ES2531274T3 - Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas - Google Patents
Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas Download PDFInfo
- Publication number
- ES2531274T3 ES2531274T3 ES10714892T ES10714892T ES2531274T3 ES 2531274 T3 ES2531274 T3 ES 2531274T3 ES 10714892 T ES10714892 T ES 10714892T ES 10714892 T ES10714892 T ES 10714892T ES 2531274 T3 ES2531274 T3 ES 2531274T3
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- Prior art keywords
- alkyl
- optionally substituted
- independently selected
- halo
- kinases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 Oxazole-substituted indazoles Chemical class 0.000 title abstract 2
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 title 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract
Un compuesto de fórmula (I):**Fórmula** en la que: R1 es un heteroarilo bicíclico de 9 o 10 miembros en el que el heteroarilo bicíclico de 9 o 10 miembros contiene de uno a tres heteroátomos seleccionados de forma independiente de entre oxígeno y nitrógeno y está sustituido opcionalmente con alquilo C1-6, cicloalquilo C3-6, halo, -CN o -NHSO2R5, o piridinilo opcionalmente sustituido con uno o dos sustituyentes seleccionados de forma independiente de entre alquilo C1-6, -OR6, halo y -NHSO2R7; R2 y R3, junto con el átomo de nitrógeno al que están fijados, están unidos para formar un heterociclilo de 6 o 7 miembros en el que el heterociclilo de 6 o 7 miembros contiene opcionalmente un átomo de oxígeno o un átomo adicional de nitrógeno y está opcionalmente sustituido con uno o dos sustituyentes seleccionados de forma independiente de alquilo C1-6; R4 es hidrógeno o metilo; R6 es hidrógeno o alquilo C1-4; y R5 y R7 son cada uno de forma independiente, alquilo C1-6 o fenilo opcionalmente sustituido con uno o dos sustituyentes seleccionados de forma independiente de halo; o una sal del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17403309P | 2009-04-30 | 2009-04-30 | |
PCT/EP2010/055666 WO2010125082A1 (en) | 2009-04-30 | 2010-04-28 | Oxazole substituted indazoles as pi3-kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2531274T3 true ES2531274T3 (es) | 2015-03-12 |
Family
ID=42225106
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10714892T Active ES2531274T3 (es) | 2009-04-30 | 2010-04-28 | Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas |
ES14194866.1T Active ES2644724T3 (es) | 2009-04-30 | 2010-04-28 | Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas |
ES17182412T Active ES2876933T3 (es) | 2009-04-30 | 2010-04-28 | Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14194866.1T Active ES2644724T3 (es) | 2009-04-30 | 2010-04-28 | Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas |
ES17182412T Active ES2876933T3 (es) | 2009-04-30 | 2010-04-28 | Indazoles sustituidos con oxazol como inhibidores de PI3-cinasas |
Country Status (40)
Country | Link |
---|---|
US (14) | US20120046286A1 (es) |
EP (3) | EP2899191B1 (es) |
JP (1) | JP5570589B2 (es) |
KR (2) | KR101771193B1 (es) |
CN (1) | CN102459253B (es) |
AR (2) | AR076435A1 (es) |
AU (1) | AU2010243613B2 (es) |
BR (1) | BRPI1016219B8 (es) |
CA (1) | CA2759476C (es) |
CL (1) | CL2011002706A1 (es) |
CO (1) | CO6390057A2 (es) |
CR (1) | CR20110603A (es) |
CY (1) | CY1119515T1 (es) |
DK (2) | DK2424864T3 (es) |
DO (1) | DOP2011000328A (es) |
EA (1) | EA021056B1 (es) |
ES (3) | ES2531274T3 (es) |
HK (2) | HK1165801A1 (es) |
HR (2) | HRP20150173T1 (es) |
HU (1) | HUE034724T2 (es) |
IL (1) | IL215803A (es) |
JO (1) | JO3025B1 (es) |
LT (1) | LT2899191T (es) |
MA (1) | MA33304B1 (es) |
ME (2) | ME02900B (es) |
MX (1) | MX2011011534A (es) |
MY (1) | MY160454A (es) |
NZ (1) | NZ596071A (es) |
PE (1) | PE20120321A1 (es) |
PL (2) | PL2899191T3 (es) |
PT (2) | PT2424864E (es) |
RS (2) | RS53830B1 (es) |
SG (2) | SG175782A1 (es) |
SI (2) | SI2899191T1 (es) |
SM (1) | SMT201500043B (es) |
TW (3) | TWI562992B (es) |
UA (1) | UA101098C2 (es) |
UY (1) | UY32585A (es) |
WO (1) | WO2010125082A1 (es) |
ZA (1) | ZA201107878B (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009147190A1 (en) * | 2008-06-05 | 2009-12-10 | Glaxo Group Limited | Novel compounds |
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EP2280705B1 (en) | 2008-06-05 | 2014-10-08 | Glaxo Group Limited | Novel compounds |
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