BR112013013434A2 - metade que tem por alvo modulador fármaco cinético em cacho de galactose para sirna - Google Patents
metade que tem por alvo modulador fármaco cinético em cacho de galactose para sirnaInfo
- Publication number
- BR112013013434A2 BR112013013434A2 BR112013013434A BR112013013434A BR112013013434A2 BR 112013013434 A2 BR112013013434 A2 BR 112013013434A2 BR 112013013434 A BR112013013434 A BR 112013013434A BR 112013013434 A BR112013013434 A BR 112013013434A BR 112013013434 A2 BR112013013434 A2 BR 112013013434A2
- Authority
- BR
- Brazil
- Prior art keywords
- sirna
- galactose cluster
- kinetic drug
- targeting
- modulator
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424195P | 2010-12-17 | 2010-12-17 | |
| PCT/US2011/065210 WO2012083046A2 (en) | 2010-12-17 | 2011-12-15 | Galactose cluster-pharmacokinetic modulator targeting moiety for sirna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013013434A2 true BR112013013434A2 (pt) | 2016-08-16 |
Family
ID=46235176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013013434A BR112013013434A2 (pt) | 2010-12-17 | 2011-12-15 | metade que tem por alvo modulador fármaco cinético em cacho de galactose para sirna |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9249179B2 (pt) |
| EP (2) | EP2652134B1 (pt) |
| JP (2) | JP2014504295A (pt) |
| KR (1) | KR20130132475A (pt) |
| CN (1) | CN103492568B (pt) |
| AU (2) | AU2011343664B2 (pt) |
| BR (1) | BR112013013434A2 (pt) |
| CA (1) | CA2816155C (pt) |
| MX (1) | MX346144B (pt) |
| RU (1) | RU2013117288A (pt) |
| SG (1) | SG189474A1 (pt) |
| WO (1) | WO2012083046A2 (pt) |
Families Citing this family (86)
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| US20080281041A1 (en) * | 1999-06-07 | 2008-11-13 | Rozema David B | Reversibly Masked Polymers |
| BR112013013434A2 (pt) * | 2010-12-17 | 2016-08-16 | Arrowhead Res Corp | metade que tem por alvo modulador fármaco cinético em cacho de galactose para sirna |
| BR122020024394B1 (pt) * | 2010-12-29 | 2021-05-11 | F. Hoffmann-La Roche Ag | conjugado e composição farmacêutica |
| WO2013033230A1 (en) | 2011-08-29 | 2013-03-07 | Isis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| AU2012377385A1 (en) | 2012-04-18 | 2014-01-23 | Arrowhead Research Corporation | Poly(acrylate) polymers for in vivo nucleic acid delivery |
| EP2838544A4 (en) * | 2012-04-18 | 2015-10-14 | Arrowhead Res Corp | POLY (ACRYLATE) POLYMERS FOR IN VIVO NUCLEIC ACID ADMINISTRATION |
| CA2889596C (en) | 2012-11-15 | 2022-08-23 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugates |
| SG11201505387PA (en) | 2013-01-30 | 2015-08-28 | Hoffmann La Roche | Lna oligonucleotide carbohydrate conjugates |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| CN105247051A (zh) | 2013-02-28 | 2016-01-13 | 箭头研究公司 | 治疗epas1相关疾病的有机组合物 |
| CN105378085B (zh) | 2013-05-01 | 2019-02-15 | Ionis制药公司 | 用于调节hbv和ttr表达的组合物和方法 |
| JP2016518842A (ja) | 2013-05-01 | 2016-06-30 | レグルス セラピューティクス インコーポレイテッド | マイクロＲＮＡ化合物およびｍｉＲ−１２２をモジュレートする方法 |
| TWI680767B (zh) | 2013-05-01 | 2020-01-01 | 美商雷格勒斯治療公司 | 用於增強的細胞攝取之化合物及方法 |
| KR102245421B1 (ko) | 2013-05-30 | 2021-04-29 | 큐라디즘 | 약학적 조성물, 이의 제조방법 및 이의 용도 |
| CA2915316C (en) * | 2013-06-27 | 2024-01-02 | Roche Innovation Center Copenhagen A/S | Antisense oligomers and conjugates targeting pcsk9 |
| GB201315335D0 (en) * | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| US9994846B2 (en) | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
| CA2928349A1 (en) * | 2013-11-14 | 2015-05-21 | Roche Innovation Center Copenhagen A/S | Apob antisense conjugate compounds |
| JP6482475B2 (ja) * | 2014-01-07 | 2019-03-13 | レナセラピューティクス株式会社 | アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド |
| EP3137476B1 (en) | 2014-04-28 | 2019-10-09 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds |
| ES2849600T3 (es) | 2014-05-01 | 2021-08-19 | Ionis Pharmaceuticals Inc | Conjugados de oligonucleótidos antisentido modificados y su uso para modular la expresión de PKK |
| CN106459969B (zh) | 2014-05-01 | 2019-11-15 | Ionis制药公司 | 用于调节生长激素受体表达的组合物和方法 |
| MX2016014102A (es) | 2014-05-01 | 2017-05-03 | Ionis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de similar a la angiopoyetina tipo 3. |
| PE20190626A1 (es) | 2014-05-01 | 2019-04-26 | Ionis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion del factor b del complemento |
| GB201408623D0 (en) * | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
| WO2015179693A1 (en) | 2014-05-22 | 2015-11-26 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| BR112017001931A2 (pt) | 2014-08-07 | 2017-11-28 | Regulus Therapeutics Inc | direcionamento de micrornas para distúrbios metabólicos |
| US20170327524A1 (en) | 2014-10-10 | 2017-11-16 | Hoffmann-La Roche, Inc. | Galnac phosphoramidites, nucleic acid conjugates thereof and their use |
| PT3223796T (pt) * | 2014-11-25 | 2021-09-28 | Curadigm Sas | Composições farmacêuticas, preparação e suas utilizações |
| PL3229776T3 (pl) | 2014-11-25 | 2023-11-06 | Curadigm Sas | Kompozycja farmaceutyczna łącząca co najmniej dwie różne nanocząstki i związek farmaceutyczny, jej wytwarzanie i zastosowanie |
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| CN113797348A (zh) * | 2016-03-07 | 2021-12-17 | 箭头药业股份有限公司 | 用于治疗性化合物的靶向配体 |
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| AU2019269702A1 (en) * | 2018-05-17 | 2020-12-24 | Housey Pharmaceutical Research Laboratories, L.L.C. | Inhibition of follistatin |
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| EP4090744A4 (en) * | 2020-01-17 | 2024-04-10 | Anastasia Khvorova | UNIVERSAL DYNAMIC PHARMACOKINETIC MODIFYING ANCHORS |
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-
2011
- 2011-12-15 BR BR112013013434A patent/BR112013013434A2/pt not_active Application Discontinuation
- 2011-12-15 SG SG2013029814A patent/SG189474A1/en unknown
- 2011-12-15 RU RU2013117288/10A patent/RU2013117288A/ru not_active Application Discontinuation
- 2011-12-15 EP EP11848708.1A patent/EP2652134B1/en active Active
- 2011-12-15 MX MX2013006748A patent/MX346144B/es active IP Right Grant
- 2011-12-15 US US13/327,271 patent/US9249179B2/en active Active
- 2011-12-15 EP EP17157064.1A patent/EP3192800A1/en not_active Withdrawn
- 2011-12-15 WO PCT/US2011/065210 patent/WO2012083046A2/en active Application Filing
- 2011-12-15 CA CA2816155A patent/CA2816155C/en active Active
- 2011-12-15 KR KR1020137015388A patent/KR20130132475A/ko not_active Application Discontinuation
- 2011-12-15 AU AU2011343664A patent/AU2011343664B2/en not_active Ceased
- 2011-12-15 CN CN201180060354.XA patent/CN103492568B/zh active Active
- 2011-12-15 JP JP2013544786A patent/JP2014504295A/ja active Pending
-
2015
- 2015-12-17 US US14/972,385 patent/US9796756B2/en active Active
-
2016
- 2016-01-04 AU AU2016200000A patent/AU2016200000B2/en active Active
- 2016-05-20 JP JP2016101260A patent/JP6261144B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20160102120A1 (en) | 2016-04-14 |
| SG189474A1 (en) | 2013-05-31 |
| MX2013006748A (es) | 2013-07-17 |
| EP3192800A1 (en) | 2017-07-19 |
| EP2652134A2 (en) | 2013-10-23 |
| EP2652134B1 (en) | 2017-03-01 |
| RU2013117288A (ru) | 2015-01-27 |
| JP2014504295A (ja) | 2014-02-20 |
| CA2816155C (en) | 2020-10-27 |
| US20120157509A1 (en) | 2012-06-21 |
| CN103492568A (zh) | 2014-01-01 |
| AU2011343664A1 (en) | 2013-05-09 |
| JP6261144B2 (ja) | 2018-01-17 |
| WO2012083046A3 (en) | 2012-09-27 |
| US9796756B2 (en) | 2017-10-24 |
| EP2652134A4 (en) | 2014-05-21 |
| US9249179B2 (en) | 2016-02-02 |
| JP2016185968A (ja) | 2016-10-27 |
| WO2012083046A2 (en) | 2012-06-21 |
| CA2816155A1 (en) | 2012-06-21 |
| AU2016200000B2 (en) | 2018-01-04 |
| KR20130132475A (ko) | 2013-12-04 |
| MX346144B (es) | 2017-03-09 |
| AU2011343664B2 (en) | 2015-10-08 |
| CN103492568B (zh) | 2017-04-12 |
| AU2016200000A1 (en) | 2016-01-28 |
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