AR106683A1 - FOSFORAMIDITA DE AGRUPACIÓN DE GalNAc - Google Patents

FOSFORAMIDITA DE AGRUPACIÓN DE GalNAc

Info

Publication number
AR106683A1
AR106683A1 ARP160103468A ARP160103468A AR106683A1 AR 106683 A1 AR106683 A1 AR 106683A1 AR P160103468 A ARP160103468 A AR P160103468A AR P160103468 A ARP160103468 A AR P160103468A AR 106683 A1 AR106683 A1 AR 106683A1
Authority
AR
Argentina
Prior art keywords
galnac
phosphoramidite
grouping
integer
formula
Prior art date
Application number
ARP160103468A
Other languages
English (en)
Inventor
Trussardi Ren
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR106683A1 publication Critical patent/AR106683A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/08—Polyoxyalkylene derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Comprende además un proceso para la preparación de los derivados de fosforamidita de GalNAc de fórmula (1) y su uso en la preparación de conjugados de agrupación de GalNAc-oligonucleótidos terapéuticamente valiosos. Reivindicación 1: Derivados de fosforamidita de GalNAc de fórmula (1) en donde R¹ es un grupo protector de hidroxi, n es un número entero de 0 a 10 y m es un número entero de 0 a 20, a los enantiómeros correspondientes y/o a los isómeros ópticos de los mismos.
ARP160103468A 2015-11-16 2016-11-14 FOSFORAMIDITA DE AGRUPACIÓN DE GalNAc AR106683A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15194811 2015-11-16

Publications (1)

Publication Number Publication Date
AR106683A1 true AR106683A1 (es) 2018-02-07

Family

ID=54695483

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103468A AR106683A1 (es) 2015-11-16 2016-11-14 FOSFORAMIDITA DE AGRUPACIÓN DE GalNAc

Country Status (14)

Country Link
US (1) US10590156B2 (es)
EP (1) EP3377510B1 (es)
JP (1) JP6649482B2 (es)
KR (1) KR102117172B1 (es)
CN (1) CN108738321B (es)
AR (1) AR106683A1 (es)
AU (1) AU2016357980B2 (es)
BR (1) BR112018003910B1 (es)
CA (1) CA2994787A1 (es)
ES (1) ES2848122T3 (es)
IL (1) IL258149B (es)
MX (1) MX2018005733A (es)
PL (1) PL3377510T3 (es)
WO (1) WO2017084987A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201807854SA (en) 2016-03-14 2018-10-30 Hoffmann La Roche Oligonucleotides for reduction of pd-l1 expression
JP7048574B2 (ja) 2017-03-10 2022-04-05 国立研究開発法人国立成育医療研究センター アンチセンスオリゴヌクレオチドおよび糖原病Ｉａ型予防または治療用組成物
EP3679139B1 (en) 2017-09-08 2022-11-02 MiNA Therapeutics Limited Stabilized hnf4a sarna compositions and methods of use
KR20200100601A (ko) * 2017-09-14 2020-08-26 얀센 바이오파마, 인크. GalNAc 유도체
JP6884268B2 (ja) 2018-03-09 2021-06-09 第一三共株式会社 糖原病Ｉａ型治療薬
US20220259248A1 (en) * 2019-05-20 2022-08-18 Hoffmann-La Roche Inc. Process for the preparation of galnac phosphoramidite epimers
WO2021049504A1 (ja) 2019-09-10 2021-03-18 第一三共株式会社 肝臓送達用ＧａｌＮＡｃ－オリゴヌクレオチドコンジュゲートおよび製造方法
CN110668933A (zh) * 2019-09-30 2020-01-10 兰州交通大学 一种合成烯丙基脂肪醇聚氧乙烯醚羧酸（apea-7）的新方法
CN110759824A (zh) * 2019-09-30 2020-02-07 兰州交通大学 一种合成烯丙基脂肪醇聚氧乙烯醚羧酸（apea-3）的新方法
KR20240023420A (ko) 2021-06-14 2024-02-21 제너레이션 바이오 컴퍼니 양이온성 지질 및 이의 조성물
WO2023143571A1 (zh) * 2022-01-30 2023-08-03 大睿生物医药科技(上海)有限公司 含有n-乙酰半乳糖胺的靶向配体
WO2024040222A1 (en) 2022-08-19 2024-02-22 Generation Bio Co. Cleavable closed-ended dna (cedna) and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3222617T3 (pl) 2009-03-19 2023-01-02 The Johns Hopkins University Związki do kierunkowania w psma i ich zastosowania
CA2788600C (en) 2010-02-24 2019-12-03 Arrowhead Research Corporation Compositions for targeted delivery of sirna
US8501930B2 (en) * 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system
CA2816155C (en) * 2010-12-17 2020-10-27 Arrowhead Research Corporation Galactose cluster-pharmacokinetic modulator targeting moiety for sirna
PL2992009T3 (pl) * 2013-05-01 2020-11-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji apolipoproteiny(a)
PE20160158A1 (es) * 2013-06-27 2016-03-18 Roche Innovation Ct Copenhagen As Oligomeros antisentido y conjugados con diana en pcsk9
KR20160083876A (ko) 2013-11-14 2016-07-12 로슈 이노베이션 센터 코펜하겐 에이/에스 ApoB 안티센스 접합체 화합물
DK3137605T3 (da) * 2014-05-01 2020-12-14 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af angiopoietin-lignende-3-ekspression

Also Published As

Publication number Publication date
WO2017084987A1 (en) 2017-05-26
EP3377510A1 (en) 2018-09-26
AU2016357980B2 (en) 2020-06-25
ES2848122T3 (es) 2021-08-05
JP2018532764A (ja) 2018-11-08
AU2016357980A1 (en) 2018-02-22
IL258149B (en) 2020-06-30
US20180258122A1 (en) 2018-09-13
EP3377510B1 (en) 2020-12-02
BR112018003910A2 (pt) 2018-09-25
CN108738321A (zh) 2018-11-02
KR20180041225A (ko) 2018-04-23
CN108738321A9 (zh) 2021-01-29
MX2018005733A (es) 2018-08-09
BR112018003910B1 (pt) 2022-03-22
IL258149A (en) 2018-05-31
CA2994787A1 (en) 2017-05-26
PL3377510T3 (pl) 2021-05-04
CN108738321B (zh) 2021-06-11
US10590156B2 (en) 2020-03-17
JP6649482B2 (ja) 2020-02-19
KR102117172B1 (ko) 2020-06-01

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