PL3377510T3 - Amidofosforyn klastra GalNAc - Google Patents
Amidofosforyn klastra GalNAcInfo
- Publication number
- PL3377510T3 PL3377510T3 PL16797831T PL16797831T PL3377510T3 PL 3377510 T3 PL3377510 T3 PL 3377510T3 PL 16797831 T PL16797831 T PL 16797831T PL 16797831 T PL16797831 T PL 16797831T PL 3377510 T3 PL3377510 T3 PL 3377510T3
- Authority
- PL
- Poland
- Prior art keywords
- galnac cluster
- cluster phosphoramidite
- phosphoramidite
- galnac
- cluster
- Prior art date
Links
- 150000008300 phosphoramidites Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/08—Polyoxyalkylene derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15194811 | 2015-11-16 | ||
| EP16797831.1A EP3377510B1 (en) | 2015-11-16 | 2016-11-14 | Galnac cluster phosphoramidite |
| PCT/EP2016/077516 WO2017084987A1 (en) | 2015-11-16 | 2016-11-14 | GalNAc CLUSTER PHOSPHORAMIDITE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3377510T3 true PL3377510T3 (pl) | 2021-05-04 |
Family
ID=54695483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16797831T PL3377510T3 (pl) | 2015-11-16 | 2016-11-14 | Amidofosforyn klastra GalNAc |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10590156B2 (pl) |
| EP (1) | EP3377510B1 (pl) |
| JP (1) | JP6649482B2 (pl) |
| KR (1) | KR102117172B1 (pl) |
| CN (1) | CN108738321B (pl) |
| AR (1) | AR106683A1 (pl) |
| AU (1) | AU2016357980B2 (pl) |
| BR (1) | BR112018003910B1 (pl) |
| CA (1) | CA2994787A1 (pl) |
| ES (1) | ES2848122T3 (pl) |
| IL (1) | IL258149B (pl) |
| MX (1) | MX378999B (pl) |
| PL (1) | PL3377510T3 (pl) |
| WO (1) | WO2017084987A1 (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3013683C (en) | 2016-03-14 | 2021-07-13 | F. Hoffmann-La Roche Ag | Oligonucleotides for reduction of pd-l1 expression |
| JP7048574B2 (ja) | 2017-03-10 | 2022-04-05 | 国立研究開発法人国立成育医療研究センター | アンチセンスオリゴヌクレオチドおよび糖原病Ｉａ型予防または治療用組成物 |
| WO2019048632A1 (en) | 2017-09-08 | 2019-03-14 | Mina Therapeutics Limited | STABILIZED COMPOSITIONS OF SMALL ACTIVATORY RNA (PARNA) OF HNF4A AND METHODS OF USE |
| SG11202002149XA (en) * | 2017-09-14 | 2020-04-29 | Janssen Biopharma Inc | Galnac derivatives |
| WO2019172286A1 (ja) | 2018-03-09 | 2019-09-12 | 第一三共株式会社 | 糖原病Ｉａ型治療薬 |
| US11510939B1 (en) | 2019-04-19 | 2022-11-29 | Apellis Pharmaceuticals, Inc. | RNAs for complement inhibition |
| CA3134494A1 (en) * | 2019-05-20 | 2020-11-26 | Simon Adolf BREITLER | Process for the preparation of galnac phosphoramidite epimers |
| IL291251B2 (en) | 2019-09-10 | 2026-06-01 | Daiichi Sankyo Co Limited | CONJUGATE OF GalNAC-OLIGONUCLEOTIDE FOR DELIVERY TO LIVER AND MANUFACTURING METHOD THEREOF |
| CN110668933B (zh) * | 2019-09-30 | 2024-09-24 | 兰州交通大学 | 一种合成烯丙基脂肪醇聚氧乙烯醚羧酸（apea-7）的方法 |
| CN110759824B (zh) * | 2019-09-30 | 2024-09-24 | 兰州交通大学 | 一种合成烯丙基脂肪醇聚氧乙烯醚羧酸（apea-3）的方法 |
| US12534435B2 (en) | 2020-03-27 | 2026-01-27 | Generation Bio Co. | Lipids and nanoparticle compositions thereof |
| CN117642380A (zh) | 2021-06-14 | 2024-03-01 | 世代生物公司 | 阳离子脂质及其组合物 |
| EP4471140A1 (en) * | 2022-01-30 | 2024-12-04 | Rona Bioscience, Limited | Targeting ligand containing n-acetylgalactosamine |
| IL315659A (en) | 2022-03-16 | 2024-11-01 | Daiichi Sankyo Co Ltd | siRNA FOR SUPPRESSING EXPRESSION OF TRANSFERRIN RECEPTOR-2 |
| EP4495241A1 (en) | 2022-03-16 | 2025-01-22 | Daiichi Sankyo Company, Limited | Chemically-modified oligonucleotide having rnai activity |
| WO2024040222A1 (en) | 2022-08-19 | 2024-02-22 | Generation Bio Co. | Cleavable closed-ended dna (cedna) and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4420730A3 (en) | 2009-03-19 | 2024-11-13 | The Johns Hopkins University | Psma-targeting compounds and uses thereof |
| PH12012501596A1 (en) | 2010-02-24 | 2017-02-03 | Arrowhead Res Corporation | Compositions for targeted delivery of sirna |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| RU2013117288A (ru) * | 2010-12-17 | 2015-01-27 | Эрроухэд Рисерч Корпорейшн | СОДЕРЖАЩАЯ ГАЛАКТОЗНЫЙ КЛАСТЕР НАЦЕЛИВАЮЩАЯ ГРУППА ДЛЯ миРНК, МОДУЛИРУЮЩАЯ ФОРМАКОКИНЕТИЧЕСКИЕ СВОЙСТВА |
| PL2992098T3 (pl) * | 2013-05-01 | 2019-09-30 | Ionis Pharmaceuticals, Inc. | Kompozycje i sposoby modulowania ekspresji hbv i ttr |
| MX367083B (es) * | 2013-06-27 | 2019-08-05 | Roche Innovation Ct Copenhagen As | Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9). |
| KR20160083876A (ko) | 2013-11-14 | 2016-07-12 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | ApoB 안티센스 접합체 화합물 |
| WO2015168589A2 (en) * | 2014-05-01 | 2015-11-05 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating angiopoietin-like 3 expression |
-
2016
- 2016-11-14 WO PCT/EP2016/077516 patent/WO2017084987A1/en not_active Ceased
- 2016-11-14 AR ARP160103468A patent/AR106683A1/es active IP Right Grant
- 2016-11-14 BR BR112018003910-1A patent/BR112018003910B1/pt active IP Right Grant
- 2016-11-14 CN CN201680065443.6A patent/CN108738321B/zh active Active
- 2016-11-14 EP EP16797831.1A patent/EP3377510B1/en active Active
- 2016-11-14 AU AU2016357980A patent/AU2016357980B2/en active Active
- 2016-11-14 CA CA2994787A patent/CA2994787A1/en active Pending
- 2016-11-14 PL PL16797831T patent/PL3377510T3/pl unknown
- 2016-11-14 JP JP2018523484A patent/JP6649482B2/ja active Active
- 2016-11-14 KR KR1020187008037A patent/KR102117172B1/ko active Active
- 2016-11-14 ES ES16797831T patent/ES2848122T3/es active Active
- 2016-11-14 MX MX2018005733A patent/MX378999B/es unknown
-
2018
- 2018-03-15 IL IL258149A patent/IL258149B/en active IP Right Grant
- 2018-05-14 US US15/978,815 patent/US10590156B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018532764A (ja) | 2018-11-08 |
| EP3377510B1 (en) | 2020-12-02 |
| ES2848122T3 (es) | 2021-08-05 |
| US10590156B2 (en) | 2020-03-17 |
| BR112018003910A2 (pt) | 2018-09-25 |
| KR102117172B1 (ko) | 2020-06-01 |
| AU2016357980A1 (en) | 2018-02-22 |
| MX2018005733A (es) | 2018-08-09 |
| IL258149B (en) | 2020-06-30 |
| BR112018003910B1 (pt) | 2022-03-22 |
| CA2994787A1 (en) | 2017-05-26 |
| MX378999B (es) | 2025-03-10 |
| AU2016357980B2 (en) | 2020-06-25 |
| CN108738321B (zh) | 2021-06-11 |
| WO2017084987A1 (en) | 2017-05-26 |
| IL258149A (en) | 2018-05-31 |
| EP3377510A1 (en) | 2018-09-26 |
| CN108738321A9 (zh) | 2021-01-29 |
| US20180258122A1 (en) | 2018-09-13 |
| AR106683A1 (es) | 2018-02-07 |
| CN108738321A (zh) | 2018-11-02 |
| KR20180041225A (ko) | 2018-04-23 |
| JP6649482B2 (ja) | 2020-02-19 |
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