NO20070400L - Organiske forbindelser - Google Patents

Organiske forbindelser

Info

Publication number
NO20070400L
NO20070400L NO20070400A NO20070400A NO20070400L NO 20070400 L NO20070400 L NO 20070400L NO 20070400 A NO20070400 A NO 20070400A NO 20070400 A NO20070400 A NO 20070400A NO 20070400 L NO20070400 L NO 20070400L
Authority
NO
Norway
Prior art keywords
quinolin
organic compounds
substituted oxy
halo
hydroxyethyl
Prior art date
Application number
NO20070400A
Other languages
English (en)
Other versions
NO339079B1 (no
Inventor
Stephan Abel
Caspar Vogel
Olivier Lohse
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32799952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20070400(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20070400L publication Critical patent/NO20070400L/no
Publication of NO339079B1 publication Critical patent/NO339079B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/04—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D251/06—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En prosess for å fremstille 8-substituert oksy-5-((R)-2-halo-l-hydroksy-etyl)-(1H)-quinolin-2-on forbindelser eller akseptable oppløsninger av disse. Prosessen medfører å reagere 5-(a-haloacetyl)-8-substituert oksy-(1H)-quinolin-2-on med et reduksjonsmiddel i nærvær av et chiralt virkende middel og en base for å danne 8-(substituert oksy)-5-((R)-2-halo-l-hydroksy-etyl)-(1H)-quinolin-2-on, der det omtalte chiralt virkende middel har formel I eller II der M, L, X, R1, R2 og R3 har betydninger som indikert i spesifiseringen.
NO20070400A 2004-06-22 2007-01-22 Fremgangsmåter for fremstilling av 8-substituerte oksy-5-((R)-2-halo-1-hydroksy-etyl)-(1H)-quinolin-2-oner og 5-[(R)-2-(5,6-dietyl-indan-2-ylamino)-1-hydroksy-etyl]-8- hydroksy-(1H)-quinolin-2-on-salter NO339079B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413960.6A GB0413960D0 (en) 2004-06-22 2004-06-22 Organic compounds
PCT/EP2005/006686 WO2005123684A2 (en) 2004-06-22 2005-06-21 Enantioselektive preparation of quinoline derivative

Publications (2)

Publication Number Publication Date
NO20070400L true NO20070400L (no) 2007-03-21
NO339079B1 NO339079B1 (no) 2016-11-07

Family

ID=32799952

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070400A NO339079B1 (no) 2004-06-22 2007-01-22 Fremgangsmåter for fremstilling av 8-substituerte oksy-5-((R)-2-halo-1-hydroksy-etyl)-(1H)-quinolin-2-oner og 5-[(R)-2-(5,6-dietyl-indan-2-ylamino)-1-hydroksy-etyl]-8- hydroksy-(1H)-quinolin-2-on-salter

Country Status (33)

Country Link
US (2) US20090054653A1 (no)
EP (1) EP1791820B1 (no)
JP (1) JP5064214B2 (no)
KR (1) KR101179302B1 (no)
CN (1) CN1968927B (no)
AR (2) AR049553A1 (no)
AT (1) ATE450512T1 (no)
AU (1) AU2005254698B2 (no)
BR (1) BRPI0512298A (no)
CA (1) CA2566388C (no)
CY (1) CY1109884T1 (no)
DE (1) DE602005018076D1 (no)
DK (1) DK1791820T3 (no)
EC (1) ECSP067100A (no)
ES (1) ES2337273T3 (no)
GB (1) GB0413960D0 (no)
HK (1) HK1105121A1 (no)
HR (1) HRP20100087T1 (no)
IL (1) IL179600A (no)
MA (1) MA28687B1 (no)
MX (1) MXPA06014695A (no)
MY (1) MY142051A (no)
NO (1) NO339079B1 (no)
NZ (1) NZ551276A (no)
PE (1) PE20060304A1 (no)
PL (1) PL1791820T3 (no)
PT (1) PT1791820E (no)
RU (1) RU2383534C2 (no)
SI (1) SI1791820T1 (no)
TN (1) TNSN06408A1 (no)
TW (1) TWI347317B (no)
WO (1) WO2005123684A2 (no)
ZA (1) ZA200609257B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2654801C (en) 2006-06-30 2014-08-19 Novartis Ag Quinolinone derivatives and their pharmaceutical compositions
EP1914227A1 (en) * 2006-08-31 2008-04-23 Novartis AG Polymorphic crystal form of a indan-2-ylamino-hydroxyethyl-quinolinone maleate derivative as beta-adrenoceptor agonist
US8877930B2 (en) 2009-11-04 2014-11-04 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
WO2011109276A1 (en) 2010-03-01 2011-09-09 Massachussets Institute Of Technology Epoxidation catalysts
ES2622519T3 (es) 2010-07-14 2017-07-06 Novartis Ag Componentes heterocíclicos agonistas del receptor IP
JOP20120023B1 (ar) 2011-02-04 2022-03-14 Novartis Ag صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
EP2802583A1 (en) 2012-01-13 2014-11-19 Novartis AG Fused piperidines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
US9115129B2 (en) 2012-01-13 2015-08-25 Novartis Ag Substituted pyrido[2,3-B]pyrazines as IP receptor agonists
WO2013105066A1 (en) 2012-01-13 2013-07-18 Novartis Ag Salts of an ip receptor agonist
AR089698A1 (es) 2012-01-13 2014-09-10 Novartis Ag Compuestos heterociclicos antagonistas del receptor ip
EP2802582A1 (en) 2012-01-13 2014-11-19 Novartis AG Fused dihydropyrido [2,3 -b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
EP2802581A1 (en) 2012-01-13 2014-11-19 Novartis AG 7,8- dihydropyrido [3, 4 - b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
WO2014008640A1 (zh) * 2012-07-11 2014-01-16 上海威智医药科技有限公司 茚达特罗中间体及茚达特罗的合成方法
WO2014044288A1 (en) 2012-09-21 2014-03-27 Crystal Pharma Sa Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
EP3848354B1 (en) 2012-09-21 2022-07-27 Crystal Pharma, S.A.U. Process for the preparation of indacaterol and intermediates thereof
EA028509B1 (ru) 2012-12-19 2017-11-30 Новартис Аг Ингибиторы аутотаксина, фармацевтические композиции и комбинации, содержащие их, и их применение в лечении заболеваний и состояний, опосредованных аутотаксином
JP2016507582A (ja) 2013-02-13 2016-03-10 ノバルティス アーゲー Ｉｐ受容体アゴニスト複素環式化合物
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
BR112015020443A8 (pt) 2013-03-14 2019-11-12 Novartis Ag formulação em pó para inalação, seus usos e seu processo de preparação, e composição farmacêutica
CZ306252B6 (cs) 2013-03-15 2016-10-26 Zentiva, K.S. Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)
ES2626829T3 (es) 2013-03-27 2017-07-26 Laboratorios Lesvi, S.L. Procedimiento para la fabricación de (R)-5[2-(5,6-dietil-indan-2-ilamino)-1-hidroxietil]-8-hidroxi-(1H)-quinolin-2-ona
WO2015008229A1 (en) 2013-07-18 2015-01-22 Novartis Ag Autotaxin inhibitors
WO2015008230A1 (en) 2013-07-18 2015-01-22 Novartis Ag Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core
PL3092217T3 (pl) 2014-01-09 2020-11-16 Davuluri, Ramamohan Rao Nowy sposób wytwarzania indakaterolu lub jego farmaceutycznie dopuszczalnych soli
RU2016141948A (ru) 2014-03-27 2018-04-27 Новартис Аг Высушенные распылением дисперсии твердое-в-масле-в-воде активных фармацевтических ингредиентов для ингаляции
WO2015162558A1 (en) 2014-04-24 2015-10-29 Novartis Ag Autotaxin inhibitors
CN105693603B (zh) * 2014-11-24 2019-11-29 上海医药工业研究院 改良的马来酸茚达特罗制备工艺
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법
WO2017055506A1 (en) 2015-09-29 2017-04-06 Laboratorios Lesvi, S.L. Mixed solvate of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl] -8-hydroxy-1h-quinolin-2-one l-tartrate
CN107394260B (zh) 2016-05-17 2020-06-09 财团法人工业技术研究院 金属离子电池
CN107868045A (zh) * 2016-09-28 2018-04-03 四川海思科制药有限公司 一种茚达特罗中间体的制备方法
CN113731406B (zh) * 2021-10-12 2023-07-28 南京工业大学 一种提高钯碳活性加氢脱除保护基的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405019D0 (en) * 1994-03-15 1994-04-27 Smithkline Beecham Plc Novel compounds
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
TWI324150B (en) * 2003-02-28 2010-05-01 Novartis Ag Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
TWI324151B (en) * 2003-04-02 2010-05-01 Novartis Ag Process for the preparation of 5-(haloacetyl)-8-substituted oxy-(1h)-quinolin-2-ones

Also Published As

Publication number Publication date
PT1791820E (pt) 2010-02-23
ATE450512T1 (de) 2009-12-15
WO2005123684A2 (en) 2005-12-29
DK1791820T3 (da) 2010-04-06
IL179600A0 (en) 2007-05-15
IL179600A (en) 2011-11-30
KR20070029752A (ko) 2007-03-14
EP1791820A2 (en) 2007-06-06
TWI347317B (en) 2011-08-21
PE20060304A1 (es) 2006-05-19
CN1968927A (zh) 2007-05-23
US20090054653A1 (en) 2009-02-26
BRPI0512298A (pt) 2008-03-25
MXPA06014695A (es) 2007-02-12
DE602005018076D1 (de) 2010-01-14
TW200615265A (en) 2006-05-16
KR101179302B1 (ko) 2012-09-03
RU2383534C2 (ru) 2010-03-10
GB0413960D0 (en) 2004-07-28
EP1791820B1 (en) 2009-12-02
ZA200609257B (en) 2008-07-30
SI1791820T1 (sl) 2010-04-30
AR082981A2 (es) 2013-01-23
ES2337273T3 (es) 2010-04-22
RU2007102228A (ru) 2008-07-27
JP2008503526A (ja) 2008-02-07
MA28687B1 (fr) 2007-06-01
PL1791820T3 (pl) 2010-05-31
TNSN06408A1 (en) 2008-02-22
WO2005123684A3 (en) 2006-06-01
NO339079B1 (no) 2016-11-07
AR049553A1 (es) 2006-08-16
JP5064214B2 (ja) 2012-10-31
AU2005254698B2 (en) 2008-09-25
CY1109884T1 (el) 2014-09-10
HRP20100087T1 (hr) 2010-06-30
HK1105121A1 (en) 2008-02-01
MY142051A (en) 2010-08-30
CA2566388A1 (en) 2005-12-29
AU2005254698A1 (en) 2005-12-29
US20120220775A1 (en) 2012-08-30
CA2566388C (en) 2013-04-16
NZ551276A (en) 2010-06-25
ECSP067100A (es) 2007-01-26
CN1968927B (zh) 2010-07-21

Similar Documents

Publication Publication Date Title
NO20070400L (no) Organiske forbindelser
NO20075626L (no) Heteroarylbenzamid-derivater for anvendelse som GLK-aktivatorer i behandling av diabetes
NO20076658L (no) Heteroarylbenzamidderivater for anvendelse som GLK aktivatorer ved behandling av diabetes
TW200728277A (en) Bicyclic derivatives as P38 inhibitors
TW200618800A (en) Heterocyclic compounds
RS54260B1 (en) AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
WO2005103037A3 (de) Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
WO2008116107A3 (en) Piperazine derivatives as glucokinase activators
WO2007023110A3 (en) P38 map kinase inhibitors and methods for using the same
NO20081003L (no) 2-Aminopyrimidinderivater som modulatorer av histamin-H4-reseptoraktivitet
TN2010000131A1 (en) Polo-like kinase inhibitors
NO20070089L (no) DPP-IV inhibitorer
GB0412769D0 (en) Organic compounds
WO2007000340A8 (en) Bicyclic derivatives as p38 kinase inhibitors
WO2007020261A3 (de) Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
NO20072753L (no) 3-Etylidenhydrazinosubstituerte heterocykliske forbindelser som trombopoietinreseptoraktivatorer
NO20075734L (no) Tiofenforbindelser og trombopoietin reseptoractivatorer
UA101963C2 (en) 4-amino-pyrimidine derivatives
NO20091817L (no) Kinase inhibitorer
TW200634013A (en) Quinoline derivative, its use, production and pharmaceutical agents containing the derivative
RS54413B1 (en) [4- (5-AMINOMETHYL-2-FLUORO-PHENYL) -PIPERIDIN-1-IL] - [7-FLUORO-1- (2-METHOXY-ETHYL) -4TRIFLUOROMETOXY-1H-INDOL-3-IL] METHANONE AS INHIBITOR MASTOCYT TRIPTASES
PE20120424A1 (es) Compuestos de quinazolina sustituidos
MX2010009276A (es) Pirrolopirimidincarboxamidas.
WO2008104473A3 (en) Pyrazolopyriidine derivatives and their use as kinase inhibitors
WO2009034029A3 (de) 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten