AR116635A1 - Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen - Google Patents

Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen

Info

Publication number
AR116635A1
AR116635A1 ARP190102897A ARP190102897A AR116635A1 AR 116635 A1 AR116635 A1 AR 116635A1 AR P190102897 A ARP190102897 A AR P190102897A AR P190102897 A ARP190102897 A AR P190102897A AR 116635 A1 AR116635 A1 AR 116635A1
Authority
AR
Argentina
Prior art keywords
bromophenil
piperazinil
etoxy
synthesis
derivatives
Prior art date
Application number
ARP190102897A
Other languages
English (en)
Inventor
Bruno Schiavi
Christophe Hardouin
Pascall Giguere
Martial Bertrand
Louis-Philippe Beauregard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR116635A1 publication Critical patent/AR116635A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

Abstract

Reivindicación 1: Un proceso para preparar un compuesto de fórmula (1), en donde: R¹ y R² independientemente uno de otro representan un átomo de halógeno, un grupo alquilo C₁₋₆ lineal o ramificado, un grupo alcoxi C₁₋₆ lineal o ramificado, un grupo alcoxi C₁₋₆alcoxi C₁₋₆ lineal o ramificado, un grupo hidroxilo o un grupo ciano; R³ representa un grupo alquilo C₁₋₆ lineal o ramificado, que comprende la etapa de hacer reaccionar un compuesto de fórmula (2), en donde R¹ y R² son como se han definido anteriormente, con un compuesto de fórmula (3), en donde R³ es como se ha definido anteriormente, y X⁻ representa un contraión aniónico monovalente, en un disolvente, a alta temperatura en presencia de una base.
ARP190102897A 2018-10-15 2019-10-11 Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen AR116635A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18306354 2018-10-15

Publications (1)

Publication Number Publication Date
AR116635A1 true AR116635A1 (es) 2021-05-26

Family

ID=63965576

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190102897A AR116635A1 (es) 2018-10-15 2019-10-11 Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen

Country Status (15)

Country Link
US (1) US11512062B2 (es)
EP (1) EP3867233A1 (es)
JP (1) JP7448532B2 (es)
KR (1) KR20210076094A (es)
CN (1) CN112930340A (es)
AR (1) AR116635A1 (es)
AU (1) AU2019362310A1 (es)
BR (1) BR112021006467A2 (es)
CA (1) CA3115608A1 (es)
EA (1) EA202190989A1 (es)
IL (1) IL282094A (es)
MA (1) MA53897A (es)
MX (1) MX2021004288A (es)
TW (1) TW202033506A (es)
WO (1) WO2020078875A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202315637A (zh) 2021-06-11 2023-04-16 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合
KR20240019330A (ko) 2021-06-11 2024-02-14 길리애드 사이언시즈, 인코포레이티드 Mcl-1 저해제와 항체 약물 접합체의 조합

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US4401824A (en) * 1982-03-08 1983-08-30 The Upjohn Company Benzopyran compounds, derivatives of prostaglandins
US6867203B2 (en) * 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
GB0500029D0 (en) 2005-01-04 2005-02-09 Univ Belfast Basic ionic liquids
US7759337B2 (en) 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
US20090099186A1 (en) * 2005-10-11 2009-04-16 Leonid Beigelman Inhibitors of viral replication
TW201107302A (en) 2009-06-26 2011-03-01 Glaxo Group Ltd Compounds
CA2778175A1 (en) * 2009-11-11 2011-05-19 Yoshihiro Horiuchi 8-azabicyclo[3.2.1]octane-8-carboxamide derivative
ES2749910T3 (es) 2011-06-17 2020-03-24 Nantenergy Inc Celda electroquímica que comprende un aditivo heteroiónico
TWI464242B (zh) * 2012-10-26 2014-12-11 Ind Tech Res Inst 負介電異方性液晶化合物、液晶顯示器、與光電裝置
KR102006994B1 (ko) * 2013-03-28 2019-08-02 주식회사 삼양사 신규 페난트렌 화합물, 이의 제조방법 및 이를 이용한 유기전자소자
WO2015024203A1 (en) 2013-08-20 2015-02-26 Leo Pharma A/S Novel neurokinin 1 receptor antagonist compounds ii
FR3015483B1 (fr) 2013-12-23 2016-01-01 Servier Lab Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2015162515A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
EP3151833A4 (en) 2014-06-04 2018-01-10 Thomas Helledays Stiftelse För Medicinsk Forskning Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
FR3037959B1 (fr) 2015-06-23 2017-08-04 Servier Lab Nouveaux derives bicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3037958B1 (fr) 2015-06-23 2019-01-25 Les Laboratoires Servier Nouveaux derives d'hydroxy-acide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3046792B1 (fr) 2016-01-19 2018-02-02 Les Laboratoires Servier Nouveaux derives d'ammonium, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2017180571A1 (en) 2016-04-11 2017-10-19 Janssen Pharmaceutica Nv Substituted benzothiophenyl derivatives as gpr40 agonists for the treatment of type ii diabetes
KR101891263B1 (ko) * 2016-07-20 2018-08-23 주식회사 엘지화학 신규한 헤테로고리 화합물 및 이를 포함하는 유기발광 소자
SG11201903326RA (en) * 2016-10-28 2019-05-30 Servier Lab Liposomal formulation for use in the treatment of cancer
CN107573360B (zh) 2017-10-27 2019-08-09 都创(上海)医药科技有限公司 一种多靶点小分子化合物s63845的制备方法

Also Published As

Publication number Publication date
CA3115608A1 (en) 2020-04-23
JP7448532B2 (ja) 2024-03-12
WO2020078875A1 (en) 2020-04-23
US11512062B2 (en) 2022-11-29
EA202190989A1 (ru) 2021-07-05
US20210380549A1 (en) 2021-12-09
EP3867233A1 (en) 2021-08-25
JP2022512694A (ja) 2022-02-07
TW202033506A (zh) 2020-09-16
CN112930340A (zh) 2021-06-08
AU2019362310A1 (en) 2021-05-13
KR20210076094A (ko) 2021-06-23
BR112021006467A2 (pt) 2021-07-13
IL282094A (en) 2021-05-31
MA53897A (fr) 2022-01-19
MX2021004288A (es) 2021-05-31

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