FR3015483B1 - Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents
Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennentInfo
- Publication number
- FR3015483B1 FR3015483B1 FR1363500A FR1363500A FR3015483B1 FR 3015483 B1 FR3015483 B1 FR 3015483B1 FR 1363500 A FR1363500 A FR 1363500A FR 1363500 A FR1363500 A FR 1363500A FR 3015483 B1 FR3015483 B1 FR 3015483B1
- Authority
- FR
- France
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- containing same
- thienopyrimidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Priority Applications (52)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1363500A FR3015483B1 (fr) | 2013-12-23 | 2013-12-23 | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JOP/2014/0353A JO3193B1 (ar) | 2013-12-23 | 2014-12-08 | مشتقات ثينوبيريميدين جديدة وعملية لتحضيرها والتركيبات الدوائية التي تحتوي عليها |
IL236143A IL236143A (en) | 2013-12-23 | 2014-12-09 | History of theonfirmidine, a process for their preparation and their pharmaceutical preparations |
CR20140569A CR20140569A (es) | 2013-12-23 | 2014-12-10 | Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contiene |
PH12014000375A PH12014000375B1 (en) | 2013-12-23 | 2014-12-10 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
NZ702851A NZ702851B (en) | 2013-12-23 | 2014-12-10 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
TN2014000516A TN2014000516A1 (en) | 2013-12-23 | 2014-12-11 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
CA2875226A CA2875226C (fr) | 2013-12-23 | 2014-12-11 | Derives de thienopyrimidine, procede de preparation desdits derives, compositions pharmaceutiques en renfermant et leur utilisation pour le traitement de troubles associes a une defaillance d'apoptose |
AU2014274644A AU2014274644B2 (en) | 2013-12-23 | 2014-12-12 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
AP2014008127A AP2014008127A0 (en) | 2013-12-23 | 2014-12-12 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
PE2014002444A PE20151064A1 (es) | 2013-12-23 | 2014-12-15 | Nuevos derivados tienopirimidina, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
DO2014000282A DOP2014000282A (es) | 2013-12-23 | 2014-12-15 | Nuevos derivados tienopirimidina, un proceso para su preparacion y composiciones farmaceuticas que lo contienen |
CUP2014000143A CU24309B1 (es) | 2013-12-23 | 2014-12-17 | Compuestos derivados tienopirimidina y composiciones farmacéuticas que los contienen |
MX2014015854A MX351581B (es) | 2013-12-23 | 2014-12-18 | Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen. |
ZA2014/09365A ZA201409365B (en) | 2013-12-23 | 2014-12-18 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
CL2014003444A CL2014003444A1 (es) | 2013-12-23 | 2014-12-18 | Compuestos derivados tienopirimidina; proceso de preparacion; composicion farmaceutica que los comprende; combinacion farmaceutica; uso en el tratamiento de canceres y enfermedades autoinmunes. |
MYPI2014703853A MY185221A (en) | 2013-12-23 | 2014-12-18 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
NI201400150A NI201400150A (es) | 2013-12-23 | 2014-12-19 | Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen. |
CN201410800069.2A CN104725397B (zh) | 2013-12-23 | 2014-12-19 | 噻吩并嘧啶衍生物、其制备方法以及含有它们的药用组合物 |
US14/576,683 US9670227B2 (en) | 2013-12-23 | 2014-12-19 | Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
JP2014257658A JP5922215B2 (ja) | 2013-12-23 | 2014-12-19 | 新規なチエノピリミジン誘導体、その製造方法及びそれを含有する医薬組成物 |
GEAP201413667A GEP201706619B (en) | 2013-12-23 | 2014-12-19 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical composition containing them |
UAA201413661A UA120341C2 (uk) | 2013-12-23 | 2014-12-19 | Похідні тієнопіримідину, спосіб їх отримання і фармацевтичні композиції, що їх містять |
LTEP14199533.2T LT2886545T (lt) | 2013-12-23 | 2014-12-22 | Nauji tienopirimidino dariniai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos |
EA201401292A EA029601B1 (ru) | 2013-12-23 | 2014-12-22 | Новые тиенопиримидиновые производные, способ их получения и фармацевтические композиции, содержащие их |
TW103144845A TWI508969B (zh) | 2013-12-23 | 2014-12-22 | 新噻吩并嘧啶衍生物、其製備方法及包含其之醫藥組合物 |
SG10201408563UA SG10201408563UA (en) | 2013-12-23 | 2014-12-22 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
PL14199533T PL2886545T3 (pl) | 2013-12-23 | 2014-12-22 | Nowe pochodne tienopirymidyn, sposób ich wytwarzania, oraz zawierające je kompozycje farmaceutyczne |
SA114360144A SA114360144B1 (ar) | 2013-12-23 | 2014-12-22 | مشتقات ثينوبيريميدين جديدة، عملية لتحضيرها وتركيبات دوائية تحتويها |
BR102014032336-8A BR102014032336B1 (pt) | 2013-12-23 | 2014-12-22 | compostos derivados de tienopirimidina, seus processos de preparação, composições farmacêuticas e seus usos |
MEP-2016-207A ME02521B (fr) | 2013-12-23 | 2014-12-22 | Nouveaux dérivés de thiénopyrimidine, leur procédé de préparation et compositions pharmaceutiques les contenant |
MDA20140137A MD4516C1 (ro) | 2013-12-23 | 2014-12-22 | Derivaţi noi de tienopirimidină, procedeu de preparare a acestora, compoziţii farmaceutice care îi conţin şi utilizările lor în calitate de agenţi proapoptotici |
RS20160802A RS55213B1 (sr) | 2013-12-23 | 2014-12-22 | Novi derivati tienopirimidina, postupak njihove izrade i farmaceutske smeše koje ih sadrže |
ES14199533.2T ES2594377T3 (es) | 2013-12-23 | 2014-12-22 | Nuevos derivados de tienopirimidina, procedimiento para su preparación y composiciones farmacéuticas que los contienen |
ARP140104847A AR098906A1 (es) | 2013-12-23 | 2014-12-22 | Derivados de tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen |
GT201400297A GT201400297A (es) | 2013-12-23 | 2014-12-22 | Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen |
PCT/EP2014/078947 WO2015097123A1 (fr) | 2013-12-23 | 2014-12-22 | Nouveaux dérivés de thiénopyrimidine, procédé pour leur préparation et compositions pharmaceutiques les contenant |
RU2014151850/04A RU2605403C2 (ru) | 2013-12-23 | 2014-12-22 | Новые тиенопиримидиновые производные, способ их получения и фармацевтические композиции, содержащие их |
HUE14199533A HUE029654T2 (en) | 2013-12-23 | 2014-12-22 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
PT141995332T PT2886545T (pt) | 2013-12-23 | 2014-12-22 | Novos derivados de tienopirimidina, um processo para a sua preparação e composições farmacêuticas que os contêm |
EP14199533.2A EP2886545B1 (fr) | 2013-12-23 | 2014-12-22 | Nouveaux dérivés de thiénopyrimidine, leur procédé de préparation et compositions pharmaceutiques les contenant |
UY0001035915A UY35915A (es) | 2013-12-23 | 2014-12-22 | Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen |
SI201430061A SI2886545T1 (sl) | 2013-12-23 | 2014-12-22 | Novi derivati tienopirimidina, postopek za njihovo pripravo in farmacevtski sestavki, ki jih vsebujejo |
DK14199533.2T DK2886545T3 (en) | 2013-12-23 | 2014-12-22 | Thienopyrimidinderivater new, a process for their preparation and pharmaceutical compositions containing them |
KR1020140187349A KR101636401B1 (ko) | 2013-12-23 | 2014-12-23 | 티에노피리미딘 유도체, 이의 제조 방법 및 이를 함유하는 약제학적 조성물 |
CO14282098A CO7210068A1 (es) | 2013-12-23 | 2014-12-23 | Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen |
HK15110667.4A HK1209750A1 (en) | 2013-12-23 | 2015-10-28 | Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
HK15112389.7A HK1211583A1 (en) | 2013-12-23 | 2015-12-16 | New thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
HRP20161203TT HRP20161203T8 (hr) | 2013-12-23 | 2016-09-20 | Novi derivati tienopirimidina, postupak za njihovu pripravu i farmaceutski pripravci koji ih sadrže |
CY20161100949T CY1118058T1 (el) | 2013-12-23 | 2016-09-22 | Νεα παραγωγα θειενοπυριμιδινης, μεθοδος για παρασκευη αυτων και φαρμακευτικες συνθεσεις που περιεχουν αυτα |
US15/492,306 US10278972B2 (en) | 2013-12-23 | 2017-04-20 | Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
US16/296,766 US20190201404A1 (en) | 2013-12-23 | 2019-03-08 | Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1363500A FR3015483B1 (fr) | 2013-12-23 | 2013-12-23 | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3015483A1 FR3015483A1 (fr) | 2015-06-26 |
FR3015483B1 true FR3015483B1 (fr) | 2016-01-01 |
Family
ID=50829005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1363500A Expired - Fee Related FR3015483B1 (fr) | 2013-12-23 | 2013-12-23 | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Country Status (48)
Families Citing this family (51)
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US20180179210A1 (en) * | 2015-05-27 | 2018-06-28 | Pharmascience Inc. | Inhibitors of the TEC Kinase Enzyme Family |
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