CO2017012786A2 - Nuevos derivados hidroxiéster, un proceso para su preparación y composiciones farmacéuticas que los contienen - Google Patents
Nuevos derivados hidroxiéster, un proceso para su preparación y composiciones farmacéuticas que los contienenInfo
- Publication number
- CO2017012786A2 CO2017012786A2 CONC2017/0012786A CO2017012786A CO2017012786A2 CO 2017012786 A2 CO2017012786 A2 CO 2017012786A2 CO 2017012786 A CO2017012786 A CO 2017012786A CO 2017012786 A2 CO2017012786 A2 CO 2017012786A2
- Authority
- CO
- Colombia
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- ester derivatives
- hydroxy ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
Compuestos de fórmula (I): (ver imagen adjunta) en la que R1, R2, R3, R4, R5, R6, R7, R13, Ra, Rb, A y n son como se han definido en la descripción. Medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1555752A FR3037957B1 (fr) | 2015-06-23 | 2015-06-23 | Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/EP2016/064433 WO2016207225A1 (en) | 2015-06-23 | 2016-06-22 | New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2017012786A2 true CO2017012786A2 (es) | 2018-04-10 |
Family
ID=54608634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2017/0012786A CO2017012786A2 (es) | 2015-06-23 | 2017-12-13 | Nuevos derivados hidroxiéster, un proceso para su preparación y composiciones farmacéuticas que los contienen |
Country Status (44)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037959B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2018015526A1 (en) | 2016-07-22 | 2018-01-25 | Les Laboratoires Servier | Combination of a bcl-2 inhibitor and a mcl-1 inhibitor, uses and pharmaceutical compositions thereof |
| EP3567043B1 (en) * | 2017-01-05 | 2023-12-06 | Henan Genuine Biotech Co., Ltd. | 2-[[5-[(4-hydroxy-3-chloro-2-methyl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl]oxy]-3-(2-methoxybenzene)propanoic acid derivatives as mcl-1 and bcl-2 inhibitors for treating cancer |
| UY37560A (es) | 2017-01-06 | 2018-07-31 | Servier Lab | Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta |
| JOP20190159B1 (ar) * | 2017-01-06 | 2023-09-17 | Servier Lab | توليفة من مثبط mcl-1 ومركب تاكسان، استخداماتها وتركيباتها الصيدلانية |
| BR112019026959A2 (pt) | 2017-06-22 | 2020-07-07 | Les Laboratoires Servier | combinação de um inibidor de mcl-1 e um tratamento com padrão de atendimento para cânceres hematológicos, seus usos e composições farmacêuticas |
| BR112020003180A2 (pt) | 2017-08-15 | 2020-09-15 | AbbVie Deutschland GmbH & Co. KG | inibidores macrocíclicos de mcl-1 e métodos de uso |
| JP2020531436A (ja) * | 2017-08-15 | 2020-11-05 | アッヴィ・インコーポレイテッド | 大環状ｍｃｌ−１阻害剤及び使用の方法 |
| CN111372936B (zh) * | 2017-11-23 | 2022-12-02 | 北京赛林泰医药技术有限公司 | Mcl-1选择性抑制剂及其制备和用途 |
| CN108424417B (zh) * | 2017-12-21 | 2019-09-20 | 河南真实生物科技有限公司 | 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用 |
| CN110964034B (zh) * | 2018-09-29 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用 |
| CN111187277B (zh) * | 2018-11-14 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用 |
| TW202038960A (zh) | 2018-11-14 | 2020-11-01 | 法商施維雅藥廠 | Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物 |
| US20220017533A1 (en) * | 2018-12-06 | 2022-01-20 | Les Laboratoires Servier | Crystalline forms of a mcl-1 inhibitor, a process for their preparation and pharmaceutical compositions containing them |
| JP2022532918A (ja) | 2019-05-20 | 2022-07-20 | ノバルティス アーゲー | Ｍｃｌ－１阻害剤抗体－薬物コンジュゲートおよび使用方法 |
| TW202114682A (zh) | 2019-06-17 | 2021-04-16 | 法商施維雅藥廠 | Mcl-1抑制劑與乳癌標準療法之組合，其用途及醫藥組合物 |
| JP2022551083A (ja) * | 2019-10-03 | 2022-12-07 | カリフォルニア インスティチュート オブ テクノロジー | Ｍｃｌ１インヒビター及びその使用 |
| JP2023553808A (ja) | 2020-11-24 | 2023-12-26 | ノバルティス アーゲー | Ｍｃｌ－１阻害剤抗体－薬物コンジュゲートおよび使用方法 |
| WO2022216946A1 (en) * | 2021-04-07 | 2022-10-13 | California Institute Of Technology | Mcl1 inhibitors and uses thereof |
| WO2022261310A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
| CA3222269A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
| CN113651663B (zh) * | 2021-08-20 | 2024-03-29 | 浙大宁波理工学院 | 一种氘代芳香羰基类化合物的制备方法 |
| WO2023057484A1 (en) | 2021-10-06 | 2023-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting and improving the efficacy of mcl-1 inhibitor therapy |
| WO2023225359A1 (en) | 2022-05-20 | 2023-11-23 | Novartis Ag | Antibody-drug conjugates of antineoplastic compounds and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| BRPI0413861A (pt) * | 2003-08-29 | 2006-10-24 | Vernalis Cambridge Ltd | compostos de pirimidotiofeno |
| EP2332536A1 (en) * | 2008-03-05 | 2011-06-15 | MethylGene Inc. | Inhibitors of protein tyrosine kinase activity |
| CN102464667B (zh) * | 2010-11-03 | 2014-06-04 | 中国科学院上海药物研究所 | 一类五元杂环并嘧啶类化合物及其制备方法和用途 |
| AR090037A1 (es) * | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037956B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037958B1 (fr) * | 2015-06-23 | 2019-01-25 | Les Laboratoires Servier | Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3037959B1 (fr) * | 2015-06-23 | 2017-08-04 | Servier Lab | Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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2015
- 2015-06-23 FR FR1555752A patent/FR3037957B1/fr not_active Expired - Fee Related
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2016
- 2016-06-16 UY UY0001036736A patent/UY36736A/es unknown
- 2016-06-22 UA UAA201800618A patent/UA122228C2/uk unknown
- 2016-06-22 KR KR1020187002033A patent/KR20180019223A/ko not_active Application Discontinuation
- 2016-06-22 TN TNP/2017/000511A patent/TN2017000511A1/en unknown
- 2016-06-22 RU RU2018102365A patent/RU2734418C2/ru active
- 2016-06-22 CU CUP2017000160A patent/CU20170160A7/es unknown
- 2016-06-22 CA CA2990088A patent/CA2990088C/en active Active
- 2016-06-22 MX MX2017016997A patent/MX2017016997A/es active IP Right Grant
- 2016-06-22 MY MYPI2017704877A patent/MY190561A/en unknown
- 2016-06-22 PL PL16733379T patent/PL3313851T3/pl unknown
- 2016-06-22 PE PE2017002534A patent/PE20180742A1/es unknown
- 2016-06-22 HU HUE16733379A patent/HUE047889T2/hu unknown
- 2016-06-22 JO JOP/2016/0128A patent/JO3675B1/ar active
- 2016-06-22 SI SI201630625T patent/SI3313851T1/sl unknown
- 2016-06-22 WO PCT/EP2016/064433 patent/WO2016207225A1/en active Application Filing
- 2016-06-22 AU AU2016282836A patent/AU2016282836B2/en active Active
- 2016-06-22 RS RS20200136A patent/RS59904B1/sr unknown
- 2016-06-22 NZ NZ738455A patent/NZ738455A/en unknown
- 2016-06-22 TW TW105119605A patent/TWI604844B/zh not_active IP Right Cessation
- 2016-06-22 EA EA201890125A patent/EA033266B1/ru unknown
- 2016-06-22 EP EP16733379.8A patent/EP3313851B1/en active Active
- 2016-06-22 JP JP2017566271A patent/JP6741697B2/ja active Active
- 2016-06-22 MD MDE20180444T patent/MD3313851T2/ro unknown
- 2016-06-22 DK DK16733379.8T patent/DK3313851T3/da active
- 2016-06-22 GE GEAP201614678A patent/GEP20207074B/en unknown
- 2016-06-22 CR CR20170564A patent/CR20170564A/es unknown
- 2016-06-22 ES ES16733379T patent/ES2759480T3/es active Active
- 2016-06-22 BR BR112017027414-0A patent/BR112017027414B1/pt active IP Right Grant
- 2016-06-22 PT PT167333798T patent/PT3313851T/pt unknown
- 2016-06-22 MA MA42239A patent/MA42239B1/fr unknown
- 2016-06-22 CN CN201680036383.5A patent/CN107709333B/zh active Active
- 2016-06-22 US US15/737,479 patent/US10227358B2/en active Active
- 2016-06-23 AR ARP160101881A patent/AR105103A1/es unknown
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2017
- 2017-12-07 PH PH12017502246A patent/PH12017502246B1/en unknown
- 2017-12-12 SV SV2017005587A patent/SV2017005587A/es unknown
- 2017-12-12 IL IL256270A patent/IL256270A/en active IP Right Grant
- 2017-12-12 EC ECIEPI201781744A patent/ECSP17081744A/es unknown
- 2017-12-13 ZA ZA2017/08460A patent/ZA201708460B/en unknown
- 2017-12-13 CO CONC2017/0012786A patent/CO2017012786A2/es unknown
- 2017-12-18 CL CL2017003258A patent/CL2017003258A1/es unknown
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2018
- 2018-07-11 HK HK18109026.9A patent/HK1249506A1/zh unknown
- 2018-10-24 HK HK18113625.6A patent/HK1254657A1/zh unknown
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2019
- 2019-01-15 US US16/247,614 patent/US10711010B2/en active Active
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2020
- 2020-01-23 HR HRP20200107TT patent/HRP20200107T1/hr unknown
- 2020-01-31 CY CY20201100083T patent/CY1122542T1/el unknown
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