CL2009000394A1 - Compuestos derivados de n-(1h-indazol-5-il)pirrolidin-3-carboxamida sustituida, inhibidores de erk; composicion farmaceutica; y su uso en el tratamiento del cancer. - Google Patents

Compuestos derivados de n-(1h-indazol-5-il)pirrolidin-3-carboxamida sustituida, inhibidores de erk; composicion farmaceutica; y su uso en el tratamiento del cancer.

Info

Publication number
CL2009000394A1
CL2009000394A1 CL2009000394A CL2009000394A CL2009000394A1 CL 2009000394 A1 CL2009000394 A1 CL 2009000394A1 CL 2009000394 A CL2009000394 A CL 2009000394A CL 2009000394 A CL2009000394 A CL 2009000394A CL 2009000394 A1 CL2009000394 A1 CL 2009000394A1
Authority
CL
Chile
Prior art keywords
pharmaceutical composition
cancer
indazol
pyrrolidin
carboxamide
Prior art date
Application number
CL2009000394A
Other languages
English (en)
Inventor
B Cooper Alan
Nan Yang
Deng Yongqi
W Shipps Gerald Jr
Shih Neng-Yang
Y Zhu Hugh
M Kelly Joseph
Gudipati Subrahmanyam
J Doll Ronald
F Patel Mehul
A Desai Jagdish
J-S Wang James
Paliwal Sunil
Tsui Hon-Chung
Babu Boga Sobhana
Alhassan Abdul-Basit
Gao Xiaolei
Zhu Liang
Yao Xin
A Samatar Ahmed
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40601237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2009000394(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CL2009000394A1 publication Critical patent/CL2009000394A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

UN COMPUESTO DE FORMULA 1.0: O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE R1, R2 Y Q SON COMO SE DESCRIBEN EN LA MEMORIA DESCRIPTIVA; COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO; Y USO DE DICHO COMPUESTO PARA PREPARAR UN MEDICAMENTE UTIL EN EL TRATAMIENTO DE CANCER.
CL2009000394A 2008-02-21 2009-02-20 Compuestos derivados de n-(1h-indazol-5-il)pirrolidin-3-carboxamida sustituida, inhibidores de erk; composicion farmaceutica; y su uso en el tratamiento del cancer. CL2009000394A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3040708P 2008-02-21 2008-02-21

Publications (1)

Publication Number Publication Date
CL2009000394A1 true CL2009000394A1 (es) 2011-02-11

Family

ID=40601237

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000394A CL2009000394A1 (es) 2008-02-21 2009-02-20 Compuestos derivados de n-(1h-indazol-5-il)pirrolidin-3-carboxamida sustituida, inhibidores de erk; composicion farmaceutica; y su uso en el tratamiento del cancer.

Country Status (23)

Country Link
US (1) US8716483B2 (es)
EP (1) EP2260031B1 (es)
JP (1) JP5276676B2 (es)
KR (1) KR20100117123A (es)
CN (1) CN102015693B (es)
AR (1) AR070460A1 (es)
AU (1) AU2009215534B8 (es)
BR (1) BRPI0908120A8 (es)
CA (1) CA2714479A1 (es)
CL (1) CL2009000394A1 (es)
CO (1) CO6300939A2 (es)
EC (1) ECSP10010415A (es)
ES (1) ES2556353T3 (es)
IL (1) IL207530A (es)
MX (1) MX2010009268A (es)
MY (1) MY152271A (es)
NZ (1) NZ587504A (es)
PE (1) PE20091491A1 (es)
RU (1) RU2525389C2 (es)
SG (1) SG188179A1 (es)
TW (1) TWI398441B (es)
WO (1) WO2009105500A1 (es)
ZA (2) ZA201005909B (es)

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BR112017012558A2 (pt) 2014-12-19 2018-01-02 Merck Sharp & Dohme Composições de (s)-n-(3-(6-isopropoxipiridin-3-il)-1h- indazol-5-il)-1-(2-(4-(4-(1-metil-1h-1,2,4-triazol-3-il) fenil)-3,6-diidropiridin-1(2h)-il)-2-oxoetil)-3-(metiltio) pirrolidina-3-carboxamida para preparações farmacêuticas
SI3277690T1 (sl) * 2015-04-03 2020-07-31 Recurium Ip Holdings, Llc Spirociklične spojine
WO2017040362A1 (en) * 2015-09-03 2017-03-09 Merck Sharp & Dohme Corp. Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations
CN106432182B (zh) * 2016-09-06 2019-04-30 铜仁学院 特地唑胺中间体的合成方法
CN109020789B (zh) * 2017-06-12 2021-08-13 浙江医药股份有限公司新昌制药厂 一种制备2-甲氧基丙烯的方法
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Also Published As

Publication number Publication date
ZA201400396B (en) 2014-12-23
CN102015693B (zh) 2014-10-29
BRPI0908120A2 (es) 2017-08-22
CA2714479A1 (en) 2009-08-27
AU2009215534A1 (en) 2009-08-27
BRPI0908120A8 (pt) 2017-10-24
AR070460A1 (es) 2010-04-07
ES2556353T3 (es) 2016-01-15
RU2525389C2 (ru) 2014-08-10
AU2009215534A8 (en) 2014-07-10
WO2009105500A1 (en) 2009-08-27
US20110189192A1 (en) 2011-08-04
JP2011513225A (ja) 2011-04-28
JP5276676B2 (ja) 2013-08-28
EP2260031B1 (en) 2015-10-07
IL207530A0 (en) 2010-12-30
CN102015693A (zh) 2011-04-13
ZA201005909B (en) 2014-03-26
AU2009215534A2 (en) 2010-12-23
MX2010009268A (es) 2010-09-14
ES2556353T8 (es) 2017-10-13
ECSP10010415A (es) 2010-09-30
CO6300939A2 (es) 2011-07-21
KR20100117123A (ko) 2010-11-02
TWI398441B (zh) 2013-06-11
AU2009215534B2 (en) 2014-06-26
TW200948799A (en) 2009-12-01
RU2010138635A (ru) 2012-03-27
IL207530A (en) 2014-08-31
MY152271A (en) 2014-09-15
EP2260031A1 (en) 2010-12-15
AU2009215534B8 (en) 2014-07-10
PE20091491A1 (es) 2009-09-25
NZ587504A (en) 2012-09-28
SG188179A1 (en) 2013-03-28
US8716483B2 (en) 2014-05-06

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