EA201001733A1 - Производные тиенопиридона в качестве активаторов амр-активированной протеинкиназы (амрк) - Google Patents
Производные тиенопиридона в качестве активаторов амр-активированной протеинкиназы (амрк)Info
- Publication number
- EA201001733A1 EA201001733A1 EA201001733A EA201001733A EA201001733A1 EA 201001733 A1 EA201001733 A1 EA 201001733A1 EA 201001733 A EA201001733 A EA 201001733A EA 201001733 A EA201001733 A EA 201001733A EA 201001733 A1 EA201001733 A1 EA 201001733A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- thyenopyridone
- amrc
- activators
- derivatives
- activated proteinkinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
Настоящее изобретение относится к соединениям формулы (I)где R, Rи В, Вимеют значения, указанные в пункте 1, включая их фармацевтические композиции, и их применению для лечения и/или предотвращения заболеваний и нарушений, модулируемых агонистами АМР. Изобретение также относится к промежуточным соединениям и к способу получения соединений формулы (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290423 | 2008-05-05 | ||
PCT/EP2009/002606 WO2009135580A1 (en) | 2008-05-05 | 2009-04-08 | Thienopyridone derivatives as amp-activated protein kinase (ampk) activators |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201001733A1 true EA201001733A1 (ru) | 2011-06-30 |
EA020773B1 EA020773B1 (ru) | 2015-01-30 |
Family
ID=40756916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201001733A EA020773B1 (ru) | 2008-05-05 | 2009-04-08 | Производные тиенопиридона в качестве активаторов амр-активированной протеинкиназы (амрк) |
Country Status (27)
Country | Link |
---|---|
US (1) | US8604202B2 (ru) |
EP (1) | EP2280952B1 (ru) |
JP (1) | JP5536757B2 (ru) |
KR (2) | KR20160038065A (ru) |
CN (1) | CN102015676B (ru) |
AR (1) | AR071530A1 (ru) |
AU (1) | AU2009243811B2 (ru) |
BR (1) | BRPI0910832B8 (ru) |
CA (1) | CA2723429C (ru) |
CO (1) | CO6331304A2 (ru) |
CY (1) | CY1113112T1 (ru) |
DK (1) | DK2280952T3 (ru) |
EA (1) | EA020773B1 (ru) |
EC (1) | ECSP10010654A (ru) |
ES (1) | ES2388485T3 (ru) |
HK (1) | HK1156313A1 (ru) |
HR (1) | HRP20120549T1 (ru) |
IL (1) | IL208988A (ru) |
MX (1) | MX2010011916A (ru) |
MY (1) | MY160357A (ru) |
NZ (1) | NZ589690A (ru) |
PL (1) | PL2280952T3 (ru) |
PT (1) | PT2280952E (ru) |
SI (1) | SI2280952T1 (ru) |
UA (1) | UA103617C2 (ru) |
WO (1) | WO2009135580A1 (ru) |
ZA (1) | ZA201008722B (ru) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2552435A1 (en) | 2010-04-02 | 2013-02-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1) |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
CA2809492C (en) | 2010-09-01 | 2018-12-18 | Bayer Cropscience Ag | Herbicidally active ketosultams and diketopyridines |
KR101624020B1 (ko) * | 2011-03-07 | 2016-05-24 | 글락소스미스클라인 엘엘씨 | 퀴놀리논 유도체 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
EP2679591A1 (en) | 2012-06-29 | 2014-01-01 | Poxel | Thienopyridone derivatives useful as activators of AMPK |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
WO2015103480A1 (en) | 2014-01-02 | 2015-07-09 | Massachusetts Eye & Ear Infirmary | Treating ocular neovascularization |
WO2015114663A1 (en) | 2014-01-30 | 2015-08-06 | Council Of Scientific & Industrial Research | Novel thieno [2,3-d]pyrimidin-4(3h)-one compounds with antimycobacterial properties |
US10308663B2 (en) | 2015-06-16 | 2019-06-04 | University Of Virginia Patent Foundation | Inhibitors of PTP4A3 for the treatment of cancer |
LT3322711T (lt) | 2015-06-25 | 2021-05-10 | University Health Network | Hpk1 inhibitoriai ir jų panaudojimo būdai |
EP3355876A2 (en) | 2015-09-30 | 2018-08-08 | Instituto de Medicina Molecular | Methods for attenuating parasite virulence |
WO2019067442A1 (en) * | 2017-09-26 | 2019-04-04 | Ideaya Biosciences, Inc. | DIHYDROTHIENO [3,2-B] PYRIDINE COMPOUNDS |
WO2019106087A1 (en) * | 2017-11-29 | 2019-06-06 | Syddansk Universitet | Ampk inhibitors |
JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ,インク. | Ampkアクチベーター |
CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
JP2023544026A (ja) | 2020-09-30 | 2023-10-19 | バイオベラティブ セラピューティクス インコーポレイテッド | Ampk活性化因子及びその使用方法 |
WO2022106892A1 (en) | 2020-11-17 | 2022-05-27 | Instituto De Medicina Molecular | Anti-malarial compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
DE4444815A1 (de) * | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
AR040123A1 (es) * | 2002-05-31 | 2005-03-16 | Upjohn Co | Compuestos tiofeno, antihelminticos e insecticidas |
US7119205B2 (en) * | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
WO2006093518A2 (en) * | 2004-06-25 | 2006-09-08 | Apath, Llc | Thienyl compounds for treating virus-related conditions |
US7563813B2 (en) * | 2005-05-13 | 2009-07-21 | Wyeth | Iminothiazolidinone derivatives as SFRP-1 antagonists |
EP1754483A1 (en) * | 2005-08-18 | 2007-02-21 | Merck Sante | Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them |
EP1963336A1 (en) | 2005-12-20 | 2008-09-03 | Richter Gedeon NYRT | New compounds |
ES2584278T3 (es) * | 2008-04-11 | 2016-09-26 | Merck Patent Gmbh | Derivados de tienopiridona como activadores de la proteína quinasa activada por AMP (AMPK) |
-
2009
- 2009-04-08 PT PT09741799T patent/PT2280952E/pt unknown
- 2009-04-08 MY MYPI2010005160A patent/MY160357A/en unknown
- 2009-04-08 DK DK09741799.2T patent/DK2280952T3/da active
- 2009-04-08 CN CN200980116120.5A patent/CN102015676B/zh active Active
- 2009-04-08 US US12/991,028 patent/US8604202B2/en active Active
- 2009-04-08 WO PCT/EP2009/002606 patent/WO2009135580A1/en active Application Filing
- 2009-04-08 SI SI200930319T patent/SI2280952T1/sl unknown
- 2009-04-08 ES ES09741799T patent/ES2388485T3/es active Active
- 2009-04-08 MX MX2010011916A patent/MX2010011916A/es active IP Right Grant
- 2009-04-08 BR BRPI0910832A patent/BRPI0910832B8/pt active IP Right Grant
- 2009-04-08 PL PL09741799T patent/PL2280952T3/pl unknown
- 2009-04-08 CA CA2723429A patent/CA2723429C/en active Active
- 2009-04-08 EA EA201001733A patent/EA020773B1/ru not_active IP Right Cessation
- 2009-04-08 UA UAA201014384A patent/UA103617C2/ru unknown
- 2009-04-08 KR KR1020167007434A patent/KR20160038065A/ko not_active Application Discontinuation
- 2009-04-08 KR KR1020107027208A patent/KR101648593B1/ko active IP Right Grant
- 2009-04-08 EP EP09741799A patent/EP2280952B1/en active Active
- 2009-04-08 JP JP2011507805A patent/JP5536757B2/ja active Active
- 2009-04-08 AU AU2009243811A patent/AU2009243811B2/en active Active
- 2009-04-08 NZ NZ589690A patent/NZ589690A/en unknown
- 2009-04-30 AR ARP090101562A patent/AR071530A1/es active IP Right Grant
-
2010
- 2010-10-28 CO CO10134194A patent/CO6331304A2/es active IP Right Grant
- 2010-10-28 IL IL208988A patent/IL208988A/en active IP Right Grant
- 2010-12-02 EC EC2010010654A patent/ECSP10010654A/es unknown
- 2010-12-03 ZA ZA2010/08722A patent/ZA201008722B/en unknown
-
2011
- 2011-10-06 HK HK11110571.3A patent/HK1156313A1/xx unknown
-
2012
- 2012-07-05 HR HRP20120549AT patent/HRP20120549T1/hr unknown
- 2012-09-13 CY CY20121100841T patent/CY1113112T1/el unknown
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Legal Events
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ MD TM |