JO3675B1 - مشتقات هيدروكسي إستر جديدة،عملية لتحضيرها وتركيبات صيدلية تحتوي عليها - Google Patents

مشتقات هيدروكسي إستر جديدة،عملية لتحضيرها وتركيبات صيدلية تحتوي عليها

Info

Publication number
JO3675B1
JO3675B1 JOP/2016/0128A JOP20160128A JO3675B1 JO 3675 B1 JO3675 B1 JO 3675B1 JO P20160128 A JOP20160128 A JO P20160128A JO 3675 B1 JO3675 B1 JO 3675B1
Authority
JO
Jordan
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
new
hydroxyester derivatives
Prior art date
Application number
JOP/2016/0128A
Other languages
English (en)
Inventor
Szabolcs Sipos
Balazs Balint
Maia Chanrion
Zoltan Szlavik
Andras Kotschy
Attila Paczal
James Brooke Murray
James Edward Paul Davidson
Didier Demarles
Olivier Geneste
Original Assignee
Vernalis R&D Ltd
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis R&D Ltd, Servier Lab filed Critical Vernalis R&D Ltd
Application granted granted Critical
Publication of JO3675B1 publication Critical patent/JO3675B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات لها الصيغة (I): حيث تكون R1، R2، R3، R4، R5، R6، R7، R1 3، Ra، Rb، A وn مثلما تم تحديده في الوصف. الأدوية.
JOP/2016/0128A 2015-06-23 2016-06-22 مشتقات هيدروكسي إستر جديدة،عملية لتحضيرها وتركيبات صيدلية تحتوي عليها JO3675B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1555752A FR3037957B1 (fr) 2015-06-23 2015-06-23 Nouveaux derives d'hydroxyester, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
JO3675B1 true JO3675B1 (ar) 2020-08-27

Family

ID=54608634

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2016/0128A JO3675B1 (ar) 2015-06-23 2016-06-22 مشتقات هيدروكسي إستر جديدة،عملية لتحضيرها وتركيبات صيدلية تحتوي عليها

Country Status (43)

Country Link
US (2) US10227358B2 (ar)
EP (1) EP3313851B1 (ar)
JP (1) JP6741697B2 (ar)
KR (1) KR102718253B1 (ar)
CN (1) CN107709333B (ar)
AR (1) AR105103A1 (ar)
AU (1) AU2016282836B2 (ar)
BR (1) BR112017027414B1 (ar)
CA (1) CA2990088C (ar)
CL (1) CL2017003258A1 (ar)
CO (1) CO2017012786A2 (ar)
CR (1) CR20170564A (ar)
CU (1) CU20170160A7 (ar)
CY (1) CY1122542T1 (ar)
DK (1) DK3313851T3 (ar)
EA (1) EA033266B1 (ar)
EC (1) ECSP17081744A (ar)
ES (1) ES2759480T3 (ar)
FR (1) FR3037957B1 (ar)
GE (2) GEAP201914678A (ar)
HK (1) HK1249506A1 (ar)
HR (1) HRP20200107T1 (ar)
HU (1) HUE047889T2 (ar)
IL (1) IL256270A (ar)
JO (1) JO3675B1 (ar)
MA (1) MA42239B1 (ar)
MD (1) MD3313851T2 (ar)
MX (1) MX372716B (ar)
MY (1) MY190561A (ar)
PE (1) PE20180742A1 (ar)
PH (1) PH12017502246B1 (ar)
PL (1) PL3313851T3 (ar)
PT (1) PT3313851T (ar)
RS (1) RS59904B1 (ar)
RU (1) RU2734418C2 (ar)
SI (1) SI3313851T1 (ar)
SV (1) SV2017005587A (ar)
TN (1) TN2017000511A1 (ar)
TW (1) TWI604844B (ar)
UA (1) UA122228C2 (ar)
UY (1) UY36736A (ar)
WO (1) WO2016207225A1 (ar)
ZA (1) ZA201708460B (ar)

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FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY37342A (es) 2016-07-22 2018-01-31 Servier Lab Combinación de un inhibidor de bcl-2 y un inhibidor de mcl1, usos y composiciones farmacéuticas de éstos
EP3567043B1 (en) * 2017-01-05 2023-12-06 Henan Genuine Biotech Co., Ltd. 2-[[5-[(4-hydroxy-3-chloro-2-methyl)-phenyl]-thieno[2,3-d]pyrimidin-4-yl]oxy]-3-(2-methoxybenzene)propanoic acid derivatives as mcl-1 and bcl-2 inhibitors for treating cancer
UY37560A (es) 2017-01-06 2018-07-31 Servier Lab Combinación de un inhibidor de mcl-1 y un compuesto taxano, usos y composiciones farmacéuticas de ésta
JP7179733B2 (ja) * 2017-01-06 2022-11-29 レ ラボラトワール セルヴィエ Ｍｃｌ－１阻害剤及びタキサン化合物の組み合わせ物、その使用及び医薬組成物
MA49444A (fr) * 2017-06-22 2020-04-29 Servier Lab Combinaison d'un inhibiteur de mcl-1 et d'un standard de traitement de soin pour cancers hématologiques, utilisations et compositions pharmaceutiques associées
BR112020003130A2 (pt) * 2017-08-15 2020-10-13 AbbVie Deutschland GmbH & Co. KG inibidores macrocíclicos de mcl-1 e métodos de uso
KR20200041942A (ko) 2017-08-15 2020-04-22 애브비 인코포레이티드 거대환식 mcl-1 저해제 및 이의 용도
WO2019101144A1 (zh) * 2017-11-23 2019-05-31 北京赛林泰医药技术有限公司 Mcl-1选择性抑制剂及其制备和用途
CN108424417B (zh) * 2017-12-21 2019-09-20 河南真实生物科技有限公司 噻吩并嘧啶衍生物、其制备方法及在制备抗肿瘤药物中的应用
CN110964034B (zh) * 2018-09-29 2022-04-12 江苏恒瑞医药股份有限公司 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用
TWI849001B (zh) 2018-11-14 2024-07-21 法商施維雅藥廠 Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物
CN111187277B (zh) * 2018-11-14 2022-04-12 江苏恒瑞医药股份有限公司 噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
SI3891156T1 (sl) * 2018-12-06 2024-03-29 Les Laboratoires Servier Nove kristalinične oblike tienopirimidina kot inhibitor Mcl-1
PY2020118A (es) 2019-05-20 2022-10-27 Servier Lab Conjugados de anticuerpo-fármaco inhibidores de mcl-1 y sus métodos de uso
TW202114682A (zh) 2019-06-17 2021-04-16 法商施維雅藥廠 Mcl-1抑制劑與乳癌標準療法之組合，其用途及醫藥組合物
CA3157015A1 (en) * 2019-10-03 2021-04-08 California Institute Of Technology Mcl1 inhibitors and uses thereof
CN117136076A (zh) 2020-11-24 2023-11-28 诺华股份有限公司 Mcl-1抑制剂抗体药物缀合物和使用方法
WO2022216946A1 (en) * 2021-04-07 2022-10-13 California Institute Of Technology Mcl1 inhibitors and uses thereof
EP4351564A1 (en) 2021-06-11 2024-04-17 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-cancer agents
CA3222752A1 (en) 2021-06-11 2022-12-15 Gilead Sciences, Inc. Combination mcl-1 inhibitors with anti-body drug conjugates
CN113651663B (zh) * 2021-08-20 2024-03-29 浙大宁波理工学院 一种氘代芳香羰基类化合物的制备方法
EP4413165A1 (en) 2021-10-06 2024-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting and improving the efficacy of mcl-1 inhibitor therapy
US20250387504A1 (en) 2022-05-20 2025-12-25 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
WO2025111431A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd7 antibody-drug conjugates and methods of use thereof
TW202540185A (zh) 2023-11-22 2025-10-16 法商施維雅藥廠 抗cd74抗體藥物結合物及其使用方法
WO2025126157A1 (en) 2023-12-15 2025-06-19 Advesya Anti-il-1rap binding domains and antibody-drug conjugates thereof

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ES2217956B1 (es) * 2003-01-23 2006-04-01 Almirall Prodesfarma, S.A. Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
WO2005021552A1 (en) * 2003-08-29 2005-03-10 Vernalis (Cambridge) Ltd Pyrimidothiophene compounds
NZ588355A (en) * 2008-03-05 2012-03-30 Methylgene Inc Inhibitors of protein tyrosine kinase activity
CN102464667B (zh) * 2010-11-03 2014-06-04 中国科学院上海药物研究所 一类五元杂环并嘧啶类化合物及其制备方法和用途
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
FR3015483B1 (fr) * 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) * 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037959B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
HRP20200107T1 (hr) 2020-04-03
ES2759480T3 (es) 2020-05-11
HK1254657A1 (en) 2019-07-26
PE20180742A1 (es) 2018-04-27
TW201709911A (zh) 2017-03-16
CA2990088A1 (en) 2016-12-29
CN107709333B (zh) 2021-01-01
TWI604844B (zh) 2017-11-11
EA201890125A1 (ru) 2018-06-29
BR112017027414A2 (pt) 2018-08-28
IL256270A (en) 2018-02-28
MA42239B1 (fr) 2020-02-28
CY1122542T1 (el) 2021-01-27
MY190561A (en) 2022-04-27
KR102718253B1 (ko) 2024-10-16
PH12017502246A1 (en) 2018-05-28
ECSP17081744A (es) 2018-02-28
CR20170564A (es) 2018-02-20
FR3037957A1 (ar) 2016-12-30
SV2017005587A (es) 2018-04-11
EP3313851B1 (en) 2019-11-06
CU20170160A7 (es) 2018-05-08
US20190161496A1 (en) 2019-05-30
PT3313851T (pt) 2020-01-06
GEAP201914678A (en) 2019-11-11
MD3313851T2 (ro) 2020-02-29
RU2018102365A (ru) 2019-07-23
CL2017003258A1 (es) 2018-06-01
CN107709333A (zh) 2018-02-16
RU2734418C2 (ru) 2020-10-16
JP2018522855A (ja) 2018-08-16
KR20180019223A (ko) 2018-02-23
AU2016282836B2 (en) 2020-07-09
MX2017016997A (es) 2018-09-07
PH12017502246B1 (en) 2018-05-28
TN2017000511A1 (en) 2019-04-12
UA122228C2 (uk) 2020-10-12
HK1249506A1 (zh) 2018-11-02
WO2016207225A1 (en) 2016-12-29
UY36736A (es) 2016-12-30
RU2018102365A3 (ar) 2019-09-23
JP6741697B2 (ja) 2020-08-19
AU2016282836A1 (en) 2018-01-18
AR105103A1 (es) 2017-09-06
EP3313851A1 (en) 2018-05-02
FR3037957B1 (fr) 2019-01-25
BR112017027414B1 (pt) 2023-12-19
US20180170947A1 (en) 2018-06-21
MX372716B (es) 2020-05-28
SI3313851T1 (sl) 2020-03-31
US10227358B2 (en) 2019-03-12
US10711010B2 (en) 2020-07-14
EA033266B1 (ru) 2019-09-30
DK3313851T3 (da) 2020-01-27
PL3313851T3 (pl) 2020-05-18
HUE047889T2 (hu) 2020-05-28
NZ738455A (en) 2024-03-22
CA2990088C (en) 2021-04-13
CO2017012786A2 (es) 2018-04-10
GEP20207074B (en) 2020-03-10
ZA201708460B (en) 2021-06-30
RS59904B1 (sr) 2020-03-31

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