PE20091491A1 - Compuestos novedosos que son inhibidores de erk - Google Patents
Compuestos novedosos que son inhibidores de erkInfo
- Publication number
- PE20091491A1 PE20091491A1 PE2009000250A PE2009000250A PE20091491A1 PE 20091491 A1 PE20091491 A1 PE 20091491A1 PE 2009000250 A PE2009000250 A PE 2009000250A PE 2009000250 A PE2009000250 A PE 2009000250A PE 20091491 A1 PE20091491 A1 PE 20091491A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridin
- alkyl
- cancer
- novel compounds
- indazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA 1.0, DONDE R1 ES HETEROARILO OPCIONALMENTE SUSTITUIDO POR OH, ALCOXI, -O-ALQUILEN-O-ALQUILO; R2 ES -O-ALQUILO, -S-ALQUILO; Q ES ANILLO TETRAHIDROPIRIDINILO. SON COMPUESTOS PREFERIDOS: [3-(6-ISOPROPOXI-PIRIDIN-3-IL)-1H-INDAZOL-5-IL]-AMIDA DEL ACIDO 3-METOXI-1-(2-{4-[4-(1-METIL-1H-[1,2,4]TRIAZOL-3-IL)-FENIL]-3,6-DIHIDRO-2H-PIRIDIN-1-IL}-2-OXO-ETIL)-PIRROLIDIN-3-CARBOXILICO; [3-(6-HIDROXI-PIRIDIN-3-IL)-1H-INDAZOL-5-IL]-AMIDA DEL ACIDO 3-METOXI-1-(2-{4-[4-(1-METIL-1H-[1,2,4]TRIAZOL-3-IL)-FENIL]-3,6-DIHIDRO-2H-PIRIDIN-1-IL}-2-OXO-ETIL)-PIRROLIDIN-3-CARBOXILICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE ERK1 Y ERK2, SIENDO UTILES PARA EL TRATAMIENTO DE CANCER DE PULMON, MELANOMA, CANCER DE MAMA, CANCER PANCREATICO, CANCER DE OVARIOS, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3040708P | 2008-02-21 | 2008-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091491A1 true PE20091491A1 (es) | 2009-09-25 |
Family
ID=40601237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000250A PE20091491A1 (es) | 2008-02-21 | 2009-02-20 | Compuestos novedosos que son inhibidores de erk |
Country Status (23)
Country | Link |
---|---|
US (1) | US8716483B2 (es) |
EP (1) | EP2260031B1 (es) |
JP (1) | JP5276676B2 (es) |
KR (1) | KR20100117123A (es) |
CN (1) | CN102015693B (es) |
AR (1) | AR070460A1 (es) |
AU (1) | AU2009215534B8 (es) |
BR (1) | BRPI0908120A8 (es) |
CA (1) | CA2714479A1 (es) |
CL (1) | CL2009000394A1 (es) |
CO (1) | CO6300939A2 (es) |
EC (1) | ECSP10010415A (es) |
ES (1) | ES2556353T3 (es) |
IL (1) | IL207530A (es) |
MX (1) | MX2010009268A (es) |
MY (1) | MY152271A (es) |
NZ (1) | NZ587504A (es) |
PE (1) | PE20091491A1 (es) |
RU (1) | RU2525389C2 (es) |
SG (1) | SG188179A1 (es) |
TW (1) | TWI398441B (es) |
WO (1) | WO2009105500A1 (es) |
ZA (2) | ZA201005909B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
WO2007097937A1 (en) | 2006-02-16 | 2007-08-30 | Schering Corporation | Pyrrolidine derivatives as erk inhibitors |
WO2010021978A2 (en) * | 2008-08-19 | 2010-02-25 | Schering Corporation | Il-8 biomarker |
US9229008B2 (en) | 2008-08-19 | 2016-01-05 | Merck Sharp & Dohme Corp. | IL-8 level as a determinant of responsivity of a cancer to treatment |
US8609675B2 (en) | 2009-07-02 | 2013-12-17 | Merck Sharp & Dohme Corp. | Fused Tricyclic Compounds as novel mTOR inhibitors |
JP2013506669A (ja) | 2009-09-30 | 2013-02-28 | メルク・シャープ・アンド・ドーム・コーポレーション | Erk阻害剤である新規化合物 |
WO2011163330A1 (en) * | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
BR112013009823A2 (pt) | 2010-10-22 | 2016-07-05 | Bayer Ip Gmbh | novos compostos heterocíclicos como pesticidas |
JP2014500874A (ja) * | 2010-11-16 | 2014-01-16 | メディミューン,エルエルシー | 抗igf抗体を用いた治療レジメン |
WO2013015918A1 (en) | 2011-07-22 | 2013-01-31 | Iowa State University Research Foundation, Inc. | Method of regioselective synthesis of substituted benzoates |
EP2820009B1 (en) | 2012-03-01 | 2018-01-31 | Array Biopharma, Inc. | Serine/threonine kinase inhibitors |
US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
US9434695B2 (en) * | 2012-07-18 | 2016-09-06 | Sunshine Lake Pharma Co., Ltd | Nitrogenous heterocyclic derivatives and their application in drugs |
WO2014052566A1 (en) * | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
CA2882950A1 (en) * | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
MX2015011438A (es) * | 2013-03-13 | 2016-02-03 | Hoffmann La Roche | Procedimiento para preparar compuestos benzoxazepina. |
US8871966B2 (en) | 2013-03-15 | 2014-10-28 | Iowa State University Research Foundation, Inc. | Regiospecific synthesis of terephthalates |
SG11201602572YA (en) | 2013-10-03 | 2016-04-28 | Kura Oncology Inc | Inhibitors of erk and methods of use |
EP3143166A4 (en) * | 2014-05-16 | 2018-04-18 | University of Massachusetts | Treating chronic myelogenous leukemia (cml) |
WO2016025639A1 (en) * | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Combinations of an erk inhibitor and a chemotherapeutic agent and related methods |
WO2016095088A1 (en) | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
WO2016095089A1 (en) | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
CA2970717A1 (en) * | 2014-12-18 | 2016-06-23 | Merck Sharp & Dohme Corp. | (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations |
US10058544B2 (en) | 2014-12-19 | 2018-08-28 | Merck Sharp & Dohme Corp. | (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide compositions for pharmaceutical preparations |
MX2017012553A (es) * | 2015-04-03 | 2018-04-11 | Kalyra Pharmaceuticals Inc | Compuestos espirociclicos. |
WO2017040362A1 (en) * | 2015-09-03 | 2017-03-09 | Merck Sharp & Dohme Corp. | Process for preparing spray dried solid dispersions of (s)-n-(3-(6-isopropoxypyridin-3-yl)-1h-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2h)-yl)-2-oxoethyl)-3- (methylthio)pyrrolidine-3-carboxamide for pharmaceutical preparations |
CN106432182B (zh) * | 2016-09-06 | 2019-04-30 | 铜仁学院 | 特地唑胺中间体的合成方法 |
CN109020789B (zh) * | 2017-06-12 | 2021-08-13 | 浙江医药股份有限公司新昌制药厂 | 一种制备2-甲氧基丙烯的方法 |
WO2021067266A1 (en) * | 2019-10-01 | 2021-04-08 | Recurium Ip Holdings, Llc | Pyrrolidinyl-based compounds |
KR20220081359A (ko) | 2019-10-09 | 2022-06-15 | 바이엘 악티엔게젤샤프트 | 살충제로서의 신규 헤테로아릴-트리아졸 화합물 |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2306108A (en) | 1995-10-13 | 1997-04-30 | Merck & Co Inc | Treatment of Raf-mediated cancers with imidazole derivatives |
JP2000508335A (ja) | 1996-05-30 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | 癌の治療方法 |
GB2323845A (en) | 1997-03-31 | 1998-10-07 | Merck & Co Inc | MEK inhibiting lactones |
DE69841434D1 (de) | 1997-07-18 | 2010-02-25 | Novo Nordisk Healthcare Ag | VERWENDUNG VON FVIIa ODER FVIIAi ZUR BEHANDLUNG VON ENDOTHELIALER FEHLFUNKTION BZW ZUR INHIBIERUNG DER ANGIOGENESE |
GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
BR0104424A (pt) | 2000-02-05 | 2002-01-08 | Vertex Pharma | Composições de pirazol úteis como inibidores de erk |
EP1207864A2 (en) | 2000-02-05 | 2002-05-29 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of erk |
JP2003527379A (ja) | 2000-03-15 | 2003-09-16 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Mex阻害物質としての5−アミド置換ジアリールアミン類 |
TWI310684B (en) | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
US20050009876A1 (en) | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
US7211594B2 (en) | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
EP1317450B1 (en) | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
HUP0302991A3 (en) | 2000-09-15 | 2009-10-28 | Vertex Pharma | Isoxazoles and their use as inhibitors of erk and pharmaceutical compositions containing the compounds |
DE60125980T2 (de) | 2000-11-20 | 2007-10-25 | Scios Inc., Sunnyvale | P38kinase-inhibitoren vom piperidin/piperazin-typ |
NZ526471A (en) | 2000-12-21 | 2005-08-26 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
MY130778A (en) | 2001-02-09 | 2007-07-31 | Vertex Pharma | Heterocyclic inhibitiors of erk2 and uses thereof |
WO2002083648A1 (en) | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Novel 1h-indazole compound |
CA2445568A1 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Triazole-derived kinase inhibitors and uses thereof |
WO2002088090A2 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Pyrazole derived kinase inhibitors |
EP1423380B1 (en) | 2001-08-03 | 2010-12-15 | Vertex Pharmaceuticals Incorporated | Pyrazole-derived kinase inhibitors and uses thereof |
US6750239B2 (en) | 2001-08-03 | 2004-06-15 | Vertex Pharmaceuticals Incorporated | Pyrazole-derived kinase inhibitors and uses thereof |
JP4602667B2 (ja) | 2001-10-23 | 2010-12-22 | メルク セローノ ソシエテ アノニム | アゾール誘導体および該アゾール誘導体を含有する医薬組成物 |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
EP1506189A1 (en) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
AU2003233605A1 (en) | 2002-05-24 | 2003-12-12 | The University Of Utah Research Foundation | Mitogen activated protein kinase inhibitor compositions for lymphoma therapy |
TW200406385A (en) | 2002-05-31 | 2004-05-01 | Eisai Co Ltd | Pyrazole compound and pharmaceutical composition containing the same |
US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US7205308B2 (en) | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
TWI351405B (en) | 2002-09-19 | 2011-11-01 | Schering Corp | Novel imidazopyridines as cyclin dependent kinase |
JP4808154B2 (ja) | 2003-03-13 | 2011-11-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用な組成物 |
GB2400101A (en) | 2003-03-28 | 2004-10-06 | Biofocus Discovery Ltd | Compounds capable of binding to the active site of protein kinases |
WO2005002673A1 (en) | 2003-07-03 | 2005-01-13 | Astex Therapeutics Limited | Raf kinase inhibitors |
AU2004293035A1 (en) | 2003-11-19 | 2005-06-09 | Signal Pharmaceuticals, Llc | Methods of treating diseases and disorders by targeting multiple kinases |
MXPA06007095A (es) | 2003-12-22 | 2006-09-04 | Gilead Sciences Inc | Conjugados de fosfonato inhibidores de cinasa. |
US7462612B2 (en) | 2004-03-26 | 2008-12-09 | Vertex Pharmaceuticals Incorporated | Pyridine inhibitors of ERK2 and uses thereof |
US20070208015A1 (en) | 2004-04-13 | 2007-09-06 | Astex Therapeutics, Ltd. | 5-Morpholinylmethylthiophenyl Pharmaceutical Compounds As P38 MAP Kinase Modulators |
ATE435858T1 (de) | 2004-05-14 | 2009-07-15 | Vertex Pharma | Prodrugs von als erk-proteinkinase-inhibitoren wirkenden pyrrolylpyrimidinen |
NZ551582A (en) | 2004-05-14 | 2011-01-28 | Vertex Pharma | Pyrrole compounds as inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto |
WO2006040569A1 (en) | 2004-10-14 | 2006-04-20 | Astex Therapeutics Limited | Thiophene amide compounds for use in the treatment or prophylaxis of cancers |
EP1833820A1 (en) | 2004-12-23 | 2007-09-19 | Vertex Pharmaceuticals Incorporated | Selective inhibitors of erk protein kinase and uses therof |
CN100377868C (zh) | 2005-03-24 | 2008-04-02 | 中国科学院物理研究所 | 用于磁性/非磁性/磁性多层薄膜的核心复合膜及其用途 |
WO2006136008A1 (en) | 2005-05-24 | 2006-12-28 | University Health Network | Salicylic acid hydrazones as inhibitors of the erk mapkinase pathway and for the treatment of cancer |
US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
EP1966151B1 (en) | 2005-12-13 | 2011-10-05 | Schering Corporation | Polycyclic indazole derivatives that are erk inhibitors |
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
WO2007097937A1 (en) | 2006-02-16 | 2007-08-30 | Schering Corporation | Pyrrolidine derivatives as erk inhibitors |
US20090062355A1 (en) | 2006-04-20 | 2009-03-05 | Takeda Pharmaceutical Company Limited | Pharmaceutical Product |
US7601852B2 (en) | 2006-05-11 | 2009-10-13 | Kosan Biosciences Incorporated | Macrocyclic kinase inhibitors |
MX2009000285A (es) | 2006-06-30 | 2009-06-08 | Schering Corp | Piperidinas sustituidas que incrementan la actividad de p53 y usos de las mismas. |
US7671832B2 (en) | 2006-07-10 | 2010-03-02 | Philips Lumileds Lighting Company, Llc | Multi-colored LED backlight with color-compensated clusters near edge |
EP2560007A1 (en) | 2007-03-28 | 2013-02-20 | Pharmacyclics, Inc. | Identification of bruton's tyrosine kinase inhibitors |
CN101815711A (zh) * | 2007-06-05 | 2010-08-25 | 先灵公司 | 多环吲唑衍生物及其作为erk抑制剂治疗癌症的用途 |
RU2487873C2 (ru) | 2007-06-08 | 2013-07-20 | Эбботт Лэборетриз | 5-замещенные индазолы в качестве ингибиторов киназы |
WO2008156739A1 (en) | 2007-06-18 | 2008-12-24 | Schering Corporation | Heterocyclic compounds and use thereof as erk inhibitors |
JP2013506669A (ja) | 2009-09-30 | 2013-02-28 | メルク・シャープ・アンド・ドーム・コーポレーション | Erk阻害剤である新規化合物 |
-
2009
- 2009-02-19 CN CN200980113870.7A patent/CN102015693B/zh not_active Expired - Fee Related
- 2009-02-19 EP EP09712601.5A patent/EP2260031B1/en active Active
- 2009-02-19 NZ NZ587504A patent/NZ587504A/xx not_active IP Right Cessation
- 2009-02-19 US US12/918,099 patent/US8716483B2/en active Active
- 2009-02-19 CA CA2714479A patent/CA2714479A1/en not_active Abandoned
- 2009-02-19 JP JP2010547732A patent/JP5276676B2/ja not_active Expired - Fee Related
- 2009-02-19 AU AU2009215534A patent/AU2009215534B8/en not_active Ceased
- 2009-02-19 RU RU2010138635/04A patent/RU2525389C2/ru not_active IP Right Cessation
- 2009-02-19 MX MX2010009268A patent/MX2010009268A/es active IP Right Grant
- 2009-02-19 SG SG2013013206A patent/SG188179A1/en unknown
- 2009-02-19 ES ES09712601.5T patent/ES2556353T3/es active Active
- 2009-02-19 KR KR1020107020896A patent/KR20100117123A/ko not_active Application Discontinuation
- 2009-02-19 BR BRPI0908120A patent/BRPI0908120A8/pt not_active IP Right Cessation
- 2009-02-19 MY MYPI20103904 patent/MY152271A/en unknown
- 2009-02-19 WO PCT/US2009/034447 patent/WO2009105500A1/en active Application Filing
- 2009-02-20 TW TW098105537A patent/TWI398441B/zh not_active IP Right Cessation
- 2009-02-20 CL CL2009000394A patent/CL2009000394A1/es unknown
- 2009-02-20 PE PE2009000250A patent/PE20091491A1/es active IP Right Grant
- 2009-02-20 AR ARP090100604A patent/AR070460A1/es active IP Right Grant
-
2010
- 2010-08-10 IL IL207530A patent/IL207530A/en active IP Right Grant
- 2010-08-18 ZA ZA2010/05909A patent/ZA201005909B/en unknown
- 2010-08-20 EC EC2010010415A patent/ECSP10010415A/es unknown
- 2010-09-21 CO CO10116702A patent/CO6300939A2/es active IP Right Grant
-
2014
- 2014-01-17 ZA ZA2014/00396A patent/ZA201400396B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20091491A1 (es) | Compuestos novedosos que son inhibidores de erk | |
PE20091258A1 (es) | Derivados de piridina como activadores de la guanilato ciclasa soluble | |
PE20090813A1 (es) | Inhibidores de la 11b-hidroxiesteroide-deshidrogenasa | |
PE20091010A1 (es) | Derivados de tetrahidroquinolina | |
PE20160654A1 (es) | Compuestos de inhibidor de autotaxina | |
PE20091033A1 (es) | Derivados de nicotinamida como agentes anticancerosos y su preparacion | |
PE20081545A1 (es) | Derivados de sulfonamida como inhibidores de acido graso sintasas | |
PE20080768A1 (es) | Compuestos de isoindolina 5-sustituidos | |
TW200716107A (en) | Polymorphs of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester | |
NZ587518A (en) | Crystalline form III of (3,5-bis trifluoromethyl)-N-[4-methyl-3-({ 4-(pyridin-3 yl)-pyrimidin-2-yl} amino)-phenyl]-benzamide | |
TW200732313A (en) | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators | |
MY150980A (en) | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives | |
PE20110136A1 (es) | Compuestos organicos | |
AR060489A1 (es) | Derivados del acido benzoazepin - oxi- acetico como agonistas de ppar - delta usados para aumentar hdl- c, reducir ldl-c y reducir colesterol | |
PE20091842A1 (es) | Pirrolidinonas como activadores de glucoquinasa | |
PE20131463A1 (es) | Piperidino-dihidrotienopirimidinas sustituidas | |
UA102534C2 (en) | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]-dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid | |
PE20081630A1 (es) | Quinazolinas para la inhibicion de pdk1 | |
NO20070400L (no) | Organiske forbindelser | |
PE20121431A1 (es) | Derivados de pirimidina como inhbidores de la enzima cinasa ptk2 | |
NO20092692L (no) | MAPK/ERK kinaseinhibitorer | |
EA201001733A1 (ru) | Производные тиенопиридона в качестве активаторов амр-активированной протеинкиназы (амрк) | |
CO6341581A2 (es) | Derivados de heteroarilo como inhibidores de dgat1 | |
PE20121732A1 (es) | Derivados de ciclohexano espiro-condensado como inhibidores de hsl utiles en el tratamiento de la diabetes | |
MX2009003535A (es) | Formas cristalinas de un compuesto de tiazolidinodiona, y metodos de fabricacion de las mismas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal | ||
FG | Grant, registration |