WO2009034029A3 - 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten - Google Patents

1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten Download PDF

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Publication number
WO2009034029A3
WO2009034029A3 PCT/EP2008/061771 EP2008061771W WO2009034029A3 WO 2009034029 A3 WO2009034029 A3 WO 2009034029A3 EP 2008061771 W EP2008061771 W EP 2008061771W WO 2009034029 A3 WO2009034029 A3 WO 2009034029A3
Authority
WO
WIPO (PCT)
Prior art keywords
heterocyclylpiperidines
cgrp antagonists
substituted
salts
hydrates
Prior art date
Application number
PCT/EP2008/061771
Other languages
English (en)
French (fr)
Other versions
WO2009034029A2 (de
Inventor
Dirk Gottschling
Georg Dahmann
Henri Doods
Alexander Dreyer
Annekatrin Heimann
Stephan Georg Mueller
Klaus Rudolf
Gerhard Schaenzle
Dirk Stenkamp
Original Assignee
Boehringer Ingelheim Int
Dirk Gottschling
Georg Dahmann
Henri Doods
Alexander Dreyer
Annekatrin Heimann
Stephan Georg Mueller
Klaus Rudolf
Gerhard Schaenzle
Dirk Stenkamp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int, Dirk Gottschling, Georg Dahmann, Henri Doods, Alexander Dreyer, Annekatrin Heimann, Stephan Georg Mueller, Klaus Rudolf, Gerhard Schaenzle, Dirk Stenkamp filed Critical Boehringer Ingelheim Int
Publication of WO2009034029A2 publication Critical patent/WO2009034029A2/de
Publication of WO2009034029A3 publication Critical patent/WO2009034029A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Gegenstand der vorliegenden Erfindung sind neue CGRP-Antagonisten der allgemeinen Formel (I), in der A, X, R1, R2 und R3 wie in der Beschreibung erwähnt definiert sind, deren Tautomere, deren Isomere, deren Diastereomere, deren Enantiomere, deren Hydrate, deren Gemische und deren Salze sowie die Hydrate der Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren oder Basen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung.
PCT/EP2008/061771 2007-09-07 2008-09-05 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten WO2009034029A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07115904 2007-09-07
EP07115904.0 2007-09-07

Publications (2)

Publication Number Publication Date
WO2009034029A2 WO2009034029A2 (de) 2009-03-19
WO2009034029A3 true WO2009034029A3 (de) 2009-07-09

Family

ID=39205275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061771 WO2009034029A2 (de) 2007-09-07 2008-09-05 1-substituierte 4 -heterocyclylpiperidine als cgrp antagonisten

Country Status (1)

Country Link
WO (1) WO2009034029A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0817835A2 (pt) 2007-10-18 2015-03-31 Boehringer Ingelheim Int Antagonistas cgrp
EP2065381A1 (de) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP Antagonisten
JP5385297B2 (ja) 2007-11-22 2014-01-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物
SG11201406311UA (en) * 2012-04-05 2014-11-27 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
EP3049389B1 (de) * 2013-09-26 2019-08-07 CHDI Foundation, Inc. Kynurenin-3-monooxygenase-hemmer, pharmazeutische zusammensetzungen und verfahren zur verwendung davon
JP2016536350A (ja) 2013-09-26 2016-11-24 シーエイチディーアイ ファウンデーション，インコーポレーテッド キヌレニン−３−モノオキシゲナーゼ阻害薬、医薬組成物、及びこれらの使用方法
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
CN112624979A (zh) * 2019-10-09 2021-04-09 浙江瑞博制药有限公司 一种苯并咪唑化合物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2065426A1 (de) * 1969-10-27 1973-07-19 Sumitomo Chemical Co Phenylbutanol-derivate, ihre salze, verfahren zu ihrer herstellung und die verbindungen enthaltende arzneimittel
US4455422A (en) * 1980-03-06 1984-06-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and pharmaceutical composition containing the same
WO2001032649A1 (de) * 1999-10-29 2001-05-10 Boehringer Ingelheim Pharma Kg Arylalkane, arylalkene und aryl-azaalkane, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO2001032648A1 (de) * 1999-10-29 2001-05-10 Boehringer Ingelheim Pharma Kg Neue cyclopropane als cgrp-antagonisten, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2065426A1 (de) * 1969-10-27 1973-07-19 Sumitomo Chemical Co Phenylbutanol-derivate, ihre salze, verfahren zu ihrer herstellung und die verbindungen enthaltende arzneimittel
US4455422A (en) * 1980-03-06 1984-06-19 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and pharmaceutical composition containing the same
WO2001032649A1 (de) * 1999-10-29 2001-05-10 Boehringer Ingelheim Pharma Kg Arylalkane, arylalkene und aryl-azaalkane, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO2001032648A1 (de) * 1999-10-29 2001-05-10 Boehringer Ingelheim Pharma Kg Neue cyclopropane als cgrp-antagonisten, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
WO2009034029A2 (de) 2009-03-19

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