AR091519A1 - Inhibidores pirrolopirazona de tanquirasa - Google Patents

Inhibidores pirrolopirazona de tanquirasa

Info

Publication number
AR091519A1
AR091519A1 ARP130102187A AR091519A1 AR 091519 A1 AR091519 A1 AR 091519A1 AR P130102187 A ARP130102187 A AR P130102187A AR 091519 A1 AR091519 A1 AR 091519A1
Authority
AR
Argentina
Prior art keywords
heteroaryl
aryl
optionally substituted
tanquirasa
pirrolopirazona
Prior art date
Application number
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR091519A1 publication Critical patent/AR091519A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Reivindicación 1: Compuesto de fórmula (1), R¹ se selecciona de entre el grupo que consiste de alquilo C₁₋₆, halo, ciano, hidroxialquilo C₁₋₆, o un resto del grupo de fórmulas (2); R² es (i) arilo, (ii) heteroarilo, encontrándose dicho arilo o heteroarilo opcionalmente sustituido con uno o tres grupos seleccionados independientemente de entre alquilo C₁₋₆, alcoxi C₁₋₆, haloalquilo C₁₋₆ o halógeno, (iii) piperazinilo, o (iv) piperidinilo, encontrándose dicho piperazinilo o piperidinilo opcionalmente sustituido con arilo que se encuentra opcionalmente sustituido tal como se ha indicado anteriormente, y dicho heteroarilo es piridinilo, o una sal farmacéuticamente aceptable de los mismos.
ARP130102187 2012-06-20 2013-06-19 Inhibidores pirrolopirazona de tanquirasa AR091519A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261661913P 2012-06-20 2012-06-20

Publications (1)

Publication Number Publication Date
AR091519A1 true AR091519A1 (es) 2015-02-11

Family

ID=48628701

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130102187 AR091519A1 (es) 2012-06-20 2013-06-19 Inhibidores pirrolopirazona de tanquirasa

Country Status (11)

Country Link
US (2) US8841299B2 (es)
EP (1) EP2864330A1 (es)
JP (1) JP2015520205A (es)
KR (1) KR20150011838A (es)
CN (1) CN104395314A (es)
AR (1) AR091519A1 (es)
BR (1) BR112014032053A2 (es)
CA (1) CA2870062A1 (es)
MX (1) MX2014012477A (es)
RU (1) RU2014152790A (es)
WO (1) WO2013189905A1 (es)

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MX346147B (es) 2012-03-07 2017-03-09 Inst Of Cancer Research: Royal Cancer Hospital (The) Compuestos de 3-aril-5-substituido-isoquinolin-1-ona y su uso terapeutico.
CN104169284B (zh) * 2012-03-28 2017-03-29 默克专利股份公司 双环吡嗪酮衍生物
CA2922469A1 (en) 2013-09-11 2015-03-19 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
UY36060A (es) 2014-04-02 2015-10-30 Bayer Pharma AG Compuestos de azol sustituidos con amida
WO2016006975A2 (en) * 2014-07-11 2016-01-14 St Pharm Co., Ltd. Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof
KR20160007347A (ko) 2014-07-11 2016-01-20 에스티팜 주식회사 신규한 이미다조트리아지논 또는 이미다조피라지논 유도체, 및 이들의 용도
WO2016064826A1 (en) * 2014-10-20 2016-04-28 Rowan University Asphalt concrete having a high recycled content and method of making the same
WO2017055313A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
WO2017055316A1 (en) 2015-10-01 2017-04-06 Bayer Pharma Aktiengesellschaft Amido-substituted azole compounds
US10722484B2 (en) 2016-03-09 2020-07-28 K-Gen, Inc. Methods of cancer treatment
WO2018078009A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives
WO2018078005A1 (en) 2016-10-29 2018-05-03 Bayer Pharma Aktiengesellschaft Amido-substituted azaspiro derivatives as tankyrase inhibitors
WO2018087126A1 (en) 2016-11-09 2018-05-17 Bayer Pharma Aktiengesellschaft Amido-substituted cyclohexane derivatives as inhibitors of tankyrase
CN106619622A (zh) * 2016-12-14 2017-05-10 中国科学院昆明植物研究所 以丙酰胺类化合物为活性成分的药物组合物和其在制药中的应用
JP6984357B2 (ja) * 2017-11-30 2021-12-17 日本電産トーソク株式会社 バルブ装置
JP7039969B2 (ja) * 2017-11-30 2022-03-23 日本電産トーソク株式会社 バルブ装置
WO2020224626A1 (zh) * 2019-05-08 2020-11-12 浙江同源康医药股份有限公司 用作激酶抑制剂的化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022858D0 (en) 1990-10-20 1990-12-05 Reckitt & Colmann Prod Ltd Derivatives of indoles
EP2032140A1 (en) * 2006-05-31 2009-03-11 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Pyrrolo[1,2-a]pyrazin-1(2h)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2h)-one derivatives as inhibitors of poly(adp-ribose)polymerase(parp)
GB0615809D0 (en) * 2006-08-09 2006-09-20 Istituto Di Ricerche D Biolog Therapeutic compounds
WO2008082887A2 (en) * 2006-12-28 2008-07-10 Abbott Laboratories Inhibitors of poly(adp-ribose)polymerase
US20090047246A1 (en) 2007-02-12 2009-02-19 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
WO2009130231A1 (en) * 2008-04-24 2009-10-29 Glaxo Group Limited Pyrrolo [1, 2-a] pyrazine derivatives as vasopressin vib receptor antagonists
CA2794861A1 (en) * 2010-04-16 2011-10-20 Abbvie Inc. Pyrrolopyrazinone inhibitors of kinases
CN104169284B (zh) * 2012-03-28 2017-03-29 默克专利股份公司 双环吡嗪酮衍生物
WO2013182546A1 (en) * 2012-06-07 2013-12-12 F. Hoffmann-La Roche Ag Pyrazolopyrimidone and pyrazolopyridone inhibitors of tankyrase
WO2013182580A1 (en) * 2012-06-07 2013-12-12 F. Hoffmann-La Roche Ag Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
EP2864335A1 (en) * 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG Pyranopyridone inhibitors of tankyrase

Also Published As

Publication number Publication date
CN104395314A (zh) 2015-03-04
KR20150011838A (ko) 2015-02-02
US8841299B2 (en) 2014-09-23
CA2870062A1 (en) 2013-12-27
MX2014012477A (es) 2014-12-10
US20150011556A1 (en) 2015-01-08
US20130345226A1 (en) 2013-12-26
EP2864330A1 (en) 2015-04-29
JP2015520205A (ja) 2015-07-16
RU2014152790A (ru) 2016-08-10
WO2013189905A1 (en) 2013-12-27
BR112014032053A2 (pt) 2017-06-27

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