CL2011002706A1 - Compuestos derivados de 4-(1,3-oxazol-2-il)-1h-indazol; composicion farmaceutica que los comprende; y sus usos en el tratamiento de enfermedades tales como epoc, autoinmunes, asma, entre otras. - Google Patents

Compuestos derivados de 4-(1,3-oxazol-2-il)-1h-indazol; composicion farmaceutica que los comprende; y sus usos en el tratamiento de enfermedades tales como epoc, autoinmunes, asma, entre otras.

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Publication number
CL2011002706A1
CL2011002706A1 CL2011002706A CL2011002706A CL2011002706A1 CL 2011002706 A1 CL2011002706 A1 CL 2011002706A1 CL 2011002706 A CL2011002706 A CL 2011002706A CL 2011002706 A CL2011002706 A CL 2011002706A CL 2011002706 A1 CL2011002706 A1 CL 2011002706A1
Authority
CL
Chile
Prior art keywords
treatment
epoc
oxazol
indazole
autoimmune
Prior art date
Application number
CL2011002706A
Other languages
English (en)
Inventor
Julie Nicole Hamblin
Paul Spencer Jones
Suzanne Elaine Keeling
Joelle Le
Charlotte Jane Mitchell
Nigel James Parr
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CL2011002706A1 publication Critical patent/CL2011002706A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Abstract

UN COMPUESTO DERIVADO DE 4-(1,3-OXAZO1·2·IL)·1H-INDAZOLDE LA FÓRMULA (I):   DONDE R', R2, R3 Y R4 SE DEFINEN TAL COMO EN LA MEMORIA DESCRIPTIVA.<br /> COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE UN COMPUESTO DE FÓRMULA (I) O UNA SAL DEL MISMO, Y<br /> UNO O MÁS EXCIPIENTES FARMACÉUTICAMENTE ACEPTABLES.<br /> USO DE UN COMPUESTO DE FÓRMULA (I) O UNA SAL DEL MISMO, PARA EL TRATAMIENTO DE UN TRASTORNO<br /> MEDIADO POR LA ACTIVIDAD INADECUADA DE LA CINASA-PI3.
CL2011002706A 2009-04-30 2011-10-28 Compuestos derivados de 4-(1,3-oxazol-2-il)-1h-indazol; composicion farmaceutica que los comprende; y sus usos en el tratamiento de enfermedades tales como epoc, autoinmunes, asma, entre otras. CL2011002706A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17403309P 2009-04-30 2009-04-30

Publications (1)

Publication Number Publication Date
CL2011002706A1 true CL2011002706A1 (es) 2012-04-09

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CL2011002706A CL2011002706A1 (es) 2009-04-30 2011-10-28 Compuestos derivados de 4-(1,3-oxazol-2-il)-1h-indazol; composicion farmaceutica que los comprende; y sus usos en el tratamiento de enfermedades tales como epoc, autoinmunes, asma, entre otras.

Country Status (40)

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US (14) US8575162B2 (es)
EP (3) EP2424864B1 (es)
JP (1) JP5570589B2 (es)
KR (2) KR101679642B1 (es)
CN (1) CN102459253B (es)
AR (2) AR076435A1 (es)
AU (1) AU2010243613B2 (es)
BR (1) BRPI1016219B8 (es)
CA (1) CA2759476C (es)
CL (1) CL2011002706A1 (es)
CO (1) CO6390057A2 (es)
CR (1) CR20110603A (es)
CY (1) CY1119515T1 (es)
DK (2) DK2424864T3 (es)
DO (1) DOP2011000328A (es)
EA (1) EA021056B1 (es)
ES (3) ES2876933T3 (es)
HK (2) HK1165801A1 (es)
HR (2) HRP20150173T1 (es)
HU (1) HUE034724T2 (es)
IL (1) IL215803A (es)
JO (1) JO3025B1 (es)
LT (1) LT2899191T (es)
MA (1) MA33304B1 (es)
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MX (1) MX2011011534A (es)
MY (1) MY160454A (es)
NZ (1) NZ596071A (es)
PE (1) PE20120321A1 (es)
PL (2) PL2899191T3 (es)
PT (2) PT2424864E (es)
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SI (2) SI2424864T1 (es)
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TW (3) TWI562992B (es)
UA (1) UA101098C2 (es)
UY (1) UY32585A (es)
WO (1) WO2010125082A1 (es)
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MA33304B1 (fr) 2009-04-30 2012-05-02 Glaxo Group Ltd Indazoles substitués par oxazole comme inhibiteurs de pi3-kinase
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JP5876051B2 (ja) * 2010-09-08 2016-03-02 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ インフルエンザウィルス感染の治療に使用するためのインダゾール誘導体
PL2614058T3 (pl) 2010-09-08 2015-12-31 Glaxosmithkline Ip Dev Ltd Polimorfy i sole n-[5-[4-(5-{[(2r,6s)-2,6-dimetylo-4-morfolinylo]-metylo}-1,3-oksazol-2-ilo)-1h-indazol-6-ilo]-2-(metyloksy)-3-pirydynylo]metanosulfonamidu
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GB201018124D0 (en) * 2010-10-27 2010-12-08 Glaxo Group Ltd Polymorphs and salts
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HUE036052T2 (hu) 2011-12-15 2018-06-28 Novartis Ag PI3K aktivitással vagy funkcióval rendelkezõ inhibitorok alkalmazása
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AU2013259624B2 (en) 2012-05-08 2017-10-19 Lycera Corporation Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease
CN104703604A (zh) 2012-07-16 2015-06-10 神经孔疗法股份有限公司 作为蛋白质聚集抑制剂的二-和三-杂芳基衍生物
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WO2014098232A1 (ja) * 2012-12-21 2014-06-26 Yamashita Chikamasa Ｐｉ３キナーゼ阻害剤を含む医薬組成物、ビタミンｄ受容体に作用する化合物を含む医薬組成物、凍結乾燥組成物、凍結乾燥組成物の製造方法、及び経肺投与用医薬組成物
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