BR112015021814A2 - aglomerados respiráveis de partículas carreadoras porosas e fármaco micronizado - Google Patents

aglomerados respiráveis de partículas carreadoras porosas e fármaco micronizado

Info

Publication number
BR112015021814A2
BR112015021814A2 BR112015021814A BR112015021814A BR112015021814A2 BR 112015021814 A2 BR112015021814 A2 BR 112015021814A2 BR 112015021814 A BR112015021814 A BR 112015021814A BR 112015021814 A BR112015021814 A BR 112015021814A BR 112015021814 A2 BR112015021814 A2 BR 112015021814A2
Authority
BR
Brazil
Prior art keywords
agglomerates
breathable
porous carrier
carrier particles
micronized drug
Prior art date
Application number
BR112015021814A
Other languages
English (en)
Inventor
Weers Jeffry
Hartman Michael
Teung Patrick
Tarara Thomas
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112015021814A2 publication Critical patent/BR112015021814A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

resumo patente de invenção: "aglomerados respiráveis de partículas carreadoras porosas e fármaco micronizado". a presente invenção refere-se a uma composição farmacêutica para a administração pulmonar, que é pó seco, que contém partículas carreadoras porosas e partículas do agente ativo. as partículas carreadoras porosas e as partículas do agente ativo formam uma mistura ordenada dos aglomerados respiráveis que são úteis para tratar doenças pulmonares. as partículas do agente ativo podem incluir um, dois, três ou mais ingredientes ativos. também é descrito um processo de secagem por atomização para preparar os aglomerados respiráveis.
BR112015021814A 2013-03-14 2014-03-13 aglomerados respiráveis de partículas carreadoras porosas e fármaco micronizado BR112015021814A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784842P 2013-03-14 2013-03-14
PCT/IB2014/059739 WO2014141135A1 (en) 2013-03-14 2014-03-13 Respirable agglomerates of porous carrier particles and micronized drug

Publications (1)

Publication Number Publication Date
BR112015021814A2 true BR112015021814A2 (pt) 2017-07-18

Family

ID=50478894

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015021814A BR112015021814A2 (pt) 2013-03-14 2014-03-13 aglomerados respiráveis de partículas carreadoras porosas e fármaco micronizado

Country Status (22)

Country Link
US (2) US9452139B2 (pt)
EP (1) EP2968570A1 (pt)
JP (1) JP6374414B2 (pt)
KR (1) KR20150129716A (pt)
CN (1) CN105188757B (pt)
AU (2) AU2014229265A1 (pt)
BR (1) BR112015021814A2 (pt)
CA (1) CA2905615A1 (pt)
CL (1) CL2015002632A1 (pt)
EA (1) EA201591729A1 (pt)
GT (1) GT201500295A (pt)
HK (1) HK1212616A1 (pt)
IL (1) IL240963A (pt)
MA (1) MA38397A1 (pt)
MX (1) MX2015012814A (pt)
PE (1) PE20151655A1 (pt)
PH (1) PH12015501882A1 (pt)
SA (1) SA515361055B1 (pt)
SG (1) SG11201506397QA (pt)
TN (1) TN2015000395A1 (pt)
WO (1) WO2014141135A1 (pt)
ZA (1) ZA201505768B (pt)

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Also Published As

Publication number Publication date
SG11201506397QA (en) 2015-09-29
JP2016512494A (ja) 2016-04-28
GT201500295A (es) 2017-09-28
AU2017203258B2 (en) 2019-06-20
US9744178B2 (en) 2017-08-29
US20160354388A1 (en) 2016-12-08
US9452139B2 (en) 2016-09-27
AU2017203258A1 (en) 2017-06-08
AU2014229265A1 (en) 2015-09-03
MX2015012814A (es) 2016-02-03
PE20151655A1 (es) 2015-11-26
US20140302147A1 (en) 2014-10-09
EA201591729A1 (ru) 2016-05-31
CA2905615A1 (en) 2014-09-18
HK1212616A1 (zh) 2016-06-17
ZA201505768B (en) 2017-03-29
JP6374414B2 (ja) 2018-08-15
CN105188757B (zh) 2019-04-30
TN2015000395A1 (en) 2017-01-03
SA515361055B1 (ar) 2016-11-13
PH12015501882A1 (en) 2015-12-07
KR20150129716A (ko) 2015-11-20
MA38397A1 (fr) 2018-01-31
IL240963A0 (en) 2015-11-30
CL2015002632A1 (es) 2016-03-28
EP2968570A1 (en) 2016-01-20
CN105188757A (zh) 2015-12-23
WO2014141135A1 (en) 2014-09-18
IL240963A (en) 2017-05-29

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2505 DE 08-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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