtctggaat gcagtagtgt taccttggct 79200 cactgcaagg tctgcctcct gggttcaagt gattcttgtg cctcagcctc ctaagtagct 79260 gggattacag gcatgcactc cacacccaga taatttttgt atttttagta gagacagggt 79320 tttgccacgt tggctaggct ggtctcaaac tctaacctca agtgatctac ccgcctgggc 79380 gtaccattta ttacatatac tgtactatta tattatacta tcattattgt tatactatta 79440 ttatttagat 3t3t3t3C3t tcctactata tacacatact aattatggct ggtgtcacca 79500 t3-tt3.3-3-3.3-t gtttctcagc cgggcgcagt ggctcacgcc tgtaatccca gcaccttggg 79560 aggccaagtg ggtggatcac aaggttagga gattgagacc atcctggcta acaaggtgaa 79620 accccgtttc t3Ct333333 t3C333333t tagccaggcg tggtggcagg caccagtagt 79680 cccagctact cgggaggctg aggcaggaga atggcctgaa ctcgggaggc ggagcttgca 79740 gtgagccaag atcacgccac tgcactccag tctggatgac agagcaagac tccatctcaa 79800

3333333333 3333333333 agtttctcaa attttagcaa ctatcataat cacctgggaa 79860 gtgaattaaa cagacacagc ttctctagtc caatccccag aaattttgat tctgtaattt 79920 ggactctgga atccacatgt gtacaagtgc cccaaatgac cctgatcagc caacaggacc 79980 caggccacac ttggcacagc cctgccccag cttcatatcc acgccattca ccactgtggc 80040 cctgctgcca gcaagtgcct gtgcacagtc actgtgcaac taacatccac tgaatgacag 80100 actttggcat caggacatct agatttgaga acttattctt ctttaacttc tttaattgat 80160 cacttaaact ctgagctcca aatgttctta tctgtaaaaa gggaataatg tctgtctaca 80220 gagttctagg ttgtcagtga caaagaagca 3C3CC33333 catttctggc caccttgatc 80280 agaaaagaaa taattggatc attatcacat gatccagcaa tcccacttct ggatatttat 80340 ccaaaggatt tgaagtcagt atgtcaaaga gatatctgca cccccatgtt tattgtagtt 80400 ttattcacaa tggccaagat atggaaataa tctaagtgta catcagcaga taaatgaata 80460 aagaatatgt ggtgcttata cacaatagag tactattcag ccttaaaaag aagaaaatcc 80520 tatgatttgc aacaacatgg atacacttag ttatgctaag tgaaataagc caggcataga 80580 aagacaaata catgttctca cttacatgtg gaatctaaga aaacattgaa atcacagaag 80640 tagagagtgg aatggtggtt gtcaggggtt gggggaaggg gaatggggag atattggtga 80700 aagggtacaa agtttcagtt taacaggagg actaaatggt aaatatttga catgatggat 80760

3t3tt33Ct3 gcttgataca attattccac tatatatatc 3t33t3tC3t tgtgtgcccc 80820 ataattctat acaattatag tttgtcaata tataatgaaa tt33tt333t aaataattga 80880 aaggacattg gacagctcat gaaatccctg gcaaggctga aggactgagg aaaccagggg 80940 gagctgggca gcaaggaacc atgccaagat catgccacag gggcaatcca gtgaagacat 81000 agactttcat cactcaagat tcagttttga gtgagaacac gaagctggcc atcctgggtc 81060 ttgtgtactg gctgccaggg gccttttcag atttcatagt ggaaatgggg cctcattgtc 81120 cctcaagatt tacacaagat ttctccaaaa caggaagttt tgaatgctgg gcagctaaat 81180 gtgcattatg aattaactcc aacttaagtt ggaagaaatt cagagaggtt aataacgtat 81240 aaacaagtgg cagagctgtg gttttaactc atatctcttt cctctctttg tacttagaac 81300 agagccctct tgaaggtctg ttcttttggc tttcctttga atttcagtgg tctcaggcaa 81360 tttttttccc tcatcgattc ttcccacacc aacaaggtaa gaaatgcttg accttacaga 81420 ggcgagcaga aagtagaaac tgaaaagcac actctgtttc cctgattatg cctatgatta 81480 atcactttct gacaaaacga aactgtttct 33CCtC333t taaacatttt aaaagccaac 81540 aaggcttgaa agaacagaat cacttccaat ttatggtaag aaggagcagt 33t33tC3tt 81600 gcatcacatc atctcccata tgtgccctgt attaggaatc atacctaagt tcgagagtcg 81660 tcactggtgc catcacgatg aatgagtgga catccccgtg agacttggcc ttccaaagca 81720 aagctggtca actcatgtgg ctttgaggaa gtcgactcca gaataaaagt taatggaaat 81780 gcataagcgg agcaatgatg agatagaaaa ctaccttaaa tttgaaaatc atttcacatt 81840 ttattaagca ctttcgcata ccttaacttc ttgtaatatc cctgcatatc cctttttata 81900 gatgagaaca tttggaactc 3333ttt333 tggtcagttt aagaagaatg agctgttaaa 81960 tctaggtctc ttgattctgg tgaaaatctt ggcatgcttg aagacaaggg tgctcttgca 82020 gagaagaaca tatgtcacag tggtatcacc agttgggcaa aaagctctgt catcaaccag 82080 tcgaggagag gtgaggacga gtgctacccc agaggtggta gcttgaaagt gaaaagacag 82140 gggtatttct aacagctatt aaggacagaa cacagagatt gggctgagtt agaggataaa 82200 ctggggcagt gcctctctct gagcagcagc aaaaggtcag cattgctgct ggctgatgtg 82260 gaatttataa tgaaagccat gccgtagtag gcaaggatgt tttgctttaa aaagtgacat 82320 ttgcctcttg gtaatacatg ctgcaggtgt aagtgtttgg gggctccaca ttccagtgtg 82380 atgcaaaaag cactggactt ttaatcaagg gagctggctt gagtcatgca tgtctatctc 82440 tggaggctgc cagagtcagt catgcagagg acgagaggag tgagctctta gccaacttgc 82500 ttcaagtcca tagaggtcca gtttctcctt ctgccctgaa aacctgggtc cacagagcca 82560 tcttaagtac ctcaagccca gggcaaaggt cctggtagca ccacttatct ggagtacaga 82620 tcactggagc catttgtctc ctctacaaac agggacaaca 3tt3333t33 tgagacaata 82680 ggctggtcag gaagtccccc aatacttgca tC3333tt3C ccattttagc agcttgttat 82740 tagagctatt gggcatcaac atagctcaaa agcttccctc tggccataat 3333C3tttC 82800 atgtcacaaa tcccaggcac agtggcctgg gctctgttga caggcagctg ggcaggtcca 82860 ggggcatact gatgccagtg agggccatgg ggctcatctt tcccaggtcc 3C3ttC33C3 82920 acctcatttt ggtggtttga aattggccat aatccacatg gacactggga ggggaacaac 82980 acacactgtt caggcctgtc ggggtaggag gctggggaag ggagagcacc aggataaata 83040 gctaatgcat gtgaggctta atacctaggt gatgggttga taggggcagc 333CC3CC3C 83100 agcacctgtt tacctatgta acaaacttgc acgtcctgca catgtatccc agaacttaaa 83160

3t3333tttt 333333t33t aaaaattaga 333t3333t3 cagaaaaata gagggaaaaa 83220 aattggccac ggtaagagta tgtacatcac agaaatagac aaatgccatg agtcagaact 83280 ttatattttc cagaaagctg gttgtaaagc atttaccagc agcacatcat ttttggtttt 83340 aggtgatttt tttttttttt ttttaccagt gacacaaagt ccctttgcat atcagggagg 83400 cagcatggcc ccctagtttc cattcactta atgtactacg ggcagccgct gtttttgagt 83460 tatcttctaa gacctcttat gctataatca agaaaacatg ttgtcttaga aaatttccac 83520 cactctgaga caccttgagt aaaagtatcc ctagtttgta cttttaaact cagggccagg 83580 atgtattgag tttagaaacc caagtacaca cactaaggat gctaaaattt cggtaccaca 83640 gaccacatct tttttgtaca ttgcttattg cctgcaagat agtttgctca tctgaaggca 83700 agaacagagc aatggccatg atttagttca cttttggacc ctgagtaaaa ttgaaccatg 83760 cgggaagatc aaataagcct ttctttgttt gtgacacata ggagagtatg gcataaaagt 83820 gtgaaagcca cagactttga atataaatgc agtcatgtag gtgttaatac tccacgtata 83880 taactttgtc ctacttgcct atagggcctc tgtcctgcac ccccaaagag caccctaata 83940 atgaaacaat actgttggcg attttttgct ctagccttct tatcaaaagc atcactgctg 84000 tcctgtggag gcttcctgtg aggatgctgt tctgtcaccc tgagccttca cagtcttgga 84060 gctatactgt tgtctgcaga gcagttagag ggaaggactc tctccccagt tttctgtccc 84120 acttcctaag acaatgtccc ctgggctcca aacaagcatg cttgcatcca gagatgtgat 84180 cacatagagg ctcctcaatt tggcactcaa acacctctcc catgggtcca aacagtcttt 84240 cagcttgggt acaaatgggg aattaaccac tccctctgtt gacctaatca tactcaacaa 84300 attgttactt tttgcaaaca aaacaaagtc ccttttcata ttactgaggc agatagaagg 84360 cagtataaca agaaatacaa tggaattttt cctgttgtcc cggaagggag ctaagatcta 84420 aagctgacaa gcaaaaacac taacagtgtg tgtccattaa gatgattttc taagtaacca 84480 aaattgctag gtataggttt tgtcttgagt aagaccatct ctgtatcacc tcccacttgt 84540 ttgtatggct attatcaaaa agacaagagg taactgttgg caagagtgta gcgaaaaggg 84600 aacacgtaca ctgttggtgg gagtgtaaat tagtacagtc attttggaaa atagtatgga 84660 ggttactcca aaattaaaaa tagaactatc atacgctcca gcaatccctc ttctgtgtat 84720 acacccaaac aaaatgaaat caataccttg ggctgggcac agtggctcat gcctgtaatc 84780 ccagcacttt gggagactga ggtgggcgaa tcacctgagg tcaggagtta gagaccagcc 84840 tggccaacat ggtgaaaccc catctctact aaaaatacaa aaattagctg ggtatggtgg 84900 cgggtgcctc tagtcccagc tactggggag gttgaggcag gagaatcatt ggaacccggg 84960 aggcagaggt tgcagtgagc tgagaccgcg ccattgcact ctagcctggg caacaagagt 85020 gagactctgt ctcaaaaaaa aaaaaaaaaa agaaaagaaa aagaagaaaa gaaagaagtc 85080 aataccctga agagatatct gcatccacac gttcattgca gcattactca cgatagccaa 85140 gacgtgggaa tgacctaagt gtctattgat ggaagaacgg gtaaagaaaa atgtgatcta 85200 tacatgcggt ggagtattat tcagccttta aaaagatgaa aatgctgcca tttgcaagaa 85260 cacgaatgaa cctggaggac attacactaa gtagtataag ccagacacat aaagaagcat 85320 attgcataat ctcacttata tgtgaaatcc aaaacagtca aacatataga agcagagtag 85380 tggttatcaa gggtgaggag gtgggggaaa tagagaaaca tttaaaaaat gatagattac 85440 ttaaaaacat ttttaattga ttcagaggga atattttact gattattaga ttgaagctct 85500 gtagacttcc cagctaattg tgtaaatcat atttttttta atgtattgat acttaggttt 85560 tcccctgggg gcaaaaggaa tgcattcatt ttgaatagta tattttttaa tctttttgca 85620 taaactaaag caatatgtca ttttaaaaaa gatttccatt cttttggcaa ggagcttctc 85680 catgtgttgg ttttgttgaa cctggatgta acatctggaa ttgatgcagc cactttgtgc 85740 catgagtgaa tctagcctga ggacaatttc ctaaggcagg aaggggccgc cttttacatt 85800 atccctgttt taagagctaa agtaaaaaag ttctttccca gaccccaatt ccttagaaaa 85860 gtgaaattct catggttggc ttaagaaaat aaagatttcc ccaccaagag tcttggaata 85920 tggaagaagt tgaatattca aatgaatagg gtctattaga atggtggaag tgcacaaatg 85980 gctcttgggt gggcaacagg atctgctctg tggccacatt ctatgtccaa agcaccagca 86040 gcaccaaggc tgaccaccca cagggactac caagaggcac ctgcccacca ccagcaccta 86100 agtcaatgaa atgaaaagac taggagaggt gagagagctt tgggagactg ccaggtgtat 86160 aagagaatcc ctgccctctc atttctcttc ggaactttgg caagccacta aagcagcaga 86220 gtgcttgatg tcattggagc ttggagaagg ggagacagga agacaagaag ctgagaaaag 86280 ggaaccattg agtcagcctg tttttctact gtctggcaaa gcaagtcttc tgtgggtcat 86340 gtggacactg cgggagatga ccaggcttgc ctgtcttgac agtatactgc ctccaaagga 86400 ctggcatgga gcaaggggat cccagcaaca aggggctgtg gaatatgctc ctgtggtagc 86460 agctgaagat ttgcggaagc cgttggttca gaatcgagtc tgccatatta gtttgcactg 86520 tattagggag actctgcaga gagattcagc cacatccata gagttaacag agagcagtgg 86580 ggagtaacag ggctggatag tgcctgtcgt cttgccatga aagataacca ttccatcccc 86640 aatcccttcg tccctttcag agcctggaag agggaagggg aagtatagaa caaccagact 86700 atgcttttct cacccactcc aagcctctat agtcaaagtt ttcatctatg ttagctggaa 86760 gagagaagag ctttgaatca aacattgaaa tttattcaac aaagaaataa gactatttga 86820 ataacaaaaa gtgacaaaaa gatgttatgg aatctggaag atgcctcatg agagatgcta 86880 caccaccaga aagggagagg caatatagta gagtggcagg ttattgcgga aaacttttct 86940 tcgttataca ctaacacatt gagactccat agtgaacaca ttctacagaa ggaaggtgag 87000 gtgtcgccca actctaagct ttgaaaatat tcatgtccca tttttggcct agccccaaca 87060 caatgatttt tttttttctt tgagatggag tctcacccag gctggagtac aatggcatga 87120 tctcggctcc ctgcaacctc tgcctcccga gttcaagtga tttttcctgc cttagcctcc 87180 atagtaactg ggattacagg cacctgccac tatgcccgac taatttttgt atttttagta 87240 gagccagggt ttcaccatat tggccaggct ggtcttgaac tcctgacctc aggtgatcca 87300 cctgcctcag cctcccaaaa tgcagagatt acaggcatga gccaccgcac ccggccagcc 87360 ccaacactat tactgaaggt aaataaaaat ggagtcttag gagtagagct agaggaaaaa 87420 aaacattaac aatatctagg tactgccaat gaaccttcct tggtatccgt gaggattggt 87480 tgcaagactc ccgtgtatac cagaatctat agatgctcaa gtctctgata taaaatgggg 87540 tagtatttgc atataacctg tgcacatcct cctgtatact ttaaatcatc tctagattac 87600 ttataatacc taatacaatg taaacactat gtaaatagtt atattgttta gggaataatg 87660 acaagaaaaa aatctgtaca tgttcagaac agacatggtc ctttttaaaa tatttttgat 87720 tcacagttgg ttggatccac agatgtgaaa ccctatggat aaggaaggcc gactgtattc 87780 atttggaacg taaattggag tacttggaga agatattcaa cctgtgaact tcaggcccct 87840 agtggtggtc aaagtgattg caaagagtcc tcaaccccat ctgtgagaac tggggtggac 87900 agcaaaggga tgaggcagca gaggaagttg gagagagcac caggatccac taaggacttc 87960 tccacacagg ggatagtggg aagcctttgc agcacagcaa agacacaaac agctttgtgt 88020 tttgagaaga tggttctggc tgcagtgtgg aaagtggatt gggattgggg atgggaaaag 88080 agcagttagc aagctattga agtagttgga caatggtggc tgggaatagt ttctagcagt 88140 gaaacgggag gaaagtggag aaagtcaggc tattttaaga tatacaagtg ccagctctta 88200 gagaccaaat agatatgggg attaaaggcg atgaaggagt tcaagataac ttccctggtt 88260 tttaagcaaa tttttgagca actgggtgaa tgatgatacc atttactaag acttggaata 88320 ttggagatag agcaggtttt gaggacacta agttcagttt ggggataata tgattagtga 88380 gaagtatcta ggaggcctct atgaagaaat gaccagtaat taggctattg aatagatacc 88440 aatgtgagag gacttacatg taaacttgaa ggactgggaa gagacacaca cccctaggga 88500 gagagtacac agtgagagga gcggaatagc tagttagatg aagaagagaa aagagcaaag 88560 caatatgaca ctgagaagat tacttggggg cacctgaggt ttgcagatta gctgatatca 88620 agggaacaaa gtgatatgcc aaaaactttc aaaattgcat aagggttctc ttgctggaaa 88680 atgaaactat tgacttttat ttataatgtc caggtcttca ttgatggtta taacataaat 88740 atatgccgaa tgagaaaagt agatgatgac ttattatcta catgacatat gattatatat 88800 gatgacatat gattacatta tagcgtcagt agaggagaaa caagatgagt attttgctaa 88860 tgctcactgc atgcactatg ctttaaaagc aaaagcacaa ttgcttgatc actttgacat 88920 tggtatgtgg tggcctcact gttctcagaa atctttctaa tcacagaagg tacaagccca 88980 gccactgctg aggccgaatg tgatctcatg ccagaggacc aatatgcaat ctgattttgc 89040 aacctcagga ataaggagtt ggatttgggc aagaatttgt tggactattt cagattttta 89100 ggggtttttc tcccctcctt catgaatatt tcagcctaat caaaaaaatc tcaaacctca 89160 caatattttt aaagcaataa gtcaaatcaa ataaatgatt tgaatgttga aataatgcaa 89220 cacacccctt ctggtcagca cacaggcagg gtcttcttta cctgaggaca gaccttttcc 89280 ttcccgcaaa ctgtttctgt aagtaatgct gccacctagc agtctcttgg ggaatcacca 89340 ccctacaagg taatagcttt cggtacacac gttttaggtt tgtggtggct tccctgcatt 89400 taagttgggt ttaaacaaca cttgaaatat gaatttaatt acctttgaaa aatgtctttt 89460 ctgcaggtat aggtcttgaa atcatggtgt ggcaaaaaat aggctgttga aagcagctcg 89520 ctcaagatga aaatgatggc aaaatgcaca ggatttgcac tgtccaaact catccaattg 89580 cagacactga atatgtgcag ttctttttat ataaattatt cctcaataaa gctgtttaaa 89640 aaatggtaaa ataaaaagaa aatgatgaaa aaaaataaaa caccccctgt gtaaaacttc 89700 agtacatttg tatgaaataa caaacctcta caagtaactt gtgaggagag taggtaaaaa 89760 caaagtgtgg atgatcagcg tcaaagaaga acagctcttt aaccagagaa ctctggagtc 89820 ataatctcaa agtatcacct atgtgcctac tggaaaccta aatgctgtga cattttaatt 89880 cacagcagga gcttcacttg caaactaagc aaagttactt tttcatgtac ttcacgtttt 89940 tgtgttttca caaaggttaa aaagaaacag ctaacagtta ttgaagtgtt tgctatttgc 90000 ccaacactga gtaaaacact ttccaagcac tgttatgtaa cctacacaat cccctgagat 90060 gatgttactg atactggtgg cctggggaag ttaacaaggc aaataagtgt tggagtcggg 90120 atacaaaccg agccagtctg atttcagagc ctgagctctc acctccaagg ttataatact 90180 tttctattgt gctgaaagtt atgtgggagc aaacagatgt cagatgttca gcaggttaaa 90240 acatgtgtta acaggataca gtaagtttct gttttctagt tgagtggcat gaaagaaaat 90300 gttctcaatt gtatcacagt gacatttgtc ctatctctta ctacaaacta ctttatttaa 90360 tcactgtgaa actctaccgt taactctctg tttaatacct gttgactacc tagattgtca 90420 gatactttgt ccaattatgc catctcactg ttttagtgac atttcacttt ttgatatctt 90480 gagagagagt ttccttcttg tcactgctct gcatttagat gtcagtgagt actgacatct 90540 acagtggatg tgtcctgtcc acttttacta aaataaggta tctatgcatc attttctgag 90600 gaaatgtctt gtccaaacat atctctgaag ataatttgaa tgtgcataat atctttatcc 90660 agaaatagca tgccacagca aactatgcag cttatgttag accaggccca tgcattcaaa 90720 ccacctgaga atctcgttga atgcaggacc tgagattcta cattttaaac tagctctcgg 90780 gtgaagttaa tgatgccagt ccttggatca caatttaagt accaaggttc taaattaccc 90840 agttatgctt gggtctggaa agaaaatctg attcgattcc aaagtgaagc aaaaaaaaaa 90900 cttccctata attttctcat tttatgtatc tgatgataaa aatcaggttt gatataaacc 90960 aagttatgta tttttatgtt tctaaacaag ggtatctata aaatctattt taaaaataaa 91020 ttgtttccat ttgagtttta aatctatttg tttaaatatt ttttcttctt gtcatcagag 91080 tttttgaaat ttatacctct accataagat atcatgtagt gttggacttg aaacttctag 91140 aatcatctgg ctatcagaga gctgcccaac ctccagcccc atcttagggc agacatgaat 91200 aaggcttctt tggtctaaat aagctaaatc cagagctctg ggcattaaag aaactgaagt 91260 cagattttag aattgttctg caattagttc cttgacctgg tggtcctatt tttaatagca 91320 gccaatttag gagtttccta ggtttattca gagctctctt tcaggtaact ttgtccctat 91380 actcttcccg ttcttgtcag tatcactcat ttttttgctc tcacaagaaa atatatagta 91440 cttagaggta aatgtaaaac ttctatactt gggtctcaag atcatatcac aaaagagtga 91500 aatgaattag acactgtaag aaattgacca ttcaaaaaca ggaatgttat tgcctaccaa 91560 ctcaatataa gtgactagaa taatgttatt cagtctagga atctattaat agaagaatag 91620 tgctaggaca aaggaggtaa tgggcttcct ctagcttgta ctggcaaagc cataattgag 91680 gtaatacaat gttcagatgt atgcatttaa gtgtatgcgt gtctgtggct gtgagtcaga 91740 gagtgtgatg gagaggcaaa agggaaggta gttataattt atgaggaaca atggaaaaga 91800 tcaacaggtt tcaaaaaggt aaaccaagat ggtgagagag tttcaaactg ttatcaattc 91860 aaagaaatag gagtatttac ttttgaagtg ggttttggag tggaagttag taagatcttt 91920 tatggatgga tggacagatg gatggatggg ggtggtggat ggattgaaga gttaaatccc 91980 taaacacctc actttgagaa atgtagaagc aatggagcag ttttttccca aacagattag 92040 atagtcagac agacaggcag gctatttatt gaatacattc tacatgccag tatttggccg 92100 aaccctctac atataccagg tgctttcttc tccaaacaac cctttggaat tcctattatc 92160 ctcatgtgga aagtggtaaa tatgaggcat agagaaatta agtgacctgt ccaaagtcat 92220 tgccaggctg agctcagact ttgtgctgtt aacctctagt ttataaccct gagtgacact 92280 caaaggtggc ctactcaact ctctcttaaa gaaataactt gctggccagc ggcaaggagt 92340 gcagttagct gacagcctct actgataacc tcctcgggct ctgcttcagc tttcaaccag 92400 agaccatgtt gtttctgagg aggcccagct aaggaccgag cacggttggg gtagaagagt 92460 ctgaacattt ctgcccacca tgggcccctc taataaacag tctttcctct ggagctcccc 92520 actgagctgt tgtagacttc accagatcag cattgcaatc tgaggctccc cctgcccaat 92580 tcagcctcct tcctccttct gtctatcgca ggagttgttc tgaataacct tcttttactc 92640 caatgtccat ctcagcatct gctttgcaga ggacacaact ggcacaccct gccttcatat 92700 atttggattg ccatcatata gaagactgtt tagaattgtt ttgtgttgtg ataaggggtt 92760 gaattaggac aaaattcaac cccttatcac aacacaagca taaacaaact gctagggaag 92820 cagctttcac atatacataa ggaagaacat cgtaacaact agaagtgcca aacaatagaa 92880 taacctgcct caagatcaat gagtgccctg tcactgcgtt caggctgact ggagaactgc 92940 ttttgtgtga aggttgtgtg gcattaccac tcctccactt ctacccccat gaatactgag 93000 gcacctggga tgctaaacat ccacaatgct aattgattag caaaaaccaa attgtttagg 93060 aaatcgcgcc aggaagccca aacctctgat ttcttagcag atcagtgggt ctggtttgat 93120 acatcatcct tgtccacttc cagggcagtt tagtggtact ctaggccaga ctagccagtc 93180 tacatacttt ttttttaatc aaagagcttc tagaaaatgg gataagctgt gggctgattg 93240 tccccatgga ctagttggtg ggatcaaaac ctaacttcac atatgtttat gtcagactgt 93300 aatatggggt tcaccctcta atgcagttct aatgactccc tcccctgcca catggttctc 93360 aagctcatgg acttgcacac gacagccaga gagattctct tcctcaaggc tgttgtctcc 93420 ctcccttcat gcagacacag gcacacaaag caggggactc ctactgcccc cttctaagaa 93480 ttccatgatg gtcagattat ataagtaatc atatatttca gatagcaaaa taagagatgg 93540 aaaagactgg taggaaaatc aatagcataa tcagcgttag gatctgtata taaagagaca 93600 ttcatttgct gtgcaaatat ttactgagca cctaccaaag gccggaatcc cttccacatg 93660 ctagggacgt gatgcgctcg acggagtccc caatgtcatg gagtatatat ctaatgccac 93720 tgagaaacct ggctcaccct gcactgagag aagcactcaa aaccaccatc accaatagcg 93780 ctactaaaga cagtgctttg gagcttccaa gctgatagat tatcctttct ccccaccctc 93840 agatttctcc agtgtctctg gcacttatag tccatgtttg caagaaatat tttattatag 93900 tgctctgaaa caaatttata aagtttgcaa gagaagtttt aaaaaagcaa gctcagcaat 93960 atttgggggc ttttaaagct gatgatgcag ctgacctact ggagacaaag gcagtgggag 94020 ggcccttact ggtataaata aataggagtc tctggtactg caaacccaca gcctggactc 94080 agagctcaag tctgaactct acctccagac agaatgaagt tcatctcgac atctctgctt 94140 ctcatgctgc tggtcagcag cctctctcca gtccaaggtg agaaatttca tttacatttc 94200 actgtttgtt gaacagaaat agtctttaac cacttcaatt ttctttcgat taaaaaccgc 94260 agggaagtct gactaaaggg ggaaaaaact gctctgttcc ttctagattt ctcaaagtaa 94320 ggtgtttagg aatttaactc ttcaaaactg gaagtattta tattgttaag atttttattt 94380 atagcaaaaa gagataccac aagtccaata ttcatgtgaa ttatatattc ccagcctttt 94440 tctgattcag ctcctgctat atataattct ttacatgtag ctcttctttg ttctgcctct 94500 caatgttacc cactctgacc aaaccctata cagggtttaa agattattga actctactgg 94560 tctcttgcag tgaacatgct tcatgtaact ccaaatggtt agatctgaca tcaagtacac 94620 cactgtcagt acaccagggg tatttacaca cattctgcaa agaagcagac ttccatgtct 94680 aagtggggca gctatctttg tgtcaataga taaatatcca gttgaagtag taagttttta 94740 tgtggccgaa gaaatggata tgtgcagaaa gaagccttct gctcagattt agaaggccaa 94800 atttttgttc ttaaaacaca gaggagcttt gtcccccagt tttaattttg cttcacatgt 94860 tattttcact cttcaaaacc ctaatttctt gcattctcca cggggctttc ccatggctcc 94920 cggcagaggt agctcttagt acatcttctg ttctcagcat gcatgttaga ttttgagcgt 94980 aatacaacct tctgtggtat tttagttttt gtttgcttgt ttcccctact aacttgtaca 95040 caccttgaga ggtgagcctt tttatttata aatgtatgtc aagcacagta gtaggctgga 95100 tagaaaagat ctgataaatg tctttggctt agatttcatt agatcccatt aaaattcatg 95160 agatggatac taatggtacc catccagtat taattgcttt tgttaaataa aaagactttt 95220 gaatttttat gattgccttt tgttctgtaa tgatttgcaa cccagacaga ggaccaacat 95280 atcaaacaaa aacgtctgtg acattttctg agaggaaagg ggaggatggc agagagtctg 95340 atagagaaaa ctctgttcca gcatgttatt gctcccagga ctcttgagcc aggtcatgtc 95400 ctcggttttt atgtgttggg agtgaagata atccactggt tttatattgc attaattata 95460 actgagttgt aagtccctac agaggctgtt ctcaaatttt attatgtgga ctatcacctg 95520 agtacaaata taacactatc acaaatttca aaattgctgt gtttttttga aagctaattt 95580 ttgttttgtt ttctttttgc tttgtttgtt tgctttctga gatggggtct ccgtttgttg 95640 cccaggctgg tctcaaactc ctgggttcaa ccaatcctcc caccttggcc ttccaaagtg 95700 ctgggattac aggtgtaagc cactgtgcct ggcctaaaag ctaactttat ttttaaagtt 95760 ttggtagaaa acatttgaaa atactcaagc caagacaagc agaaatatac aaactaaaga 95820 catatgggtg gaagcactga cttgaaactt ttaagtcttc aaatgcacgt tatgaaagat 95880 tagtaattaa attctagtta tgaattacat gccaatggat taaaataact gattctgtgt 95940 ttacttacag gtgttctgga ggtctattac acaagcttga ggtgtagatg tgtccaagag 96000 agctcagtct ttatccctag acgcttcatt gatcgaattc aaatcttgcc ccgtgggaat 96060 ggttgtccaa gaaaagaaat catgtaagtt tcaagagaaa aataaataag atttccttct 96120 cccaatgaaa tcagatcaaa tgttaccata cagtagtctt actcaagaat gtcgaagaga 96180 tttacttgag tgttgctaaa aattctcaaa ctaataatga aaattgttaa taattaagag 96240 cttagtttgc agcagccctg agctaagtgc tttacatgca catactcatt ttctttattc 96300 aaccacttta ttaaggtaag tctattgttc cttacagtct gaggcttagg aaggttaact 96360 aactgcctga gacacaccat cagaaaggat tagaaagtgc attagtggcc aggcgtggtg 96420 gctcacgcct gtaatcccag cactttagga ggccgaggag ggcggatcac ctgaggtcag 96480 gagttcgaga ccagcctgac caacatggag aaaccccgtc tctactaaaa atacaaaatt 96540 agccgggtgt ggtggttcat gcctataatc ctagctactt gggaggctga ggcaggagaa 96600 ccgcttgaac ctgggaggcg gaggttgcgg tgagccgaga tcacgccatt gcactccagc 96660 ctgggcaaca agagcgaaac tccatctcaa aaaaaaaaaa aagaaagaaa gaaagtgcat 96720 tagccaggac tccattcaca ttttccccgt tgcaaagcct cttctttgcg acaccttgaa 96780 gtattaggca cagcatcttt ctcagggcat ccctgacttg gcattcatga gtggcttttc 96840 ccatggactt ctttagattt ttgcaatgtt tgtaagcagc tacttcctct ttgtcacatt 96900 ttgttaccag tgcttggggc cttggaccag ttgaaatatg ggatatcaaa agtgcatatg 96960 gtagtttttc actagaaagg catttcacta acgtctttaa caataatgtc taactaaact 97020 acaattattg gcatcaaact cagagatgtg aagtctagcc atgacctact tgggagtagt 97080 tcccctggct gtttagaaaa ctgggacccc cttcttttga ttccatttcc tctgtcatga 97140 ctggtctctt gcctgtcaac caaggaaggt aatgcacctt aattttctct gctttaactt 97200 tgattgtttt gaaatgacaa aaatctgatt ttatatcttt tcatcaagtt ctgcatttgt 97260 gaattttaac cagatacaga aatgaaagtt tcaaattatt gtgagaaatt catgccagtc 97320 acaggtgaaa ataccgtgag tccagatgat cagaaatctg tctttccatc atgaactcag 97380 aaacccaatt ggaagtgtct atctgaaaac ccaactgctc catgtcctgt gacctctcta 97440 agatttacgt gcaaaagtgc agtttcagag ttagatggat ggatccttgc tgtttgtctt 97500 tattgttttg gggtttttgt ggtttgtttc tgttttttgt gttttgggtt ttttttttgt 97560 tttgttttgt tttgttttga gacaggatct cactctgctg cccaggctgg agtgcagtgg 97620 cacagtcatg gctcactgca gcctcaacct cctgggttca agcaagcctc cctcctcagc 97680 ctcccgagta gctgggacaa caggtgcaca ccaccatgcc cagctagttt tttttattat 97740 tatttctgta gagatggggt ctcattaagt tgcccaggct cctggcctca agcaatccgc 97800 ccacctcagc ctcccaaagt gctgggatta caggcatgag ctaccatgct gctggctgtt 97860 tgtcatttta taactaagat aaatgacata taaggaaatt gtgttttgtt tgagttcaca 97920 ccaatagagg gtagagtctc ccagttttct gctgtctggc agacctcact tttccacttc 97980 agataaagca tttaacacta tatctggcac ttggtaatca ctcaggtcat gctcatgaaa 98040 aacagtgaag aaaagtgtgg gctctggagt cagataatct tcatttgaat ccttctgtat 98100 catgtatttg ttgtgcaatc ttgaacaagt tatttaaatt cactgagcct aagttatcat 98160 cagaaggtaa ggaagtaata atttctccag caaaggattt ttgtgagatg aattgaaata 98220 atccatgtta cctgctaagc atagtgcctg gtgtgttata agtacctgat aaatattagc 98280 tattaattat tgctgccact tttgctattg cttaatatct tagagcagga aaaatcttgc 98340 taagtggtaa ttcgacaaaa tgcagatgtc actccaagca atctgctctg cagcatgcgt 98400 ctcatgtgaa attgcactga attttttttt ttcagtgaaa ttcaggttct caagagagtg 98460 ttttctacag cttattttgt tctcccaaat gcagtgcaac agataagcac attttaaaga 98520 tattgtgata taactttaga agtgagccaa tcttggagta agttatttgg ttgttctcca 98580 atgcacgtaa atgttatcaa caaaacacta acctctgaca tgtgaggccc tcgcagcttt 98640 ggattcaacc ccaccagctc acacatactg ttccacaaat ggttgttctc ttattcctct 98700 gaccccatac tacaaatcac ctattccaga tcccaaactg cccagctcca atttcacttc 98760 atctaggaat aattattttc ataccaaact cttttcttta ttaaaagtat aggattgact 98820 aaaatgtaag actgaattat ttaattttta ttttccccca gagtctggaa gaagaacaag 98880 tcaattgtgt gtgtggaccc tcaagctgaa tggatacaaa gaatgatgga agtattgaga 98940 aagtaagtta ggcataacaa ggggtttcag attccaactt gtactgaaga gtttcccttt 99000 cctgggcagt caaaataggg actagcttga atttatgaga agttcctaag acaaatgtgt 99060 gtttttcact gttattgctt atcagatgga gtaggggtag ctcattccag cagctcagta 99120 aaccaaacta gatgccagta tacataagag tccttgcccg gtatctccag aggaaagcca 99180 cagtttcttg tgtttctcta aacatgacaa ttttgttttt gtttctgctt cacagaagaa 99240 gttcttcaac tctaccagtt ccagtgttta agagaaagat tccctgatgc tgatatttcc 99300 actaagaaca cctgcattct tcccttatcc ctgctctgga ttttagtttt gtgcttagtt 99360 aaatcttttc caggaaaaag aacttcccca tacaaataag catgagacta tgtaaaaata 99420 accttgcaga agctgatggg gcaaactcaa gcttcttcac tcacagcacc ctatatacac 99480 ttggagtttg cattcttatt catcagggag gaaagtttct ttgaaaatag ttattcagtt 99540 ataagtaata caggattatt ttgattatat acttgttgtt taatgtttaa aatttcttag 99600 aaaacaatgg aatgagaatt taagcctcaa atttgaacat gtggcttgaa ttaagaagaa 99660 aattatggca tatattaaaa gcaggcttct atgaaagact caaaaagctg cctgggaggc 99720 agatggaact tgagcctgtc aagaggcaaa ggaatccatg tagtagatat cctctgctta 99780 aaaactcact acggaggaga attaagtcct acttttaaag aatttcttta taaaatttac 99840 tgtctaagat taatagcatt cgaagatccc cagacttcat agaatactca gggaaagcat 99900 ttaaagggtg atgtacacat gtatcctttc acacatttgc cttgacaaac ttctttcact 99960 cacatctttt tcactgactt tttttgtggg gggcggggcc ggggggactc tggtatctaa 100020 ttctttaatg attcctataa atctaatgac attcaataaa gttgagcaaa cattttactt 100080 aa 100082

<400> 43

atccaataca ggagtgactt ggaactccat tctatcacta tgaagaaaag tggtgttctt 60 ttcctcttgg gcatcatctt gctggttctg attggagtgc aaggtaaggg gttctgagtt 120 aggttgtaaa gtaagagaag tgattcactg taaaagaatc ttgattagcc agataaaggt 180 gaatgttctg cctgcattga agagtaatat ttggtcagtc ataaaagctt ctcagtgaca 240 tgaccagtta tccaaagttc ataacttcga tctgccaagt caaacacaag tctttgtagt 300 ctaggtgtat gaattcctag taagtgttca ataaatgttc attgaactgg gtaataatga 360 gaactctatc tcctaaatta ttttcttctc cctgatactg ttttttgcta agtatatctg 420 tggctaacca attaaggatc caaccaataa tcagagaatt tgtccctaat ctatttacta 480 actatctttg ttaccttgga caaattactt aatctttcta gacctcagtt tcctcatcat 540 ctgtaaaata gaactttgta gttatacctt ttctgactgc tacacaatgt atggcatatg 600 gtacaataag taccaagtaa atatatgaat ttaagaatta agataatgta ttttaagggg 660 ttttcaaaaa tttaaaacac tattgaaaag caaggcagtg gggaggagag aggatgagga 720 tgaaagtggt gattggttac aaaggagtgc tttctattca acaccaacac cagttccatt 780 ccttaaggtc agataataaa taatagatgg tttaggagtt gcttaagaaa ctgtgatcag 840 catagcatac atgaattagt tatctgtttg tcttgtgata ggcatttatt aaatattgtg 900 aaagtctctt tttctcccac ggacttacgg tgtggtagtt aagagcaacg cctttggact 960 cagagagatc tgggctaaaa ccctgcccct gctccctaaa agctgtatga ctttgttctt 1020 aatctttctg aaccttagtt tccttatgta taaaatagag atgatacctc cttcaaaggt 1080 ttgtggtgat tatttttagg cactcggtaa atgatagcaa taatcatgac tcagtcaagt 1140 gtatcatttt gatagatcac ctaaactgaa acattggcct atactgatgt gttctatctt 1200 tttctttccc tcaggaaccc cagtagtgag aaagggtcgc tgttcctgca tcagcaccaa 1260 ccaagggact atccacctac aatccttgaa agaccttaaa caatttgccc caagcccttc 1320 ctgcgagaaa attgaaatca tgtaagtaac aacccagcta acatgcatgc accatattgg 1380 caagaacatt aaatttagca tgagttttac ccttggagtg cttgcccata caaacactta 1440 aaaatcagat ggttaccccc tccataaatt tgggcagctc ctttcttttc ttctccttaa 1500 aaatgcaagg aatttctggt agattaggcc ccaagaatga cacatgttta ttgtacaaaa 1560 tgtttaatgc aggtaacaca atagaagaaa ataaaaatca cgcataattc tacccttgag 1620 tgacaaatac tgttaacccc ttagtataca gttttctaaa tcttccttac ttgcttcgtg 1680 tgcacataac atagatatgt ttttacatac acgtatataa gcacaaaaat taaatcatat 1740 actatacact gttttgtaat ctgctttttc attaacacta tatcatgaac attttctcgt 1800 gtcagtaaat ctctaataat gtcattttta cttaatgtca tttttaatgg ccaaactgta 1860 tttcatcata tggataaacc ataatttata tgaccaggat tattgttgga aatatagatt 1920 atttccaaat ttttactgct gaaataaaac ttactgtggc agtattgtgt ctgtaattct 1980 ttcctttcta gagattagga ttgctaggtt gaaggatgtg tgcatatttt gtctttataa 2040 gtcatccttg actactctta ttctcagact atacagaaaa attaaaggaa catttaaatt 2100 atttccagac agtctactgt aagtaatttt taaaatttaa ccagggccgg gtgcagtggc 2160 tcacacctgt aatcccagca ctttgggagg ctgaggtggg cagatcatga ggtcaagaga 2220 ttgagaccat cctggccaat gtggtaaaac cctgtctcta ctaaaaatac aaaaattagc 2280 tgggcgtggt ggcgcatgcc tgtagtccca gctattcggg aggctgaggc aggagaatcg 2340 cttgaatcca ggagttggaa gttgcagcaa gctgagatcg caccactgta ctccagcctg 2400 gcaacagagc gaaattctgt ctcaaaaaaa gaaaaaaaaa aaaattcaac cagtgactca 2460 tcttgtccta ggaaataatt ttaagtagtt tcattagaaa attcagcaca attcatactg 2520 attttcatta tttctgagaa gaagcattta aattattaat gagaaaaaac tatctcattg 2580 ctatttcttt ggcagtgcta cactgaagaa tggagttcaa acatgtctaa acccagattc 2640 agcagatgtg aaggaactga ttaaaaagtg ggagaaacag gttggtgaaa aggaagatca 2700 aaattttctt tcttttagaa attaacttta gaagacaaag aatctgcttt ttcattaaca 2760 ctataagaat acataacttt taagaataca tttttcattc atattatggt gcttctattt 2820 tgttcctagg acaaaattag gttcctacat atagtatccc ctctctgtct cccactggaa 2880 gaatgtgtgt tccttggggg tacagagctt gtccttattt aatacaataa atatgtaatg 2940 aattgaatgg tagacacagg atacaaagat aataaggtat agtcccttcc tgttgtagtg 3000 catatgctaa taattatggt acaatgtgag aaatataaaa gtatgcacaa gaatcttgac 3060 gacatagagg agggagtact taactttgct gggggaatgg ggcaggagaa agtgttaagg 3120 aagatttctc atgtcaggtg atatttgatt tgggtcttga aggataaata atttgccagg 3180 aaggtaagga cagcatgagc agaagagtag aatcatgaga gaacctgctg tgttcaggga 3240 gcctccatta atgtggctgg agtttgtgtg aagagagtga agggactgag gcagaaaagt 3300 agatcaggac aaagcgggag gaatcctgca tggcatacta aggagttgga tttgaagaga 3360 gccacagaat atgtgggtgg gagattgggt tctggagtct cacagactgg aggttctgcc 3420 acatactagc tgtctagatt tgggaaagtc accctctcca gaactcagcc tcctcctatg 3480 taaaacgtgg atgataatag tgccaccttc agagggttgt agctggggca ggtgagtggt 3540 aagcaaggtt gccaggagaa tgtaataagc cagaagaata gacaaaagac agccagtttg 3600 aaggctgttg cctcctcctc aaagtgagca aagtagagag aatctaaggg agcccctctg 3660 agagtgaagt gactttaatg tggttttgag actatgtggg tatgagacaa tgatcaggag 3720 agtccaaata aaaggaagta aaaatggtaa gattcagaaa cattgccctt tttccccttc 3780 ttctcacagg tcagccaaaa gaaaaagcaa aagaatggga aaaaacatca aaaaaagaaa 3840 gttctgaaag ttcgaaaatc tcaacgttct cgtcaaaaga agactacata agagaccact 3900 tcaccaataa gtattctgtg ttaaaaatgt tctattttaa ttataccgct atcattccaa 3960 aggaggatgg catataatac aaaggcttat taatttgact agaaaattta aaacattact 4020 ctgaaattgt aactaaagtt agaaagttga ttttaagaat ccaaacgtta agaattgtta 4080 aaggctatga ttgtctttgt tcttctacca cccaccagtt gaatttcatc atgcttaagg 4140 ccatgatttt agcaataccc atgtctacac agatgttcac ccaaccacat cccactcaca 4200 acagctgcct ggaagagcag ccctaggctt ccacgtactg cagcctccag agagtatctg 4260 aggcacatgt cagcaagtcc taagcctgtt agcatgctgg tgagccaagc agtttgaaat 4320 tgagctggac ctcaccaagc tgctgtggcc atcaacctct gtatttgaat cagcctacag 4380 gcctcacaca caatgtgtct gagagattca tgctgattgt tattgggtat caccactgga 4440 gatcaccagt gtgtggcttt cagagcctcc tttctggctt tggaagccat gtgattccat 4500 cttgcccgct caggctgacc actttatttc tttttgttcc cctttgcttc attcaagtca 4560 gctcttctcc atcctaccac aatgcagtgc ctttcttctc tccagtgcac ctgtcatatg 4620 ctctgattta tctgagtcaa ctcctttctc atcttgtccc caacacccca cagaagtgct 4680 ttcttctccc aattcatcct cactcagtcc agcttagttc aagtcctgcc tcttaaataa 4740 acctttttgg acacacaaat tatcttaaaa ctcctgtttc acttggttca gtaccacatg 4800 ggtgaacact caatggttaa ctaattcttg ggtgtttatc ctatctctcc aaccagattg 4860 tcagctcctt gagggcaaga gccacagtat atttccctgt ttcttccaca gtgcctaata 4920 atactgtgga actaggtttt aataattttt taattgatgt tgttatgggc aggatggcaa 4980 ccagaccatt gtctcagagc aggtgctggc tctttcctgg ctactccatg ttggctagcc 5040 tctggtaacc tcttacttat tatcttcagg acactcacta cagggaccag ggatgatgca 5100 acatccttgt ctttttatga caggatgttt gctcagcttc tccaacaata agaagcacgt 5160 ggtaaaacac ttgcggatat tctggactgt ttttaaaaaa tatacagttt accgaaaatc 5220 atataatctt acaatgaaaa ggactttata gatcagccag tgaccaacct tttcccaacc 5280 atacaaaaat tccttttccc gaaggaaaag ggctttctca ataagcctca gctttctaag 5340 atctaacaag atagccaccg agatccttat cgaaactcat tttaggcaaa tatgagtttt 5400 attgtccgtt tacttgtttc agagtttgta ttgtgattat caattaccac accatctccc 5460 atgaagaaag ggaacggtga agtactaagc gctagaggaa gcagccaagt cggttagtgg 5520 aagcatgatt ggtgcccagt tagcctctgc aggatgtgga aacctccttc caggggaggt 5580 tcagtgaatt gtgtaggaga ggttgtctgt ggccagaatt taaacctata ctcactttcc 5640 caaattgaat cactgctcac actgctgatg atttagagtg ctgtccggtg gagatcccac 5700 ccgaacgtct tatctaatca tgaaactccc tagttccttc atgtaacttc cctgaaaaat 5760 ctaagtgttt cataaatttg agagtctgtg acccacttac cttgcatctc acaggtagac 5820 agtatataac taacaaccaa agactacata ttgtcactga cacacacgtt ataatcattt 5880 atcatatata tacatacatg catacactct caaagcaaat aatttttcac ttcaaaacag 5940 tattgacttg tataccttgt aatttgaaat attttctttg ttaaaataga atggtatcaa 6000 taaatagacc attaatcag 6019

<400> 44

gcacacactc atcgaaaaaa atttggatta ttagaagaga gaggtctgcg gcttccacac 60 cgtacagcgt ggtttttctt ctcggtataa aagcaaagtt gtttttgata cgtgacagtt 120 tcccacaagc caggctgatc cttttctgtc agtccacttc accaaggtga gtgtccctgc 180 tctcccctac cagatgtggg ccccattgga ggagatggca gggaggtagg cacggcgggg 240 gggtcagggg ccctctggta cagtgggatg tacccagcta ccgtgattcc agccaggtaa 300 ggtctttaaa aaaataataa tagaataaat ggcagaagac ttaaaggtga agtacttaat 360 gcatgggcag gggcaaaaat aaatgaattc atcaattgat acgtagatgg ataggatttt 420 taaaatatgt cagctgccag tctttatgga tttcagagct ttgaacaact tgaaatgctg 480 tccaggtgca actgaaaatt tcaactgcat ctctctcatc tctttgtctc ttagctcttg 540 atgcctctca tccttctctg tctctctgct caccctgtct tgctctttta catgtttctc 600 tgcctctctt tctcccgcca tctgtctgtc gctacactca gactctcttt ccccgcatct 660 ctcctggcct ctgaccatct cccctatctc tgtctcctcc atcttgacca cactccatcg 720 atctcctttc ctccatctct cccgctctct tttcttgcct tcccccacct gccttcccag 780 ccagcatcca gcctagagct ttgtacacag ctggcgttta ataatagtaa tgtcgccgag 840 gacctttaca ttttatgaga gtgagcatca gttctgttca ccctagtagc aggaggattg 900 caaggtgccg gggcaagctg agcacttaac tgaactttgc ttgtatcgct ttagaggaga 960 cccttggggc gggggggcag ggagcacttc acaccattgt caaccgtagt ttagctgtgt 1020 ggacctaccc caggactgca tgtgtgtgac cagagtccat attcaggaag caaacaggtt 1080 gttcagggct ggggtgagct cgattctgca ggcttagcac agcgtttggc acaaagtaag 1140 tgctcacgaa gtgttagcta ttagtatttc tgtaaccaaa ttagaatcat gctatatatt 1200 ggttttgttc ctgctttatt caattaacag tagtgttttt gaagcttact aaaaattgtt 1260 tgaacacatg atctttcatg atggacaaga ctgtcctcac atcagcatga actttgattg 1320 atttgaccaa gtgccgattg ttggacattc cggttgtttc tcgttttttt ctataaacat 1380 ccctgactgc ttccttggat tcctgaaaag ggagttgctg gggcaaaggg ggcgtgcatt 1440 tttaaagttt atgaccctct ctgctaattc tccttccaaa aggttgtcct attttatgct 1500 ccctctactt aagctaaccc taggtgagta ttattatgtt ttaattattt cccaacatga 1560 caggtaagaa aaacacatta tcacattgtt gaaatttgca tcttgtgatt acttttacta 1620 ttcattggcc attcatgctt tttttttttt ttttttttgg ttgtctggtc atgtccttac 1680 tcctaatagg gtgttcatct tatttttccc ttattgattt gccacagctc tttatttgga 1740 atggttatta acctttcatc agccattaca tatatagcaa atattttccc caattcatca 1800 tttgcttttt ttctatttgt ttatggtgtt ttttgtgatg cttatgatgg ttttatacag 1860 tcaaataggt tagtcttttt ttctgtggct tctgtctctg gttttgtgct tagaaagtcc 1920 tttcctactt gaaaatgaga taaatgttca cctatgttgg cttctagtct cttttatggc 1980 ttcatttttt ccatttacta tagaggttaa gagtgtgggt actggagcca gactgtctgg 2040 gacaaaccca gcgtcacccc aagccctatg tgtgattttt agccaggcac ttaacctctc 2100 catacctcca tttcctcata tgtactgcaa tggttataat agtaccttcc tcaggagtct 2160 ttgtttagat taaaattttt aaccacagta aatacttagc acaaggcctg acacacaata 2220 aacccaagat cagcattagg tgttaaaact tatatcttga atggatctgg gcattttagg 2280 gtatatgatg atggtgacat ttcaaactgg gcagggaggg gttgttggga taatggactg 2340 actattcact caataacttt atcttctccc taattatctc agacacattt gttaaaccat 2400 actccatggt cctccagttt gaaatgccac attcatcaca aattcagttc tctccatatg 2460 tgggtccatg tccaagcttt ctattctgtt ctcttcccca gtatctgttc ttataccagg 2520 gccacactgt tttgctgatt gttgctttgc aatacaattc aatacccagc catgggtgtc 2580 cctggcacct tgcccttctt tattcttgat tatttcaggc agcatcagtt gaaccagcca 2640 gagaccagca aatgttctta tttgaggcaa tcctcctctc gcacacatgc actctggctc 2700 tccatgcatg tgtccatttc tctcaatgtc tctcactatc tcttgttctc tcttgctcgc 2760 tctttgtgtg tgtctctttg tctctatgta tccctatctc tcagccagtc ccctggatag 2820 aggggcaatt gtcaacttga agccctgcag acacctaatg acttaaccag acagcgtaga 2880 agggccctgg cccttgtcta ctccacgcct ctccgtgctc agtgtagaag ggcaaattga 2940 agaccagaga tctcagggcc tcaccgaaat gcagcggcag agttgaaatc caagcctaga 3000 tctcaggact ctaggtggga ccctggttct ggctctctcc ccaactgaag gcctcagttt 3060 acccctcagc acccagaagg gggaagggga acctgggcta ccattccccc ttctgccttc 3120 tcacacgttg gaccccaact tcccacaggt tggacgatcc acgatcacag tgtggggccc 3180 agcctcacaa gagctgggct aggtgaggcc ccggactcca taggtcagga ggcctagttg 3240 gccagagcgt ggtgatgatg gaggcatgtc agtcagtcag gctgtgtgtc cccagagctg 3300 gtgctggtcc ccgaaaacct tgattgtggg gcccctctag agagtctgat gatgggctct 3360 gtattggcga aggctgaggc ttttccagct ccccccatga ggcccagacc aaaggcacac 3420 cagcctcaac ctcctcctcc ccctgttgcc atctctggcg gagtggccat gtatttggga 3480 acgttgttcc agagtggaca gggagactga ggccctaggg aggctggctc tgtttccagg 3540 cctggtaggc aagaggccct atgaagcagc aagctgcctg actttcagat ggttccaagg 3600 agtttggaca ccagggacac tggcctacac atactgagac tttgggaccg tagaccccac 3660 agtctgtggt tttgagattc taggatcctt taaatctaag aaatgctgtt ctatgattct 3720 gaggtcctgg tgttatacta tttgaagacc ccaggggtcc cagtatctgt ggagcctgcc 3780 tggcactctc agagcttcaa acctgggtcc tctccacaac ccaagaaggg ccaggtcttc 3840 agagctaggg gcttgtcata gtggccagat ggacatcacc taccacatcc accagcaccc 3900 atgtcacccc acctgggcca agcctgctgc aggacagggc agccagttct cggaacgaaa 3960 cctgtggggt ggggtatctg ccctcttctc ttcctccgtg gtgtcgatga agcccggcgc 4020 atccggccgc catgacgtca atggcggaaa aatctgggca agtcgggggc tgtgacaaca 4080 gggcccagat gcagaccccg atatgaaaac ataatctgtg tcccagaaac atcccccatt 4140 cagcttctga gaaacccagt cagaaaggga cgtcccaaca gacagtgcag gaagccggct 4200 gcccagcccg gccctctagg tcctctaccc ccagacagat catctccatg tccctgtctg 4260 agaatgtatc tatgctttgc tgagtcaggc catcccacat gtgtttgggg agaattctta 4320 gctctggcca agtgtccagg cagcttcaga agtgaccaca ggccagccac atgggccagg 4380 ccagagtggt ggaaaacatc catttgcacc gaaatcggta ttagtttgtt ctggctgcta 4440 taacaaagta ccacaactga gtggcttcag caacagaaat tgatcatctc acagttctgg 4500 aggccagagt ccaagatcaa ggtgttgcca gggttggttc cttctggggg ccataaggga 4560 gaagctgctc caggcctctc ccccagcttc tggtggttgc tggcaatctt tgttatttct 4620 tggcttgaag gagcatcacc ccatctctgg cttcattcat tcactcacct tctcatctca 4680 ccagtgctct cccaggccct tgttcggagc ctccacagac ccacactcct gtttctcacg 4740 cagtaatgtt ctaagccccc aggagactaa gaacttaata cctggattct cacactcatc 4800 tccctcagca ccacagctct gacaaccacc cccaggaggt gacagcaaag aaaggaagga 4860 gcaactgctc ccccagaacc cttctatact cccccgggct gctctcagca gctgtgtgcc 4920 caactcagtg ctgtgaggtg gaacggggag atggagacac acacacacac acaccagaga 4980 gtttataaaa tgtgcacacg gaaacacttc ctaaagaaag aagtggagtt ctcaagtcac 5040 tatgggacta cggaactcgg catctgagca tccccttctg tataatgggg ttggctgggc 5100 agtcccttcc agctctggct tcctctcaga ccaggattat aggatcctga aaagccagtg 5160 cttccctcag ggagtggaag gttctggggc tcagcagggg gcccggagcc attgtggagg 5220 gctttcaagg tgaggacaat agaagagcag gtcttgcgtg gcttggacag ggaaagagga 5280 gaaggagtgg gcatttgagg cagggggtgt agcatgagcc aggcttgagg gccagaaatt 5340 ggggtgaact ctgatggggg ctgggtagag aagcttctac aggccccagc tcaagagacc 5400 ccatctctcc tcctctctgt cacttgccat gctggatccg tgcatgatca cactcctgga 5460 ctcgcctcct tgccctgaga tccagacccc cgtattcagc tgccccctca gctcctccac 5520 tcacatattt aatgccagac tcttcatgtc tatctacacc tgcacttttg cacccaatcc 5580 aactccccgc catgtccccc atctcaggta atgtcagctc ggtccttcca gctgctcaag 5640 ctaaaaccca tgtcactttg actctccctc ttgcccacta catccaagct gctagcactg 5700 ctcctgatcc agcttcagat taagtctcag aatctaccca cttctcgcct tctccactgc 5760 caccagccca ttctgtgcca gcatcatcac ttgccaggac tgttacaata gcctcctcac 5820 tagccccact cacagcagcc agatgaatct tttgagtcca tgcctagtca ctggggcaaa 5880 ataggactcc gaggagaaag tccgagacca gctccggcaa gatgagcaaa cacagcctgt 5940 gcagggtgca gggagggcta gaggcctgag gcttgaaaca gctctcaagt ggagggggaa 6000 acaaccattg ccctcataga ggacacatcc acaccagggc tgtgctagcg tgggcaggca 6060 agccaggtgc tggacctctg cacgtggggc atgtgtgggt atgtacatgt acctgtgttc 6120 ttggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtctaga gctggggtgc aactatgggg 6180 cccctcggga catgtcccag ccaatgcctg ctttgaccag aggagtgtcc acgtggctca 6240 ggtggtcgag tatctcatac cgccctagca cacgtgtgac tcctttcccc tattgtctac 6300 gcagcctgcc cttggacaag gacccgatgc ccaaccccag gcctggcaag ccctcggccc 6360 cttccttggc ccttggccca tccccaggag cctcgcccag ctggagggct gcacccaaag 6420 cctcagacct gctgggggcc cggggcccag ggggaacctt ccagggccga gatcttcgag 6480 gcggggccca tgcctcctct tcttccttga accccatgcc accatcgcag ctgcaggtga 6540 ggccctgggc ccaggatggg gcaggcaggg tggggtacct ggacctacag gtgccgacct 6600 ttactgtggc actgggcggg aggggggctg gctggggcac aggaagtggt ttctgggtcc 6660 caggcaagtc tgtgacttat gcagatgttg cagggccaag aaaatcccca cctgccaggc 6720 ctcagagatt ggaggctctc cccgacctcc caatccctgt ctcaggagag gaggaggccg 6780 tattgtagtc ccatgagcat agctatgtgt ccccatcccc atgtgacaag agaagaggac 6840 tggggccaag taggtgaggt gacagggctg aggccagctc tgcaacttat tagctgtttg 6900 atctttaaaa agttactcga tctccatgag cctcagtttc catacgtgta aaagggggat 6960 gatcatagca tctaccatgt gggcttgcag tgcagagtat ttgaattaga cacagaacag 7020 tgaggatcag gatggcctct cacccacctg cctttctgcc cagctgccca cactgcccct 7080 agtcatggtg gcaccctccg gggcacggct gggccccttg ccccacttac aggcactcct 7140 ccaggacagg ccacatttca tgcaccaggt atggacggtg aatgggcagg gaggagggag 7200 caggtgggag aactgtgggg aggggccccg agtcaggctg aaccacagcc cacatgtgcc 7260 ccccagctct caacggtgga tgcccacgcc cggacccctg tgctgcaggt gcaccccctg 7320 gagagcccag ccatgatcag cctcacacca cccaccaccg ccactggggt cttctccctc 7380 aaggcccggc ctggcctccc acctggtaac acctcagccc gtaccccatg gcttcacaga 7440 acccccaagt ccccagatcc ttggctgtga gcagtgtagg ctattctgaa ttgcagtact 7500 ctgggggtca aaggtgtcag gtctcagagg cttggaaact ccaccctcca aaaaacgtca 7560 ggtgcagaac cttaaagatg cagaatgtca aaatcacaaa accacagagc tttacaaagc 7620 tagtcaaaat gtcagcacct gcgaatggcc gtctttaagc ttctctgcca gaagcctggg 7680 actttgggga cagcagagcc ccctgggagt cagggttttc gaggctcagg agggtgggaa 7740 gctcaaaatg agaggccttg tgggccaagc tccagagccc agcccacagc ctccataggt 7800 gccctgtccc cacccacagg gatcaacgtg gccagcctgg aatgggtgtc cagggagccg 7860 gcactgctct gcaccttccc aaatcccagt gcacccagga aggacaggtc agtggacagg 7920 gctgggaagg atcctcgccc tcctatcccc tcccctgaca ccctctgtcc ccccagcacc 7980 ctttcggctg tgccccagag ctcctaccca ctgctggcaa atggtgtctg caagtggccc 8040 ggatgtgaga aggtcttcga agagccagag gacttcctca agtgagtggc ccaggcctgt 8100 gccagtctac cggccctggc ttgtggggag aggtctaggg tgcagatctc agctcaggct 8160 tcatcccaat aagtagtaag atgcaagagc taaactctga gactgtgggt tcaaatccca 8220 gctccatccc tgactggctg tgtgaccttg gacaaattac ttagcttctc tcgacctcag 8280 ttttctcgta tgtataataa gaaacgtttg tgctgttatt tacccccatt ttacagacaa 8340 ggagactgag gccaaagagg ttaagtgtct tgatcaaaat ctcccagttc ctgagtgaca 8400 gagctgggat ttgaacccat gtagccaggc tctagaatct gcactcctgc tttgccctgc 8460 tactcctcat gccaacatgc cagccttatt ccactgttcc caaagttcta gctcctctag 8520 atggctgctg ctgcctcccc tcagtccccc catatgtctc tctctctctc tctctctctc 8580 tctctctctc tctctctctc tctctctttc tctctctctc acacacacac acacacaaat 8640 acacaccaca ctacacacaa cccttagcag caaccccaca tgtcctgtcc tccttgcagc 8700 caggcctttg cacaggccgt ccctccaccc agaatgcttt gcccactctc acctccctgg 8760 cccattctca actcaccaca cttccaacat tatctccagc actctggcca ggctcaagtg 8820 gtgagttcag gcctgacatg cagtaggtgc tgaggggcat gtgttaaggg aacgaggggt 8880 gtgagaggga gactgaggta gagaggggag gggagctggg gctcagagga gagaactccc 8940 agagggtctg ggccctcccc attcagagca ttgagccaga ccaggcctgt cgtggtcacc 9000 tgcatggaat cttctcccta cttaggcact gccaggcgga ccatcttctg gatgagaagg 9060 gcagggcaca atgtctcctc cagagagaga tggtacagtc tctggagcag caggtaatgc 9120 cagggcggtg gagggtaagg gatagggata gtgcgcaaaa ccttctgtcc accatgtgcc 9180 agaaaccaag ttcacctggg acgagggctg gtataaagga aggaagagga gcgggcactc 9240 ccagggaaga ccgtagcctg ggcaaagatg tggcagagaa gggccaggct gaggcctcat 9300 gtttgtgcca tttcacagct ggtgctggag aaggagaagc tgagtgccat gcaggcccac 9360 ctggctggga aaatggcact gaccaaggct tcatctgtgg tgagcgaccc caggactggt 9420 ggtggcagac tcagactgct ggggggcagg gaggaggtct gcacggtgca gggaacctaa 9480 cctcacattc aggtcctgag agctaggggc ccctgtcccc agctccaaac atgcccagac 9540 ctggaaatct gtccccttct acttacaaac cctctgaccc cggctgggcg tggtggctca 9600 cgcctgtaat cccagcactt tgggaggccg aggcgggtgg atcacgaggt caggagttca 9660 agaccagcct cgccaagatg gtgaaaccct gtgtctacta aaagtacaaa aaattagcca 9720 ggcgtggtgg caggtgtctg tagtcccaac tacttgggag gctgaggcag agaattgctt 9780 gaacctggga ggcggagttt gcagtgagct gagatcatac cactgcactc cagcctaggc 9840 gacagatcaa gactccgtct caagaaaaaa aaaaaaaaaa aaccctctga ctctaagatc 9900 cccaaacact gtgatcctga gttgttaaag caaatgcaaa tagccagact tgccagatgc 9960 aggctgtgtg ccagcaggac cagctatgta acctgcaggg ccccttgttc agatttcaag 10020 atggcgacca cagagcatta aacaaagcac agggtgccac 3t33CC3C3t aggtcacacg 10080 cccatgaagc cagccctgga ggccaggcac tgtttctgag cgctttgctg gtggtaattt 10140 atttctcatg atgcgaatgt acagatgagg aatattgagg ccaggggggt ttaggtgact 10200 ttcccaaggt cacagttggg tggtaaagag ccctattcaa ccccagttca tggtcccagc 10260 atcagtggcc acatacgaca tccgcacctg tgctctaata aatacggctc atgctgtttt 10320 gtgggattcc acctcagact ggaatttaga agagggcgtc cttgctttga aaaacactga 10380 ttt3-3.3-3-3.t3- aagtggagcc aggcgcagtg gctcatgcct gtaatcccag cactttggga 10440 ggctgaagcg ggtggatcac atgaggtcag gagttcgaga ccagcctggc taacatggtg 10500 aaaccccatc tct3CC3333 3t3C33333t tagctgggcg tagtgacggg cacctgtagt 10560 cccagctact cgggaggctg aggcagaaga cttgcttgaa tctgggaggt gggggttgca 10620 gtgagccgag attgcaccac tgcactccag cctgggcgac agagcaagac tcagtatcaa 10680

333333t333 333C3t3333 tagaaagtaa aaagtgggaa gtttaagcct ctgggtcacc 10740 agcctctccc cctcacccag gcatcatccg acaagggctc ctgctgcatc gtagctgctg 10800 gcagccaagg ccctgtcgtc ccagcctggt ctggcccccg ggaggcccct gacagcctgt 10860 ttgctgtccg gaggcacctg tggggtagcc atggaaacag cacattccca ggtaagaatg 10920 gtccttgcac tacacggtgc ccccaagctc ctaatcctga caggctctgg gtggagggtg 10980 caaaggagct ccatgctgcc ccttcccacc accaccacca ctgcagctgc cgccactcag 11040 cctttgggaa aatgcatccg ctcacaaaag cttcctttcg ggatgtccgt ggcctgaaag 11100 ccccccatat ggtctcgagt gtcgggcccc tagccctgac tcccttgggg attggggcca 11160 tgcctcaccc actctggact ccagctacta tattcggcca tcagaaggga gggaccctgc 11220 taagtaattc caggagcacc tcctttcctc ccctgaccaa ggaaaatcgg ggtggattcg 11280 cccgagctca cctatccact gctctccacc aggcctggcc tgtgggctta gcagggatca 11340 gagaccttga ctgtcatcct ggctctgcca tttaacctct tgcatccttt ggtgtgcaag 11400 ttactccgct tcttttcaac ctcggggaga actattttgg cagaagtggt gcaaagaata 11460 aatgatacaa cttatgtcag gtgctcagca aacagtacct gtgcccgtgg acacgggtgt 11520 tgacggtgag atctcaggcc tgtagactca ccttgtaggg ggaggggaca gggagctagc 11580 taggaggtcc tgcatggggc ttgattcatc cccaccctct gacagagttc ctccacaaca 11640 tggactactt caagttccac aacatgcgac cccctttcac ctacgccacg ctcatccgct 11700 gggtaagcag ggcagctcgg ccccaaggag gaggaagaca aagatggggt gggggacctg 11760 cctcccaaac tcctgtctcc ctctgagtgc cctcagagtg ggttcctcca ttcccaagcc 11820 ccagccccaa ggatccccaa gccgtgcctc aaatgtgacc cctcatgctg gcttcacccc 11880 aaacctgtcc gcaaatccaa 3CCt333CC3 ccatccaggc cagagcatgc caaattctga 11940 ccctaaacct acccctttcc agatgtccac ctcagcccca tacctaaccc tctcctggac 12000

CC3t3333t3 gcctaaagct aaccccatct ctgcaccttg ccctaaacgt accccagctc 12060 ttactctaac tccttcccca gcctttatgc caacccaacc ccatctcctt ccctggcccc 12120 aacgtacccc agtatgtcaa tacaccccca actgggcacc attcccaacc tttccttgta 12180 acacccattt gatccttaac ttcatcaccc catcccaact ccttcatctc agcctcccca 12240 atgccttctc agaaccttca tcctagcgcc acacctaacc ccaaacctga acctcacccc 12300 tacatgatac cagatattcc ccgactgtct ctgaactgaa accctgacct agccccatcc 12360 tgactgatag cctcactgca atcatcatcg ctgactctgt aatcccattc ctgaatccaa 12420 actgatcaaa ttccctgacc ctcagcctca ctccacaccg 33CCCC3C33 ctaacctcat 12480 ccttgccctg agcctaacca cctaaccatg tccctgacac gtaagatact cgataattca 12540 aaccatctct ggcttctgac ctaaagccaa gtcatcccat ccctcacccc tagacccccc 12600 acctgagtcc accccagcct gactcttaac ccaccccttc cctgaccctt aagttggcct 12660 ggccctttac cccttccaaa tccttgaccc cacttctgac ccttcacctt ccccaaccct 12720 gaaatgtcac ctccacagag aaccccaact ccaactccat cccagacctt tcacctcact 12780 tcagccctag ccctgaacaa gaccccactc ccaacctcag tcctgatccc ttacctaatc 12840 ccagaacaac catacccaca cccatctaac cctgcccaac ccgacacttc accccttttc 12900 taaccccatc tttgacccca tgcttcaccc cacatctagt cctgtccctg attacctgcc 12960 cctacaattc cgcccccatg tcagatggct cggggtaggt catagcccct ctaaacccca 13020 agtttgggga atgtgcccct taccccaccc cccaacttcc aggccatcct ggaggctcca 13080 gagaagcagc ggacactcaa tgagatctac cactggttca cacgcatgtt tgccttcttc 13140 agaaaccatc ctgccacctg gaaggtgagc tcctctgagg tggcggtgac tgggatggcc 13200 tcaagtgcca tcgcagctca aagtgggcag gcctgggtct gggctcatag gcacattggg 13260 gaggaacggg atgtgggttg ttggtggtgg ctgctggcct cagaggttga cgcccacctg 13320 ctccctgtcc ccggccttcc acagaacgcc atccgccaca acctgagtct gcacaagtgc 13380 tttgtgcggg tggagagcga gaagggggct gtgtggaccg tggatgagct ggagttccgc 13440 aagaaacgga gccagaggcc cagcaggtgt tccaacccta cacctggccc ctgacctcaa 13500 gatcaaggaa aggaggatgg acgaacaggg gccaaactgg tgggaggcag aggtggtggg 13560 ggcagggatg ataggccctg gatgtgccca cagggaccaa gaagtgaggt ttccactgtc 13620 ttgcctgcca gggcccctgt tcccccgctg gcagccaccc cctcccccat catatccttt 13680 gccccaaggc tgctcagagg ggccccggtc ctggccccag cccccacctc cgccccagac 13740 acacccccca gtcgagccct gcagccaaac agagccttca caaccagcca cacagagcct 13800 gcctcagctg ctcgcacaga ttacttcagg gctggaaaag tcacacagac acacaaaatg 13860 tcacaatcct gtccctcact C33C3C333C CCC3333C3C agagagcctg cctcagtaca 13920

CtC333C33C ctcaaagctg catcatcaca C33tC3C3C3 caagcacagc cctgacaacc 13980 cacacacccc aaggcacgca cccacagcca gcctcagggc ccacaggggc actgtcaaca 14040 caggggtgtg cccagaggcc tacacagaag cagcgtcagt accctcagga tctgaggtcc 14100 caacacgtgc tcgctcacac acacggcctg ttagaattca cctgtgtatc tcacgcatat 14160 gcacacgcac agccccccag tgggtctctt gagtcccgtg cagacacaca cagccacaca 14220 cactgccttg CC33333t3C cccgtgtctc ccctgccact cacctcactc ccattccctg 14280 agccctgatc catgcctcag cttagactgc agaggaacta ctcatttatt tgggatccaa 14340 ggcccccaac ccacagtacc gtccccaata aactgcagcc gagctcccca ca 14392

<400> 45

aatttctcac tgcccctgtg ataaactgtg gtcactggct gtggcagcaa ctattataag 60 atgctctgaa aactcttcag acactgaggg gcaccagagg agcagactac aagaatggca 120 cacgctatgg aaaactcctg gacaatcagt aaagagtacc atattgatga agaagtgggc 180 tttgctctgc caaatccaca ggtaagagaa ggcagtaaaa tgtgggaaaa tgcattcttc 240 ttctcattcc ttacctggcc aagttaactt ctactgaaca actgtggttc agtaacttct 300 agtaaacaaa cacataaagc tgtgtaaaaa ttagagagct gtaataactg catctcactt 360 aatttgtctt acattttctc cctagaaatg gagtcatcta tgcatttctt acttacctaa 420 catggatacg gagagtggtg agaaaggaaa ctatagaaag tgtatcagct ttacataaga 480 attatatagt aaaatacaaa caatgaggtt attacagttg tattttgaga aaaggtgttt 540 tgcaaaagcc agagttttaa atgagccatg agtcaaacag aaatcccttt ctcttaggga 600 tataacttaa attatgcaaa acatgtgttt ctaatttgat ggggtttatg agattgcaca 660 tcaagcacct tccatgttat attatcattg cttgttattt actgagcgta agattcaagt 720 gagagtctga actacctttt ttcttgtttg caagtcttac ctataaagta caaggtatgt 780 ggaaaaaagg tttgccttaa aaactacatt ttctagtctg tcttctaacg aatgctatgt 840 aaaccaattt atcatcaata ttttaattat caaatacagc atttttctaa gcaatttaca 900 aattaaccct ttccattctc atagccatcc caaaagttat gtatgttatt tatttattat 960 tattattatt attttgagat ggagtctcgc tctgtcacct gggctggagt gcagtggcac 1020 gatctcagct cactgcaacc tctgcctcct aggttcaagc gattctcctg cctcagcctc 1080 ccaagtagct gggattatag gcacctgcca ccacacccag ctactttttt gtatttttag 1140 tagagacggg gtttcaccat gttggccagg ctggtctcga actcctgacc tcaggtgatc 1200 caccgatctt ggcctcccaa agtgctagga ttacaggcgt gagccactgc acccggccag 1260 aaacgtatgt tattatcctc atgttcctaa tgagaagtat aaggcatgca gaatgtaatt 1320 atcaaactat gtagctagca agtgccagag gccagtatga gcctaagcag cctgtctcca 1380 gagtctatga tcttaaaacc attattccac actgcctctc ttaagaaggg ataataagac 1440 attgcttatt ttctttcttt caatcttcag tttaacaagg tacatgggat tccaggagaa 1500 gatttctatg aacatgttat aataattctg tagacgagtg tatttttgtt tgtagctcaa 1560 acagttacag tccacatact agagagcacc tttaaacaca gcaaatgttt agtcagagat 1620 ttcaacctaa ctgtgcttag aaatgaaatc ctgtaaacaa tttggtgata ctggcaaatt 1680 taaagcatct acctccttcc aatctaattt tcctcttcag attgttaatt aaagaaaatg 1740 aaaagtatac tttaatttta ttgccaaaag cactagtttg ctttattcat gcaaaacaat 1800 aatactcaaa cttgctattt gcccgcagat ctacaaaaat gctgggactg gatgatttca 1860 aggatgtact tatcaatggt acaataaaac catctttttc agaaactact aaactttgta 1920 tcatgggttt tgtttctcag atattcgatt ctccttaaaa atgcaacaac tgtgataatt 1980 atgaatacct gtagaacaga ttccaaggag taaagcaaaa ccccaaaaga aaacaaacga 2040 aactcttcct tagctactta aaaaaaagat tctcggctgg ggacgggtgg ctcacgcctg 2100 taatcccagc actttgggag acggaggcgg gtggatcatg aggtcaggag ttcgagacca 2160 gcctggccaa tgtggtgaaa ccccgtctct actaaaaaaa tacaaaaatt cgcagggcat 2220 agtggcatac acctgtaatc ctcgctactc aggaggctga ggcaggagaa tcgcttgaac 2280 ctgggagtcg gaggttgcag tgagctgaga tcacgccacc gcactccagc ctgggtgaca 2340 gagcgagact ccatctcagg aaataataat aataatagta attctgacaa ggtgcagtgg 2400 cttacacctg taatcccagc actttgggag gctaaggtgg gtggatcact tgaggtcagg 2460 agtttgagac cagcctggcc aacatggtga aacccctgac tctactaaaa atgcaaaaaa 2520 aaattaccca gcatgttggt gtgcccgtag tcccagctac ttgagaggct aagacaggag 2580 aattgtttga acctgggagg cggaggttac agtgaactga gattgcgcca ctgcactcca 2640 gcctgggtga cagagtgagg ccctgtctga aaacaataac aataataaca attctgctag 2700 ctgagatgct gcagaagcta gattcactgt cccggaaaca tgaaaaaaaa ttattggtta 2760 cttttatttc ttcactgaag atctttccta gaaattatga accaaaaaat gtctgtttta 2820 tctctcataa tctatctgct tcttagtcca aaggaaaata atatgttttc tgattccata 2880 tagatagata caaggcacaa tctctaatct agcagaattt gaatgatcct cagtatgatt 2940 catttttaat ttatattata ccatttaggg atcctctgaa ccagagcata ttactgatta 3000 aattttatac ttgttgaaag tgctgtcaaa taaaatgatc atcattgtgc agaacaaaaa 3060 agtattctgt tatttggaga aaatcacaac aaccaaaaaa ataagatgta ctagatggtg 3120 aaacatagaa taaaaacaac aaaaatacat ttattacatt tcttttgaaa gttggaaact 3180 tcacaataaa ctcgatatac aaaaatcgtt atgtaaactg tataagcctg ggtttcctta 3240 tttatgatac agagataact tcttgggcca ttacaataat taaatatgta tcttttatat 3300 atatgaaatt atcgagcaga gtgcctagtc cactattgac atttaaaaca tctcattttc 3360 cttccattca aagaacttaa aatctagcca agataaacca aagtaggcca ggcgcagtgg 3420 ctcatgcctg taatcccagc actttgggag gccgaggcag gcagatcacc tgaggttagg 3480 aggtcgagac caacttggcc aacatggcaa aaccccatct ctactaaaaa tacaaaaatt 3540 agccaggcat ggtggctcat gcctgtaatc ccagctactt gggaggctga ggcaggagaa 3600 ttgcttgaac ccaggagaca gaagttgtag tgagccaaga ttgcgccact gcactccagc 3660 ctgggcaaca gagtgagact ccaattcaaa aaagaaaaga aaagaaaaac caaagcagca 3720 gataataatt gtttaacaat ttgaaaaggc ataatccata gaatttatag tggaggagat 3780 tggtttcaaa tagagtagtc aggaggattt tagtgaaacc tttgaggtga actttgaaaa 3840 gctgcaaatg gcagtgtttg aagagagagg aagaggtgga acacagagag ggtcttcagc 3900 cctgcgtgtg cagatgacaa gacagaggct ggtgtttcca gacaggtaag ccatatgcca 3960 gggcaacatt gcacagaatg gatgtgaagg caaggcatac tatcagtggg aagccaaatc 4020 tacaataact gctactacta aataaagatc tttttttttt ttcaaggaaa atctacctga 4080 tttttataat gactggatgt tcattgctaa acatctgcct gatctcatag agtctggcca 4140 gcttcgagaa agagttgaga aggtttgaca tatgtattac atttgtcttc ttgtatagct 4200 tcttaacatt gttaacttgg ttttgaagca taaaacatta ctgagattga tttgagtcaa 4260 ttgctccatt tgttttcagt taaacatgct cagcattgat catctcacag accacaagtc 4320 acagcgcctt gcacgtctag ttctgggatg catcaccatg gcatatgtgt ggggcaaagg 4380 tcatggagat gtccgtaagg tttggagatt ttctcagatt tcttatgcta tgtgacagat 4440 tttcatctaa tttacattta actttccaaa aattttctaa aagcattata actgcatcat 4500 gcaaagttta gataacacga caaaatgata aagaaaatat gccctggctt gacatgtcca 4560 ctgttatcat tattatattt ttagtctttt acttcatttt tcatcctgta ttttatctgg 4620 caaccctaat tacataaaac taatacagac tgcaatatct aacctttaaa acacacatgg 4680 gcctcccagc actttgagag gccaaggccg gaggatcacc tgaggtcagg agttcaagac 4740 caacttggct aacatagtga aaccccatct ctactaaaaa tacaaaaaat agccaggcat 4800 ggtggcaggt gcctataatc ccagctactc gggaggctga ggtgggagaa tcacttgaac 4860 ctgggaggca gaggttgcag tgagccgaga tcctgccact gcgctccagc ctgggggaca 4920 ggagcaagac tccatctcaa aaaaaaaaaa aaaaaaaaaa acaacaacaa caacaacaaa 4980 aaacctaact actgtatttt aatcaggtct tgccaagaaa tattgctgtt ccttactgcc 5040 aactctccaa gaaactggaa ctgcctccta ttttggttta tgcagactgt gtcttggcaa 5100 actggaagaa aaaggatcct aataagtatg taaacagtga taacaacagg aatttttgga 5160 gtgtgtgccg attaaataaa acaggggttg ttcattggct taattttggg cagcgcagct 5220 ttcctctcag ctgggtatgg ttcctctcag ttcctcggct gggtacggtt tcttggactg 5280 ctgtgtctac cactacaaat gtacacatat gtgacaggtg tatagttaac acagtaaaat 5340 gcacaaatct taagtgttca gcttgaattt aactattata tacatacata cacccaccat 5400 tctcagtaag atacagaatt ttttatcacc tcagaaaatt tctttgtgcc tctttcaatt 5460 ccctttcctg ccacagacaa atatattttt atttgcctta tcaaaaatta gatgattttt 5520 gttattgggt ttcatatcaa tgaaaccaca gagtatagac tcttgtgtct ggcttctttt 5580 gatgagcatg tctttgagat tctattaatt taatttttta gcagccaatt gtggttaaga 5640 gtcaacacat ctttaattac aggcagcaat gactggtttc tcagagcagt ctgctcagga 5700 tataggtgat ttttacccat ttaggcataa gatctgctac aataaaggaa agggagaacc 5760 aaagcccacg tctctgggtg tgtgcctgta gaaaaatatt ctgcaaatgg gaatatcata 5820 aaatgaaagg attcaatcta gaaagtttct tcttattaaa aattagtttt tttaaaaaaa 5880 aattcaccgg gaatggtggc gtatgtctgt ggtcccagct acacagggag ttaaggcagg 5940 aggatcactt cagcccaaga agttgaggct gcagtgagcc atgttcgtgc cactgcacac 6000 cagcctgggt gacagaatga gaccctgtct caaaaaaata aaaataaaac aactagtttt 6060 gactgtccat gtgtgttcct tgcatattta attatttcat tcatttgtaa gttattaagt 6120 taaatgtaat gcctactgaa gaaacatttt aataagcttt ttctttttac ctatgtctta 6180 cctctgatag tagcattcaa tcaaatagca acaactcatc attatttgat gttaaattgg 6240 ttttctttct ctcttccaat tggtccattg cttcatggct gctttcataa ggcccctgac 6300 ttatgagtaa gtatctgatt cttgtttgat tctaagaatt atttgttact tatagttgaa 6360 tgtaggttta tcaatagact ccaaatgcat ttttaaatga ttaattgaat tcagccaaaa 6420 aataatttaa gtgactattt agagaacaaa taatctcagt ctttaattgt atctatgatt 6480 gtgttacaac tatgtctatc tgatattata gctatagata tatacaagaa tactactcaa 6540 atacatctgt aggaaattaa tatgcaaaca tacaaaatgc acatacatct gtgtatctat 6600 gatttaataa ctcccatgtc cataactagt taccggtgtc aataagtaac catataccaa 6660 cttgttcttt ttgacccaat ccttactact tttgacctat aatatatact aaacataggc 6720 taagagatgg aaaacctggg ctgggtgcat ggctcacgcc tgtaatccct gcactttggg 6780 atgccgaggc aggtggatca cctgaggtca ggagttcaag accagcctgg gcaacatggt 6840 gaaacctcgt ctctactaaa aatacaaaaa attagccggg cctggtggcg ggcgcctgta 6900 atctcagcta ctcaggaggc tgaggcagga gaatcaattg aacccaggag gtggaggttg 6960 cagtgagcgg aaatcacgcc actgcattcc agcctgggtg acagaacaag actccatctc 7020 aaaaaaaaaa aaaagatgga aaaactaagg taaatatcat cagtataaac ccaccttggt 7080 gaagctagac taatgaagag gaaaggcagt atatgaaaat tatgtaaatt gcgatatgat 7140 aaagataagg cataagaagt taaagtattg ggatccctaa ccaaataaaa ggagtgatgg 7200 gggaaccctt gaagcaagtt atttgaggaa ttagctagag gaaaaaggta agagtattca 7260 tagcggaaga aacagcaaaa gtgagacctt gaagtgacaa acatcttggt gcgttatcaa 7320 agctgaagga tggctaatgt cactgataat aagtgataaa aataacagtg tgagaaaaag 7380 attaattttt ttttttaaag atcgctggga aaagtgggtg aatcacctga ggtcaggcat 7440 tcgagaccag cctggccaac atagtgaaaa ccctcctctt ctgaaaatgc aaaaattagc 7500 ggggcatggt ggcacatgcc tgtaatctca gctactcggg agactgaagc aggagaatag 7560 cttgaaccca ggaggcagat gtggcagtga gacgagattg tgccattgca ctccagcctg 7620 ggcgacagag taagacccca tctcaaaaaa ttaaaataaa aataaataaa gattatgtag 7680 gattttatta gctatgataa ggagttaaaa cagtatctta agggagaaac tggaaggttt 7740 ttaaaaacga ggatgacatc agcagtcagt ctcactttac agatgagaac accaaggcag 7800 acggtgtcat atcttgctca aggtcacaca gcaagtaagt tgcagagatg gtctggcttc 7860 agataccatg aatttaacca ccacaaaact catagatata cagatagtaa gactatgttt 7920 gcaccaacgc ccaaacttca attaaaaaga aaaacagggt ctaatcagtt atttgaattt 7980 cgcagtcaat tcctttgtaa agcatataaa ccactgagaa attgaattag gctcacaaat 8040 taaaatgtga atatgaatat aattatttaa acaaaagact acctcttaaa actctacctc 8100 gcagatatcc tgtgagaagt tgacgggata atagaaacag aactagtttg ggaatttcta 8160 attctgagtg ttttttgttg ttgttgtttt gttttgttta tttgttttct gagacgagtc 8220 tcgctcttgt cgcccaggct ggagtgcaat ggagtgatct tggctcactg caacctccgc 8280 ctcctgtgtt caagtgattc tcctgcctca gcctcccgag tagctgggat tacaggcgcc 8340 catcaccatg cccacctaat ttttgtattc ttagtagaga cggggtttca ccacattggc 8400 caggctggtc tcaaactcct gacctcaggt gatccacccg ccttggcctc ctaaagtgcc 8460 ggaattacag atacagatgt gaactaccat gcccggccct agttctgagt tctaatatga 8520 aactttaggt ctcagtttaa cctacttact attaattata tgatcttgga caatgggcct 8580 aaaaaaggag tcttaatatt cccaactaca taatggagat agtaaggcct gccacacctc 8640 tctcataaaa ttatgttgaa actaaaatag cataaataaa aatgtcaaaa aatatcccat 8700 aatttttgct aaacttcttg ccttccttat ccaatttcct caggaacatg gacgttttgt 8760 tctcatttcg tgatggagac tgcagtaaag gattcttcct ggtctctcta ttggtggaaa 8820 tagcagctgc ttctgcaatc aaagtacgtc tatcctcact tcaaaattta tatgtcaatt 8880 tacgtaagca gagcaatcac ttcggagcct aaactatact aagcatgagt taactttatc 8940 cttaacaagt acaacatggg atcatttaat tgggggtaaa ggatcaatta tttatttttg 9000 tgtattacct aaaatataaa atctcagagc catatactta aaatccaact tgaaacctct 9060 gtaggagata aaaattttca ataaaatctg gctttggaac tatgatacag tgtcataaat 9120 tcaatagttt tgattatcaa aaatagaaat gaaacatata caactatata aatatcttta 9180 aattaaatgc tatgtgaata aaaacaaatc caagcttcta taaatgtaag gaaattagtc 9240 aaatagagtg tccagcccag gaaagaaatg taaaaatccc aaatttaatt tatggattaa 9300 gacgggggaa tttggcaggg cacagtggct cacacctgta atcccagcac tttgggaggc 9360 tgaagtgggc ggatcacttg aagtcaggag ttcgagacca gcctggccaa catggcgaaa 9420 ccccgtctct actaaaaata taaaaattag ccgggcatgg tggtgggcac ctgtagtccc 9480 9540 9600 9660 9720 9780 9840 9900 9960 10020 10080 10140 10200 10260 10320 10380 10440 10500 10560 10620 10680 10740 10800 10860 10920 10980 11040 11100 11160 11220 11280 11340 11400 11460 11520 11580 11640 11700 11760 11820 11880 11940 12000 12060 12120 12180 12240 12300 12360 12420 12480 12540 12600 12660 12720 12780 12840 12900 12960 13020 13080 13140 13200 13260 13320 13380 13440 13500 13560 13620 13680 13740 13800 13860 13920 13980 14040 14100 14160 tgacgcctgt gtgaaagctc tggtctccct gaggagctac catctgcaaa tcgtgactaa 14220 gtacatcctg attcctgcaa gccagcagcc aaaggagaat aagacctctg aagacccttc 14280 aaaactggaa gccaaaggaa ctggaggcac tgatttaatg aatttcctga agactgtaag 14340 aagtacaact gagaaatccc ttttgaagga aggttaatgt aacccaacaa gagcacattt 14400 tatcatagca gagacatctg tatgcattcc tgtcattacc cattgtaaca gagccacaaa 14460 ctaatactat gcaatgtttt accaataatg caatacaaaa gacctcaaaa tacctgtgca 14520 tttcttgtag gaaaacaaca aaaggtaatt atgtgtaatt atactagaag ttttgtaatc 14580 tgtatcttat cattggaata aaatgacatt caataaataa aaatgcataa gatatattct 14640 gtcggctggg cgcggtggct cacgcctgta atcccagcac tttgggaggc cgaggcgggc 14700 ggatcacaag gtcaggagat cgagaccatc ttggctaaca cggtgaaacc ccgtctctac 14760 taaaaataca aaaaattagc cgggcgcggt ggcgggcacc tgtagtccca gctactcggg 14820 aggctgaggc aggagaatgg cgtgaacctg ggaggcggag cttgcagtga gccaagattg 14880 tgccactgca atccggcctg ggctaaagag cgggactccg tctcaaaaaa aaaaaaaaaa 14940 agatatattc tgtcataata aataaaaatg cataagatat aa 14982

<400> 46

gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag ttgaaatctg 60 gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc aaagtacagt 120 ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca gagcaggaca 180 gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca gactacgaga 240 aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc gtcacaaaga 300 gcttcaacag gggagagtgt tag 323

<400> 47

agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg 60 ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg 120 gctggcggcc aggatggttc ttaggtaggt ggggtcggcg gtcaggtgtc ccagagccag 180 gggtctggag ggaccttcca ccctcagtcc ctggcaggtc ggggggtgct gaggcgggcc 240 tggccctggc agcccagggg tcccggagcg aggggtctgg agggaccttt cactctcagt 300 ccctggcagg tcggggggtg ctgtggcagg cccagccttg gcccccagct ctgcccctta 360 ccctgagctg tgtggctttg ggcagctcga actcctgggt tcctctctgg gccccaactc 420 ctcccctggc ccaagtcccc tctttgctcc tgggcaggca ggacctctgt cccctctcag 480 ccggtccttg gggctgcgtg tttctgtaga atgacgggtc aggctggcca gaaccccaaa 540 ccttggccgt ggggagtctg cgtggcggct ctgccttgcc caggcatcct tggtcctcac 600 tcgagttttc ctaaggatgg gatgagcccc atgtgggact aaccttggct ttacgacgtc 660 aaagtttaga tgagctggtg atatttttct cattatatcc aaagtgtacc tgttcgagtg 720 aggacagttc ttctgtctcc aggatccctc ctgggtgggg attgtgcccg cctgggtctc 780 tgcccagatt ccagggctct ccccgagccc tgttcagacc atccgtgggg gaggccttgg 840 cctcactctc ccggatcgag gagagaggga gcctcttcct gggctgcccg tgaccctggg 900 ccctctgtgt acactgtgac cacagcccgc tcctggaccc tctgtgcccg gctggccctc 960 tgtgcccagc cagcctgcac ctggggatgc caaggcctgg ggagggtggt ttcacccagg 1020 ccaagcctaa gacagtccct ctgggccctg ctgggtaccg gggtgtgaca ccactgggag 1080 gacaagatga ggggcacccc tggggccgcc ctgacacccc ctcgaggctc ctgccccggg 1140 ggtcctggtg ccccttcact gtggcaggcg actgggggtt ccccacctcg gcccctctcc 1200 cggggcctgc tccccggcac ctgaggcagc atccttgtca gggccgtgcc ttcctgcctc 1260 agcgccacct cttaaggttg gcccgtgggt cactcaggac tcagaactgg agattctggg 1320 caaaaggcaa agagcaaagg gccaaaaggc atcccaggga gacgactgcg ggggaaccag 1380 agggcagagg ggcgctcgtc acaggggagg gggagctgag cgaggcagga ggggagccga 1440 gcctctcccc ccgtgtcccg gctcttcagg cacgccctcg ggacgccacc ctccccgacc 1500 caggcgggaa agataagagc aaggtgtccg cagcctgaca ctcgtgcctc aggtgcccgc 1560 gcttgtgccg gacaagactc tcacaggtgg catgcctcgg tttccccact ggtaacagca 1620 cagggcactc agcaaggcgc agtgggcatg actggggtcc tgtgggtcct gacccagatg 1680 tggccacccc ggccgcagtg gtcttcattc caggatgcct cttttccctc ctgatctatt 1740 cactgcgttc gccattcggt cattcccggg gccaccactc ccacctcagg tgtgtgcttc 1800 ccttgtgttt tatgagatat ccccaacccg gctgcttatt ggccccgtcc gagggcagga 1860 gcataaataa gagcctctgc tttggcgtgg gaccactgtg agctccagtc agcgctgcca 1920 ctgctgagct ctgggccttc gacaggactt ggccccttac tgacttctcc gtgtgctttg 1980 ggtcatgggt gaggacgcct cctggcaagg ctgcgtcctg aggattaaat cgggtcatct 2040 gtgaaaacta cccagcccag cccctgacac ttttttgttt gtttctttta gtgacagggt 2100 cttgctctgt cacccaggct ggagtgcagt ggtgtgatct cggctcactc gacctccggg 2160 gctcaagcaa ttctcccacc tctgcctcca gagtagctgg gactataggc acgtgccacc 2220 ctgccaggct aatttcttcc atttttttta gagacagggt ctcgctatgt tccccaggct 2280 gggctcaaat ggtcctccca cctcagcctc cccaagtact gggattacag gcataagcca 2340 ctgcatctgg cctccatgac acatattttt aaagtctgat ttttaaagtc aaacttttga 2400 agtcagattt taaacggact attttgaaaa atatacaaaa acgtttaaaa acaatgaata 2460 tccctcacct agaatcaata actaagaata ttgacacatt tgctttgggg actgggcggc 2520 tggagctgcc atgacaaagc tccgccgacc gagtggcttt taaacagagc ctgccctctc 2580 gccgactgag ggctggacgt gcaggatgga gctccgcagg gtcggctccc ctgtgctctg 2640 aggggctctg ctcagcctct cccggctgtg gcttaaaaac agagcctgtc ctcccgccgt 2700 ggggggctgg acatgcagga ccgaggggcc acagggtcgg ctccctgtgc tccgagaggg 2760 ctctgctcag cttctcctgg ctggggggtt ttgtggccac cctctgtgtt cctgggttca 2820 gaagcatccc ccaggctctg ccttcatctc tgcacgggtg actctgtaca ggaagccagg 2880 cctgctggtc aatggccacc cagccctgtg ccctcatctt acctagtccc agctgccgtc 2940 accctattcc taataaggcc gccttctgag gtcatggggt taggacttcc acataggaat 3000 ctgtggggac acggttcggc ccacagccct tcccacctcc acacacacac acgactgtga 3060 ggagttggaa gacctcactc ctcacccctg ccaggtcctc tagggacaag ctcgctgtcc 3120 tcatcccagc acagcccgtg ggacggtttc cttgtcccta atgggaccac ggtcagagat 3180 gccgggtctg gtctgggcca gcaggttcct ccgcccgggg caggcagcct tcttctgtgc 3240 gcttctggaa agcaatgtcc tgtaatgcgg tctctctgcg ggagcacccc caccgccacc 3300 tcacaggcct gttccacagc cccgggatgg gctctgtctc cctcctgacc ctgcataggg 3360 cacagccctc tctcatcaac ccacgatcct acgtggatcc gagagggagc acctggggaa 3420 acaatggaat cccatagaaa caccccaaat ctaacttgat ccaggaccag ccagtggtca 3480 cttctgaata ttcaccttcc tagtagacac taccagccaa gggaggccag gaagccttcc 3540 tggaggaggt ggcctgagga ctggggtgag gcaggccctg cgtgggggtc gccacccagc 3600 acccccacac tgggtgggag ccagtctctg agactggctg ggggaggtgg gagagggggc 3660 tgcttgaact gcagacaccg aggtctagcc cccaccccac ccagccagtt ggtggaggca 3720 ggggaggccg aggggcccag ctggacctgc tccccggggt ggattccaaa ataggggggt 3780 tggggggggc ggaacaggag cccagggtcc tggcttgagg cccagtggct gagggctggt 3840 gcaagccaga caggaaaagg gttgagcctg tcagcgccag cacagatcaa gtcaggagca 3900 ggtccctcca ccaatgtgtg caaataaata gcagctaagt ttccagttac aagaacaatg 3960 cacagatggt cccagggaca ttgcggtgtg gacacacagc ggccattgtc ctgtcgccag 4020 cacctcgccc tacagctggg gggtccctta gcacttccta gccatgcagg gtccctgctc 4080 acagtacccg tgatgacttc tgttcctcac ctgcctgtct gtcccgacag ctgcatggca 4140 gccctggcct gggagatgga gaccccgagg ggctgcctgc ggtggtgggg cccctgggtc 4200 cccactgcat tcccagaaac ccagagggca gggcatttcc cctgctctgt gccgagtcca 4260 cccagcccca gcctaggccc agtaagggct gcagcccacc ctgtcccagg ctgcctccca 4320 ggagccctct tggccctgat gccagaagcc catcttcctc cattcaggca ggtctctgag 4380 tgccctggcc tggctgcctg ctggccctga gagtcacact accccacagc cctccttggt 4440 caaaatccac tctggagtgg ctggaagatt ccccgggccc acgccgcaca cgcctatgca 4500 gggagcttcc cctggccggc cggcagacaa gggcggtctc agagaggggg ctcacctcag 4560 cagccccttg tgtagctggc cctcgcccct gccacctctg ggaacaccac caggaagctg 4620 ggggacaggc acgcaggtga aggaggcgag cgcttgtcag ccgggaggcc atgggcacag 4680 agggaacagg gacaccctgg gtggcctcaa ggtcacttca aacccctcac tcgtcccctg 4740 ggagggtgcc cagtgaggtt ggcactagga gttggtcctg gtcacatgac agacccaccc 4800 acctctggtg tccagccagc acgccgtggg ccagcctggc tgcagggaca cgagggcagc 4860 agccccctcc tcctctgagc tggttgctcc ttgagtcatc accaccgcct gccacggagg 4920 ccgcctgtcc caggaagcag agggaccgca gctgtggcaa ccagggcctg gtctctgtgt 4980 cacctcgctg gggggccgtg cccaggcctg agacggaact gagtgacagt gcactgggtc 5040 tgacagtgtg gggctggcgc catgtttggg gaaccctgtg gcatgggacc tgtgggtgag 5100 ccgggaaaat caccccgttg catggcatct cgggcctgga tcttaagcgc ctgtgttggt 5160 gcctccgcct ggcggaagag ccgcgacccc cacgttgcca tgcgggtatc ccaagccctg 5220 accctggcag gcatatgttt caggaggtcc ttgtcttggg agcccagggt cgggggcccc 5280 gtgtctgtcc acatccgagt caatggccca tctcgtctct gaagcatctt tgctgtgagc 5340 tctagtcccc actgtcttgc tggaaaatgt ggaggcccca ctgcccactg cccagggcag 5400 caatgcccat accacgtggt cccagctccg agcttgtcct gaaaaggggg caaagactgg 5460 accctgagcc tgccaagggg ccacactcct cccagggctg gggtctccat gggcagcccc 5520 ccacccaccc agaccagtta cactcccctg tgccagagca gtgcagacag gaccaggcca 5580 ggatgcccaa gggtcagggg ctggggatgg gtagccccca aacagccctt tctgggggaa 5640 ctggcctcaa cggggaaggg ggtgaaggct cttagtagga aatcagggag acccaagtca 5700 gagccaggtg ctgtgcagaa gctgcagcct cacgtagaag gaagaggctc tgcagtggag 5760 gccagtgccc atccccgggt ggcagaggcc ccagcagaga cttctcaatg acattccagc 5820 tggggtggcc cttccagagc ccttgctgcc cgagggatgt gagcaggtgg ccggggaggc 5880 tttgtggggc cacccagccc cttcctcacc tctctccatc tctcagactc cccagacagg 5940 ccctggaacc cccccacctt ctccccagcc ctgctcgtgg tgaccgaagg ggacaacgcc 6000 accttcacct gcagcttctc caacacatcg gagagcttcg tgctaaactg gtaccgcatg 6060 agccccagca accagacgga caagctggcc gccttccccg aggaccgcag ccagcccggc 6120 caggactgcc gcttccgtgt cacacaactg cccaacgggc gtgacttcca catgagcgtg 6180 gtcagggccc ggcgcaatga cagcggcacc tacctctgtg gggccatctc cctggccccc 6240 aaggcgcaga tcaaagagag cctgcgggca gagctcaggg tgacaggtgc ggcctcggag 6300 gccccggggc aggggtgagc tgagccggtc ctggggtggg tgtcccctcc tgcacaggat 6360 caggagctcc agggtcgtag ggcagggacc ccccagctcc agtccagggc tctgtcctgc 6420 acctggggaa tggtgaccgg catctctgtc ctctagctct ggaagcaccc cagcccctct 6480 agtctgccct cacccctgac cctgaccctc caccctgacc ccgtcctaac ccctgacctt 6540 tgtgcccttc cagagagaag ggcagaagtg cccacagccc accccagccc ctcacccagg 6600 ccagccggcc agttccaaac cctggtggtt ggtgtcgtgg gcggcctgct gggcagcctg 6660 gtgctgctag tctgggtcct ggccgtcatc tgctcccggg ccgcacgagg taacgtcatc 6720 ccagcccctc ggcctgccct gccctaaccc tgctggcggc cctcactccc gcctcccctt 6780 cctccaccct tccctcaccc caccccacct ccccccatct ccccgccagg ctaagtccct 6840 gatgaaggcc cctggactaa gaccccccac ctaggagcac ggctcagggt cggcctggtg 6900 accccaagtg tgtttctctg cagggacaat aggagccagg cgcaccggcc agcccctggt 6960 gagtctcact cttttcctgc atgatccact gtgccttcct tcctgggtgg gcagaggtgg 7020 aaggacaggc tgggaccaca cggcctgcag gactcacatt ctattatagc caggacccca 7080 cctccccagc ccccaggcag caacctcaat ccctaaagcc atgatctggg gccccagccc 7140 acctgcggtc tccgggggtg cccggcccat gtgtgtgcct gcctgcggtc tccaggggtg 7200 cctggcccac gcgtgtgccc gcctgcggtc tctgggggtg cccggcccac atatgtgcct 7260 gcctgcggtc tccaggtgtg cccggcccat gcgtgtgccc acctgcgagg gcgtggggtg 7320 ggcttggtca tttcttatct tacattggag acaggagagc ttgaaaagtc acattttgga 7380 atcctaaatc tgcaagaatg ccagggacat ttcagagggg gacattgagc cagagaggag 7440 gggtggtgtc cccagatcac acagagggca gtggtgggac agctcagggt aagcagctca 7500 tagtgggggg cccaggttcg gtgccggtac tgcagccagg ctgtggagcc gcgggcctcc 7560 ttcctgcggt gggccgtggg gctgactccc tctccctttc tcctcaaaga aggaggaccc 7620 ctcagccgtg cctgtgttct ctgtggacta tggggagctg gatttccagt ggcgagagaa 7680 gaccccggag ccccccgtgc cctgtgtccc tgagcagacg gagtatgcca ccattgtctt 7740 tcctagcgga atgggcacct catcccccgc ccgcaggggc tcagctgacg gccctcggag 7800 tgcccagcca ctgaggcctg aggatggaca ctgctcttgg cccctctgac cggcttcctt 7860 ggccaccagt gttctgcaga ccctccacca tgagcccggg tcagcgcatt tcctcaggag 7920 aagcaggcag ggtgcaggcc attgcaggcc gtccaggggc tgagctgcct gggggcgacc 7980 ggggctccag cctgcacctg caccaggcac agccccacca caggactcat gtctcaatgc 8040 ccacagtgag cccaggcagc aggtgtcacc gtcccctaca gggagggcca gatgcagtca 8100 ctgcttcagg tcctgccagc acagagctgc ctgcgtccag ctccctgaat ctctgctgct 8160 gctgctgctg ctgctgctgc tgcctgcggc ccggggctga aggcgccgtg gccctgcctg 8220 acgccccgga gcctcctgcc tgaacttggg ggctggttgg agatggcctt ggagcagcca 8280 aggtgcccct ggcagtggca tcccgaaacg ccctggacgc agggcccaag actgggcaca 8340 ggagtgggag gtacatgggg ctggggactc cccaggagtt atctgctccc tgcaggccta 8400 gagaagtttc agggaaggtc agaagagctc ctggctgtgg tgggcagggc aggaaacccc 8460 tccaccttta cacatgccca ggcagcacct caggcccttt gtggggcagg gaagctgagg 8520 cagtaagcgg gcaggcagag ctggaggcct ttcaggccca gccagcactc tggcctcctg 8580 ccgccgcatt ccaccccagc ccctcacacc actcgggaga gggacatcct acggtcccaa 8640 ggtcaggagg gcagggctgg ggttgactca ggcccctccc agctgtggcc acctgggtgt 8700 tgggagggca gaagtgcagg cacctagggc cccccatgtg cccaccctgg gagctctcct 8760 tggaacccat tcctgaaatt atttaaaggg gttggccggg ctcccaccag ggcctgggtg 8820 ggaaggtaca ggcgttcccc cggggcctag tacccccgcc gtggcctatc cactcctcac 8880 atccacacac tgcaccccca ctcctggggc agggccacca gcatccaggc ggccagcagg 8940 cacctgagtg gctgggacaa gggatccccc ttccctgtgg ttctattata ttataattat 9000 aattaaatat gagagcatgc taagga 9026

<400> 48

ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag 60 gctccgcacc agccgcgctt ctgtccgcct gcaggtaggg agcgttgttc ctccgcgggt 120 gcccacggcc cagtatctct ggctagctcg ctgggcactt taggacggag ggtctctaca 180 ccctttcttt gggatggaga gaggagaagg gaaagggaac gcgatggtct agggggcagt 240 agagccaatt acctgttggg gttaataaga acaggcaatg catctggcct tcctccaggc 300 gcgattcagt tttgctctaa aaataattta tacctctaaa aataaataag ataggtagta 360 taggataggt agtcattctt atgcgactgt gtgttcagaa tatagctctg atgctaggct 420 ggaggtctgg acacgggtcc aagtccaccg ccagctgctt gctagtaaca tgacttgtgt 480 aagttatccc agctgcagca tctaagtaag tctcttcctg cgctaagcag gtccaggatc 540 cctgaacgga atttatttgc tctgtccatt ctgagaaccc aaaggagtcc taaaagagga 600 atggaggagc ctaagaataa aaatagtata ataaaacatt tcttagacac attgaccttg 660 gcctatgtca aagttcagtc tgggtttgtc ttataacaca aggagtaaaa gtaccattgt 720 tctacctctt tttttaatac ttgaaaaaaa tttactgtgg atgcttttct atgaattaaa 780 taaccttcta aaaaatgttt tcattgctgc attcgattag attgggtaac taaatgaaat 840 taattcctca ctgttgggta taaaggttat ttacagtggt tctgtcttag ccattcactg 900 aactcattgc atatatatct ctggaatatt gctgattgtt tccttcaagt aaacttagaa 960 gtgtaactac ttagtcaaag agcctgaata ttttaaaggc cttttgaaga aaactgaaaa 1020 tgctttccag aaaggatgta tcagttgaca atgacagtcg tcaacagtat ttaaggagaa 1080 ctatgatact ctgaagaaaa acttagcctt tctcagtaaa agtaggtagg cagaggccac 1140 atgacagcag ttagagtgtg gtcttcaagg aagtcacaga aatactgtgg ggaattgaaa 1200 ccccatgtgg aaaatgtaca agagtgtctc agtgtgactg agaaggaggt tgggcatggg 1260 gtttcatgga gtttaataaa gtttggtcac ttagtagagg tttaataaat caactgtctt 1320 aatctttgat cctacttaag aatttttttt ttgtttttgt agagatgggg ctcttgttat 1380 gttgcccagg ctgttctcga actcctagcc tcaggcgatc ctccctcctc aggctccaga 1440 agtcctggga ttactggcgg gagccaccat gcaggcctct tgctcctact tttgagaaag 1500 gaagtttaac cggttttttt tgtctttttt tttttttttt tgagacagag tctcactctg 1560 ttgcccatgc tggagtgcag tggtgcaatc tcagctcact gcctcccggg ttcaagtgat 1620 tctcctgcct cagcctcccg agtagctggg actacaggca cctgccacca cgcccagcta 1680 atttttgtat ttttagtaga aatggggttt caccatattg gccaggctga tctcgaactc 1740 ctgacctcag gtgatccgcc tgcctcggcc tcccaaagtg ctgggattac aggcatgagc 1800 cactgctcct ggctgcttaa ctttttctct atctcatcct cctacccatc ctacccttgg 1860 aagatagaga agtagtatta gttccatagt gttatactgg gcttccccca gggacaaacc 1920 cacttcccca acctgaatga gccatcactt cttccccagt ttacatttca ttgctcttta 1980 aatgtctcca ttcggatatg ggaattcaca tatggtcata attcttacct gaagaagatg 2040 tcagtcttct tctcttagac caactgccct gatatgaggt ttagaggtta aagaacatgt 2100 gtgtatttac atgatctttg tattctgcct tttcgtccct cactaatgac agctgcaccc 2160 caaggaaatg gagctgtgga agagagggtt tgataagaaa ttaagtaaat attggatcta 2220 atccatcacc ctccaggaag cctttattac tcctaaaaat ttcaaccaaa ttcattaaag 2280 gacaagaact ccaccagagt aggccataaa cattggcaaa attagttgta atccatgact 2340 agatttaatg tccctttgtt ttattcccat atggttataa tgctttgctt ggcattaggg 2400 gtattttaag ttttcttctg cctagtaagt gaatttgtgt ttataataca ataatcataa 2460 aatatcacat taatatttta taactgtaca gttataaaat attttataag taatatttat 2520 attttataag taatatttta taactgtaca gttaactctg gcccaaggaa aagatagtct 2580 gatagatgct gcagccccat tttagcaaat gtgacctcac aggcctgaat gccatcgcta 2640 ttccacatct acaggataga cggaaaggaa agaaataaaa aaataggtac ctaacactgg 2700 caagaggatg atgactcatg ttatttcact taaccttttt atcttttaac atgaaggact 2760 catacaggtt gataagaaac cagtgacata aacagaccaa aaaatgatca gatctttcaa 2820 attagcaaaa aaataatatt ttttaaacaa tgggtgaaaa tacagtgtaa cagtaccaat 2880 tatcaacatg tgttgagaac cagaaaaatg ttctttttct ttgatcagca acactatttg 2940 ggaaaatcta tcctcagggc ctagcctggg gccctggcac acagtaggca ctcaacgaat 3000 atttgctgaa cacacaaata cttatgatat tttaaaaaat tggcaacaat ctgataccta 3060 acaatagagg gattaaatat tatggaactg ttaaataaga tgcttatgaa taccatgcag 3120 taagatgggc aatatttatg ccataagctt taatgaaaca aatgggtatt aaatgtatga 3180 taaggttata aattactttt taaaagatta cagggaaaaa aattgaaaga tatacactga 3240 aatgtttttt gctcacagtg gtgacaaggt ttctcagcac tggcactgtt gacgttttag 3300 gctgtatgtc tttgctgtgg gaggctggcc tgtgcactgc agggtgtttg gcagcactct 3360 tggcctctgc ccctagatag caatagcagt cctccctcaa ccagcccaat tttgacaacc 3420 aaaaatgttt ccaggcatca ccagatgctc cctgggtgag agtgatgaaa tagtagggga 3480 ttttcccctt cttttcttat tttctgtaat tccattatat tactttaata ataaagaaaa 3540 aaacataaaa aataaacgaa tgttattatt ctacgtcagt ttggatgttt ggactccatt 3600 ttggggttct ttccattata tcacttggtc tgctaaacat tctacggttt ggtaaggtga 3660 agtgattcat gaaattttgg ttttattttt ttcctgatac taaaaataaa acattctttc 3720 acttggaaat ttggacacag aacaccaaaa aaaatccata atctcatctc tctttttctg 3780 tcttttcctt ccttttttcc ctttaaaaac aataaagagt gaaacctacc tgttctccct 3840 ctaatttaat tcctaaatat aatcactgtc aatatcttgg acatttcctg tgtctaaaca 3900 cacacacaca cttttttttt tcagcaaaag tggatttctg ctacatgtag tgttctgcaa 3960 cttactttct atgtgtttac aaaatcagta catgtacata tgctgaattc agtccttaat 4020 ggtattatat tttgtgaata taccaaaatt tgtttaacca cttagacaat ctaggatatt 4080 ctcagtttgc tgttatgagc aatgctcttc ctttacatat acagacatat atatatatat 4140 gtgtgtgtgt gtgtttttgt tttagtagga tagatttcta ggagagggtg aaaggtctta 4200 tgacatccgc atttacgatt gtaataggaa gtatcaaagt gccccctaaa gaaaaaaatc 4260 ctcccattag tgggtaagaa agcctatttg ttcatatctt cacaaacact aaatattaga 4320 aatatttaca attgtggtca agctcataag tgaaaatggt atttcatatc ttatattttt 4380 tattgtgaga ttgaacatct ttcatatgtt tacatgtcac ctgtatttct tattctctga 4440 actatatgtt atgacctttc actttttttc ctcatgggtt atgtgtagtt tgtatagttg 4500 tcttattgat tgttaggagc tatttatata ttaggaacat taatctcctg tcttatatat 4560 acgtggcatc gattagttga tcatttgtga gttcatgtct gtatacaaag attggagagg 4620 cactaagagg gaaaacttac ctctttctta tcaaagtttg taaatatatg tataacagaa 4680 gagggagaaa atattaataa atgcacagat tggctgaaat agagtataaa tcttttactc 4740 ccctacttca acataaactg caaaaggaga gtgacttttc tttcactctg acttccgtat 4800 tcctcatgct taaaatagtg cctagcacag aagaggtgct caatcagtgt ttgctaaacg 4860 aaataattag tcacatttca agcaggatga ctaaatgaag aatagaatct aggcagatac 4920 tctggaagag tggctgtgag tcattcatat cttagtatga attagtcaaa tccaactctc 4980 tccccttccc actccccact gttagtagaa gaatctgttt attgagagaa tagatttata 5040 atttagaata agtgagaggg gcagaagagg agattttgaa ggatggcacc tgaaggagga 5100 ctagcatggc tgagacagtg aagtggaagc cttgaatagc taaagggtaa gatgaaagta 5160 tttagctgta gggggaaaaa gcattgacag gttggaaaag taaaagtcag attctccttg 5220 ctctgaaatt ttgtacaggg caggttctac taggtatgtt acaatgcaga aaaaacatga 5280 aataattgag aggaatttgg tgcaatatta tcttcttggc ttcttttgag tgggcagatt 5340 tttttcacgg cctgtaacta taataaattt gaaacttctc atcttttagt aacttttttc 5400 acttaagttt atgtggctgt gggcaatgga atgaagatat tgaacttcca attccctgtt 5460 gggtttccac aattacaagt caatcatgac tggttattag aagactattt cagttagaac 5520 caccaagtcc catattgtca tattgtatgt ttaattatta agtgaagcag tcttcttttc 5580 gtgttttcca taattagggc attccagaaa gatgaggata tttgctgtct ttatattcat 5640 gacctactgg catttgctga acggtaagac accaaatcct tccattaggt tctatatttt 5700 aaatatttta accatgagtt taaaactaaa atgatcattt aaaatgcatg caattttctt 5760 atagagagaa cattctattc tttcttctac tttacacaat ggcaaagtct tctttctact 5820 ttacgcaatg ataaagttac ctgtgtcatt ttgtaaaaat atagagaata tagacaaatt 5880 gaaagacaca aaataatcta ttacccattt cccagggtta actactgaaa atatctgggg 5940 aaatggcctg tatgtataca tttatttgtt tgctttcaac aaggccaaga tcctttgatc 6000 tttcagtctt ggttgctctg tgacatgcct ttcctgatga ggatacttta aggaagaatt 6060 gtaagataca tggaaaatgt caggctaaca cagtactggc atcaccctgt gctctttcct 6120 gaactccata ccaatgtact tcttgccaga aaactgatca aaagtttagg gaagtaaaaa 6180 gagatgactg ttagaatcta ccattccctc tatgtaggaa gcaaataggt gtcctgtcaa 6240 aggacattct ggggatgtct acatgaaacc aactctccct ggttgtaagg actccatctc 6300 catataatat ttatacagta atatatgttt ataaattgtg ggggcaactt gtttagctaa 6360 ttttattatt ctgctattgg gacactgtgt ctcagcatga gatatagtgt cccaaaacat 6420 atttcaagcc cattggataa aatatgtgtt tagcaagttc ttaaatataa tgataacata 6480 accgaccaga taaagtgatt tataaacgct gtgccaattt tgtaaatgtt tcgaggaatt 6540 ttcccttttc tgaagattgt ccttctttct ttttagcatt tactgtcacg gttcccaagg 6600 acctatatgt ggtagagtat ggtagcaata tgacaattga atgcaaattc ccagtagaaa 6660 aacaattaga cctggctgca ctaattgtct attgggaaat ggaggataag aacattattc 6720 aatttgtgca tggagaggaa gacctgaagg ttcagcatag tagctacaga cagagggccc 6780 ggctgttgaa ggaccagctc tccctgggaa atgctgcact tcagatcaca gatgtgaaat 6840 tgcaggatgc aggggtgtac cgctgcatga tcagctatgg tggtgccgac tacaagcgaa 6900 ttactgtgaa agtcaatggt aagaattatt atagatgaga ggcctgatct ttattgaaaa 6960 catattccaa gtgttgaaga cttttcattc ttgtaagtcc atacttattt tcaaacagaa 7020 cagcatagtc tgttcattca ttcattcaat tcatgaattc attcacataa ttatccaatt 7080 tcttgagcac ctatttgata gtcactggaa atccagagac aaacaacaca gagccatgtt 7140 ctacagtatg tacagttttc caaaaagaat ttctagtctt tactttttta ttacaaatgg 7200 aatacgtata cttgcaaata attcagatac tgtggaagag atcaaatgaa ttgcaaaagt 7260 gtccctcctc ccttcaccac tatctcccat ggcatgcaga gagagtaacc attatttgtg 7320 tgtccctcca gaaatttttt tattcaacta ctattttttt attttattag gtccgtcagt 7380 tttccttttt tgagcctctc tatatcaaat gcaaataaat atattcagaa caaaccccac 7440 tgtaaggttc acattaaaaa agacttgaag tcaccctatg aagacaaaaa ataatcacat 7500 taagtgtgaa agaacctatt cttccagtac aggataagcc atacttactg ggcatatatt 7560 catcttgaaa atctatactg atgttgtctt ggggaattga aaaggaacta ggagtgttag 7620 ttcctcggta ttgacccaca gttatgttat caggtcactt gagttcaaag ttttgtgttg 7680 gcactagcta agtaaaggaa aacacctctg ctttcattgt tgagtttcac agaattgaga 7740 gctgaaagga tcccaggcag gagcagctaa tccaaactcc cacaaagaac aaaaatcccc 7800 cagaggatct tctgttctta tatttcctgc aatggcgtcc ctgtcatatc ccacaatggc 7860 ctccctgcca tttggatatc ccttccatat cctgttgaaa ttactcccta atagtaagct 7920 gaaatctgcc cctctagttg tagtcttggg attatttcat ttacatgatg accttttaat 7980 atttgactag aattaaatca tctccccttg gtctttccat tcctgggcta actaccatca 8040 atctgagggc taacaataca agtagaaaaa gtatacattt gtcactgatc actgatcaat 8100 8160 8220 8280 8340 8400 8460 8520 8580 8640 8700 8760 8820 8880 8940 9000 9060 9120 9180 9240 9300 9360 9420 9480 9540 9600 9660 9720 9780 9840 9900 9960 10020 10080 10140 10200 10260 10320 10380 10440 10500 10560 10620 10680 10740 10800 10860 10920 10980 11040 11100 11160 11220 11280 11340 11400 11460 11520 11580 11640 11700 11760 11820 11880 11940 12000 12060 12120 12180 12240 12300 12360 12420 12480 12540 12600 12660 12720 12780 3-3.3-CC3-t3.tt gttacttaat aaacattcag cagatattta tggaatatac cttttgttcc 12840 atgcattgta gtactcattg gatacacata gaataataag actcagttca cactcttcag 12900 gaaacagata aaaaactaag 333C333C33 aaaacaggca atccaacacc atgtgggaaa 12960 tgctttcata gccgggaaac ctggggaata cctgagagga atactcaatt caggccttgt 13020 ttcaggaatc caaatcctgg cacatcagag ctgcttccct ctttccaggg tggcaggaaa 13080 taaatggaac atatttttct atcttatgcc aaacatgagg gaccctttct ccccggtgcc 13140 tctcccaagg tagtctacaa tatttcaact ctagcagtct gcttagtgca tagaacatga 13200 ggctgtgtgt ccctgggcaa attactagac ttctgtgtgc ttcactttcc ctgtaggatt 13260 ataatctact gagcaagctt attgtaaggg tcagattagc aacagtgtat gaaaatgatt 13320 tgagaccatt gcctgcacaa attcaactat ttttttttat ctcactactc tacagaagta 13380 ggtagggtgg gagacagagt ctgatgagag gctcagaatg tgaaagaaag tgaggcgagt 13440 gagcatgata ttt33t3t33 acacaaagat attctgagaa gagctgctca ctgccccctc 13500 ccccaataca tgttgatagg aaaatgccac gtacttcagc 33333C33Ct gaaaaattag 13560 atagaaaagt caatcaatag gaaaagataa tccaggacgg tgttgtgaac agaaagaggg 13620 ggaaaaaact ttagaaaatg atggggatgc tcttactggg gtacgagtcc tcaggtattg 13680 aactggcttt cagtaaaagc tagattagtg ggttcctgcc atttacaagc tgttttatga 13740 caacttactt gttgggtggc ctacagtaac tcacctaact gcactgagtc tgtttcctca 13800 tctgtaaatt ggggattttt ttttaaatac ctggcatgcc t33CtC3t33 agttgttctg 13860 aaactgaaat aaaacatacg tgaacaggca ttgtaaactg taagttacgg aaaaagctgg 13920 ctgttgttgt gtctttaaag tttcacctgg gtagtcaaag atggatcatg ggtctcagtg 13980 gagagctgag ccaggcagga gctgactaag ggtgagaggt gggagttagc agcctctgaa 14040 catctgtgta ccatgggacc ccctttcctc ctgcatggta ccccagacaa ggagcctagt 14100 aagagatact aatggcttgt tgtccagaga tgttcaaact gcagagaaag ataagacaac 14160 aagcattggc ctccaatcat gatgacagat aggaggaggt gggagctcct tagcagtgct 14220 ggttggcctt ccatgttcta ctgtgggcca tctctgccat gtactgtagg ctactagctt 14280

Ct3t3tt333 gaatgcaaga ggggccagga gcggaggctc atgcctgtaa tctcagcact 14340 ttgggaggcc aaggtgggca gatcacttga ggtcaggagt ttgtgaccag cctggccaac 14400 atggtgaaac tctgccttta Ct33333t3t aaaaattagc tgggtgtggt ggtgtgcacc 14460 tgtaatccca gctactcggg agactgaggc acaagaattg cttgaacctg ggaggcggaa 14520 gttgcagtga gcccagattg cgccactgca ctccaccctg ggcaacagag aaagactctg 14580

CCtC333333 3333333333 agcaagagga agtgaaataa tcaaggccgc catttaatag 14640 tgagcagcca ctccatgtgg tactgtgcaa gcacattata aatattagcc tcacaagaaa 14700 tgtattagca tttgtatttt gtacactggt taagtatctt gcccaagacc tcaaaactgg 14760 ttaagggcag cagaatttag ccccagcacc accttttcaa agcctgggct tctcacactt 14820 ctccatgctg ttcccatttt aacacaggta tctcgccatt ccagccactc aaactttggc 14880 atttaagaaa attatcctaa agctaaacta aacttcaagg atgaccattc tcctgacccc 14940 ttcccatcaa aattttatct ttagtcagtt tgttttcgtt ttgttttgtt tttcagaact 15000 acctctggca catcctccaa atgaaaggac tcacttggta attctgggag ccatcttatt 15060 atgccttggt gtagcactga cattcatctt ccgtttaaga aaaggtagta tttccttaat 15120 tgcagtggtc tccactgggg gtgaggaagg ggtgagaatt ggatcatggc tgcaaggaaa 15180 cccgacttaa cctctgcaag gtggtgcaaa ggcattccac tgttcaacag caattatatt 15240 gaagctgagt gggatcactg ggtgaagatg aagcgtaagg ggtgaggggc aggagaatgg 15300 gtatggatgg aggtagaaga tgcagtgtca tacagttttt ttctatcatg 3333t33CC3 15360 cagacttaca gaagagaaag agctaaaatg cccgtcattt tcagttgcat tttagtcttg 15420 cattagttgc aaccagctgg tttctgggta ccctaagtaa taaaaatagt tcctctgtag 15480 aactgtagta tgtttaccat agagtatttt gcaaaatttt tggtagagga tgttacataa 15540 tttgcatgtg ttcatttctc catttacctg tgggaacaat taaaatccag gaaaatgagt 15600

3t3ttC333t aatttcctcc catttaagat gagtcagagt 333t33ttCC tccaatactt 15660 agagaagtat accaagagat ccagtgatgg tatagagttg tctgatgtta aatagggaag 15720 tagaatatgg aaggggattc caatagtcgt tgaaaaattc cccataaccc cttacatggg 15780 ggaaagtagt gttaactgag agagtagaga taagctgttt CC33333tt3 tattcttaac 15840 aggactgaga tagccagaat ataaggatca agtttcaatg acagtaagat cctgagatgg 15900 agttgatttg cacaaagaaa taattgttgc cagcatgcat tttgaatatt tctctggaaa 15960 aaaagattag ttggcagtag aaatggatag aaatcaatag 3t3tt3333t acctcagaat 16020 ttggttcatc tctgggaaaa gatgaaaaat aaaagtgtat actcctcaag aacatctagg 16080 atcaaaagca tgtgccctac actattgaat taattaacct cataagttgg gacctgtgga 16140 ataaggatgt ccaccagact tcctagggat tacaaatgtt tcacagaact tgaaatttaa 16200 acttgggtca ctgtatggga tgtagagctg tgctatatgg 333t33333t gatttctttt 16260 tctcaaggga gaatgatgga tgtgaaaaaa tgtggcatcc aagatacaaa ctcaaagaag 16320 caaagtggta agaatatcag aaggaattgg gaagtaaaag tcaaaggaaa caaaaagcta 16380 aagcaataac aaagagaaat ccatcagtca taatctcctc tccttttaaa gaatgctggt 16440 tcccctttgc ctcacagcta acacaagaac tcctccaccg tctgaggagg tttaggagca 16500 gggaagggga aggagtcagc ttcatttgct aatcttctgt tgccctgcac cctagcagct 16560 ccttgcagca ggggacaagg atgacttagg tggatggata attaattgat tct3333t3t 16620 tgtgtgtcag tattgtaata ctatgttaat tgcaccatgc acggtatctc atttaatccc 16680 ccaccccttg ccattaccaa agagagagag agagagagag agagaaatac tagaatttat 16740 cctcatttta cagtagagaa aacagagggt caagaagata atgtaaagtg cccaagaaca 16800 cacagctgat C3C33333tC aagcttgggg gccattagcc taaccacaga cccttactct 16860 taacccatct gcttcaatcc attttgctac aaatgtttac atttataagc agggcagaaa 16920 aacctcatcc aggttattga actaagaaga aagttatatt aaggtttcta atttttttaa 16980 tgtagttaga 33CC333Ctt aacaatgagc ccaagtttaa agcagtctaa ttaacctgga 17040 caagctcagg caagtttcat tctgtggccc atagcatcat ctgtgttgta aagctaagta 17100 gcaaatgttg tttgggtcat gctgggggac aagccatccc aatttgctca ggactgaggg 17160 gttttccagg atatcatgta aggataattg ggtacaaata taacctgctg ctttctctca 17220 tttcaaattt atcatttatc atatcagcaa ctatgagtta tgttttttat tagatttctt 17280 gttacttttt ccccagacca cttcccatga 33tt33t3t3 ctattatcac tctccagata 17340 cacatttgga ggagacgtaa tccagcattg gaacttctga tcttcaagca gggattctca 17400 acctgtggtt taggggttca tcggggctga gcgtgacaag aggaaggaat gggcccgtgg 17460 gatgcaggca atgtgggact taaaaggccc aagcactgaa aatggaacct ggcgaaagca 17520 gaggaggaga atgaagaaag atggagtcaa acagggagcc tggagggaga ccttgatact 17580 ttcaaatgcc tgaggggctc atcgacgcct gtgacaggga gaaaggatac ttctgaacaa 17640 ggagcctcca agcaaatcat ccattgctca tcctaggaag acgggttgag aatccctaat 17700 ttgagggtca gttcctgcag aagtgccctt tgcctccact caatgcctca atttgttttc 17760 tgcatgactg agagtctcag tgttggaacg ggacagtatt tatgtatgag tttttcctat 17820 ttattttgag tctgtgaggt cttcttgtca tgtgagtgtg gttgtgaatg atttcttttg 17880 aagatatatt gtagtagatg ttacaatttt gtcgccaaac taaacttgct gcttaatgat 17940 ttgctcacat ctagtaaaac atggagtatt tgtaaggtgc ttggtctcct ctataactac 18000 aagtatacat tggaagcata aagatcaaac cgttggttgc ataggatgtc acctttattt 18060 aacccattaa tactctggtt gacctaatct tattctcaga cctcaagtgt ctgtgcagta 18120 tctgttccat ttaaatatca gctttacaat tatgtggtag cctacacaca taatctcatt 18180 tcatcgctgt aaccaccctg ttgtgataac cactattatt ttacccatcg tacagctgag 18240 gaagcaaaca gattaagtaa cttgcccaaa ccagtaaata gcagacctca gactgccacc 18300 cactgtcctt ttataataca atttacagct atattttact ttaagcaatt cttttattca 18360 aaaaccattt attaagtgcc cttgcaatat caatcgctgt gccaggcatt gaatctacag 18420 atgtgagcaa gacaaagtac ctgtcctcaa ggagctcata gtataatgag gagattaaca 18480 agaaaatgta ttattacaat ttagtccagt gtcatagcat aaggatgatg cgaggggaaa 18540 acccgagcag tgttgccaag aggaggaaat aggccaatgt ggtctgggac ggttggatat 18600 acttaaacat cttaataatc agagtaattt tcatttacaa agagaggtcg gtacttaaaa 18660 taaccctgaa aaataacact ggaattcctt ttctagcatt atatttattc ctgatttgcc 18720 tttgccatat aatctaatgc ttgtttatat agtgtctggt attgtttaac agttctgtct 18780 tttctattta aatgccacta aattttaaat tcataccttt ccatgattca aaattcaaaa 18840 gatcccatgg gagatggttg gaaaatctcc acttcatcct ccaagccatt caagtttcct 18900 ttccagaagc aactgctact gcctttcatt catatgttct tctaaagata gtctacattt 18960 ggaaatgtat gttaaaagca cgtattttta aaattttttt cctaaatagt aacacattgt 19020 atgtctgctg tgtactttgc tatttttatt tattttagtg tttcttatat agcagatgga 19080 atgaatttga agttcccagg gctgaggatc catgccttct ttgtttctaa gttatctttc 19140 ccatagcttt tcattatctt tcatatgatc cagtatatgt taaatatgtc ctacatatac 19200 atttagacaa ccaccatttg ttaagtattt gctctaggac agagtttgga tttgtttatg 19260 tttgctcaaa aggagaccca tgggctctcc agggtgcact gagtcaatct agtcctaaaa 19320 agcaatctta ttattaactc tgtatgacag aatcatgtct ggaacttttg ttttctgctt 19380 tctgtcaagt ataaacttca ctttgatgct gtacttgcaa aatcacattt tctttctgga 19440 aattccggca gtgtaccttg actgctagct accctgtgcc agaaaagcct cattcgttgt 19500 gcttgaaccc ttgaatgcca ccagctgtca tcactacaca gccctcctaa gaggcttcct 19560 ggaggtttcg agattcagat gccctgggag atcccagagt ttcctttccc tcttggccat 19620 attctggtgt caatgacaag gagtaccttg gctttgccac atgtcaaggc tgaagaaaca 19680 gtgtctccaa cagagctcct tgtgttatct gtttgtacat gtgcatttgt acagtaattg 19740 gtgtgacagt gttctttgtg tgaattacag gcaagaattg tggctgagca aggcacatag 19800 tctactcagt ctattcctaa gtcctaactc ctccttgtgg tgttggattt gtaaggcact 19860 ttatcccttt tgtctcatgt ttcatcgtaa atggcatagg cagagatgat acctaattct 19920 gcatttgatt gtcacttttt gtacctgcat taatttaata aaatattctt atttattttg 19980 ttacttggta caccagcatg tccattttct tgtttatttt gtgtttaata aaatgttcag 20040 tttaacatcc cagtggagaa agtta 20065

Claims

Claims

A method for predicting a response and/or survival after anti-HER2 containing therapy and/or chemotherapy in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer, said method comprises the determination of the expression level of at least one of the following 12 genes: CCL5, CD21, CD80, CD8A, CTLA4, CXCL13, CXCL9, FOXP3, IDOl, IGKC, PDl, PDLl in a tumor sample from said patient, wherein said expression levels indicate a) the likelihood of benefit from inclusion of Carboplatin in a chemotherapy regimen, a high expression level of the said at least one marker gene generally indicates an increased likelihood of benefit from inclusion of Carboplatin in a chemotherapy regimen and a low expression level of the said at least one marker gene indicates a decreased likelihood of benefit from inclusion of Carboplatin in a chemotherapy regimen;

b) the likelihood of response to chemotherapy, a high expression level of the said at least one marker gene generally indicates an increased likelihood of response to chemotherapy and a low expression level of the said at least one marker gene indicates a decreased likelihood of re^¬ sponse to chemotherapy;

c) the likelihood that the tumor is infiltrated with leucocytes as evaluat^¬ ed by a pathologist; a high expression level of the said at least one marker gene generally indicates that the tumor is infiltrated with leuco^¬ cytes and a low expression level of the said at least one marker gene indicates a decreased infiltration with leucocytes;

d) the likelihood of benefit from anti-HER2 containing therapy, a high expression level of the said at least one marker gene generally indicates an increased likelihood of benefit from inclusion of anti-HER2 containing therapy in a chemotherapy regimen and a low expression level of the said at least one marker gene indicates a decreased likelihood of benefit from inclusion of anti-HER2 containing therapy in a chemotherapy regimen;

e) the likelihood of developing metastases after treatment; a high ex^¬ pression level of the said at least one marker gene generally indicates a decreased residual risk of recurrence after anti-HER2 containing therapy and/or chemotherapy treatment and a low expression level of the said at least one marker gene ind icates an increased risk of recu rrence after anti- H ER2 containing therapy and/or chemotherapy treatment.

2. The method of any one of the foregoing claims, wherein said expression level is determined as a non-protein such as a gene expression level .

3. The method of any one of the foregoing claims, wherein said expression level is determined by at least one of the fol lowing methods :

a PCR based method,

a micorarray based method ,

a hybridization based method ,

a seq uencing and/or

next generation seq uencing approach .

4. The method of any one of the foregoing claims, wherein said determina^¬ tion of expression levels is in a formal in-fixed paraffin-embedded tumor sample or in a fresh-frozen tumor sample.

5. The method of any one of the foregoing claims, wherein the expression levels are determined relative to at least one reference gene or to a computed average expression value.

6. The method of any one of the foregoing claims, wherein said expression levels are mathematical ly combined to a combined score. The method comprises a step of applying an algorith m to values representative of an expression level of a g iven gene.

7. The method of any one of the foregoing claims, wherein said algorithm is a mathematical combination of said val ues representative of an ex^¬ pression level of a given gene.

8. The method of any one of the foregoing claims, wherein a val ue for a representative of an expression level of a given gene is multipl ied with a coefficient.

9. The method of any one of the foregoing claims, wherein one, two or more thresholds are determined for said expression levels and/or com- bined scores and d iscriminated into g rou ps by applying the th reshold on the gene expression levels and/or combined scores.

10. The method of any one of the foregoing claims, wherein one, two or more thresholds are determined for said gene expression levels and/or combined scores and discriminated into ( 1) "predicted benefit" and "predicted non-benefit", (2) "predicted benefit" and "predicted adverse effect", (3) "predicted benefit", "predicted indifferent effect" and "predicted adverse effect", or more risk groups with different probabilities of benefit by applying the threshold on the gene expression levels and/or combined scores.

11. Use of a kit for performing a method of at least one of the foregoing claims, said kit comprising a set of oligonucleotides capable of specifically binding sequences or to sequences of fragments of the genes.