AR098818A1 - Derivados de oxindol, preparación de los mismos y uso terapéutico de los mismos - Google Patents
Derivados de oxindol, preparación de los mismos y uso terapéutico de los mismosInfo
- Publication number
- AR098818A1 AR098818A1 ARP140104745A ARP140104745A AR098818A1 AR 098818 A1 AR098818 A1 AR 098818A1 AR P140104745 A ARP140104745 A AR P140104745A AR P140104745 A ARP140104745 A AR P140104745A AR 098818 A1 AR098818 A1 AR 098818A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituted
- unsubstituted
- alkyl group
- alkyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente solicitud se refiere a compuestos y procesos para la preparación de estos y usos terapéuticos de los mismos. Reivindicación 1: Un compuesto que corresponde a la fórmula (1) en donde R¹ representa: un grupo arilo C₆₋₁₀, sin sustituir o sustituido con uno o más sustituyentes seleccionados entre un átomo de halógeno, un grupo -ORᵃ, en donde Rᵃ representa un átomo de hidrógeno, un grupo alquilo C₁₋₃ o un grupo -CF₃, un grupo alquilo C₁₋₃, sin sustituir o sustituido con uno o más átomos de halógeno, un grupo carboxilo, un grupo ciano, un grupo heterocicloalquilo C₃₋₆, sin sustituir o sustituido con uno o más grupos alquilo C₁₋₃; un grupo heteroarilo C₂₋₁₀, sin sustituir o sustituido con uno o más sustituyentes seleccionados entre un átomo de halógeno, un grupo alquilo C₁₋₄, un grupo cicloalquilo C₃₋₆, un grupo -ORᵉ, en donde Rᵉ representa un átomo de hidrógeno o un grupo alquilo C₁₋₄, estando dicho grupo alquilo C₁₋₄ sin sustituir o sustituido con uno o más grupos alcoxi C₁₋₄ o heterocicloalquilo, un grupo -NRᶠRᶠ, en donde Rᶠ y Rᶠ, independientemente, idénticos o diferentes, representan un grupo alquilo C₁₋₃; R² representa: un grupo arilo C₆₋₁₀, sin sustituir o sustituido con uno o más sustituyentes seleccionados entre: un átomo de halógeno, un grupo ciano, un grupo de fórmula (2), un grupo de fórmula (3), un grupo, un grupo alquilo C₁₋₃ sin sustituir o sustituido con uno o más sustituyentes seleccionados entre un átomo de halógeno, un grupo hidroxilo y un grupo alquenilo C₁₋₄, un grupo cicloalquilo C₃₋₆, sin sustituir o sustituido con un grupo hidroxialquilo C₁₋₃, un grupo hidroxilo o un grupo alcoxi C₁₋₄, un grupo -ORᵇ, en donde Rᵇ representa un átomo de hidrógeno, un grupo -CF₃, un grupo cicloalquilo C₃₋₆, sin sustituir o sustituido con un grupo hidroxilo, un grupo heterocicloalquilo C₃₋₆, estando dicho grupo heterocicloalquilo C₃₋₆ sin sustituir o sustituido con un grupo alquilo C₁₋₃, o un grupo alquilo C₁₋₃, estando dicho grupo alquilo C₁₋₃ sin sustituir o sustituido con uno o más: grupo hidroxilo, grupo alcoxi C₁₋₄, grupo heteroarilo C₂₋₁₀, grupo acetamido, grupo dialquil C₁₋₃-amino, grupo cicloalquilo C₃₋₆, estando dicho grupo cicloalquilo C₃₋₆ sin sustituir o sustituido con uno o más grupos hidroxilo, o grupo heterocicloalquilo C₃₋₆, estando dicho grupo heterocicloalquilo C₃₋₆ sin sustituir o sustituido con un grupo alquilo C₁₋₃; un grupo heterocicloalquilo C₃₋₆ sin sustituir o sustituido con uno o más de átomo de halógeno, grupo alquilo C₁₋₃, grupo hidroxilo, grupo hidroxialquilo C₁₋₃, grupo alcoxi C₁₋₄ o grupo fluoroalquilo C₁₋₄, un grupo arilo C₆₋₁₀, sin sustituir o sustituido con uno o más grupos -ORᶜ, en donde Rᶜ representa un átomo de hidrógeno o un grupo alquilo C₁₋₃, un grupo heteroarilo C₂₋₁₀, sin sustituir o sustituido con uno o más grupos -NH₂, un grupo -NRᵈRᵈ, en donde Rᵈ y Rᵈ, independientemente, idénticos o diferentes, representan un átomo de hidrógeno, un grupo alquilo C₁₋₃, un grupo hidroxi-alquilo C₁₋₄ o un grupo cicloalquilo C₃₋₆, o un grupo heteroarilo C₂₋₁₀, sin sustituir o sustituido con uno o más sustituyentes seleccionados entre: un grupo alquilo C₁₋₃, un grupo cicloalquilo C₃₋₆, sin sustituir o sustituido con un grupo hidroxi-alquilo C₁₋₃, un grupo -NRᵍRᵍ, en donde Rᵍ y Rᵍ, independientemente, idénticos o diferentes, representan un grupo alquilo C₁₋₃; R³ represente: un átomo de halógeno, un grupo alquilo C₁₋₃; R⁴ representa: un átomo de halógeno, un átomo de hidrógeno; en la forma de la base, enantiómeros, diastereómeros o de una sal de adición con un ácido o con una base. Reivindicación 18: Compuestos de fórmula (4), (5), (6), (7) y (8) en donde R¹, R², R³ son como se han definido en la reivindicación 1 y R representa un grupo alquilo, PG y PG² representan grupos protectores, R² representa un grupo arilo sustituido con un grupo arilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13306793.4A EP2886541A1 (en) | 2013-12-19 | 2013-12-19 | Oxindole derivatives, preparation thereof and therapeutic use in the treatment of AMPK-related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
AR098818A1 true AR098818A1 (es) | 2016-06-15 |
Family
ID=49989457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140104745A AR098818A1 (es) | 2013-12-19 | 2014-12-18 | Derivados de oxindol, preparación de los mismos y uso terapéutico de los mismos |
Country Status (13)
Country | Link |
---|---|
US (1) | US10077237B2 (es) |
EP (2) | EP2886541A1 (es) |
JP (1) | JP6436999B2 (es) |
KR (1) | KR20160093073A (es) |
CN (1) | CN106029656B (es) |
AR (1) | AR098818A1 (es) |
AU (1) | AU2014368476B2 (es) |
CA (1) | CA2932343A1 (es) |
IL (1) | IL245738A0 (es) |
MX (1) | MX2016007989A (es) |
RU (1) | RU2016129018A (es) |
TW (1) | TW201609644A (es) |
WO (1) | WO2015091937A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2646993B1 (es) * | 2016-06-17 | 2018-09-25 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados de indolin-2-ona y su uso terapéutico |
CN110818611B (zh) * | 2018-08-13 | 2023-01-24 | 中国科学院上海药物研究所 | 一类吲哚酮类化合物、其制备方法、药物组合物和用途 |
WO2020061231A1 (en) * | 2018-09-18 | 2020-03-26 | 1Globe Biomedical Co., Ltd. | Treatment for obesity |
RU2734495C1 (ru) * | 2019-09-13 | 2020-10-19 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ лечения сахарного диабета |
CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
KR102566028B1 (ko) * | 2021-08-10 | 2023-08-10 | 계명대학교 산학협력단 | 신규한 다중 단백질 키나아제 억제제 |
WO2023196640A1 (en) | 2022-04-08 | 2023-10-12 | Bioverativ Therapeutics Inc. | Oxindole derivatives as ampk activators for use in the treatment of rare blood disorders |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3767653A (en) * | 1971-06-28 | 1973-10-23 | Squibb & Sons Inc | Thiazines |
US3984405A (en) | 1971-06-28 | 1976-10-05 | E. R. Squibb & Sons, Inc. | Anti-inflammatory agents |
HU163625B (es) * | 1971-06-28 | 1973-09-27 | ||
US3923996A (en) | 1972-07-31 | 1975-12-02 | Sandoz Ag | 3-Substituted-oxindoles in compositions and methods of treating obesity |
NL7310394A (es) * | 1972-07-31 | 1974-02-04 | ||
US4853409A (en) * | 1988-04-13 | 1989-08-01 | Pfizer Inc. | 3-substituted-2-oxindole-1-carboxamides for suppressing T-cell function |
HU215112B (hu) * | 1989-01-10 | 1998-12-28 | Pfizer Inc. | Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására |
US5006547A (en) * | 1990-03-19 | 1991-04-09 | Pfizer Inc. | Tenidap as an inhibitor of the release of elastase by neutrophils |
CN102666485A (zh) * | 2009-09-21 | 2012-09-12 | 霍夫曼-拉罗奇有限公司 | 烯烃羟吲哚衍生物及其用于治疗肥胖症,糖尿病和高脂血症的应用 |
WO2011032320A1 (en) | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
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2013
- 2013-12-19 EP EP13306793.4A patent/EP2886541A1/en not_active Ceased
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2014
- 2014-12-18 AR ARP140104745A patent/AR098818A1/es unknown
- 2014-12-19 JP JP2016538501A patent/JP6436999B2/ja active Active
- 2014-12-19 MX MX2016007989A patent/MX2016007989A/es unknown
- 2014-12-19 US US15/102,366 patent/US10077237B2/en active Active
- 2014-12-19 AU AU2014368476A patent/AU2014368476B2/en not_active Ceased
- 2014-12-19 WO PCT/EP2014/078715 patent/WO2015091937A1/en active Application Filing
- 2014-12-19 EP EP14815740.7A patent/EP3083611B1/en active Active
- 2014-12-19 RU RU2016129018A patent/RU2016129018A/ru not_active Application Discontinuation
- 2014-12-19 KR KR1020167018996A patent/KR20160093073A/ko not_active Application Discontinuation
- 2014-12-19 TW TW103144658A patent/TW201609644A/zh unknown
- 2014-12-19 CA CA2932343A patent/CA2932343A1/en not_active Abandoned
- 2014-12-19 CN CN201480075617.8A patent/CN106029656B/zh active Active
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2016
- 2016-05-19 IL IL245738A patent/IL245738A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2016540784A (ja) | 2016-12-28 |
JP6436999B2 (ja) | 2018-12-12 |
CN106029656B (zh) | 2019-07-26 |
US10077237B2 (en) | 2018-09-18 |
CN106029656A (zh) | 2016-10-12 |
EP2886541A1 (en) | 2015-06-24 |
IL245738A0 (en) | 2016-08-02 |
AU2014368476A1 (en) | 2016-06-30 |
TW201609644A (zh) | 2016-03-16 |
MX2016007989A (es) | 2016-09-13 |
CA2932343A1 (en) | 2015-06-25 |
RU2016129018A (ru) | 2018-01-25 |
EP3083611B1 (en) | 2019-02-13 |
WO2015091937A1 (en) | 2015-06-25 |
US20160311770A1 (en) | 2016-10-27 |
EP3083611A1 (en) | 2016-10-26 |
KR20160093073A (ko) | 2016-08-05 |
AU2014368476B2 (en) | 2018-10-04 |
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