BR112015020443A8 - formulação em pó para inalação, seus usos e seu processo de preparação, e composição farmacêutica - Google Patents
formulação em pó para inalação, seus usos e seu processo de preparação, e composição farmacêutica Download PDFInfo
- Publication number
- BR112015020443A8 BR112015020443A8 BR112015020443A BR112015020443A BR112015020443A8 BR 112015020443 A8 BR112015020443 A8 BR 112015020443A8 BR 112015020443 A BR112015020443 A BR 112015020443A BR 112015020443 A BR112015020443 A BR 112015020443A BR 112015020443 A8 BR112015020443 A8 BR 112015020443A8
- Authority
- BR
- Brazil
- Prior art keywords
- spray dried
- dried powder
- active ingredient
- spray
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo patente de invenção: "desamorfização de formulações secadas por atomização via mistura por atomização". a presente invenção refere-se a formulações de pó seco para inalação e seu uso no tratamento de doenças e condições. a formulação contém uma mistura uniforme de um primeiro pó secado por atomização e um segundo pó secado por atomização. o primeiro pó secado por atomização contém partículas secadas por atomização de um ingrediente terapeuticamente ativo disperso num excipiente hidrofóbico farmaceuticamente aceitável. o segundo pó secado por atomização contém partículas secadas por atomização formadas a partir de um excipiente hidrófobo farmaceuticamente aceitável, mas são substancialmente livres de qualquer ingrediente terapeuticamente ativo. o ingrediente ativo no primeiro pó secado por atomização é carregado sob carga suficientemente elevada para compensar o segundo pó secado por atomização que é substancialmente isento de qualquer ingrediente ativo. um processo para a preparação de tais formulações é também descrito.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361784865P | 2013-03-14 | 2013-03-14 | |
PCT/IB2014/059632 WO2014141069A1 (en) | 2013-03-14 | 2014-03-11 | Deamorphization of spray-dried formulations via spray-blending |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015020443A2 BR112015020443A2 (pt) | 2017-07-18 |
BR112015020443A8 true BR112015020443A8 (pt) | 2019-11-12 |
Family
ID=50391236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015020443A BR112015020443A8 (pt) | 2013-03-14 | 2014-03-11 | formulação em pó para inalação, seus usos e seu processo de preparação, e composição farmacêutica |
Country Status (11)
Country | Link |
---|---|
US (1) | US20150374623A1 (pt) |
EP (1) | EP2968110A1 (pt) |
JP (1) | JP6232079B2 (pt) |
KR (1) | KR102074543B1 (pt) |
CN (1) | CN105209013B (pt) |
AU (1) | AU2014229361B2 (pt) |
BR (1) | BR112015020443A8 (pt) |
CA (1) | CA2898700C (pt) |
MX (1) | MX2015012529A (pt) |
RU (1) | RU2698331C2 (pt) |
WO (1) | WO2014141069A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016142708A2 (en) | 2015-03-10 | 2016-09-15 | Cipla Limited | Pharmaceutical composition |
US20220296521A1 (en) | 2019-06-10 | 2022-09-22 | Respira Therapeutics, Inc. | Carrier-based formulations and related methods |
KR102330428B1 (ko) * | 2019-10-14 | 2021-11-24 | 한미약품 주식회사 | 흡입 제형용 건조 분말 및 이의 제조방법 |
CN114344285B (zh) * | 2020-10-14 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 改良的可吸入团聚物 |
Family Cites Families (38)
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US2956062A (en) | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
IT1016489B (it) | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
DE3260474D1 (en) | 1981-02-02 | 1984-09-06 | Schering Corp | Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
HU214602B (hu) | 1991-06-26 | 1998-04-28 | Schering Corp. | Inhalálókészülék por alakú gyógyszerekhez |
UA27961C2 (uk) | 1992-12-18 | 2000-10-16 | Шерінг Корпорейшн | Інгалятор для порошкових ліків |
US5837699A (en) | 1994-01-27 | 1998-11-17 | Schering Corporation | Use of mometasone furoate for treating upper airway passage diseases |
ES2302332T3 (es) | 1994-09-21 | 2008-07-01 | Nektar Therapeutics | Aparato y metodos para dispersar medicamentos en polvo seco. |
PL327616A1 (en) | 1996-01-03 | 1998-12-21 | Glaxo Group Ltd | Inhaler |
SK287878B6 (sk) | 1996-02-21 | 2012-02-03 | Schering Corporation | Powdered medication inhaler |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
HU228273B1 (en) | 1996-11-11 | 2013-02-28 | Meda Pharma Gmbh & Co Kg | Pure enantiomer basic aryl-cycloalkyl-hydroxycarboxylic acid esters,process for preparing the same and their use in medicaments |
US6613795B2 (en) | 1996-11-11 | 2003-09-02 | Christian Noe | Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments |
US6010935A (en) | 1997-08-21 | 2000-01-04 | Micron Technology, Inc. | Self aligned contacts |
US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
UA73924C2 (en) | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
ATE331544T1 (de) | 1999-05-28 | 2006-07-15 | Nektar Therapeutics | Gerät und verfahren zur aerosolisierung einer pharmazeutischen pulverzusammensetzung |
US6858199B1 (en) * | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
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US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
AU2002342241B2 (en) * | 2001-11-01 | 2007-07-19 | Novartis Ag | Spray drying methods and compositions thereof |
CN1642533A (zh) * | 2002-03-18 | 2005-07-20 | 山之内制药株式会社 | 吸入用粉末医药组合物及其制备方法 |
JP2005520843A (ja) * | 2002-03-20 | 2005-07-14 | アドバンスト インハレーション リサーチ,インコーポレイテッド | 呼吸用持続性治療製剤 |
ES2391174T3 (es) | 2002-06-27 | 2012-11-22 | Novartis Ag | Dispositivo y método para controlar el flujo de un polvo |
SI1610850T2 (sl) | 2003-04-09 | 2020-11-30 | Novartis Ag | Naprava za aerosolizacijo s ščitom za vstopni zrak |
GB0317374D0 (en) | 2003-07-24 | 2003-08-27 | Glaxo Group Ltd | Medicament dispenser |
GB2407042B (en) | 2003-10-17 | 2007-10-24 | Vectura Ltd | Inhaler |
RU2379062C2 (ru) | 2004-02-24 | 2010-01-20 | Майкродоуз Терапьютикс, Инк. | Способ и устройство для доставки медикамента на основе синтезирующей струи |
GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
GB0413960D0 (en) | 2004-06-22 | 2004-07-28 | Novartis Ag | Organic compounds |
RU2403059C2 (ru) * | 2006-02-22 | 2010-11-10 | Маннкайнд Корпорейшн | Способ улучшения фармацевтических свойств микрочастиц, содержащих дикетопиперазин и активный агент |
EP2044025B1 (en) | 2006-06-30 | 2012-10-03 | Novartis AG | Quinolinone derivatives and their pharmaceutical compositions |
ES2596263T3 (es) | 2006-10-25 | 2017-01-05 | Novartis Ag | Aparato de dispersión de polvo |
BRPI1011229B8 (pt) * | 2009-05-29 | 2021-05-25 | Pearl Therapeutics Inc | co-suspensão dispensável a partir de um inalador de dose medida compreendendo propelente, partículas de agente ativo e partículas em suspensão |
JOP20120023B1 (ar) * | 2011-02-04 | 2022-03-14 | Novartis Ag | صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية |
-
2014
- 2014-03-11 CN CN201480014917.5A patent/CN105209013B/zh active Active
- 2014-03-11 CA CA2898700A patent/CA2898700C/en active Active
- 2014-03-11 BR BR112015020443A patent/BR112015020443A8/pt active Search and Examination
- 2014-03-11 JP JP2015562483A patent/JP6232079B2/ja active Active
- 2014-03-11 WO PCT/IB2014/059632 patent/WO2014141069A1/en active Application Filing
- 2014-03-11 KR KR1020157024622A patent/KR102074543B1/ko active IP Right Grant
- 2014-03-11 RU RU2015143927A patent/RU2698331C2/ru active
- 2014-03-11 AU AU2014229361A patent/AU2014229361B2/en active Active
- 2014-03-11 EP EP14713918.2A patent/EP2968110A1/en not_active Withdrawn
- 2014-03-11 MX MX2015012529A patent/MX2015012529A/es unknown
- 2014-03-11 US US14/768,257 patent/US20150374623A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20150119087A (ko) | 2015-10-23 |
US20150374623A1 (en) | 2015-12-31 |
CN105209013A (zh) | 2015-12-30 |
MX2015012529A (es) | 2016-07-05 |
BR112015020443A2 (pt) | 2017-07-18 |
AU2014229361A1 (en) | 2015-08-13 |
CA2898700C (en) | 2022-07-19 |
AU2014229361B2 (en) | 2016-08-04 |
WO2014141069A1 (en) | 2014-09-18 |
KR102074543B1 (ko) | 2020-02-06 |
CA2898700A1 (en) | 2014-09-18 |
EP2968110A1 (en) | 2016-01-20 |
CN105209013B (zh) | 2019-04-26 |
RU2698331C2 (ru) | 2019-08-26 |
JP6232079B2 (ja) | 2017-11-15 |
RU2015143927A (ru) | 2017-04-20 |
JP2016512224A (ja) | 2016-04-25 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |