AR108388A2 - Compuestos de oxazol sustituidos con indazol como inhibidores de pi3-quinasas - Google Patents

Compuestos de oxazol sustituidos con indazol como inhibidores de pi3-quinasas

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Publication number
AR108388A2
AR108388A2 ARP170101175A ARP170101175A AR108388A2 AR 108388 A2 AR108388 A2 AR 108388A2 AR P170101175 A ARP170101175 A AR P170101175A AR P170101175 A ARP170101175 A AR P170101175A AR 108388 A2 AR108388 A2 AR 108388A2
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
independently selected
inhibitors
halo
Prior art date
Application number
ARP170101175A
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English (en)
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Glaxo Group Ltd
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Publication date
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Publication of AR108388A2 publication Critical patent/AR108388A2/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Abstract

Los compuestos son inhibidores de la actividad quinasa, en particular de la actividad de la Pl3-quinasa. Reivindicación 1: Un compuesto de fórmula (1), en la que: R¹ es un heteroarilo bicíclico de 9 ó 10 miembros, en el que el heteroarilo bicíclico de 9 ó 10 miembros contiene de uno a tres heteroátomos seleccionados de forma independiente de entre oxígeno y nitrógeno, y está sustituido opcionalmente con alquilo C₁₋₆, cicloalquilo C₃₋₆, halo, -CN o -NHSO₂R⁵, o piridinilo opcionalmente sustituido con uno o dos sustituyentes seleccionados de forma independiente de entre alquilo C₁₋₆, -OR⁶, halo y -NHSO₂R⁷; R² y R³, junto con el átomo de nitrógeno al que están fijados, están unidos para formar un heterociclilo de 6 ó 7 miembros en el que el heterociclilo de 6 ó 7 miembros contiene, opcionalmente, un átomo de oxígeno u otro átomo de nitrógeno y está opcionalmente sustituido con uno o dos sustituyentes seleccionados de forma independiente de alquilo C₁₋₆; R⁴ es hidrógeno o metilo; R⁶ es hidrógeno o alquilo C₁₋₄; y R⁵ y R⁷ son, cada uno de forma independiente, alquilo C₁₋₆ o fenilo opcionalmente sustituido con uno o dos sustituyentes seleccionados de forma independiente de halo; o una sal de los mismos.
ARP170101175A 2009-04-30 2017-05-05 Compuestos de oxazol sustituidos con indazol como inhibidores de pi3-quinasas AR108388A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17403309P 2009-04-30 2009-04-30

Publications (1)

Publication Number Publication Date
AR108388A2 true AR108388A2 (es) 2018-08-15

Family

ID=42225106

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP100101429A AR076435A1 (es) 2009-04-30 2010-04-28 Compuestos de indazoles sustituidos, composiciones farmaceuticas que los contienen y procesos de obtencion de los mismos
ARP170101175A AR108388A2 (es) 2009-04-30 2017-05-05 Compuestos de oxazol sustituidos con indazol como inhibidores de pi3-quinasas

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Application Number Title Priority Date Filing Date
ARP100101429A AR076435A1 (es) 2009-04-30 2010-04-28 Compuestos de indazoles sustituidos, composiciones farmaceuticas que los contienen y procesos de obtencion de los mismos

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US (14) US8575162B2 (es)
EP (3) EP3260453B1 (es)
JP (1) JP5570589B2 (es)
KR (2) KR101679642B1 (es)
CN (1) CN102459253B (es)
AR (2) AR076435A1 (es)
AU (1) AU2010243613B2 (es)
BR (1) BRPI1016219B8 (es)
CA (1) CA2759476C (es)
CL (1) CL2011002706A1 (es)
CO (1) CO6390057A2 (es)
CR (1) CR20110603A (es)
CY (1) CY1119515T1 (es)
DK (2) DK2899191T3 (es)
DO (1) DOP2011000328A (es)
EA (1) EA021056B1 (es)
ES (3) ES2644724T3 (es)
HK (2) HK1165801A1 (es)
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HU (1) HUE034724T2 (es)
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NZ (1) NZ596071A (es)
PE (1) PE20120321A1 (es)
PL (2) PL2424864T3 (es)
PT (2) PT2899191T (es)
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SI (2) SI2424864T1 (es)
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UA (1) UA101098C2 (es)
UY (1) UY32585A (es)
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